|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US5672502A
(en)
|
1985-06-28 |
1997-09-30 |
Celltech Therapeutics Limited |
Animal cell culture
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US6048728A
(en)
|
1988-09-23 |
2000-04-11 |
Chiron Corporation |
Cell culture medium for enhanced cell growth, culture longevity, and product expression
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
ATE139900T1
(de)
|
1992-11-13 |
1996-07-15 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
JPH08507549A
(ja)
|
1993-12-27 |
1996-08-13 |
バクスター、インターナショナル、インコーポレイテッド |
水溶性の非免疫原性ポリアミド架橋剤
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
JPH11513391A
(ja)
|
1995-10-03 |
1999-11-16 |
ザ スクリップス リサーチ インスティテュート |
Ｃｃ−１０６５ 及びズオカーマイシンのｃｂｉ 類縁体
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
IL131016A
(en)
|
1997-01-21 |
2004-12-15 |
Gen Hospital Corp |
Selection of proteins using RNA-protein blends
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
JP4118462B2
(ja)
|
1999-07-19 |
2008-07-16 |
株式会社リコー |
携帯電子機器
|
|
EP1074563A1
(en)
|
1999-08-02 |
2001-02-07 |
F. Hoffmann-La Roche Ag |
Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
JP2003528632A
(ja)
|
2000-03-31 |
2003-09-30 |
インスティティ・パスツール |
血管内皮成長因子（ｖｅｇｆ）−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法
|
|
US7556925B2
(en)
|
2001-04-04 |
2009-07-07 |
University Of Rochester |
ανβ3 integrin-binding polypeptide monobodies and their use
|
|
KR20030033007A
(ko)
|
2001-05-31 |
2003-04-26 |
코울터 파머수티컬, 인코포레이티드 |
세포독소, 약물전구체, 링커 및 이에 유용한 안정화제
|
|
US7180074B1
(en)
|
2001-06-27 |
2007-02-20 |
Crosetto Dario B |
Method and apparatus for whole-body, three-dimensional, dynamic PET/CT examination
|
|
CA2488753A1
(en)
|
2002-06-07 |
2003-12-18 |
Immunomedics, Inc. |
Neutrophil imaging methods in cyctic fibrosis
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
NZ540194A
(en)
|
2002-11-08 |
2008-07-31 |
Ablynx Nv |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
KR20060080535A
(ko)
|
2003-05-14 |
2006-07-10 |
이뮤노젠 아이엔씨 |
약물 콘쥬게이트 조성물
|
|
ES2605443T3
(es)
|
2003-11-06 |
2017-03-14 |
Seattle Genetics, Inc. |
Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
|
|
BRPI0417302A
(pt)
|
2003-12-05 |
2007-03-06 |
Compound Therapeutics Inc |
inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
|
|
CN102816241B
(zh)
|
2004-02-09 |
2015-07-22 |
人类基因科学公司 |
清蛋白融合蛋白
|
|
US7778814B2
(en)
|
2004-03-30 |
2010-08-17 |
Siemens Aktiengesellschaft |
Method and device for simulating an automation system
|
|
BRPI0510909A2
(pt)
|
2004-05-19 |
2008-12-16 |
Medarex Inc |
composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
EA016577B1
(ru)
|
2005-09-26 |
2012-06-29 |
Медарекс, Инк. |
Конъюгаты антитело-лекарство и их применение
|
|
WO2007038868A2
(en)
|
2005-10-03 |
2007-04-12 |
The University Of British Columbia |
Novel enediyne compound and uses thereof
|
|
BRPI0619331A2
(pt)
|
2005-10-26 |
2011-09-27 |
Medarex Inc |
método para fazer um composto para preparar um análogo de cbi cc-1065, método para preparar um análogo de cbi cc-1065 e composto
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
AR062448A1
(es)
|
2006-05-25 |
2008-11-12 |
Endocyte Inc |
Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos
|
|
PE20080316A1
(es)
|
2006-05-25 |
2008-04-10 |
Bristol Myers Squibb Co |
Compuestos de aziridinil-epotilona
|
|
AU2007325838B2
(en)
|
2006-11-22 |
2013-09-19 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
|
|
EP2111237B1
(en)
|
2006-12-11 |
2015-03-18 |
BRACCO IMAGING S.p.A. |
Fibrin-binding peptides and conjugates thereof
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
JP2010519310A
(ja)
|
2007-02-21 |
2010-06-03 |
メダレックス インコーポレイテッド |
単一のアミノ酸を有する化学リンカーおよびその複合体
|
|
US20090028786A1
(en)
|
2007-07-23 |
2009-01-29 |
Rcp Diagnostics, Llc |
Methods and apparatus for imaging agents for disease detection
|
|
EP2036576A1
(en)
|
2007-09-17 |
2009-03-18 |
Bayer Schering Pharma Aktiengesellschaft |
ED-B fibronectin as stratification marker for antitumor drugs
|
|
CN101918027A
(zh)
|
2007-11-02 |
2010-12-15 |
森托科尔奥索生物科技公司 |
半合成GLP-1肽-Fc融合构造、方法及其用途
|
|
EP2072525A1
(en)
|
2007-12-21 |
2009-06-24 |
Affibody AB |
New polypeptides having affinity for HER2
|
|
AU2008345424A1
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
EP2247615B1
(en)
|
2008-02-14 |
2014-07-30 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins that bind egfr
|
|
CN102076713B
(zh)
*
|
2008-05-02 |
2015-03-25 |
诺华股份有限公司 |
改进的基于纤连蛋白的结合分子及其用途
|
|
AR071874A1
(es)
|
2008-05-22 |
2010-07-21 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
|
|
US9217210B2
(en)
|
2009-03-24 |
2015-12-22 |
North Carolina State University |
Process of making composite inorganic/polymer nanofibers
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
DK2558491T3
(en)
|
2010-04-13 |
2018-10-15 |
Bristol Myers Squibb Co |
Fibronectin-based Scaffold domain proteins that bind PCSK9
|
|
MX368648B
(es)
|
2010-04-15 |
2019-10-09 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
|
|
CN103068405A
(zh)
|
2010-04-15 |
2013-04-24 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
EP3091028A1
(en)
|
2010-05-26 |
2016-11-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
EP3415528B1
(en)
|
2011-04-13 |
2021-05-26 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
|
RU2623161C2
(ru)
*
|
2011-04-15 |
2017-06-22 |
Компуджен Лтд. |
Полипептиды и полинуклеотиды и их применение для лечения иммунологических нарушений и рака
|
|
US20120288442A1
(en)
|
2011-05-11 |
2012-11-15 |
Atomic Energy Council-Institute Of Nuclear Energy Research |
Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis
|
|
US8852599B2
(en)
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
WO2013010573A1
(en)
|
2011-07-18 |
2013-01-24 |
Universitaet Muenster |
Compounds with matrix-metalloproteinase inhibitory activity
|
|
US9399641B2
(en)
|
2011-09-20 |
2016-07-26 |
Medimmune Limited |
Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
|
|
US9522951B2
(en)
|
2011-10-31 |
2016-12-20 |
Bristol-Myers Squibb Company |
Fibronectin binding domains with reduced immunogenicity
|
|
PL2814829T3
(pl)
|
2012-02-13 |
2017-06-30 |
Bristol-Myers Squibb Company |
Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
US9175082B2
(en)
*
|
2012-05-31 |
2015-11-03 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind PD-L1
|
|
RS58801B1
(sr)
|
2012-09-13 |
2019-07-31 |
Bristol Myers Squibb Co |
Skafold domenski proteini na bazi fibronektina koji se vezuju za miostatin
|
|
ES2972124T3
(es)
|
2012-12-03 |
2024-06-11 |
Curasight As |
Péptidos marcados con un radionúclido que emite positrones para obtención de imágenes de PET del uPAR humana
|
|
US20150361159A1
(en)
|
2013-02-01 |
2015-12-17 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins
|
|
WO2014124017A1
(en)
|
2013-02-06 |
2014-08-14 |
Bristol-Myers Squibb Company |
Fibronectin type iii domain proteins with enhanced solubility
|
|
DK2956173T3
(en)
|
2013-02-14 |
2017-07-17 |
Bristol Myers Squibb Co |
TUBULYSIS RELATIONSHIPS, METHODS OF PRODUCING AND USING THEREOF
|
|
CA2901231C
(en)
|
2013-02-15 |
2020-06-23 |
Thomas Jefferson University |
Kit comprising lyophilized compositions for tumor imaging
|
|
US9433689B2
(en)
|
2013-03-12 |
2016-09-06 |
The Board Of Trustees Of The Leland Stanford Junio |
Probes and methods of imaging non-Hodgkins lymphoma
|
|
US10556024B2
(en)
|
2013-11-13 |
2020-02-11 |
Whitehead Institute For Biomedical Research |
18F labeling of proteins using sortases
|
|
UA122479C2
(uk)
|
2014-01-24 |
2020-11-25 |
Дана-Фарбер Кенсер Інстітьют, Інк. |
Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
|
|
AU2015231170B2
(en)
|
2014-03-20 |
2019-10-03 |
Bristol-Myers Squibb Company |
Serum albumin-binding fibronectin type III domains
|
|
SG11201607818WA
(en)
|
2014-03-20 |
2016-10-28 |
Bristol Myers Squibb Co |
Stabilized fibronectin based scaffold molecules
|
|
WO2015190613A1
(en)
|
2014-06-09 |
2015-12-17 |
Takeda Pharmaceutical Company Limited |
Radiolabeled compounds
|
|
EP3177640B1
(en)
|
2014-08-08 |
2020-05-06 |
The Board of Trustees of the Leland Stanford Junior University |
High affinity pd-1 agents and methods of use
|
|
US9856292B2
(en)
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
JP6622814B2
(ja)
|
2014-11-25 |
2019-12-18 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
イメージングのための新規ｐｄ−ｌ１結合ポリペプチド
|
|
WO2016086036A2
(en)
|
2014-11-25 |
2016-06-02 |
Bristol-Myers Squibb Company |
Methods and compositions for 18f-radiolabeling of biologics
|
|
WO2016162368A1
(en)
|
2015-04-07 |
2016-10-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Non-invasive imaging of tumor pd-l1 expression
|
|
EP3353198B1
(en)
|
2015-09-23 |
2020-06-17 |
Bristol-Myers Squibb Company |
Glypican-3binding fibronectin based scafflold molecules
|
|
US10766946B2
(en)
|
2015-09-23 |
2020-09-08 |
Bristol-Myers Squibb Company |
Fast-off rate serum albumin binding fibronectin type III domains
|
|
EP3368557B1
(en)
|
2015-10-30 |
2026-03-25 |
Affibody AB |
New polypeptide
|
|
CA3001264A1
(en)
|
2015-10-30 |
2017-05-04 |
Affibody Ab |
Pd-l1 binding polypeptide
|
|
US20190023775A1
(en)
|
2016-01-11 |
2019-01-24 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
|
DK3402537T3
(da)
|
2016-01-15 |
2021-03-29 |
Rigshospitalet |
Kvantitativ PET-afbildning af vævsfaktorekspression under anvendelse af 18-F mærket, aktiv positions-inhiberet faktor VII
|
|
WO2017210335A1
(en)
|
2016-06-01 |
2017-12-07 |
Bristol-Myers Squibb Company |
Imaging methods using 18f-radiolabeled biologics
|
|
CN109562195A
(zh)
|
2016-06-01 |
2019-04-02 |
百时美施贵宝公司 |
用pd-l1结合多肽进行pet成像
|
|
TWI758788B
(zh)
|
2020-07-16 |
2022-03-21 |
富世達股份有限公司 |
具多摩擦對之扭力可變單軸轉軸結構
|