DE602004017426D1 - Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression - Google Patents
Benutzung von intronischen rna sequenzen zur quantifizierung der genexpressionInfo
- Publication number
- DE602004017426D1 DE602004017426D1 DE602004017426T DE602004017426T DE602004017426D1 DE 602004017426 D1 DE602004017426 D1 DE 602004017426D1 DE 602004017426 T DE602004017426 T DE 602004017426T DE 602004017426 T DE602004017426 T DE 602004017426T DE 602004017426 D1 DE602004017426 D1 DE 602004017426D1
- Authority
- DE
- Germany
- Prior art keywords
- gene expression
- quantification
- rna sequences
- intronic rna
- intronic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000014509 gene expression Effects 0.000 title abstract 5
- 238000011002 quantification Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000011223 gene expression profiling Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44899103P | 2003-02-20 | 2003-02-20 | |
PCT/US2004/005287 WO2004074518A1 (en) | 2003-02-20 | 2004-02-19 | Use of intronic rna to measure gene expression |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004017426D1 true DE602004017426D1 (de) | 2008-12-11 |
Family
ID=32908682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004017426T Expired - Lifetime DE602004017426D1 (de) | 2003-02-20 | 2004-02-19 | Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression |
Country Status (11)
Country | Link |
---|---|
US (1) | US7767391B2 (de) |
EP (1) | EP1597391B1 (de) |
JP (2) | JP4568716B2 (de) |
AT (1) | ATE412779T1 (de) |
AU (1) | AU2004213871B9 (de) |
CA (1) | CA2516553C (de) |
DE (1) | DE602004017426D1 (de) |
DK (1) | DK1597391T3 (de) |
ES (1) | ES2314378T3 (de) |
PT (1) | PT1597391E (de) |
WO (1) | WO2004074518A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1918386B9 (de) * | 2002-03-13 | 2012-08-08 | Genomic Health, Inc. | Genexpressionsprofilierung in einer Biopsie unterzogenem Tumorgewebe |
EP1570080A4 (de) | 2002-11-15 | 2006-03-01 | Genomic Health Inc | Genexpressionsprofilierung einer egfr-positiven krebserkrankung |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
PT1597391E (pt) * | 2003-02-20 | 2008-12-19 | Genomic Health Inc | Utilização de arn intrónico para medir a expressão genética |
US20050064455A1 (en) * | 2003-05-28 | 2005-03-24 | Baker Joffre B. | Gene expression markers for predicting response to chemotherapy |
CA2530738C (en) * | 2003-06-24 | 2020-01-21 | Genomic Health, Inc. | Prediction of likelihood of cancer recurrence |
US7871769B2 (en) | 2004-04-09 | 2011-01-18 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
AU2012200431B2 (en) * | 2004-04-09 | 2013-06-27 | Fondazione Irccs Istituto Nazionale Dei Tumori | Gene expression markers for predicting response to chemotherapy |
AU2006270063A1 (en) * | 2005-07-15 | 2007-01-25 | Applied Biosystems, Llc. | Methods for RNA profiling |
WO2007025044A2 (en) * | 2005-08-24 | 2007-03-01 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
ES2491222T3 (es) | 2006-01-11 | 2014-09-05 | Genomic Health, Inc. | Marcadores de expresión génica para el pronóstico de cáncer colorrectal |
US7888019B2 (en) | 2006-03-31 | 2011-02-15 | Genomic Health, Inc. | Genes involved estrogen metabolism |
MX2008014608A (es) | 2006-05-18 | 2009-03-31 | Molecular Profiling Inst Inc | Sistema y metodo para determinar la intervencion medica individualizada para un estado de enfermedad. |
US20100113299A1 (en) * | 2008-10-14 | 2010-05-06 | Von Hoff Daniel D | Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type |
US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
WO2008058018A2 (en) | 2006-11-02 | 2008-05-15 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
US20090125247A1 (en) * | 2007-08-16 | 2009-05-14 | Joffre Baker | Gene expression markers of recurrence risk in cancer patients after chemotherapy |
EP2288727B1 (de) * | 2008-05-14 | 2013-07-10 | Genomic Health, Inc. | Vorhersageindikatoren des ansprechens von patienten auf eine behandlung mit egf-rezeptor-inhibitoren |
AU2009253675A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
US10359425B2 (en) * | 2008-09-09 | 2019-07-23 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
US20100221752A2 (en) * | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
US20120041274A1 (en) | 2010-01-07 | 2012-02-16 | Myriad Genetics, Incorporated | Cancer biomarkers |
US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
SG10201401722XA (en) * | 2009-05-01 | 2014-08-28 | Genomic Health Inc | Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer andresponse to chemotherapy |
US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
US20120053253A1 (en) | 2010-07-07 | 2012-03-01 | Myriad Genetics, Incorporated | Gene signatures for cancer prognosis |
CN104777313B (zh) | 2010-07-09 | 2017-09-26 | 私募蛋白质体公司 | 肺癌生物标记及其用途 |
DE102010033575B4 (de) | 2010-08-02 | 2016-01-14 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | ASPP2-Splicevariante |
SG187045A1 (en) | 2010-08-13 | 2013-02-28 | Somalogic Inc | Pancreatic cancer biomarkers and uses thereof |
EP2611941A4 (de) | 2010-08-30 | 2014-01-22 | Myriad Genetics Inc | Gensignaturen zur krebsdiagnose und -prognose |
WO2012174203A2 (en) * | 2011-06-14 | 2012-12-20 | Anthony Albino | Methods and kits for the detection and treatment of recurring prostate cancer |
WO2013010074A1 (en) | 2011-07-13 | 2013-01-17 | Primeradx, Inc. | Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample |
GB201114919D0 (en) * | 2011-08-30 | 2011-10-12 | Glaxosmithkline Biolog Sa | Method |
AU2012352153B2 (en) | 2011-12-13 | 2018-07-26 | Veracyte, Inc. | Cancer diagnostics using non-coding transcripts |
WO2014028884A2 (en) | 2012-08-16 | 2014-02-20 | Genomedx Biosciences, Inc. | Cancer diagnostics using biomarkers |
WO2014078700A1 (en) | 2012-11-16 | 2014-05-22 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
CA2947624A1 (en) | 2014-05-13 | 2015-11-19 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
CN114606309A (zh) | 2014-11-05 | 2022-06-10 | 威拉赛特公司 | 使用机器学习和高维转录数据的诊断系统和方法 |
EP3504348B1 (de) | 2016-08-24 | 2022-12-14 | Decipher Biosciences, Inc. | Verwendung von genomischen signaturen zur vorhersage des ansprechens von patienten mit prostatakrebs auf postoperative strahlentherapie |
AU2018210695A1 (en) | 2017-01-20 | 2019-08-08 | The University Of British Columbia | Molecular subtyping, prognosis, and treatment of bladder cancer |
EP3593140A4 (de) | 2017-03-09 | 2021-01-06 | Decipher Biosciences, Inc. | Subtypisierung von prostatakrebs zur vorhersage der reaktion auf eine hormontherapie |
EP3622087A4 (de) | 2017-05-12 | 2021-06-16 | Decipher Biosciences, Inc. | Genetische signaturen zur vorhersage der prostatakrebsmetastasierung und identifizierung von tumoraggressivität |
US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4699877A (en) * | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
USRE35491E (en) * | 1982-11-04 | 1997-04-08 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
CA1252046A (en) | 1982-11-04 | 1989-04-04 | Martin J. Cline | Methods for oncogenic detection |
US7838216B1 (en) * | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
US4968603A (en) * | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
US5858678A (en) * | 1994-08-02 | 1999-01-12 | St. Louis University | Apoptosis-regulating proteins |
US5830753A (en) * | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
US6416635B1 (en) * | 1995-07-24 | 2002-07-09 | Tokyo Electron Limited | Method and apparatus for sputter coating with variable target to substrate spacing |
ES2255715T3 (es) * | 1995-12-18 | 2006-07-01 | Sugen, Inc. | Diagnostico y tratamiento de transtornos relacionados con la aur-1 y/o la aur-2. |
US6716575B2 (en) * | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
US5821082A (en) * | 1996-05-23 | 1998-10-13 | St. Louis University Health Sciences Center | Anti-proliferation domain of a human Bcl-2 and DNA encoding the same |
US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6146828A (en) | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
US6203993B1 (en) * | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US5952178A (en) * | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
US6143529A (en) * | 1996-08-14 | 2000-11-07 | Exact Laboratories, Inc. | Methods for improving sensitivity and specificity of screening assays |
US5861278A (en) * | 1996-11-01 | 1999-01-19 | Genetics Institute, Inc. | HNF3δ compositions |
JP4672092B2 (ja) * | 1996-11-20 | 2011-04-20 | イェール ユニバーシティ | 細胞アポトーシスを阻害するタンパク質であるサービビン(Survivin)、およびその調節 |
US5830665A (en) * | 1997-03-03 | 1998-11-03 | Exact Laboratories, Inc. | Contiguous genomic sequence scanning |
US6033893A (en) | 1997-06-26 | 2000-03-07 | Incyte Pharmaceuticals, Inc. | Human cathepsin |
WO1999002714A1 (en) | 1997-07-07 | 1999-01-21 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
US6020135A (en) * | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
GB2339200B (en) * | 1998-06-06 | 2001-09-12 | Genostic Pharma Ltd | Genostics |
US6696558B2 (en) * | 1998-09-09 | 2004-02-24 | The Burnham Institute | Bag proteins and nucleic acid molecules encoding them |
WO2000050595A2 (en) | 1999-02-25 | 2000-08-31 | Ivan Gout | Nucleic acid molecules associated with melanoma and thyroid tumors |
AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
US20020039764A1 (en) * | 1999-03-12 | 2002-04-04 | Rosen Craig A. | Nucleic, acids, proteins, and antibodies |
US6692916B2 (en) * | 1999-06-28 | 2004-02-17 | Source Precision Medicine, Inc. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
US6960439B2 (en) * | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
US6326148B1 (en) | 1999-07-12 | 2001-12-04 | The Regents Of The University Of California | Detection of copy number changes in colon cancer |
US6710170B2 (en) * | 1999-09-10 | 2004-03-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
US6271002B1 (en) * | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
AU777096B2 (en) | 1999-10-06 | 2004-09-30 | Regents Of The University Of California, The | Differentially expressed genes associated with Her-2/neu overexpression |
CA2494705A1 (en) | 1999-12-01 | 2001-06-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6750013B2 (en) | 1999-12-02 | 2004-06-15 | Protein Design Labs, Inc. | Methods for detection and diagnosing of breast cancer |
US6248535B1 (en) * | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
AU2001232485A1 (en) * | 2000-01-13 | 2001-07-24 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
US6322986B1 (en) * | 2000-01-18 | 2001-11-27 | Albany Medical College | Method for colorectal cancer prognosis and treatment selection |
AU2001234608A1 (en) * | 2000-01-28 | 2001-08-07 | Genetrace Systems, Inc. | Methods for analysis of gene expression |
WO2001055321A2 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
US20030165831A1 (en) | 2000-03-21 | 2003-09-04 | John Lee | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
AU2001249600A1 (en) * | 2000-03-31 | 2001-10-15 | University Of Louisville Research Foundation, Inc. | Microarrays to screen regulatory genes |
AU2001266787A1 (en) | 2000-06-07 | 2002-01-08 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
AU2001280008A1 (en) * | 2000-07-21 | 2002-02-05 | Global Genomics Ab | A method and an algorithm for mRNA expression analysis |
WO2002008282A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Bstp-ras/rerg protein and related reagents and methods of use thereof |
WO2002008262A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Bstp-5 proteins and related reagents and methods of use thereof |
WO2002008260A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Bstp-ecg1 protein and related reagents and methods of use thereof |
US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
US6582919B2 (en) * | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
US6602670B2 (en) * | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
EP1353947A2 (de) | 2000-12-08 | 2003-10-22 | Ipsogen | Erstellung von genexpressionsprofilen bei primärem brustkrebs unter verwendung von arrays mit putativ involvierten genen |
AU2002255478A1 (en) | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
AU2002246970B2 (en) * | 2001-01-12 | 2007-06-14 | Yale University | Detection of survivin in the biological fluids of cancer patients |
US7776518B2 (en) * | 2001-01-12 | 2010-08-17 | Yale University | Detection of survivin in the biological fluids of cancer patients |
CA2440703A1 (en) | 2001-01-24 | 2002-08-01 | Protein Design Labs, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
KR20030094281A (ko) * | 2001-03-12 | 2003-12-11 | 모노젠, 인크. | 세포에 기초한 질병상태의 검출 및 질병상태의 구별 |
DK1410011T3 (da) | 2001-06-18 | 2011-07-18 | Netherlands Cancer Inst | Diagnose og prognose for brystcancerpatienter |
US7125680B2 (en) | 2001-07-27 | 2006-10-24 | The Regents Of The University Of California | Methods and materials for characterizing and modulating interaction between heregulin and HER3 |
US7026123B1 (en) * | 2001-08-29 | 2006-04-11 | Pioneer Hi-Bred International, Inc. | UTR tag assay for gene function discovery |
EP1444361A4 (de) * | 2001-09-28 | 2006-12-27 | Whitehead Biomedical Inst | Klassifizierung von lungenkarzinomen mittels genexpressionsanalyse |
US6964850B2 (en) * | 2001-11-09 | 2005-11-15 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
US20030198972A1 (en) * | 2001-12-21 | 2003-10-23 | Erlander Mark G. | Grading of breast cancer |
US20050216961A1 (en) | 2002-03-28 | 2005-09-29 | Delaney Allen D | Cancer associated protein kinases and their uses |
EP1900827A3 (de) | 2002-05-21 | 2008-04-16 | Bayer HealthCare AG | Verfahren und Zusammensetzungen zur Vorhersage, Diagnose, Prognose, Verhinderung und Behandlung maligner Neoplasien |
PT1597391E (pt) * | 2003-02-20 | 2008-12-19 | Genomic Health Inc | Utilização de arn intrónico para medir a expressão genética |
-
2004
- 2004-02-19 PT PT04712947T patent/PT1597391E/pt unknown
- 2004-02-19 AU AU2004213871A patent/AU2004213871B9/en not_active Expired
- 2004-02-19 WO PCT/US2004/005287 patent/WO2004074518A1/en active Application Filing
- 2004-02-19 CA CA2516553A patent/CA2516553C/en not_active Expired - Lifetime
- 2004-02-19 AT AT04712947T patent/ATE412779T1/de active
- 2004-02-19 ES ES04712947T patent/ES2314378T3/es not_active Expired - Lifetime
- 2004-02-19 JP JP2006503799A patent/JP4568716B2/ja not_active Expired - Lifetime
- 2004-02-19 US US10/783,884 patent/US7767391B2/en active Active
- 2004-02-19 DK DK04712947T patent/DK1597391T3/da active
- 2004-02-19 DE DE602004017426T patent/DE602004017426D1/de not_active Expired - Lifetime
- 2004-02-19 EP EP04712947A patent/EP1597391B1/de not_active Expired - Lifetime
-
2006
- 2006-12-25 JP JP2006348657A patent/JP2007075127A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2004213871B2 (en) | 2009-01-29 |
AU2004213871B9 (en) | 2009-09-03 |
ES2314378T3 (es) | 2009-03-16 |
AU2004213871A1 (en) | 2004-09-02 |
US20040191817A1 (en) | 2004-09-30 |
WO2004074518A1 (en) | 2004-09-02 |
JP2007075127A (ja) | 2007-03-29 |
PT1597391E (pt) | 2008-12-19 |
US7767391B2 (en) | 2010-08-03 |
CA2516553A1 (en) | 2004-09-02 |
EP1597391A1 (de) | 2005-11-23 |
DK1597391T3 (da) | 2009-01-12 |
JP4568716B2 (ja) | 2010-10-27 |
JP2006518602A (ja) | 2006-08-17 |
ATE412779T1 (de) | 2008-11-15 |
EP1597391B1 (de) | 2008-10-29 |
CA2516553C (en) | 2013-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602004017426D1 (de) | Benutzung von intronischen rna sequenzen zur quantifizierung der genexpression | |
ATE469968T1 (de) | Verfahren und mittel zur überwachung und modulation des gen-silencing | |
DE60328618D1 (de) | Verfahren für die behandlung von proliferativen erkrankungen von brustzellen | |
ATE444377T1 (de) | Nukleinsäurecharakterisierung | |
ATE542918T1 (de) | Verfahren zur quantifizierung von mikro-rnas und kleinen interferenz-rnas | |
DK1730315T3 (da) | Polymorphismer i NOD2/Card15 gen | |
DE60324188D1 (de) | Verfahren zur verwendung von riboprimern zur strangverdrängungsreplikation von zielsequenzen | |
ATE410524T1 (de) | Verfahren und nukleinsäuren für die analyse von zellulären proliferationsstörungen | |
WO2006137941A3 (en) | Methods and compositions involving mirna and mirna inhibitor molecules | |
DE602005008146D1 (de) | Methode für die Quantifizierung der Ausgangs-Konzentration von Nukleinsäuren ausgehend von real-time Amplifikationsdaten | |
ATE552350T1 (de) | Elektrokatalytischer nukleinsäurehybridisierungsnachweis | |
ATE522627T1 (de) | Verfahren zur herstellung von nukleinsäuresonden | |
ATE527385T1 (de) | Mit tumoren assoziierte genetische variationen | |
DE602006013831D1 (de) | Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz | |
ES2530843T3 (es) | Métodos basados en microARN para el diagnóstico de cáncer de páncreas | |
WO2010062913A3 (en) | Methods and systems for analysis of sequencing data | |
DE602004020220D1 (de) | Mittel und verfahren zum nachweis von zielnukleotidsequenzen unter verwendung von ligationstests mit verbesserten oligonukleotidsondenpaaren | |
ATE456666T1 (de) | Verfahren zur auswertung von ribonukleotidsequenzen | |
WO2005059108A3 (en) | Gene expression profiles and methods of use | |
DE602005017252D1 (de) | Verfahren zur amplifikation von nukleinsäuren mittels promotor-templates | |
ATE376596T1 (de) | Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen | |
DE602008006254D1 (de) | Doppel-oligonukleotid-nukleinsäurenachweisverfahren | |
DE60326748D1 (de) | Verfahren zur identifizierung des brustkrebsrisikos | |
WO2004029285A3 (en) | Methods for detecting endocrine cancer | |
WO2004043232A3 (en) | Methods for identifying risk of melanoma and treatments thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |