JP2017532962A5 - - Google Patents
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- Publication number
- JP2017532962A5 JP2017532962A5 JP2017520492A JP2017520492A JP2017532962A5 JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5 JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5
- Authority
- JP
- Japan
- Prior art keywords
- rna polynucleotide
- helicase
- dna
- polynucleotide
- leader sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 108060004795 Methyltransferase Proteins 0.000 claims 11
- 108090000133 DNA helicases Proteins 0.000 claims 10
- 102000003844 DNA helicases Human genes 0.000 claims 10
- 239000011148 porous material Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 4
- 241000588653 Neisseria Species 0.000 claims 2
- 101710203389 Outer membrane porin F Proteins 0.000 claims 2
- 101710203388 Outer membrane porin G Proteins 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102100022536 Helicase POLQ-like Human genes 0.000 claims 1
- 108010006464 Hemolysin Proteins Proteins 0.000 claims 1
- 101000899334 Homo sapiens Helicase POLQ-like Proteins 0.000 claims 1
- 108010014603 Leukocidins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 241000187480 Mycobacterium smegmatis Species 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 108010073429 Type V Secretion Systems Proteins 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000003228 hemolysin Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 108010014203 outer membrane phospholipase A Proteins 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201418459A GB201418459D0 (en) | 2014-10-17 | 2014-10-17 | Method |
| GB1418459.2 | 2014-10-17 | ||
| GB1508270.4 | 2015-05-14 | ||
| GBGB1508270.4A GB201508270D0 (en) | 2015-05-14 | 2015-05-14 | Method |
| GBPCT/GB2015/052916 | 2015-10-06 | ||
| GBGB1517634.0A GB201517634D0 (en) | 2015-10-06 | 2015-10-06 | Method |
| PCT/GB2015/052916 WO2016055777A2 (en) | 2014-10-07 | 2015-10-06 | Modified enzymes |
| GB1517634.0 | 2015-10-06 | ||
| PCT/GB2015/053097 WO2016059436A1 (en) | 2014-10-17 | 2015-10-19 | Method for nanopore rna characterisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532962A JP2017532962A (ja) | 2017-11-09 |
| JP2017532962A5 true JP2017532962A5 (enExample) | 2018-11-29 |
| JP6824881B2 JP6824881B2 (ja) | 2021-02-03 |
Family
ID=54337815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520492A Active JP6824881B2 (ja) | 2014-10-17 | 2015-10-19 | ナノ細孔ｒｎａを特徴付けるための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10480026B2 (enExample) |
| EP (1) | EP3207155B1 (enExample) |
| JP (1) | JP6824881B2 (enExample) |
| KR (1) | KR102457147B1 (enExample) |
| CN (2) | CN107109489B (enExample) |
| WO (1) | WO2016059436A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2013057495A2 (en) | 2011-10-21 | 2013-04-25 | Oxford Nanopore Technologies Limited | Enzyme method |
| IN2014DN06796A (enExample) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| WO2013185137A1 (en) | 2012-06-08 | 2013-12-12 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| CN118256603A (zh) | 2013-10-18 | 2024-06-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201417712D0 (en) * | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| JP6824881B2 (ja) | 2014-10-17 | 2021-02-03 | オックスフォード ナノポール テクノロジーズ リミテッド | ナノ細孔ｒｎａを特徴付けるための方法 |
| WO2017149316A1 (en) | 2016-03-02 | 2017-09-08 | Oxford Nanopore Technologies Limited | Mutant pore |
| US11514289B1 (en) * | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| CN118326018B (zh) | 2016-04-06 | 2025-11-07 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| US12215384B2 (en) * | 2016-05-25 | 2025-02-04 | Oxford Nanopore Technologies Plc | Methods of characterising target polynucleotides |
| GB201609221D0 (en) * | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201617886D0 (en) * | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201620450D0 (en) * | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| US11578362B2 (en) * | 2017-04-27 | 2023-02-14 | The Regents Of The University Of California | Methods of producing ribosomal ribonucleic acid complexes |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| EP3646025B1 (en) * | 2017-06-29 | 2021-08-04 | President and Fellows of Harvard College | Deterministic stepping of polymers through a nanopore |
| AU2018294660B2 (en) | 2017-06-30 | 2022-05-19 | Oxford Nanopore Technologies Plc | Novel protein pores |
| GB2569977A (en) * | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| US12475812B2 (en) | 2018-02-02 | 2025-11-18 | Bayer Aktiengesellschaft | Control of resistent harmful organisms |
| WO2019226822A1 (en) * | 2018-05-23 | 2019-11-28 | The Regents Of The University Of California | Methods of analyzing capped ribonucleic acids |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| EP3650558A1 (en) * | 2018-11-07 | 2020-05-13 | Siemens Healthcare GmbH | Liquid sample workflow for nanopore sequencing |
| ES2927412T3 (es) * | 2018-11-08 | 2022-11-04 | Siemens Healthcare Gmbh | Secuenciación directa de nanoporos de ARN con la ayuda de un polinucleótido de horquilla |
| CN111455031A (zh) * | 2019-01-18 | 2020-07-28 | 中国科学院微生物研究所 | 基于Nanopore测序技术的多组学测序及分析方法 |
| CN110093399A (zh) * | 2019-04-22 | 2019-08-06 | 武汉大学 | 一种利用二磷酸尿嘧啶脱氧核苷酸检测核酸中腺嘌呤n6位发生甲基化修饰的方法 |
| GB201907244D0 (en) * | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| US11926819B2 (en) | 2019-05-28 | 2024-03-12 | The Regents Of The University Of California | Methods of adding polymers to ribonucleic acids |
| WO2021036995A1 (en) * | 2019-08-23 | 2021-03-04 | Nanjing University | Direct microrna sequencing using enzyme assisted sequencing |
| CN110568039B (zh) * | 2019-09-06 | 2021-05-04 | 中国科学院生物物理研究所 | 使用新型电化学传感器的氨基酸特异实时检测方法 |
| EP4036106A4 (en) * | 2019-09-29 | 2024-01-17 | Qitan Technology Ltd., Beijing | MNEP MONOMER VARIANT AND THEIR USE |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| GB202107192D0 (en) * | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
| WO2023116575A1 (zh) * | 2021-12-21 | 2023-06-29 | 成都齐碳科技有限公司 | 用于表征目标多核苷酸的衔接体、方法及其用途 |
| GB202204919D0 (en) | 2022-04-04 | 2022-05-18 | Oxford Nanopore Tech Plc | Method |
| CN119213145A (zh) * | 2022-05-27 | 2024-12-27 | 深圳华大生命科学研究院 | 一种维持纳米孔测序速度的方法 |
| EP4616402A1 (en) | 2022-11-10 | 2025-09-17 | Bayer Aktiengesellschaft | Targeted crop protection product application based on genetic profiles |
| CN116478983B (zh) * | 2022-11-21 | 2023-10-24 | 北京普译生物科技有限公司 | 一种rna-dna嵌合接头及其应用 |
| CN116622822A (zh) * | 2023-03-17 | 2023-08-22 | 四川大学 | 一种多重混样直接rna纳米孔测序方法 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| EP0675965A4 (en) | 1992-01-29 | 1999-01-20 | Hitachi Chemical Co Ltd | CARRIERS FOR IMMOBILIZING POLYNUCLEOTIDES. |
| US6426231B1 (en) | 1998-11-18 | 2002-07-30 | The Texas A&M University System | Analyte sensing mediated by adapter/carrier molecules |
| CA2384100C (en) | 1999-09-07 | 2011-03-29 | The Regents Of The University Of California | Methods of determining the presence of double stranded nucleic acids in a sample |
| EP1097993A3 (en) * | 1999-11-05 | 2004-01-07 | National Institute of Advanced Industrial Science and Technology | Functional ribozyme chimeric molecules capable of sliding |
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| US6706203B2 (en) | 2001-10-30 | 2004-03-16 | Agilent Technologies, Inc. | Adjustable nanopore, nanotome, and nanotweezer |
| WO2004041843A2 (en) | 2002-05-17 | 2004-05-21 | Board Of Regents, The University Of Texas System | Hop - a novel cardiac-restricted transcriptional factor potentially useful for cardiac regeneration and specification |
| AU2003272438B2 (en) * | 2002-09-20 | 2009-04-02 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| ATE533857T1 (de) | 2003-01-17 | 2011-12-15 | Univ Hong Kong Chinese | Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen |
| US20050250094A1 (en) | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
| US7347921B2 (en) | 2003-07-17 | 2008-03-25 | Agilent Technologies, Inc. | Apparatus and method for threading a biopolymer through a nanopore |
| EP1732571A4 (en) | 2004-03-05 | 2009-09-09 | Archemix Corp | CONTROLLED MODULATION OF PHARMACOKINETICS AND BIOLOGICAL DISTRIBUTION OF APTAMERIC THERAPY |
| US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| US9233846B2 (en) | 2005-10-14 | 2016-01-12 | The Regents Of The University Of California | Formation and encapsulation of molecular bilayer and monolayer membranes |
| EP1954838B1 (en) | 2005-11-14 | 2014-02-26 | Life Technologies Corporation | Coded molecules for detecting target analytes |
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| WO2007098427A2 (en) | 2006-02-18 | 2007-08-30 | Michael Strathmann | Massively multiplexed sequencing |
| US20100291548A1 (en) | 2006-03-12 | 2010-11-18 | Applera Corporation | Methods of Detecting Target Nucleic Acids |
| US20110118187A1 (en) | 2006-10-19 | 2011-05-19 | Duke University | Reversible platelet inhibition |
| EP2126588A1 (en) | 2007-02-20 | 2009-12-02 | Oxford Nanopore Technologies Limited | Formation of lipid bilayers |
| KR101521990B1 (ko) | 2007-04-04 | 2015-05-20 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 나노포어 사용을 위한 조성물, 장치, 시스템 및 방법 |
| EP2212434A1 (en) | 2007-10-01 | 2010-08-04 | Applied Biosystems Inc. | Chase ligation sequencing |
| US20100298152A1 (en) | 2007-10-12 | 2010-11-25 | Pronota Nv | Use of aptamers in proteomics |
| JP2011500076A (ja) | 2007-10-22 | 2011-01-06 | プロノタ・エヌブイ | アプタマーを選択する方法 |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| US20110263459A1 (en) | 2008-03-12 | 2011-10-27 | Borer Philip N | Direct selection of structurally defined aptamers |
| US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| AU2009269792A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| EP2682460B1 (en) | 2008-07-07 | 2017-04-26 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US20100092960A1 (en) | 2008-07-25 | 2010-04-15 | Pacific Biosciences Of California, Inc. | Helicase-assisted sequencing with molecular beacons |
| WO2010047797A2 (en) | 2008-10-21 | 2010-04-29 | Research Foundation Of The City University Of New York | Single quantum-dot-based aptameric sensors |
| JP2012507565A (ja) * | 2008-10-30 | 2012-03-29 | グオ・ペイシュエン | Ｄｎａのシークエンシング及び他の用途のための、膜に組み込まれたウイルスｄｎａパッケージングモータタンパク質コネクタバイオセンサ |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| CN102482330A (zh) | 2009-01-30 | 2012-05-30 | 牛津纳米孔技术有限公司 | 酶突变体 |
| CA2750879C (en) | 2009-01-30 | 2018-05-22 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2010117470A2 (en) | 2009-04-10 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
| EP2422198B1 (en) | 2009-04-20 | 2013-09-25 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor array |
| AU2010326349B2 (en) | 2009-12-01 | 2015-10-29 | Oxford Nanopore Technologies Limited | Biochemical analysis instrument |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| WO2011103424A2 (en) | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| US8557529B2 (en) | 2010-04-09 | 2013-10-15 | International Business Machines Corporation | Nanopore capture system |
| US9395353B2 (en) | 2010-07-14 | 2016-07-19 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acid |
| EP2614156B1 (en) * | 2010-09-07 | 2018-08-01 | The Regents of The University of California | Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme |
| GB2500360B (en) | 2010-12-22 | 2019-10-23 | Genia Tech Inc | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps |
| AU2012215135B9 (en) * | 2011-02-11 | 2017-03-09 | Oxford Nanopore Technologies Limited | Mutant pores |
| US9290815B2 (en) * | 2011-02-21 | 2016-03-22 | Qiagen Gmbh | Method for quantifying human DNA |
| WO2012129242A2 (en) | 2011-03-23 | 2012-09-27 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| EP2715343B1 (en) | 2011-05-27 | 2019-10-02 | Oxford Nanopore Technologies Limited | Coupling method |
| US10228347B2 (en) * | 2011-06-24 | 2019-03-12 | Electronic Biosciences, Inc. | High contrast signal to noise ratio device components |
| US9957560B2 (en) * | 2011-07-25 | 2018-05-01 | Oxford Nanopore Technologies Ltd. | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| EP3385992B1 (en) | 2011-07-27 | 2024-09-04 | The Board of Trustees of the University of Illinois | Nanopore sensors for biomolecular characterization |
| US9206418B2 (en) | 2011-10-19 | 2015-12-08 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| WO2013057495A2 (en) * | 2011-10-21 | 2013-04-25 | Oxford Nanopore Technologies Limited | Enzyme method |
| CN102430153A (zh) * | 2011-12-24 | 2012-05-02 | 中国人民解放军第三军医大学第二附属医院 | 一种基于交联技术的仿生骨界面、构建方法及其应用 |
| US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
| AU2012360244B2 (en) * | 2011-12-29 | 2018-08-23 | Oxford Nanopore Technologies Limited | Enzyme method |
| IN2014DN06796A (enExample) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| BR102012007246A2 (pt) | 2012-03-30 | 2016-02-10 | Fundação Antonio Prudente | métodos para prognóstico e classificação de resultados de um evento |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| AU2013291763B2 (en) * | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| AU2013291765C1 (en) | 2012-07-19 | 2019-08-08 | Oxford Nanopore Technologies Limited | Enzyme construct |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| BR112015021788B1 (pt) | 2013-03-08 | 2023-02-28 | Oxford Nanopore Technologies Plc | Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN118256603A (zh) | 2013-10-18 | 2024-06-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| CN106460061B (zh) | 2014-04-04 | 2020-03-06 | 牛津纳米孔技术公司 | 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法 |
| JP6824881B2 (ja) | 2014-10-17 | 2021-02-03 | オックスフォード ナノポール テクノロジーズ リミテッド | ナノ細孔ｒｎａを特徴付けるための方法 |
-
2015
- 2015-10-19 JP JP2017520492A patent/JP6824881B2/ja active Active
- 2015-10-19 CN CN201580069027.9A patent/CN107109489B/zh active Active
- 2015-10-19 EP EP15784137.0A patent/EP3207155B1/en active Active
- 2015-10-19 CN CN202111321280.2A patent/CN113981055A/zh active Pending
- 2015-10-19 KR KR1020177013136A patent/KR102457147B1/ko active Active
- 2015-10-19 US US15/519,599 patent/US10480026B2/en active Active
- 2015-10-19 WO PCT/GB2015/053097 patent/WO2016059436A1/en not_active Ceased
-
2019
- 2019-09-19 US US16/575,610 patent/US11021747B2/en active Active
-
2021
- 2021-04-30 US US17/246,462 patent/US12129518B2/en active Active
-
2024
- 2024-09-19 US US18/889,917 patent/US20250084472A1/en active Pending
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