JP2009519705A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009519705A5 JP2009519705A5 JP2008540686A JP2008540686A JP2009519705A5 JP 2009519705 A5 JP2009519705 A5 JP 2009519705A5 JP 2008540686 A JP2008540686 A JP 2008540686A JP 2008540686 A JP2008540686 A JP 2008540686A JP 2009519705 A5 JP2009519705 A5 JP 2009519705A5
- Authority
- JP
- Japan
- Prior art keywords
- pore
- nucleotide
- individual nucleotides
- sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 239000011148 porous material Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 230000003993 interaction Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 108091005703 transmembrane proteins Proteins 0.000 claims 3
- 102000035160 transmembrane proteins Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 108060002716 Exonuclease Proteins 0.000 claims 2
- 102000013165 exonuclease Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 150000004712 monophosphates Chemical class 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0523282.2 | 2005-11-15 | ||
| GBGB0523282.2A GB0523282D0 (en) | 2005-11-15 | 2005-11-15 | Methods using pores |
| PCT/GB2006/004265 WO2007057668A1 (en) | 2005-11-15 | 2006-11-15 | Methods using pores |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519705A JP2009519705A (ja) | 2009-05-21 |
| JP2009519705A5 true JP2009519705A5 (enExample) | 2010-01-07 |
| JP5328362B2 JP5328362B2 (ja) | 2013-10-30 |
Family
ID=35516986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540686A Active JP5328362B2 (ja) | 2005-11-15 | 2006-11-15 | 細孔を使用する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8105846B2 (enExample) |
| EP (2) | EP1951898B1 (enExample) |
| JP (1) | JP5328362B2 (enExample) |
| KR (1) | KR20080083281A (enExample) |
| CN (1) | CN101356288B (enExample) |
| AT (1) | ATE545712T1 (enExample) |
| AU (1) | AU2006314296B2 (enExample) |
| BR (1) | BRPI0618391A2 (enExample) |
| CA (1) | CA2629009C (enExample) |
| GB (1) | GB0523282D0 (enExample) |
| IL (1) | IL191319A (enExample) |
| MY (1) | MY149161A (enExample) |
| NZ (1) | NZ568163A (enExample) |
| RU (1) | RU2008123842A (enExample) |
| UA (1) | UA95087C2 (enExample) |
| WO (1) | WO2007057668A1 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| US8968545B2 (en) * | 2012-04-02 | 2015-03-03 | Lux Bio Group, Inc. | Apparatus and method for molecular separation, purification, and sensing |
| EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| GB2453377A (en) * | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
| CN102245760A (zh) | 2008-07-07 | 2011-11-16 | 牛津纳米孔技术有限公司 | 酶-孔构建体 |
| CN102144037A (zh) * | 2008-07-07 | 2011-08-03 | 牛津纳米孔技术有限公司 | 检测碱基的孔 |
| EP2851433B1 (en) * | 2008-08-01 | 2017-10-11 | Brown University | System and methods for determining molecules using mass spectrometry and related techniques |
| GB0820927D0 (en) * | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| WO2010062903A2 (en) * | 2008-11-26 | 2010-06-03 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| US9222082B2 (en) | 2009-01-30 | 2015-12-29 | Oxford Nanopore Technologies Limited | Hybridization linkers |
| WO2010086622A1 (en) | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2010117470A2 (en) | 2009-04-10 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
| US9017937B1 (en) | 2009-04-10 | 2015-04-28 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using ratiometric impedance |
| AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
| CN102741430B (zh) | 2009-12-01 | 2016-07-13 | 牛津楠路珀尔科技有限公司 | 生化分析仪器、用于进行生化分析的第一模块以及相关方法 |
| US9005425B2 (en) | 2010-03-05 | 2015-04-14 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| WO2011109825A2 (en) * | 2010-03-05 | 2011-09-09 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| US8652779B2 (en) | 2010-04-09 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using charge blockade labels |
| EP2622343B1 (en) | 2010-10-01 | 2016-01-20 | Oxford Nanopore Technologies Limited | Biochemical analysis apparatus using nanopores |
| US8673757B2 (en) * | 2010-10-28 | 2014-03-18 | International Business Machines Corporation | Structure and method for using high-k material as an etch stop layer in dual stress layer process |
| JP6169976B2 (ja) | 2011-02-11 | 2017-07-26 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体細孔 |
| AU2012264497B2 (en) | 2011-05-27 | 2017-06-15 | Oxford Nanopore Technologies Limited | Coupling method |
| RU2467218C1 (ru) * | 2011-06-16 | 2012-11-20 | Закрытое Акционерное Общество "Научно-производственное объединение "Гидравлические аппараты" (ЗАО "НПО "Гидроаппарат") | Гидромуфта |
| JP6364348B2 (ja) | 2011-07-20 | 2018-07-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ２細孔装置 |
| WO2013014451A1 (en) | 2011-07-25 | 2013-01-31 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| CN104039979B (zh) | 2011-10-21 | 2016-08-24 | 牛津纳米孔技术公司 | 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法 |
| US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
| WO2013098562A2 (en) | 2011-12-29 | 2013-07-04 | Oxford Nanopore Technologies Limited | Enzyme method |
| US10739341B2 (en) | 2012-02-15 | 2020-08-11 | Oxford Nanopore Technologies Limited | Aptamer method |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| WO2014013259A1 (en) * | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
| EP2875152B1 (en) * | 2012-07-19 | 2019-10-09 | Oxford Nanopore Technologies Limited | Enzyme construct |
| JP6614972B2 (ja) | 2012-07-19 | 2019-12-04 | オックスフォード ナノポール テクノロジーズ リミテッド | 修飾ヘリカーゼ |
| EP2895618B1 (en) | 2012-09-14 | 2017-07-26 | Oxford Nanopore Technologies Limited | Sample preparation method |
| US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| SG11201507138RA (en) | 2013-03-08 | 2015-10-29 | Oxford Nanopore Tech Ltd | Enzyme stalling method |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| CN103267785B (zh) * | 2013-05-14 | 2016-04-13 | 西北大学 | 一种检测药物包裹或释放过程的单分子分析方法 |
| AU2014268322B2 (en) | 2013-05-24 | 2019-01-24 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed FRET detection |
| ES2817425T3 (es) | 2013-05-24 | 2021-04-07 | Illumina Cambridge Ltd | Secuenciado pirofosforolítico usando nanoporos |
| GB201316849D0 (en) | 2013-09-23 | 2013-11-06 | Isis Innovation | Method |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| US10724018B2 (en) | 2013-10-18 | 2020-07-28 | Oxford Nanopore Technologies Ltd. | Modified helicases |
| US10385389B2 (en) | 2014-01-22 | 2019-08-20 | Oxford Nanopore Technologies Ltd. | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| CN106460061B (zh) | 2014-04-04 | 2020-03-06 | 牛津纳米孔技术公司 | 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法 |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| WO2015166275A1 (en) | 2014-05-02 | 2015-11-05 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201411285D0 (en) | 2014-06-25 | 2014-08-06 | Prosser Joseph | Sequencer |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| CA2963604C (en) | 2014-10-10 | 2023-02-14 | Quantapore, Inc. | Nanopore-based polymer analysis with mutually-quenching fluorescent labels |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| JP6824881B2 (ja) | 2014-10-17 | 2021-02-03 | オックスフォード ナノポール テクノロジーズ リミテッド | ナノ細孔ｒｎａを特徴付けるための方法 |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| EP3209800B1 (en) | 2014-10-24 | 2022-02-16 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
| WO2016069806A2 (en) | 2014-10-31 | 2016-05-06 | Genia Technologies, Inc. | Alpha-hemolysin variants with altered characteristics |
| US10060903B2 (en) * | 2014-11-05 | 2018-08-28 | Genia Technologies, Inc. | Exporting measurements of nanopore arrays |
| US9557294B2 (en) | 2014-12-19 | 2017-01-31 | Genia Technologies, Inc. | Nanopore-based sequencing with varying voltage stimulus |
| US9863904B2 (en) | 2014-12-19 | 2018-01-09 | Genia Technologies, Inc. | Nanopore-based sequencing with varying voltage stimulus |
| HK1244318A1 (zh) * | 2015-02-02 | 2018-08-03 | 奥特拉公司 | 用於生物标志物检测的不稳定的接头 |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) * | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| US10126262B2 (en) | 2015-09-24 | 2018-11-13 | Genia Technologies, Inc. | Differential output of analog memories storing nanopore measurement samples |
| EP3766987B1 (en) * | 2015-09-24 | 2023-08-02 | F. Hoffmann-La Roche AG | Alpha-hemolysin variants |
| CN105259229B (zh) * | 2015-10-22 | 2018-04-20 | 清华大学 | 一种检测药物的单分子分析方法 |
| US10280411B2 (en) | 2015-10-27 | 2019-05-07 | Pacific Biosciences of California, In.c | Methods, systems, and reagents for direct RNA sequencing |
| US10976300B2 (en) | 2015-12-08 | 2021-04-13 | Katholieke Universiteit Leuven | Modified nanopores, compositions comprising the same, and uses thereof |
| JP6579948B2 (ja) * | 2015-12-24 | 2019-09-25 | 株式会社日立ハイテクノロジーズ | 生体ポリマを分析するための測定試薬及び分析デバイス |
| CN116200476A (zh) | 2016-03-02 | 2023-06-02 | 牛津纳米孔科技公开有限公司 | 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔 |
| EP3440098B1 (en) | 2016-04-06 | 2022-07-27 | Oxford Nanopore Technologies plc | Mutant pore |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| CN109196116B (zh) * | 2016-05-25 | 2022-09-27 | 牛津纳米孔科技公开有限公司 | 一种表征靶多核苷酸的方法 |
| EP3482196B1 (en) | 2016-07-05 | 2022-02-23 | Quantapore, Inc. | Optically based nanopore sequencing |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| CN119530363A (zh) * | 2017-02-10 | 2025-02-28 | 牛津纳米孔科技公开有限公司 | 修饰的纳米孔、包含其的组合物及其用途 |
| EP4026916B1 (en) * | 2017-04-19 | 2023-10-18 | Electronic Biosciences Inc. | Nanopore/nanowell electrode enabled exonuclease sequencing |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| CN110914290A (zh) | 2017-06-30 | 2020-03-24 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| EP3717905A1 (en) * | 2017-11-27 | 2020-10-07 | H. Hoffnabb-La Roche Ag | Normalization and baseline shift removal for nanopore-sbs signals |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB202202716D0 (en) | 2022-02-28 | 2022-04-13 | Oxford Nanopore Tech Plc | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| JP2025527266A (ja) | 2022-08-02 | 2025-08-20 | グリフィック バイオテクノロジーズ，インク． | 重合性分子の結合を介したタンパク質の配列決定 |
| GB202401864D0 (en) | 2024-02-12 | 2024-03-27 | Fund Centre De Regulacio Genòmica | A method of detecting non-canonical bases in sequencing data |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI82266C (fi) | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| CA2160909A1 (en) | 1993-04-28 | 1994-11-10 | Hagan Bayley | Cell-targeted lytic pore-forming agents |
| US5777078A (en) | 1993-04-28 | 1998-07-07 | Worcester Foundation For Experimental Biology | Triggered pore-forming agents |
| US5795782A (en) * | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| WO1999005167A1 (en) * | 1997-07-25 | 1999-02-04 | University Of Massachusetts | Designed protein pores as components for biosensors |
| US6087099A (en) | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
| US6127166A (en) | 1997-11-03 | 2000-10-03 | Bayley; Hagan | Molluscan ligament polypeptides and genes encoding them |
| JPH11137260A (ja) | 1997-11-06 | 1999-05-25 | Soyaku Gijutsu Kenkyusho:Kk | 抗インフルエンザウイルス環状ダンベル型ｒｎａ−ｄｎａキメラ化合物及び抗インフルエンザウイルス剤 |
| US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
| DE19826758C1 (de) | 1998-06-15 | 1999-10-21 | Soft Gene Gmbh | Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte |
| US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
| US6426231B1 (en) | 1998-11-18 | 2002-07-30 | The Texas A&M University System | Analyte sensing mediated by adapter/carrier molecules |
| NO986133D0 (no) | 1998-12-23 | 1998-12-23 | Preben Lexow | FremgangsmÕte for DNA-sekvensering |
| EP1192103A1 (en) | 1999-06-22 | 2002-04-03 | President And Fellows of Harvard College | Control of solid state dimensional features |
| AU5668100A (en) | 1999-06-29 | 2001-01-22 | University Health Network | Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes |
| JP2003532380A (ja) | 1999-12-02 | 2003-11-05 | モレキュラー ステージング，インコーポレイテッド | 線状自己アニーリングセグメントからの一本鎖環状ｄｎａの産出 |
| US6916665B2 (en) * | 2000-02-11 | 2005-07-12 | The Texas A&M University System | Biosensor compositions and methods of use |
| US7001792B2 (en) | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
| US6936433B2 (en) | 2000-11-27 | 2005-08-30 | The Regents Of The University Of California | Methods and devices for characterizing duplex nucleic acid molecules |
| US7807408B2 (en) | 2001-03-19 | 2010-10-05 | President & Fellows Of Harvard College | Directed evolution of proteins |
| JP4211603B2 (ja) * | 2001-05-29 | 2009-01-21 | 旭硝子株式会社 | シゾサッカロマイセス・ポンベ（Ｓｃｈｉｚｏｓａｃｃｈａｒｏｍｙｃｅｓｐｏｍｂｅ）宿主の構築方法および異種タンパク質の製造方法 |
| US6863833B1 (en) | 2001-06-29 | 2005-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Microfabricated apertures for supporting bilayer lipid membranes |
| AU2003245272A1 (en) | 2002-05-10 | 2003-11-11 | The Texas A And M University System | Stochastic sensing through covalent interactions |
| US7163658B2 (en) | 2003-04-23 | 2007-01-16 | Rouvain Bension | Rapid sequencing of polymers |
| WO2005056750A2 (en) | 2003-12-11 | 2005-06-23 | Quark Biotech, Inc. | Inversion-duplication of nucleic acids and libraries prepared thereby |
| US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| AU2005272823B2 (en) | 2004-08-13 | 2012-04-12 | President And Fellows Of Harvard College | An ultra high-throughput opti-nanopore DNA readout platform |
| EP1842061A4 (en) | 2004-12-21 | 2009-05-13 | Texas A & M Univ Sys | HIGH-TEMPERATURE ION CHANNELS AND ION PORES |
| GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| ATE518010T1 (de) | 2005-12-22 | 2011-08-15 | Pacific Biosciences California | Aktive oberflächengekoppelte polymerasen |
| US7932029B1 (en) | 2006-01-04 | 2011-04-26 | Si Lok | Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities |
| WO2008045575A2 (en) | 2006-10-13 | 2008-04-17 | J. Craig Venter Institute, Inc. | Sequencing method |
| AU2008217579A1 (en) | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Formation of lipid bilayers |
| US20110005918A1 (en) | 2007-04-04 | 2011-01-13 | Akeson Mark A | Compositions, devices, systems, and methods for using a nanopore |
| GB2453377A (en) | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
| CA2719747C (en) | 2008-03-28 | 2018-02-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| CN102144037A (zh) * | 2008-07-07 | 2011-08-03 | 牛津纳米孔技术有限公司 | 检测碱基的孔 |
| CN102245760A (zh) | 2008-07-07 | 2011-11-16 | 牛津纳米孔技术有限公司 | 酶-孔构建体 |
| WO2010034018A2 (en) | 2008-09-22 | 2010-03-25 | University Of Washington | Msp nanopores and related methods |
-
2005
- 2005-11-15 GB GBGB0523282.2A patent/GB0523282D0/en not_active Ceased
-
2006
- 2006-11-15 BR BRPI0618391-3A patent/BRPI0618391A2/pt not_active IP Right Cessation
- 2006-11-15 CA CA2629009A patent/CA2629009C/en active Active
- 2006-11-15 MY MYPI20081556A patent/MY149161A/en unknown
- 2006-11-15 UA UAA200806147A patent/UA95087C2/ru unknown
- 2006-11-15 KR KR1020087014358A patent/KR20080083281A/ko not_active Ceased
- 2006-11-15 AT AT06808555T patent/ATE545712T1/de active
- 2006-11-15 NZ NZ568163A patent/NZ568163A/en not_active IP Right Cessation
- 2006-11-15 US US12/093,610 patent/US8105846B2/en active Active
- 2006-11-15 JP JP2008540686A patent/JP5328362B2/ja active Active
- 2006-11-15 EP EP06808555A patent/EP1951898B1/en active Active
- 2006-11-15 EP EP10010418A patent/EP2272981B1/en active Active
- 2006-11-15 RU RU2008123842/13A patent/RU2008123842A/ru not_active Application Discontinuation
- 2006-11-15 AU AU2006314296A patent/AU2006314296B2/en active Active
- 2006-11-15 CN CN200680050878.XA patent/CN101356288B/zh active Active
- 2006-11-15 WO PCT/GB2006/004265 patent/WO2007057668A1/en not_active Ceased
-
2008
- 2008-05-07 IL IL191319A patent/IL191319A/en not_active IP Right Cessation
-
2011
- 2011-12-28 US US13/338,794 patent/US8785211B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009519705A5 (enExample) | ||
| RU2008123842A (ru) | Способы с использованием пор | |
| US20220348998A1 (en) | Methods for labelling nucleic acids | |
| US10704092B2 (en) | Detection methods based on sequencing | |
| JP6329624B2 (ja) | 加ピロリン酸分解式配列決定法 | |
| ES2876432T3 (es) | Técnicas de síntesis de ácidos nucleicos | |
| ES2958715T3 (es) | Composiciones y métodos para la secuenciación de polinucleótidos | |
| CN104854246B (zh) | 无限制酶的靶标富集 | |
| JP2010539966A5 (enExample) | ||
| JP2012516146A5 (enExample) | ||
| JP2016510218A5 (enExample) | ||
| WO2007106534A3 (en) | Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides | |
| JP6664575B2 (ja) | 核酸分子数計測法 | |
| CN112480218A (zh) | 用于装配具有多个亚基的蛋白的方法 | |
| JP2014513557A5 (enExample) | ||
| JP2017530714A (ja) | 方法 | |
| WO2008051530A3 (en) | Polymerase enzymes and reagents for enhanced nucleic acid sequencing | |
| JP2015231383A (ja) | マルチプレックス配列決定反応における核酸鋳型の完全性および同定を維持するための方法 | |
| CN105026577A (zh) | 通过序列捕获检测基因组重排 | |
| WO2007130519A3 (en) | Viral nucleic acid microarray and method of use | |
| CN104480534A (zh) | 一种快速建库方法 | |
| JP2010534474A5 (enExample) | ||
| WO2008070144A3 (en) | Imprinted genes and disease | |
| US12385160B2 (en) | Enzyme screening methods | |
| WO2003052135A8 (en) | Method and nucleic acids for the analysis of a lung cell proliferative disorder |