GB0523282D0 - Methods using pores - Google Patents

Methods using pores

Info

Publication number
GB0523282D0
GB0523282D0 GBGB0523282.2A GB0523282A GB0523282D0 GB 0523282 D0 GB0523282 D0 GB 0523282D0 GB 0523282 A GB0523282 A GB 0523282A GB 0523282 D0 GB0523282 D0 GB 0523282D0
Authority
GB
United Kingdom
Prior art keywords
nucleotide
pore
relates
pores
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0523282.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to GBGB0523282.2A priority Critical patent/GB0523282D0/en
Publication of GB0523282D0 publication Critical patent/GB0523282D0/en
Priority to RU2008123842/13A priority patent/RU2008123842A/ru
Priority to CN200680050878.XA priority patent/CN101356288B/zh
Priority to EP10010418A priority patent/EP2272981B1/en
Priority to AT06808555T priority patent/ATE545712T1/de
Priority to KR1020087014358A priority patent/KR20080083281A/ko
Priority to BRPI0618391-3A priority patent/BRPI0618391A2/pt
Priority to UAA200806147A priority patent/UA95087C2/ru
Priority to JP2008540686A priority patent/JP5328362B2/ja
Priority to EP06808555A priority patent/EP1951898B1/en
Priority to US12/093,610 priority patent/US8105846B2/en
Priority to PCT/GB2006/004265 priority patent/WO2007057668A1/en
Priority to AU2006314296A priority patent/AU2006314296B2/en
Priority to NZ568163A priority patent/NZ568163A/en
Priority to MYPI20081556A priority patent/MY149161A/en
Priority to CA2629009A priority patent/CA2629009C/en
Priority to IL191319A priority patent/IL191319A/en
Priority to US13/338,794 priority patent/US8785211B2/en
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60Detection means characterised by use of a special device
    • C12Q2565/631Detection means characterised by use of a special device being a biochannel or pore

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
GBGB0523282.2A 2005-11-15 2005-11-15 Methods using pores Ceased GB0523282D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GBGB0523282.2A GB0523282D0 (en) 2005-11-15 2005-11-15 Methods using pores
CA2629009A CA2629009C (en) 2005-11-15 2006-11-15 Methods using pores
JP2008540686A JP5328362B2 (ja) 2005-11-15 2006-11-15 細孔を使用する方法
US12/093,610 US8105846B2 (en) 2005-11-15 2006-11-15 Methods using pores
EP10010418A EP2272981B1 (en) 2005-11-15 2006-11-15 Methods using pores
AT06808555T ATE545712T1 (de) 2005-11-15 2006-11-15 Verfahren mit verwendung von poren
KR1020087014358A KR20080083281A (ko) 2005-11-15 2006-11-15 공극을 사용한 방법
BRPI0618391-3A BRPI0618391A2 (pt) 2005-11-15 2006-11-15 método para identificar um nucleotìdeo individual, método para seqüenciar uma seqüência de ácido nucleico alvo, e, kit para seqüenciar um ácido nucleico
UAA200806147A UA95087C2 (en) 2005-11-15 2006-11-15 Methods for pores using
RU2008123842/13A RU2008123842A (ru) 2005-11-15 2006-11-15 Способы с использованием пор
EP06808555A EP1951898B1 (en) 2005-11-15 2006-11-15 Methods using pores
CN200680050878.XA CN101356288B (zh) 2005-11-15 2006-11-15 使用孔的方法
PCT/GB2006/004265 WO2007057668A1 (en) 2005-11-15 2006-11-15 Methods using pores
AU2006314296A AU2006314296B2 (en) 2005-11-15 2006-11-15 Methods using pores
NZ568163A NZ568163A (en) 2005-11-15 2006-11-15 Methods of identifying individual nucleotides using pores
MYPI20081556A MY149161A (en) 2005-11-15 2006-11-15 Methods using pores
IL191319A IL191319A (en) 2005-11-15 2008-05-07 Method of identifying an individual nucleotide using a transmembrane protein pore
US13/338,794 US8785211B2 (en) 2005-11-15 2011-12-28 Methods using pores

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0523282.2A GB0523282D0 (en) 2005-11-15 2005-11-15 Methods using pores

Publications (1)

Publication Number Publication Date
GB0523282D0 true GB0523282D0 (en) 2005-12-21

Family

ID=35516986

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0523282.2A Ceased GB0523282D0 (en) 2005-11-15 2005-11-15 Methods using pores

Country Status (16)

Country Link
US (2) US8105846B2 (enExample)
EP (2) EP2272981B1 (enExample)
JP (1) JP5328362B2 (enExample)
KR (1) KR20080083281A (enExample)
CN (1) CN101356288B (enExample)
AT (1) ATE545712T1 (enExample)
AU (1) AU2006314296B2 (enExample)
BR (1) BRPI0618391A2 (enExample)
CA (1) CA2629009C (enExample)
GB (1) GB0523282D0 (enExample)
IL (1) IL191319A (enExample)
MY (1) MY149161A (enExample)
NZ (1) NZ568163A (enExample)
RU (1) RU2008123842A (enExample)
UA (1) UA95087C2 (enExample)
WO (1) WO2007057668A1 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
GB2453377A (en) * 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
JP2011527191A (ja) * 2008-07-07 2011-10-27 オックスフォード ナノポア テクノロジーズ リミテッド 塩基検出細孔
CN103695530B (zh) * 2008-07-07 2016-05-25 牛津纳米孔技术有限公司 酶-孔构建体
EP2342359B1 (en) * 2008-08-01 2015-03-04 Brown University System and methods for determining molecules using mass spectrometry and related techniques
GB0820927D0 (en) * 2008-11-14 2008-12-24 Isis Innovation Method
US20100148126A1 (en) * 2008-11-26 2010-06-17 Board Of Regents, The University Of Texas System Genomic sequencing using modified protein pores and ionic liquids
AU2010209528B2 (en) 2009-01-30 2015-10-01 Oxford Nanopore Technologies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
CA2750874A1 (en) * 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Hybridization linkers
GB0905140D0 (en) * 2009-03-25 2009-05-06 Isis Innovation Method
US8986928B2 (en) * 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
US9017937B1 (en) 2009-04-10 2015-04-28 Pacific Biosciences Of California, Inc. Nanopore sequencing using ratiometric impedance
CA2808576A1 (en) 2009-09-30 2011-04-07 Quantapore, Inc. Ultrafast sequencing of biological polymers using a labeled nanopore
BR112012013074B1 (pt) 2009-12-01 2018-09-18 Oxford Nanopore Technologies Limited instrumento de análise e módulo para realizar análise bioquímica, e, método para operar um instrumento de análise para realizar análise bioquímica
GB2490846A (en) * 2010-03-05 2012-11-14 Univ Utah Res Found Detection of nucleic acid lesions and adducts using nanopores
US9005425B2 (en) 2010-03-05 2015-04-14 University Of Utah Research Foundation Detection of nucleic acid lesions and adducts using nanopores
US8652779B2 (en) 2010-04-09 2014-02-18 Pacific Biosciences Of California, Inc. Nanopore sequencing using charge blockade labels
CN103370617B (zh) 2010-10-01 2015-11-25 牛津纳米孔技术有限公司 生物化学分析设备和旋转阀
US8673757B2 (en) 2010-10-28 2014-03-18 International Business Machines Corporation Structure and method for using high-k material as an etch stop layer in dual stress layer process
EP2673638B1 (en) 2011-02-11 2019-10-30 Oxford Nanopore Technologies Limited Mutant pores
WO2012164270A1 (en) 2011-05-27 2012-12-06 Oxford Nanopore Technologies Limited Coupling method
RU2467218C1 (ru) * 2011-06-16 2012-11-20 Закрытое Акционерное Общество "Научно-производственное объединение "Гидравлические аппараты" (ЗАО "НПО "Гидроаппарат") Гидромуфта
EP2734840B3 (en) * 2011-07-20 2017-06-07 The Regents of the University of California Dual-pore device
WO2013014451A1 (en) 2011-07-25 2013-01-31 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US9758823B2 (en) 2011-10-21 2017-09-12 Oxford Nanopore Technologies Limited Enzyme method
CN104136631B (zh) 2011-12-29 2017-03-01 牛津纳米孔技术公司 使用xpd解旋酶表征多核苷酸的方法
US10385382B2 (en) 2011-12-29 2019-08-20 Oxford Nanopore Technologies Ltd. Enzyme method
IN2014DN06796A (enExample) 2012-02-15 2015-05-22 Oxford Nanopore Tech Ltd
WO2013151532A1 (en) * 2012-04-02 2013-10-10 Lux Bio Group, Inc. Apparatus and method for molecular separation, purification, and sensing
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
EP2875154B1 (en) * 2012-07-19 2017-08-23 Oxford Nanopore Technologies Limited SSB method for characterising a nucleic acid
AU2013291765C1 (en) 2012-07-19 2019-08-08 Oxford Nanopore Technologies Limited Enzyme construct
WO2014013260A1 (en) 2012-07-19 2014-01-23 Oxford Nanopore Technologies Limited Modified helicases
EP2895618B1 (en) 2012-09-14 2017-07-26 Oxford Nanopore Technologies Limited Sample preparation method
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
EP2917366B1 (en) 2012-11-06 2017-08-02 Oxford Nanopore Technologies Limited Quadruplex method
GB201318465D0 (en) 2013-10-18 2013-12-04 Oxford Nanopore Tech Ltd Method
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
KR102168813B1 (ko) 2013-03-08 2020-10-22 옥스포드 나노포어 테크놀로지즈 리미티드 효소 정지 방법
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
CN103267785B (zh) * 2013-05-14 2016-04-13 西北大学 一种检测药物包裹或释放过程的单分子分析方法
AU2014268322B2 (en) 2013-05-24 2019-01-24 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
ES2994071T3 (en) * 2013-05-24 2025-01-16 Illumina Cambridge Ltd Pyrophosphorolytic sequencing using nanopores
GB201316849D0 (en) 2013-09-23 2013-11-06 Isis Innovation Method
CN117947149A (zh) 2013-10-18 2024-04-30 牛津纳米孔科技公开有限公司 经修饰的酶
GB201406151D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
GB201406155D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
CN106103741B (zh) 2014-01-22 2020-03-13 牛津纳米孔技术公司 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
EP3126515B1 (en) 2014-04-04 2018-08-29 Oxford Nanopore Technologies Limited Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid
WO2015166276A1 (en) 2014-05-02 2015-11-05 Oxford Nanopore Technologies Limited Method of improving the movement of a target polynucleotide with respect to a transmembrane pore
GB201417712D0 (en) 2014-10-07 2014-11-19 Oxford Nanopore Tech Ltd Method
GB201411285D0 (en) 2014-06-25 2014-08-06 Prosser Joseph Sequencer
EP4053150A1 (en) 2014-09-01 2022-09-07 Vib Vzw Mutant csgg pores
US10266885B2 (en) 2014-10-07 2019-04-23 Oxford Nanopore Technologies Ltd. Mutant pores
WO2016057829A1 (en) 2014-10-10 2016-04-14 Quantapore, Inc. Nanopore-based polymer analysis with mutually-quenching fluorescent labels
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
US10480026B2 (en) 2014-10-17 2019-11-19 Oxford Nanopore Technologies Ltd. Method for nanopore RNA characterisation
GB201418469D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Method
WO2016065339A1 (en) 2014-10-24 2016-04-28 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
WO2016069806A2 (en) * 2014-10-31 2016-05-06 Genia Technologies, Inc. Alpha-hemolysin variants with altered characteristics
US10060903B2 (en) * 2014-11-05 2018-08-28 Genia Technologies, Inc. Exporting measurements of nanopore arrays
US9863904B2 (en) 2014-12-19 2018-01-09 Genia Technologies, Inc. Nanopore-based sequencing with varying voltage stimulus
US9557294B2 (en) 2014-12-19 2017-01-31 Genia Technologies, Inc. Nanopore-based sequencing with varying voltage stimulus
AU2016215455A1 (en) * 2015-02-02 2017-08-17 Ontera Inc. Labile linkers for biomarker detection
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
EP3283887B1 (en) 2015-04-14 2021-07-21 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
EP3766987B1 (en) * 2015-09-24 2023-08-02 F. Hoffmann-La Roche AG Alpha-hemolysin variants
US10126262B2 (en) 2015-09-24 2018-11-13 Genia Technologies, Inc. Differential output of analog memories storing nanopore measurement samples
CN105259229B (zh) * 2015-10-22 2018-04-20 清华大学 一种检测药物的单分子分析方法
US10280411B2 (en) 2015-10-27 2019-05-07 Pacific Biosciences of California, In.c Methods, systems, and reagents for direct RNA sequencing
CN109072295B (zh) 2015-12-08 2022-05-31 鲁汶大学研究与发展中心 修饰的纳米孔,包含其的组合物及其应用
JP6579948B2 (ja) * 2015-12-24 2019-09-25 株式会社日立ハイテクノロジーズ 生体ポリマを分析するための測定試薬及び分析デバイス
EP3423486B1 (en) 2016-03-02 2021-12-29 Oxford Nanopore Technologies PLC Mutant pore
CA3020203A1 (en) 2016-04-06 2017-10-12 Oxford Nanopore Technologies Limited Mutant pore
WO2017203268A1 (en) 2016-05-25 2017-11-30 Oxford Nanopore Technologies Limited Method
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
US10823721B2 (en) 2016-07-05 2020-11-03 Quantapore, Inc. Optically based nanopore sequencing
GB201619930D0 (en) 2016-11-24 2017-01-11 Oxford Nanopore Tech Apparatus and methods for controlling insertion of a membrane channel into a membrane
US11840556B2 (en) * 2017-02-10 2023-12-12 Oxford Nanopore Technologies Plc Modified nanopores, compositions comprising the same, and uses thereof
WO2018195222A1 (en) 2017-04-19 2018-10-25 Electronic Biosciences, Inc. Nanopore/nanowell electrode enabled exonuclease sequencing
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
CN117106037B (zh) 2017-06-30 2025-07-25 弗拉芒区生物技术研究所 新颖蛋白孔
JP7042910B2 (ja) * 2017-11-27 2022-03-28 エフ.ホフマン-ラ ロシュ アーゲー ナノポア-sbs信号のための規格化およびベースラインシフト除去
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
GB202202716D0 (en) 2022-02-28 2022-04-13 Oxford Nanopore Tech Plc Apparatus and methods for controlling insertion of a membrane channel into a membrane
EP4565882A1 (en) 2022-08-02 2025-06-11 Glyphic Biotechnologies, Inc. Protein sequencing via coupling of polymerizable molecules
GB202401864D0 (en) 2024-02-12 2024-03-27 Fund Centre De Regulacio Genòmica A method of detecting non-canonical bases in sequencing data

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56026B1 (en) 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US5777078A (en) 1993-04-28 1998-07-07 Worcester Foundation For Experimental Biology Triggered pore-forming agents
CA2160909A1 (en) 1993-04-28 1994-11-10 Hagan Bayley Cell-targeted lytic pore-forming agents
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
AU8586298A (en) 1997-07-25 1999-02-16 University Of Massachusetts Designed protein pores as components for biosensors
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
US6127166A (en) 1997-11-03 2000-10-03 Bayley; Hagan Molluscan ligament polypeptides and genes encoding them
JPH11137260A (ja) 1997-11-06 1999-05-25 Soyaku Gijutsu Kenkyusho:Kk 抗インフルエンザウイルス環状ダンベル型rna−dnaキメラ化合物及び抗インフルエンザウイルス剤
US6123819A (en) 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
US6267872B1 (en) * 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US6426231B1 (en) 1998-11-18 2002-07-30 The Texas A&M University System Analyte sensing mediated by adapter/carrier molecules
NO986133D0 (no) 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
AU5763000A (en) 1999-06-22 2001-01-09 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
WO2001002425A2 (en) 1999-06-29 2001-01-11 University Health Network Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes
AU1804001A (en) 1999-12-02 2001-06-12 Molecular Staging, Inc. Generation of single-strand circular dna from linear self-annealing segments
WO2001059453A2 (en) 2000-02-11 2001-08-16 The Texas A & M University System Biosensor compositions and methods of use
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6936433B2 (en) 2000-11-27 2005-08-30 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US7807408B2 (en) 2001-03-19 2010-10-05 President & Fellows Of Harvard College Directed evolution of proteins
JP4211603B2 (ja) * 2001-05-29 2009-01-21 旭硝子株式会社 シゾサッカロマイセス・ポンベ(Schizosaccharomycespombe)宿主の構築方法および異種タンパク質の製造方法
US6863833B1 (en) 2001-06-29 2005-03-08 The Board Of Trustees Of The Leland Stanford Junior University Microfabricated apertures for supporting bilayer lipid membranes
AU2003245272A1 (en) 2002-05-10 2003-11-11 The Texas A And M University System Stochastic sensing through covalent interactions
US7163658B2 (en) 2003-04-23 2007-01-16 Rouvain Bension Rapid sequencing of polymers
WO2005056750A2 (en) 2003-12-11 2005-06-23 Quark Biotech, Inc. Inversion-duplication of nucleic acids and libraries prepared thereby
WO2006028508A2 (en) 2004-03-23 2006-03-16 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US7972858B2 (en) 2004-08-13 2011-07-05 President And Fellows Of Harvard College Ultra high-throughput opti-nanopore DNA readout platform
EP1842061A4 (en) 2004-12-21 2009-05-13 Texas A & M Univ Sys HIGH-TEMPERATURE ION CHANNELS AND ION PORES
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
GB0523282D0 (en) * 2005-11-15 2005-12-21 Isis Innovation Methods using pores
ATE518010T1 (de) 2005-12-22 2011-08-15 Pacific Biosciences California Aktive oberflächengekoppelte polymerasen
US7932029B1 (en) 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
WO2008045575A2 (en) 2006-10-13 2008-04-17 J. Craig Venter Institute, Inc. Sequencing method
DK2122344T3 (da) 2007-02-20 2019-07-15 Oxford Nanopore Tech Ltd Lipiddobbeltlags-sensorsystem
KR101521990B1 (ko) 2007-04-04 2015-05-20 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 나노포어 사용을 위한 조성물, 장치, 시스템 및 방법
GB2453377A (en) 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
JP2011527191A (ja) * 2008-07-07 2011-10-27 オックスフォード ナノポア テクノロジーズ リミテッド 塩基検出細孔
CN103695530B (zh) 2008-07-07 2016-05-25 牛津纳米孔技术有限公司 酶-孔构建体
CA3092369C (en) 2008-09-22 2025-09-23 University Of Washington MSP NANOPORES AND ASSOCIATED PROCESSES

Also Published As

Publication number Publication date
EP1951898A1 (en) 2008-08-06
CA2629009C (en) 2016-02-02
US20120219960A1 (en) 2012-08-30
RU2008123842A (ru) 2009-12-27
CA2629009A1 (en) 2007-05-24
EP2272981A1 (en) 2011-01-12
JP5328362B2 (ja) 2013-10-30
CN101356288B (zh) 2016-02-03
WO2007057668A1 (en) 2007-05-24
IL191319A (en) 2011-10-31
ATE545712T1 (de) 2012-03-15
EP2272981B1 (en) 2013-01-09
KR20080083281A (ko) 2008-09-17
US20080311582A1 (en) 2008-12-18
AU2006314296B2 (en) 2012-08-23
EP1951898B1 (en) 2012-02-15
NZ568163A (en) 2011-11-25
AU2006314296A1 (en) 2007-05-24
CN101356288A (zh) 2009-01-28
UA95087C2 (en) 2011-07-11
US8785211B2 (en) 2014-07-22
BRPI0618391A2 (pt) 2011-08-30
JP2009519705A (ja) 2009-05-21
MY149161A (en) 2013-07-31
US8105846B2 (en) 2012-01-31

Similar Documents

Publication Publication Date Title
GB0523282D0 (en) Methods using pores
DE602006019261D1 (de) Verfahren zur sequenzierung einer polynukleotidmatrize
JP2009519705A5 (enExample)
EA200702203A1 (ru) Способы и нуклеиновые кислоты для анализов клеточных пролиферативных нарушений
WO2009076485A3 (en) Sequencing of nucleic acids
ATE515573T1 (de) Verfahren zum nachweis der grösse von nukleinsäuren
WO2008039769A3 (en) Methods and devices for analyzing small rna molecules
DE602004017426D1 (de) Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression
DE602005021336D1 (de) Verfahren zur identifizierung von proteinen mit stärkephosphorylierender enzymatischer aktivität
ATE414169T1 (de) Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
HK1248286A1 (zh) 血浆dna的单分子测序
WO2017201102A8 (en) Method of improved sequencing by strand identification
ATE515488T1 (de) Click-chemie zur herstellung von reportermolekülen
EP3636776C0 (en) METHODS FOR ANALYSIS OF NUCLEIC SEQUENCE INFORMATION USING GC BIAS, POSSIBLY FOR THE DETECTION OF FETAL NUCLEIC ACID ABNORMALITIES
DE10084146D2 (de) Verfahren zur schnellen Bestimmung von Mikrobieller DNS/RNS, Kit dafür und Verwendung des Verfahrens
DK2258871T3 (da) Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser
WO2008073378A3 (en) High throughput dna sequencing method and apparatus
ATE430812T1 (de) Materialien und verfahren zum einfangen von krankheitserregern und zur abtrennung von aurintricarbonsäure aus einer probe
ATE519116T1 (de) Verfahren zur normierung der konzentration von analyten in einer urinprobe
JP2017521086A5 (enExample)
DE60108337D1 (de) Methode und testsatz zur detektion von schistosomiasis mittels polymerasekettenreaktion
DE602005019156D1 (de) Verfahren zur auswertung von ribonukleotidsequenzen
WO2011001274A3 (en) Methods for distinguishing between natural and artificial dna samples
DE602006021131D1 (de) Verfahren zur Bestimmung des Phänotyps von Zellen
WO2005100611A3 (en) Detection of viral nucleic acid and method for reverse transcribing rna

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)