JP2010539966A5 - - Google Patents

Info

Publication number

JP2010539966A5

JP2010539966A5 JP2010527535A JP2010527535A JP2010539966A5 JP 2010539966 A5 JP2010539966 A5 JP 2010539966A5 JP 2010527535 A JP2010527535 A JP 2010527535A JP 2010527535 A JP2010527535 A JP 2010527535A JP 2010539966 A5 JP2010539966 A5 JP 2010539966A5

Authority

JP

Japan

Prior art keywords

pore

transmembrane protein

analyte

adapter

nucleotide

Prior art date

2008-10-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000011148 porous material Substances 0.000 claims 32
• 108091005703 transmembrane proteins Proteins 0.000 claims 15
• 102000035160 transmembrane proteins Human genes 0.000 claims 15
• 239000012491 analyte Substances 0.000 claims 13
• 239000002773 nucleotide Substances 0.000 claims 9
• 125000003729 nucleotide group Chemical group 0.000 claims 9
• 230000003993 interaction Effects 0.000 claims 5
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 229920000858 Cyclodextrin Polymers 0.000 claims 2
• 108060002716 Exonuclease Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 125000003636 chemical group Chemical group 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• 102000013165 exonuclease Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 2
• 238000012163 sequencing technique Methods 0.000 claims 2
• 101710092462 Alpha-hemolysin Proteins 0.000 claims 1
• 239000004971 Cross linker Substances 0.000 claims 1
• OZBFLQITCMCIOY-FOUAGVGXSA-N OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO OZBFLQITCMCIOY-FOUAGVGXSA-N 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 230000001588 bifunctional effect Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 230000000149 penetrating effect Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1