HK1244318A1 - 用於生物標誌物檢測的不穩定的接頭 - Google Patents

用於生物標誌物檢測的不穩定的接頭

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Publication number
HK1244318A1
HK1244318A1 HK18103778.2A HK18103778A HK1244318A1 HK 1244318 A1 HK1244318 A1 HK 1244318A1 HK 18103778 A HK18103778 A HK 18103778A HK 1244318 A1 HK1244318 A1 HK 1244318A1
Authority
HK
Hong Kong
Prior art keywords
biomarker detection
labile linkers
labile
linkers
biomarker
Prior art date
Application number
HK18103778.2A
Other languages
English (en)
Inventor
T‧J‧莫林
W‧B‧鄧巴
D‧A‧海勒
T‧施羅普施雷
Original Assignee
奧特拉公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 奧特拉公司 filed Critical 奧特拉公司
Publication of HK1244318A1 publication Critical patent/HK1244318A1/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14Streptococcus; Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/988Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
HK18103778.2A 2015-02-02 2018-03-19 用於生物標誌物檢測的不穩定的接頭 HK1244318A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562111073P 2015-02-02 2015-02-02
PCT/US2016/016235 WO2016126748A1 (en) 2015-02-02 2016-02-02 Labile linkers for biomarker detection

Publications (1)

Publication Number Publication Date
HK1244318A1 true HK1244318A1 (zh) 2018-08-03

Family

ID=56564619

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103778.2A HK1244318A1 (zh) 2015-02-02 2018-03-19 用於生物標誌物檢測的不穩定的接頭

Country Status (12)

Country Link
US (1) US20180023114A1 (zh)
EP (1) EP3254109A4 (zh)
JP (1) JP2018503830A (zh)
KR (1) KR20170109046A (zh)
CN (1) CN107209182A (zh)
AU (1) AU2016215455A1 (zh)
CA (1) CA2973729A1 (zh)
HK (1) HK1244318A1 (zh)
IL (1) IL253382A0 (zh)
MX (1) MX2017009768A (zh)
RU (1) RU2712245C2 (zh)
WO (1) WO2016126748A1 (zh)

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US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
ES2704902T3 (es) 2013-05-06 2019-03-20 Two Pore Guys Inc Un método de detección de objetivos biológicos usando un nanoporo y un agente de unión a proteínas de fusión
KR102245192B1 (ko) * 2013-05-06 2021-04-29 온테라 인크. 나노포어를 이용한 표적 검출
CN107205818B (zh) 2015-02-05 2019-05-10 卡迪尔维尔福股份有限公司 带有轴向滑动框架的人工瓣膜
MX2018006146A (es) * 2015-11-23 2019-05-27 Two Pore Guys Inc Modificación de diana para seguimiento y detección.
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
CN114587712A (zh) 2016-08-10 2022-06-07 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
KR102137178B1 (ko) * 2016-10-24 2020-08-31 온테라 인크. 시료 내 폴리뉴클레오타이드 서열의 분포 분율
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
EP3727470A1 (en) * 2017-12-18 2020-10-28 Ventana Medical Systems, Inc. Peptide nucleic acid conjugates
CN108760657B (zh) * 2018-05-31 2021-06-08 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 一种凝血酶检测方法及其试剂盒
US11732009B2 (en) * 2018-06-08 2023-08-22 Glympse Bio, Inc. Activity sensor with tunable analyte
US11028425B2 (en) 2018-06-08 2021-06-08 Glympse Bio, Inc. Diagnosis and monitoring of liver disease
WO2023130146A2 (en) * 2022-01-03 2023-07-06 Nighthawk Biosciences, Inc. Cellular uptake peptide-therapeutic payload compositions and methods of use

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* Cited by examiner, † Cited by third party
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NZ268292A (en) * 1993-06-21 1997-09-22 Selectide Corp Solid phase peptide synthesis and supports therefor
DE10015797B4 (de) * 2000-03-26 2006-02-02 Bruker Daltonik Gmbh Multiplex-Analyse von DNA-Gemischen mittels photolytisch ablesbarer DNA-Chips
GB0523282D0 (en) * 2005-11-15 2005-12-21 Isis Innovation Methods using pores
AU2008311820A1 (en) * 2007-10-17 2009-04-23 Ohmx Corporation Novel chemistry used in biosensors
WO2010030716A1 (en) * 2008-09-10 2010-03-18 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US9551703B2 (en) * 2009-08-04 2017-01-24 The Johns Hopkins University High precision quantitative assay composition and methods of use therefor
US20130231260A1 (en) * 2012-02-17 2013-09-05 NVS Technologies, Inc. Polymer scaffolds for assay applications
US9670526B2 (en) * 2012-11-09 2017-06-06 Stratos Genomics, Inc. Concentrating a target molecule for sensing by a nanopore
ES2704902T3 (es) * 2013-05-06 2019-03-20 Two Pore Guys Inc Un método de detección de objetivos biológicos usando un nanoporo y un agente de unión a proteínas de fusión
EP3039155B1 (en) * 2013-08-26 2019-10-09 Ontera Inc. Molecule detection using boronic acid substituted probes
CN104458813B (zh) * 2014-11-28 2016-08-31 中国科学院重庆绿色智能技术研究院 基于类金刚石薄膜的纳米孔测量系统及其制备方法
EP3268732A4 (en) * 2015-03-11 2018-07-25 Two Pore Guys, Inc. Nanopore detection of small molecules through competition assays

Also Published As

Publication number Publication date
WO2016126748A1 (en) 2016-08-11
EP3254109A4 (en) 2018-07-04
RU2017130853A3 (zh) 2019-03-04
CN107209182A (zh) 2017-09-26
JP2018503830A (ja) 2018-02-08
CA2973729A1 (en) 2016-08-11
RU2017130853A (ru) 2019-03-04
IL253382A0 (en) 2017-09-28
KR20170109046A (ko) 2017-09-27
US20180023114A1 (en) 2018-01-25
RU2712245C2 (ru) 2020-01-27
AU2016215455A1 (en) 2017-08-17
EP3254109A1 (en) 2017-12-13
MX2017009768A (es) 2017-12-11

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