JP2018503679A5 - - Google Patents
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- JP2018503679A5 JP2018503679A5 JP2017545878A JP2017545878A JP2018503679A5 JP 2018503679 A5 JP2018503679 A5 JP 2018503679A5 JP 2017545878 A JP2017545878 A JP 2017545878A JP 2017545878 A JP2017545878 A JP 2017545878A JP 2018503679 A5 JP2018503679 A5 JP 2018503679A5
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- Prior art keywords
- protein
- radiolabeled
- based probe
- group
- radiolabeled protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000018102 proteins Nutrition 0.000 claims 30
- 102000004169 proteins and genes Human genes 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 30
- 239000000523 sample Substances 0.000 claims 24
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- ZUHQCDZJPTXVCU-UHFFFAOYSA-N C1#CCCC2=CC=CC=C2C2=CC=CC=C21 Chemical compound C1#CCCC2=CC=CC=C2C2=CC=CC=C21 ZUHQCDZJPTXVCU-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- ZPWOOKQUDFIEIX-UHFFFAOYSA-N cyclooctyne Chemical compound C1CCCC#CCC1 ZPWOOKQUDFIEIX-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- ZJJAWGLRWHRNGC-UHFFFAOYSA-N 1,2-dimethoxy-1-azacyclooct-7-yne Chemical compound COC1CCCCC#CN1OC ZJJAWGLRWHRNGC-UHFFFAOYSA-N 0.000 claims 2
- 206010061818 Disease progression Diseases 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 230000005750 disease progression Effects 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- VVFZXPZWVJMYPX-UHFFFAOYSA-N dbco-peg4--maleimide Chemical compound C1C2=CC=CC=C2C#CC2=CC=CC=C2N1C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O VVFZXPZWVJMYPX-UHFFFAOYSA-N 0.000 claims 1
- LKSAMQQFMTVPKD-UHFFFAOYSA-N dbco-peg4-acid Chemical compound OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N1CC2=CC=CC=C2C#CC2=CC=CC=C12 LKSAMQQFMTVPKD-UHFFFAOYSA-N 0.000 claims 1
- KTIOBJVNCOFWCL-UHFFFAOYSA-N dbco-peg4-amine Chemical compound NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC2=CC=CC=C12 KTIOBJVNCOFWCL-UHFFFAOYSA-N 0.000 claims 1
- RRCXYKNJTKJNTD-UHFFFAOYSA-N dbco-peg4-nhs ester Chemical compound C1C2=CC=CC=C2C#CC2=CC=CC=C2N1C(=O)CCC(=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O RRCXYKNJTKJNTD-UHFFFAOYSA-N 0.000 claims 1
- QXKHPYSXPCJSPR-UHFFFAOYSA-M dbco-sulfo-nhs ester Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCC(=O)N1C2=CC=CC=C2C#CC2=CC=CC=C2C1 QXKHPYSXPCJSPR-UHFFFAOYSA-M 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084366P | 2014-11-25 | 2014-11-25 | |
| US62/084,366 | 2014-11-25 | ||
| PCT/US2015/062502 WO2016086036A2 (en) | 2014-11-25 | 2015-11-24 | Methods and compositions for 18f-radiolabeling of biologics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081102A Division JP7027480B2 (ja) | 2014-11-25 | 2020-05-01 | 生物学的製剤の１８ｆ－放射性標識方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503679A JP2018503679A (ja) | 2018-02-08 |
| JP2018503679A5 true JP2018503679A5 (enExample) | 2018-12-20 |
| JP6701217B2 JP6701217B2 (ja) | 2020-05-27 |
Family
ID=54834953
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545878A Active JP6701217B2 (ja) | 2014-11-25 | 2015-11-24 | 生物学的製剤の１８ｆ−放射性標識方法および組成物 |
| JP2020081102A Active JP7027480B2 (ja) | 2014-11-25 | 2020-05-01 | 生物学的製剤の１８ｆ－放射性標識方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081102A Active JP7027480B2 (ja) | 2014-11-25 | 2020-05-01 | 生物学的製剤の１８ｆ－放射性標識方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11229713B2 (enExample) |
| EP (2) | EP3223866B1 (enExample) |
| JP (2) | JP6701217B2 (enExample) |
| CN (1) | CN107207379B (enExample) |
| CA (1) | CA2968961A1 (enExample) |
| EA (1) | EA034516B1 (enExample) |
| ES (1) | ES2941895T3 (enExample) |
| MX (1) | MX385081B (enExample) |
| WO (1) | WO2016086036A2 (enExample) |
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| ES2644022T3 (es) * | 2013-03-14 | 2017-11-27 | Bristol-Myers Squibb Company | Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| MX2018014028A (es) | 2016-05-19 | 2019-04-04 | Squibb Bristol Myers Co | Inmunomoduladores de produccion de imagenes de tomografia por emision de positrones (pet). |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| KR102397783B1 (ko) * | 2016-06-01 | 2022-05-12 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-l1 결합 폴리펩티드에 의한 pet 영상화 |
| WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| WO2018111976A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Pd-l1 binding fibronectin type iii domains |
| JP7104703B2 (ja) * | 2016-12-14 | 2022-07-21 | ヤンセン バイオテツク，インコーポレーテツド | Ｃｄ８ａ結合フィブロネクチンｉｉｉ型ドメイン |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| WO2018237153A1 (en) | 2017-06-23 | 2018-12-27 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of pd-1 |
| JP7257393B2 (ja) | 2017-10-03 | 2023-04-13 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| EP3758742A1 (en) | 2018-03-01 | 2021-01-06 | Vrije Universiteit Brussel | Human pd-l1-binding immunoglobulins |
| US11766243B2 (en) * | 2018-03-13 | 2023-09-26 | Trust Bio-Sonics, Inc. | Composition and methods for sensitive molecular analysis |
| CN108680637A (zh) * | 2018-05-15 | 2018-10-19 | 苏州大学 | 基于马来酰亚胺衍生物组合的非同位素双标记方法 |
| CN109239758B (zh) * | 2018-07-27 | 2022-08-12 | 国家海洋局南海环境监测中心（中国海监南海区检验鉴定中心） | 一种生物样品中伽马能谱核素检测分析方法 |
| CN109350751B (zh) * | 2018-09-05 | 2021-08-31 | 南方医科大学南方医院 | 一种靶向egfr的多肽类pet显像剂及其制备方法和应用 |
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| EP4045061A4 (en) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | FIBRONECTIN TYPE III DOMAINS BINDING TO CD137 |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| JP2023510737A (ja) | 2020-01-06 | 2023-03-15 | ブリストル－マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| CN116568341A (zh) | 2020-02-28 | 2023-08-08 | 百时美施贵宝公司 | 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途 |
| CN115362166A (zh) | 2020-03-30 | 2022-11-18 | 百时美施贵宝公司 | 免疫调节剂 |
| CN111856546B (zh) * | 2020-06-23 | 2022-07-29 | 中国辐射防护研究院 | 一种关于海洋生物灰中Cs-137放化分析的制样方法 |
| BR112023021318A2 (pt) | 2021-04-14 | 2023-12-19 | Aro Biotherapeutics Company | Conjugados de domínio fn3-sirna e usos dos mesmos |
| JP2024517610A (ja) | 2021-04-14 | 2024-04-23 | アロ・バイオセラピューティクス・カンパニー | Ｃｄ７１に結合するフィブロネクチンｉｉｉ型ドメイン |
| GB202108605D0 (en) * | 2021-06-16 | 2021-07-28 | Ge Healthcare Uk Ltd | Effect of water content |
| US20250135047A1 (en) * | 2021-08-06 | 2025-05-01 | The Johns Hopkins University | Improved aluminum fluoride radiosynthesis of [18f]dk222 |
| CN116036318A (zh) * | 2022-12-08 | 2023-05-02 | 河南省肿瘤医院 | 一种靶向pd-l1的spect分子影像探针及其制备方法与应用 |
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| EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
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