ATE376596T1 - Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen - Google Patents
Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellenInfo
- Publication number
- ATE376596T1 ATE376596T1 AT03742934T AT03742934T ATE376596T1 AT E376596 T1 ATE376596 T1 AT E376596T1 AT 03742934 T AT03742934 T AT 03742934T AT 03742934 T AT03742934 T AT 03742934T AT E376596 T1 ATE376596 T1 AT E376596T1
- Authority
- AT
- Austria
- Prior art keywords
- disorders
- analyzing
- nucleic acids
- cell proliferation
- colorectal cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 210000001072 colon Anatomy 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 230000030933 DNA methylation on cytosine Effects 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000001973 epigenetic effect Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02004551A EP1340818A1 (de) | 2002-02-27 | 2002-02-27 | Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE376596T1 true ATE376596T1 (de) | 2007-11-15 |
Family
ID=27675653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03742934T ATE376596T1 (de) | 2002-02-27 | 2003-02-13 | Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen |
| AT03714760T ATE431429T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebszellen |
| AT03742964T ATE491038T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebs |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03714760T ATE431429T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebszellen |
| AT03742964T ATE491038T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebs |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US8691503B2 (de) |
| EP (4) | EP1340818A1 (de) |
| JP (3) | JP2005518218A (de) |
| AT (3) | ATE376596T1 (de) |
| AU (3) | AU2003210265A1 (de) |
| CA (1) | CA2451982A1 (de) |
| DE (3) | DE60317045T2 (de) |
| ES (2) | ES2295607T3 (de) |
| WO (3) | WO2003072812A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9201067B2 (en) * | 2003-03-05 | 2015-12-01 | Posco | Size-controlled macromolecule |
| EP1340818A1 (de) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen |
| US20040029128A1 (en) * | 2002-08-08 | 2004-02-12 | Epigenomics, Inc. | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| WO2005071111A1 (en) * | 2004-01-23 | 2005-08-04 | Lingvitae As | Improving polynucleotide ligation reactions |
| WO2005089414A2 (en) * | 2004-03-17 | 2005-09-29 | The Johns Hopkins University | Neoplasia diagnostic compositions and methods of use |
| EP1778865A1 (de) * | 2004-06-23 | 2007-05-02 | Epigenomics AG | Verfahren und nukleinsäuren zum nachweis der metastasierung proliferativer kolonzellerkrankungen |
| KR100617649B1 (ko) | 2004-09-24 | 2006-09-04 | (주)지노믹트리 | 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도 |
| ES2521115T3 (es) * | 2004-09-30 | 2014-11-12 | Epigenomics Ag | Método para proveer fragmentos de ADN derivados de una muestra archivada |
| US7932027B2 (en) | 2005-02-16 | 2011-04-26 | Epigenomics Ag | Method for determining the methylation pattern of a polynucleic acid |
| WO2006088978A1 (en) | 2005-02-16 | 2006-08-24 | Epigenomics, Inc. | Method for determining the methylation pattern of a polynucleic acid |
| AU2006236363B2 (en) | 2005-04-15 | 2012-11-01 | Epigenomics Ag | A method for providing DNA fragments derived from a remote sample |
| US20100143899A1 (en) * | 2005-05-17 | 2010-06-10 | University Of Vermont And State Agricultural College | Methods and products for diagnosing cancer |
| US20080076134A1 (en) * | 2006-09-21 | 2008-03-27 | Nuclea Biomarkers, Llc | Gene and protein expression profiles associated with the therapeutic efficacy of irinotecan |
| WO2008134020A1 (en) * | 2007-04-26 | 2008-11-06 | University Of Vermont And State Agricultural College | Ccl18 and ccl3 methods and compositions for detecting and treating cancer |
| JP2010540534A (ja) * | 2007-09-28 | 2010-12-24 | イントレキソン コーポレーション | 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用 |
| CN101835803B (zh) * | 2007-10-19 | 2016-05-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗tenb2抗体和抗体药物偶联物 |
| ES2685678T3 (es) * | 2007-10-23 | 2018-10-10 | Clinical Genomics Pty Ltd | Un método para el diagnóstico de neoplasias - II |
| KR100969692B1 (ko) * | 2008-01-18 | 2010-07-14 | 한국생명공학연구원 | 대장암 과발현 유전자를 이용한 대장암 진단 마커 |
| US20100112713A1 (en) * | 2008-11-05 | 2010-05-06 | The Texas A&M University System | Methods For Detecting Colorectal Diseases And Disorders |
| WO2010070572A1 (en) * | 2008-12-18 | 2010-06-24 | Koninklijke Philips Electronics N. V. | Method for the detection of dna methylation patterns |
| JP2014519310A (ja) | 2011-02-02 | 2014-08-14 | エクザクト サイエンシーズ コーポレイション | Ｄｎａメチル化のデジタル配列分析 |
| US9994900B2 (en) | 2011-10-17 | 2018-06-12 | King Abdullah University Of Science And Technology | Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer |
| US9598735B2 (en) * | 2012-11-14 | 2017-03-21 | JBS Science Inc. | Detection of a panel of urine DNA markers for HCC screening and disease management |
| EP2886659A1 (de) * | 2013-12-20 | 2015-06-24 | AIT Austrian Institute of Technology GmbH | Genmethylierung basierend auf der Diagnose von Kolorektalkrebs |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585481A (en) * | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5023090A (en) * | 1989-08-16 | 1991-06-11 | Levin Robert H | Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE |
| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| US5180808A (en) * | 1989-11-27 | 1993-01-19 | La Jolla Cancer Research Foundation | Versican core protein, nucleic acid sequences encoding the same, nucleic acid probes, anti-versican antibodies, and methods of detecting the same |
| US5245022A (en) * | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5574142A (en) * | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| WO1995015373A2 (en) | 1993-11-30 | 1995-06-08 | Mcgill University | Inhibition of dna methyltransferase |
| US5597696A (en) * | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5786146A (en) * | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| WO1998032849A2 (en) | 1997-01-29 | 1998-07-30 | Institut Pasteur | Polynucleotide associated with the bo or bor syndrome, its corresponding polypeptide and diagnostic and therapeutic applications |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| JP2003528564A (ja) * | 1998-06-06 | 2003-09-30 | ジェノスティック ファーマ リミテッド | 遺伝的プロファイリングに使用するプローブ |
| US7700324B1 (en) * | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US5958773A (en) * | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US6335170B1 (en) * | 1999-02-22 | 2002-01-01 | Torben F. Orntoft | Gene expression in bladder tumors |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| DE19935772C2 (de) * | 1999-07-26 | 2002-11-07 | Epigenomics Ag | Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben |
| CZ2002329A3 (cs) * | 1999-07-30 | 2002-07-17 | Epidauros Biotechnologie Aktiengesellschaft | Polymorfismy v lidském genu MDR-1 a jejich pouľití v diagnostických a terapeutických aplikacích |
| DE10019058A1 (de) | 2000-04-06 | 2001-12-20 | Epigenomics Ag | Detektion von Variationen des DNA-Methylierungsprofils |
| WO2001068911A2 (en) * | 2000-03-15 | 2001-09-20 | Epigenomics Ag | Diagnosis of diseases associated with the cell cycle |
| JP2003528630A (ja) * | 2000-03-28 | 2003-09-30 | カイロン コーポレイション | ヒト遺伝子および発現産物 |
| DE10029915B4 (de) * | 2000-06-19 | 2005-06-16 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen |
| AU2001277521A1 (en) * | 2000-06-30 | 2002-01-14 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| NZ524229A (en) * | 2000-09-01 | 2006-01-27 | Epigenomics Ag | Method for simultaneous detection of many different methylation positions of specific cytosine residues in genomic DNA in the sequence context of 5'-CpG-3' |
| US7029851B2 (en) * | 2001-03-15 | 2006-04-18 | Clemson University | Polynucleotide encoding a gene conferring resistance to Bacillus thuringiensis toxins |
| DE10120798B4 (de) * | 2001-04-27 | 2005-12-29 | Genovoxx Gmbh | Verfahren zur Bestimmung der Genexpression |
| EP1468110A4 (de) * | 2001-06-10 | 2008-01-30 | Irm Llc | Molekulare signaturen normalerweise zum tod führender karzinome |
| AU2003212878A1 (en) * | 2002-01-30 | 2003-09-02 | Epigenomics Ag | Identification of cell differentiation states based on methylation patterns |
| EP1340818A1 (de) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen |
| US7501430B2 (en) * | 2006-04-17 | 2009-03-10 | Arqule, Inc. | RAF inhibitors and their uses |
-
2002
- 2002-02-27 EP EP02004551A patent/EP1340818A1/de not_active Withdrawn
-
2003
- 2003-02-13 ES ES03742934T patent/ES2295607T3/es not_active Expired - Lifetime
- 2003-02-13 AU AU2003210265A patent/AU2003210265A1/en not_active Abandoned
- 2003-02-13 CA CA002451982A patent/CA2451982A1/en not_active Abandoned
- 2003-02-13 JP JP2003571492A patent/JP2005518218A/ja active Pending
- 2003-02-13 DE DE60317045T patent/DE60317045T2/de not_active Expired - Lifetime
- 2003-02-13 US US10/482,823 patent/US8691503B2/en not_active Expired - Fee Related
- 2003-02-13 AT AT03742934T patent/ATE376596T1/de not_active IP Right Cessation
- 2003-02-13 EP EP03742934A patent/EP1478784B1/de not_active Expired - Lifetime
- 2003-02-13 WO PCT/EP2003/001457 patent/WO2003072812A2/en not_active Ceased
- 2003-02-27 AU AU2003219002A patent/AU2003219002B2/en not_active Ceased
- 2003-02-27 EP EP03714760A patent/EP1478778B1/de not_active Expired - Lifetime
- 2003-02-27 JP JP2003571501A patent/JP2005518220A/ja active Pending
- 2003-02-27 DE DE60327600T patent/DE60327600D1/de not_active Expired - Lifetime
- 2003-02-27 US US10/506,111 patent/US20060246433A1/en not_active Abandoned
- 2003-02-27 JP JP2003571500A patent/JP2005518219A/ja active Pending
- 2003-02-27 AU AU2003248349A patent/AU2003248349B2/en not_active Ceased
- 2003-02-27 WO PCT/EP2003/002035 patent/WO2003072821A2/en not_active Ceased
- 2003-02-27 AT AT03714760T patent/ATE431429T1/de not_active IP Right Cessation
- 2003-02-27 DE DE60335245T patent/DE60335245D1/de not_active Expired - Lifetime
- 2003-02-27 ES ES03714760T patent/ES2325363T3/es not_active Expired - Lifetime
- 2003-02-27 EP EP03742964A patent/EP1481095B1/de not_active Expired - Lifetime
- 2003-02-27 US US10/506,089 patent/US20060234224A1/en not_active Abandoned
- 2003-02-27 AT AT03742964T patent/ATE491038T1/de not_active IP Right Cessation
- 2003-02-27 WO PCT/EP2003/002034 patent/WO2003072820A2/en not_active Ceased
-
2010
- 2010-06-04 US US12/794,449 patent/US9988683B2/en not_active Expired - Lifetime
-
2014
- 2014-02-21 US US14/186,984 patent/US20140179563A1/en not_active Abandoned
- 2014-11-25 US US14/553,566 patent/US20150275312A1/en not_active Abandoned
Also Published As
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