JP2017532962A5 - - Google Patents
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- Publication number
- JP2017532962A5 JP2017532962A5 JP2017520492A JP2017520492A JP2017532962A5 JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5 JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5
- Authority
- JP
- Japan
- Prior art keywords
- rna polynucleotide
- helicase
- dna
- polynucleotide
- leader sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 108060004795 Methyltransferase Proteins 0.000 claims 11
- 108090000133 DNA helicases Proteins 0.000 claims 10
- 102000003844 DNA helicases Human genes 0.000 claims 10
- 239000011148 porous material Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 4
- 241000588653 Neisseria Species 0.000 claims 2
- 101710203389 Outer membrane porin F Proteins 0.000 claims 2
- 101710203388 Outer membrane porin G Proteins 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102100022536 Helicase POLQ-like Human genes 0.000 claims 1
- 108010006464 Hemolysin Proteins Proteins 0.000 claims 1
- 101000899334 Homo sapiens Helicase POLQ-like Proteins 0.000 claims 1
- 108010014603 Leukocidins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 241000187480 Mycobacterium smegmatis Species 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 108010073429 Type V Secretion Systems Proteins 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000003228 hemolysin Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 108010014203 outer membrane phospholipase A Proteins 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418459.2 | 2014-10-17 | ||
| GB201418459A GB201418459D0 (en) | 2014-10-17 | 2014-10-17 | Method |
| GB1508270.4 | 2015-05-14 | ||
| GBGB1508270.4A GB201508270D0 (en) | 2015-05-14 | 2015-05-14 | Method |
| GB1517634.0 | 2015-10-06 | ||
| GBGB1517634.0A GB201517634D0 (en) | 2015-10-06 | 2015-10-06 | Method |
| GBPCT/GB2015/052916 | 2015-10-06 | ||
| PCT/GB2015/052916 WO2016055777A2 (en) | 2014-10-07 | 2015-10-06 | Modified enzymes |
| PCT/GB2015/053097 WO2016059436A1 (en) | 2014-10-17 | 2015-10-19 | Method for nanopore rna characterisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532962A JP2017532962A (ja) | 2017-11-09 |
| JP2017532962A5 true JP2017532962A5 (enExample) | 2018-11-29 |
| JP6824881B2 JP6824881B2 (ja) | 2021-02-03 |
Family
ID=54337815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520492A Active JP6824881B2 (ja) | 2014-10-17 | 2015-10-19 | ナノ細孔ｒｎａを特徴付けるための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10480026B2 (enExample) |
| EP (1) | EP3207155B1 (enExample) |
| JP (1) | JP6824881B2 (enExample) |
| KR (1) | KR102457147B1 (enExample) |
| CN (2) | CN107109489B (enExample) |
| WO (1) | WO2016059436A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| EP2987870B1 (en) | 2011-10-21 | 2020-02-19 | Oxford Nanopore Technologies Limited | Method of characterizing a target polynucleotide using a transmembrane pore and molecular motor |
| EP2815235B1 (en) | 2012-02-15 | 2020-04-15 | Oxford Nanopore Technologies Limited | Aptamer method |
| JP6271505B2 (ja) | 2012-04-10 | 2018-01-31 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体ライセニンポア |
| US9116118B2 (en) | 2012-06-08 | 2015-08-25 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| US10808231B2 (en) | 2012-07-19 | 2020-10-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| CN107109489B (zh) | 2014-10-17 | 2021-11-30 | 牛津纳米孔技术公司 | 纳米孔rna表征方法 |
| CN107427808B (zh) | 2015-01-12 | 2020-10-23 | 10X基因组学有限公司 | 用于制备核酸测序文库的方法和系统以及用其制备的文库 |
| AU2017225374B2 (en) | 2016-03-02 | 2020-03-05 | Oxford Nanopore Technologies Limited | Mutant pore |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP4122949B1 (en) | 2016-04-06 | 2024-06-05 | Oxford Nanopore Technologies plc | Mutant pore |
| GB201609221D0 (en) * | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| CN109196116B (zh) * | 2016-05-25 | 2022-09-27 | 牛津纳米孔科技公开有限公司 | 一种表征靶多核苷酸的方法 |
| GB201617886D0 (en) * | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| WO2018200847A1 (en) * | 2017-04-27 | 2018-11-01 | The Regents Of The University Of California | Methods of producing ribosomal ribonucleic acid complexes |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| EP3646025B1 (en) * | 2017-06-29 | 2021-08-04 | President and Fellows of Harvard College | Deterministic stepping of polymers through a nanopore |
| CN117106037B (zh) | 2017-06-30 | 2025-07-25 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| GB2569977A (en) * | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| US12475812B2 (en) | 2018-02-02 | 2025-11-18 | Bayer Aktiengesellschaft | Control of resistent harmful organisms |
| WO2019226822A1 (en) * | 2018-05-23 | 2019-11-28 | The Regents Of The University Of California | Methods of analyzing capped ribonucleic acids |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| EP3650558A1 (en) * | 2018-11-07 | 2020-05-13 | Siemens Healthcare GmbH | Liquid sample workflow for nanopore sequencing |
| EP3650559B1 (en) | 2018-11-08 | 2022-06-29 | Siemens Healthcare GmbH | Direct rna nanopore sequencing with help of a stem-loop polynucleotide |
| CN111455031A (zh) * | 2019-01-18 | 2020-07-28 | 中国科学院微生物研究所 | 基于Nanopore测序技术的多组学测序及分析方法 |
| CN110093399A (zh) * | 2019-04-22 | 2019-08-06 | 武汉大学 | 一种利用二磷酸尿嘧啶脱氧核苷酸检测核酸中腺嘌呤n6位发生甲基化修饰的方法 |
| GB201907244D0 (en) * | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| US11926819B2 (en) | 2019-05-28 | 2024-03-12 | The Regents Of The University Of California | Methods of adding polymers to ribonucleic acids |
| WO2021036995A1 (en) * | 2019-08-23 | 2021-03-04 | Nanjing University | Direct microrna sequencing using enzyme assisted sequencing |
| CN110568039B (zh) * | 2019-09-06 | 2021-05-04 | 中国科学院生物物理研究所 | 使用新型电化学传感器的氨基酸特异实时检测方法 |
| US12509491B2 (en) | 2019-09-29 | 2025-12-30 | Qitan Technology Ltd., Beijing | Mnep monomer variant and application thereof |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| GB202107192D0 (en) * | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
| WO2023116575A1 (zh) * | 2021-12-21 | 2023-06-29 | 成都齐碳科技有限公司 | 用于表征目标多核苷酸的衔接体、方法及其用途 |
| GB202204919D0 (en) | 2022-04-04 | 2022-05-18 | Oxford Nanopore Tech Plc | Method |
| EP4534691A4 (en) * | 2022-05-27 | 2026-03-25 | Bgi Shenzhen | METHOD FOR MAINTAINING THE SEQUENCING SPEED OF NANOPORES |
| EP4616402A1 (en) | 2022-11-10 | 2025-09-17 | Bayer Aktiengesellschaft | Targeted crop protection product application based on genetic profiles |
| CN116478983B (zh) * | 2022-11-21 | 2023-10-24 | 北京普译生物科技有限公司 | 一种rna-dna嵌合接头及其应用 |
| CN116676175B (zh) * | 2023-03-17 | 2024-04-09 | 四川大学 | 一种多条形码直接rna纳米孔测序分类器 |
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| CA2128891A1 (en) | 1992-01-29 | 1993-08-05 | Cylia Keller | Polynucleotide immobilized support |
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| CA2384100C (en) | 1999-09-07 | 2011-03-29 | The Regents Of The University Of California | Methods of determining the presence of double stranded nucleic acids in a sample |
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| EP2673638B1 (en) * | 2011-02-11 | 2019-10-30 | Oxford Nanopore Technologies Limited | Mutant pores |
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| EP3633370B1 (en) | 2011-05-27 | 2024-05-01 | Oxford Nanopore Technologies plc | Method and apparatus for determining the presence, absence or characteristics of an analyte |
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| IN2014DN00221A (enExample) * | 2011-07-25 | 2015-06-05 | Oxford Nanopore Tech Ltd | |
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| EP2987870B1 (en) * | 2011-10-21 | 2020-02-19 | Oxford Nanopore Technologies Limited | Method of characterizing a target polynucleotide using a transmembrane pore and molecular motor |
| CN102430153A (zh) * | 2011-12-24 | 2012-05-02 | 中国人民解放军第三军医大学第二附属医院 | 一种基于交联技术的仿生骨界面、构建方法及其应用 |
| WO2013098562A2 (en) | 2011-12-29 | 2013-07-04 | Oxford Nanopore Technologies Limited | Enzyme method |
| WO2013098561A1 (en) | 2011-12-29 | 2013-07-04 | Oxford Nanopore Technologies Limited | Method for characterising a polynucelotide by using a xpd helicase |
| EP2815235B1 (en) | 2012-02-15 | 2020-04-15 | Oxford Nanopore Technologies Limited | Aptamer method |
| BR102012007246A2 (pt) | 2012-03-30 | 2016-02-10 | Fundação Antonio Prudente | métodos para prognóstico e classificação de resultados de um evento |
| JP6271505B2 (ja) | 2012-04-10 | 2018-01-31 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体ライセニンポア |
| US10808231B2 (en) * | 2012-07-19 | 2020-10-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| JP6429773B2 (ja) | 2012-07-19 | 2018-11-28 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素構築物 |
| WO2014013259A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
| WO2014041337A1 (en) | 2012-09-14 | 2014-03-20 | Oxford Nanopore Technologies Limited | Sample preparation method |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201318465D0 (en) * | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| BR112015021788B1 (pt) | 2013-03-08 | 2023-02-28 | Oxford Nanopore Technologies Plc | Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit |
| CN117947149A (zh) | 2013-10-18 | 2024-04-30 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| EP3126515B1 (en) | 2014-04-04 | 2018-08-29 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| CN107109489B (zh) | 2014-10-17 | 2021-11-30 | 牛津纳米孔技术公司 | 纳米孔rna表征方法 |
-
2015
- 2015-10-19 CN CN201580069027.9A patent/CN107109489B/zh active Active
- 2015-10-19 CN CN202111321280.2A patent/CN113981055A/zh active Pending
- 2015-10-19 WO PCT/GB2015/053097 patent/WO2016059436A1/en not_active Ceased
- 2015-10-19 JP JP2017520492A patent/JP6824881B2/ja active Active
- 2015-10-19 KR KR1020177013136A patent/KR102457147B1/ko active Active
- 2015-10-19 EP EP15784137.0A patent/EP3207155B1/en active Active
- 2015-10-19 US US15/519,599 patent/US10480026B2/en active Active
-
2019
- 2019-09-19 US US16/575,610 patent/US11021747B2/en active Active
-
2021
- 2021-04-30 US US17/246,462 patent/US12129518B2/en active Active
-
2024
- 2024-09-19 US US18/889,917 patent/US20250084472A1/en active Pending
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