GB2453377A - Transmembrane protein pores and molecular adapters therefore. - Google Patents

Info

Publication number

GB2453377A

GB2453377A GB0719531A GB0719531A GB2453377A GB 2453377 A GB2453377 A GB 2453377A GB 0719531 A GB0719531 A GB 0719531A GB 0719531 A GB0719531 A GB 0719531A GB 2453377 A GB2453377 A GB 2453377A

Authority

GB

United Kingdom

Prior art keywords

pore

misc

thr

lys

feature

Prior art date

2007-10-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 102000035160 transmembrane proteins Human genes 0.000 title claims abstract description 62
• 239000012491 analyte Substances 0.000 claims abstract description 163
• 239000002773 nucleotide Substances 0.000 claims abstract description 90
• 238000000034 method Methods 0.000 claims abstract description 87
• 125000003729 nucleotide group Chemical group 0.000 claims abstract description 87
• 150000007523 nucleic acids Chemical group 0.000 claims abstract description 63
• 230000003993 interaction Effects 0.000 claims abstract description 54
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 36
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 36
• 108060002716 Exonuclease Proteins 0.000 claims abstract description 32
• 102000013165 exonuclease Human genes 0.000 claims abstract description 32
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• 239000004971 Cross linker Substances 0.000 claims abstract description 21
• 230000001588 bifunctional effect Effects 0.000 claims abstract description 17
• 238000012163 sequencing technique Methods 0.000 claims abstract description 17
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 33
• 125000003636 chemical group Chemical group 0.000 claims description 19
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 16
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