ATE431429T1 - Verfahren und nukleinsäuren zur analyse von kolonkrebszellen - Google Patents

Verfahren und nukleinsäuren zur analyse von kolonkrebszellen

Info

Publication number
ATE431429T1
ATE431429T1 AT03714760T AT03714760T ATE431429T1 AT E431429 T1 ATE431429 T1 AT E431429T1 AT 03714760 T AT03714760 T AT 03714760T AT 03714760 T AT03714760 T AT 03714760T AT E431429 T1 ATE431429 T1 AT E431429T1
Authority
AT
Austria
Prior art keywords
nucleic acids
cancer cells
colon cancer
analyzing
analyzing colon
Prior art date
Application number
AT03714760T
Other languages
English (en)
Inventor
Peter Adorjan
Matthias Burger
Sabine Maier
Inko Nimmrich
Evelyne Becker
Ralf Lesche
Tamas Rujan
Armin Schmitt
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Application granted granted Critical
Publication of ATE431429T1 publication Critical patent/ATE431429T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT03714760T 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen ATE431429T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004551A EP1340818A1 (de) 2002-02-27 2002-02-27 Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
PCT/EP2003/002035 WO2003072821A2 (en) 2002-02-27 2003-02-27 Method and nucleic acids for the analysis of a colon cell proliferactive disorder

Publications (1)

Publication Number Publication Date
ATE431429T1 true ATE431429T1 (de) 2009-05-15

Family

ID=27675653

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03742934T ATE376596T1 (de) 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
AT03742964T ATE491038T1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs
AT03714760T ATE431429T1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT03742934T ATE376596T1 (de) 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
AT03742964T ATE491038T1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs

Country Status (9)

Country Link
US (6) US8691503B2 (de)
EP (4) EP1340818A1 (de)
JP (3) JP2005518218A (de)
AT (3) ATE376596T1 (de)
AU (3) AU2003210265A1 (de)
CA (1) CA2451982A1 (de)
DE (3) DE60317045T2 (de)
ES (2) ES2295607T3 (de)
WO (3) WO2003072812A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
EP1340818A1 (de) 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
US20080248536A1 (en) * 2004-01-23 2008-10-09 Lingvitae As Polynucleotide Ligation Reactions
WO2005089414A2 (en) * 2004-03-17 2005-09-29 The Johns Hopkins University Neoplasia diagnostic compositions and methods of use
US7943308B2 (en) * 2004-06-23 2011-05-17 Epigenomics Ag Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
KR100617649B1 (ko) 2004-09-24 2006-09-04 (주)지노믹트리 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도
EP3061833B1 (de) * 2004-09-30 2018-03-14 Epigenomics AG Verfahren zur bereitstellung von dna-fragmenten aus einer archivierten probe
EP1693468A1 (de) 2005-02-16 2006-08-23 Epigenomics AG Verfahren zur Bestimmung des Methylierungsmusters einer Polynukleinsäure
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
CA2603815C (en) 2005-04-15 2017-09-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
US20100143899A1 (en) * 2005-05-17 2010-06-10 University Of Vermont And State Agricultural College Methods and products for diagnosing cancer
EP2081950B1 (de) * 2006-09-21 2013-03-20 Nuclea Biomarkers LLC Mit irinotecan-behandlung assoziierte expressionsprofile
US8445442B2 (en) * 2007-04-26 2013-05-21 University Of Vermont And State Agricultural College CCL18 and CCL3 methods and compositions for detecting and treating cancer
CA2715080C (en) * 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
EP2209808B1 (de) * 2007-10-19 2014-01-15 Genentech, Inc. Cysteinmodifizierte anti-tenb2-antikörper und antikörper-arzneimittel-konjugate
WO2009052567A1 (en) * 2007-10-23 2009-04-30 Clinical Genomics Pty. Ltd. A method of diagnosing neoplasms - ii
KR100969692B1 (ko) * 2008-01-18 2010-07-14 한국생명공학연구원 대장암 과발현 유전자를 이용한 대장암 진단 마커
US20100112713A1 (en) * 2008-11-05 2010-05-06 The Texas A&M University System Methods For Detecting Colorectal Diseases And Disorders
WO2010070572A1 (en) * 2008-12-18 2010-06-24 Koninklijke Philips Electronics N. V. Method for the detection of dna methylation patterns
EP2670893B1 (de) 2011-02-02 2018-06-27 Exact Sciences Development Company, LLC Digitale sequenzanalyse einer dna-methylierung
AU2012324545A1 (en) * 2011-10-17 2014-06-05 King Abdullah University Of Science And Technology Composite biomarker for non-invasive screening, diagnosis and prognosis of colorectal cancer
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
EP2886659A1 (de) * 2013-12-20 2015-06-24 AIT Austrian Institute of Technology GmbH Genmethylierung basierend auf der Diagnose von Kolorektalkrebs

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5023090A (en) * 1989-08-16 1991-06-11 Levin Robert H Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US5180808A (en) * 1989-11-27 1993-01-19 La Jolla Cancer Research Foundation Versican core protein, nucleic acid sequences encoding the same, nucleic acid probes, anti-versican antibodies, and methods of detecting the same
US5245022A (en) 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
JPH09506253A (ja) 1993-11-30 1997-06-24 マクギル・ユニヴァーシティ Ｄｎａメチルトランスフェラーゼの阻害
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU6293798A (en) 1997-01-29 1998-08-18 Institut Pasteur Polynucleotide associated with the bo or bor syndrome, its corresponding polypeptide and diagnostic and therapeutic applications
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
JP2003528564A (ja) * 1998-06-06 2003-09-30 ジェノスティック ファーマ リミテッド 遺伝的プロファイリングに使用するプローブ
US7700324B1 (en) * 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
WO2000052204A2 (en) 1999-02-22 2000-09-08 Orntoft Torben F Gene expression in bladder tumors
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
DE19935772C2 (de) * 1999-07-26 2002-11-07 Epigenomics Ag Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben
EE200200049A (et) * 1999-07-30 2003-04-15 Epidauros Polümorfismid inimese MDR-1 geenis ning nende kasutamine diagnostikas ja terapeutilistes rakendustes
DE10019058A1 (de) * 2000-04-06 2001-12-20 Epigenomics Ag Detektion von Variationen des DNA-Methylierungsprofils
JP2004507214A (ja) * 2000-03-15 2004-03-11 エピゲノミクス　アーゲー 腫瘍抑制遺伝子と腫瘍遺伝子に関連する疾患の診断
JP2003528630A (ja) 2000-03-28 2003-09-30 カイロン コーポレイション ヒト遺伝子および発現産物
DE10029915B4 (de) * 2000-06-19 2005-06-16 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen
WO2002000926A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
EP1423528B1 (de) * 2000-09-01 2008-01-02 Epigenomics AG Verfahren zur bestimmung des methylierungsgrades von bestimmten cytosinen in genomischer dna im sequenzkontext 5'-cpg-3'
WO2002074079A2 (en) * 2001-03-15 2002-09-26 Clemson University Polynucleotide encoding a gene conferring resistance to bacillus thuringiensis toxins
DE10120798B4 (de) * 2001-04-27 2005-12-29 Genovoxx Gmbh Verfahren zur Bestimmung der Genexpression
US20030138793A1 (en) * 2001-06-10 2003-07-24 Irm Llc, A Delaware Limited Liability Company Molecular signatures of commonly fatal carcinomas
EP1470255A2 (de) * 2002-01-30 2004-10-27 Epigenomics AG Nachweis des zelldifferenzierungszustandes mittels methylierungsmuster
EP1340818A1 (de) 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
US7501430B2 (en) * 2006-04-17 2009-03-10 Arqule, Inc. RAF inhibitors and their uses

Also Published As

Publication number Publication date
AU2003248349B2 (en) 2008-05-01
AU2003248349A1 (en) 2003-09-09
US20050003463A1 (en) 2005-01-06
US20060234224A1 (en) 2006-10-19
DE60317045D1 (de) 2007-12-06
ATE491038T1 (de) 2010-12-15
DE60335245D1 (de) 2011-01-20
AU2003210265A1 (en) 2003-09-09
DE60327600D1 (de) 2009-06-25
EP1478778A2 (de) 2004-11-24
US8691503B2 (en) 2014-04-08
EP1340818A1 (de) 2003-09-03
JP2005518218A (ja) 2005-06-23
WO2003072812A3 (en) 2003-10-23
WO2003072812A2 (en) 2003-09-04
EP1481095B1 (de) 2010-12-08
EP1481095A2 (de) 2004-12-01
ATE376596T1 (de) 2007-11-15
CA2451982A1 (en) 2003-09-04
WO2003072821A3 (en) 2004-04-01
WO2003072821A2 (en) 2003-09-04
AU2003219002A1 (en) 2003-09-09
EP1478784B1 (de) 2007-10-24
ES2325363T3 (es) 2009-09-02
DE60317045T2 (de) 2008-08-07
US20150275312A1 (en) 2015-10-01
EP1478778B1 (de) 2009-05-13
JP2005518219A (ja) 2005-06-23
AU2003219002B2 (en) 2008-04-24
WO2003072820A2 (en) 2003-09-04
EP1478784A2 (de) 2004-11-24
US20110046005A1 (en) 2011-02-24
US9988683B2 (en) 2018-06-05
US20060246433A1 (en) 2006-11-02
JP2005518220A (ja) 2005-06-23
ES2295607T3 (es) 2008-04-16
WO2003072820A3 (en) 2004-04-08
US20140179563A1 (en) 2014-06-26

Similar Documents

Publication Publication Date Title
ATE431429T1 (de) Verfahren und nukleinsäuren zur analyse von kolonkrebszellen
WO2002077272A3 (en) Methods and nucleic acids for the analysis of hematopoietic cell proliferative disorders
WO2002002808A3 (en) Method and nucleic acids for the analysis of astrocytomas
ATE437962T1 (de) Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
AU7633001A (en) Diagnosis of diseases associated with apoptosis
WO2003052135A3 (en) Method and nucleic acids for the analysis of a lung cell proliferative disorder
WO2004020662A3 (en) Method and nucleic acids for the analysis of breast cell proliferative disorders
WO2003012046A3 (en) Stk15 (stk6) gene polymorphism and methods of determining cancer risk
WO2004005465A3 (en) Compositions and methods for the detection of human t cell receptor variable family gene expression
ATE451611T1 (de) Verfahren zum nachweis einzelner nukleotidpolymorphismen (snp) und punktmutationen in genen
WO2003014388A3 (en) Method and nucleic acids for the analysis of colon cancer
WO2002103042A3 (en) Method and nucleic acids for the differentiation of prostate tumors
WO2003044226A3 (en) Method and nucleic acids for the analysis of a lymphoid cell proliferative disorder
WO2005001142A3 (en) Methods and nucleic acids for the analysis of colorectal cell proliferative disorders
US11034996B2 (en) Nucleic acid sequence and capture by formation of an abasic site-derived cross-link
WO2005001140A3 (en) Methods and nucleic acids for the analysis of colon cell proliferative disorders
EP1358345B1 (de) Multitemperature "single strand conformation polymorphism" (msscp)
WO2002103041A3 (en) Method and nucleic acids for the differentiation of prostate and renal carcinomas
ATE350489T1 (de) Diagnose von mit humos assoziierten krankheiten
EP3348650B1 (de) Kit und verfahren zum nachweis von einzelnukleotid-polymorphismus
Vorechovsky Single-strand conformation polymorphism (SSCP) analysis
EP2620509A1 (de) Verfahren zur erkennung von dna-mutationen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties