JP2010529435A5 - - Google Patents
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- Publication number
- JP2010529435A5 JP2010529435A5 JP2010510550A JP2010510550A JP2010529435A5 JP 2010529435 A5 JP2010529435 A5 JP 2010529435A5 JP 2010510550 A JP2010510550 A JP 2010510550A JP 2010510550 A JP2010510550 A JP 2010510550A JP 2010529435 A5 JP2010529435 A5 JP 2010529435A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- electrospray
- electrolyte
- ion signal
- cyclohexanecarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 6
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 6
- 150000002500 ions Chemical group 0.000 claims 5
- 239000003792 electrolyte Substances 0.000 claims 4
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims 4
- 239000005711 Benzoic acid Substances 0.000 claims 3
- 235000010233 benzoic acid Nutrition 0.000 claims 3
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000132 electrospray ionisation Methods 0.000 claims 2
- 239000012488 sample solution Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000005378 cyclohexanecarboxylic acids Chemical class 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93264407P | 2007-06-01 | 2007-06-01 | |
| US60/932,644 | 2007-06-01 | ||
| PCT/US2008/065513 WO2008151121A1 (en) | 2007-06-01 | 2008-06-02 | Atmospheric pressure ion source performance enhancement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529435A JP2010529435A (ja) | 2010-08-26 |
| JP2010529435A5 true JP2010529435A5 (enExample) | 2011-05-19 |
| JP5613557B2 JP5613557B2 (ja) | 2014-10-22 |
Family
ID=40094160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510550A Expired - Fee Related JP5613557B2 (ja) | 2007-06-01 | 2008-06-02 | 大気圧イオン源の性能強化 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7800057B2 (enExample) |
| EP (1) | EP2153455B1 (enExample) |
| JP (1) | JP5613557B2 (enExample) |
| CN (1) | CN101809706B (enExample) |
| CA (1) | CA2692317C (enExample) |
| WO (1) | WO2008151121A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE44887E1 (en) | 2005-05-19 | 2014-05-13 | Perkinelmer Health Sciences, Inc. | Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry |
| US7872225B2 (en) | 2006-08-25 | 2011-01-18 | Perkinelmer Health Sciences, Inc. | Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry |
| WO2008151121A1 (en) * | 2007-06-01 | 2008-12-11 | Analytica Of Branford, Inc. | Atmospheric pressure ion source performance enhancement |
| US20090095899A1 (en) * | 2007-10-16 | 2009-04-16 | Whitehouse Craig M | Atmospheric pressure ion source performance enhancement |
| EP2387791A1 (en) * | 2009-01-14 | 2011-11-23 | Sociedad Europea De Analisis Diferencial De Movilidad S.L. | Improved ionizer for vapor analysis decoupling the ionization region from the analyzer |
| US8063362B1 (en) * | 2009-07-09 | 2011-11-22 | The United States Of America As Represented By The Secretary Of The Air Force | Ionic liquid membrane for air-to-vacuum sealing and ion transport |
| CN102221576B (zh) * | 2010-04-15 | 2015-09-16 | 岛津分析技术研发（上海）有限公司 | 一种产生、分析离子的方法与装置 |
| IL213522A (en) | 2011-06-13 | 2016-07-31 | Kramer Electronics Ltd | Install a reversible electric cable extension |
| CN102568998B (zh) * | 2011-12-22 | 2015-02-18 | 清华大学 | 一种非接触式交流电喷雾离子化装置及方法 |
| US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
| TWI488216B (zh) * | 2013-04-18 | 2015-06-11 | Univ Nat Sun Yat Sen | 多游離源的質譜游離裝置及質譜分析系統 |
| CN103258711B (zh) * | 2013-05-21 | 2015-07-08 | 中国科学院上海有机化学研究所 | 一种溶剂辅助电喷雾离子化装置及使用该装置实现电喷雾离子化的方法 |
| TWI633100B (zh) * | 2013-07-19 | 2018-08-21 | 半導體能源研究所股份有限公司 | 有機化合物、發光元件、顯示器模組、照明模組、發光裝置、顯示裝置、照明設備及電子裝置 |
| CN103545166B (zh) * | 2013-11-04 | 2016-01-27 | 清华大学深圳研究生院 | 便携式电喷雾离子源装置及质谱仪 |
| CN108417473B (zh) * | 2013-11-15 | 2020-06-19 | 蒙特利尔史密斯安检仪公司 | 同心apci表面电离离子源和离子导向器及其使用方法 |
| GB201410472D0 (en) * | 2014-06-12 | 2014-07-30 | Micromass Ltd | Secondary electrospray ionization at reduced pressure |
| US10217623B2 (en) | 2014-06-12 | 2019-02-26 | Micromass Uk Limited | Secondary electrospray ionization at reduced pressure |
| CN105632870B (zh) * | 2014-10-28 | 2017-09-15 | 中国科学院大连化学物理研究所 | 一种用于质谱的大气压化学电离源 |
| CN104616963B (zh) * | 2015-01-30 | 2017-03-22 | 昆山禾信质谱技术有限公司 | 一种等离子体喷雾质谱电离源 |
| WO2017103743A1 (en) * | 2015-12-18 | 2017-06-22 | Dh Technologies Development Pte. Ltd. | System for minimizing electrical discharge during esi operation |
| WO2017154153A1 (ja) * | 2016-03-09 | 2017-09-14 | 株式会社島津製作所 | 質量分析装置及び該装置を用いた生体試料の分析方法 |
| CN110024076B (zh) * | 2016-11-29 | 2022-05-10 | 株式会社岛津制作所 | 离子化装置以及质谱分析装置 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0655769A1 (en) * | 1993-11-17 | 1995-05-31 | Hewlett-Packard Company | Method and apparatus for preparing an electrospray ion source sample |
| DE4415480C2 (de) * | 1994-05-02 | 1999-09-02 | Bruker Daltonik Gmbh | Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI) |
| US6504149B2 (en) * | 1998-08-05 | 2003-01-07 | National Research Council Canada | Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer |
| EP1876442A3 (en) | 1998-09-17 | 2008-03-05 | Advion BioSciences, Inc. | Integrated monolithic microfabricated liquid chromatography system and method |
| US6633031B1 (en) * | 1999-03-02 | 2003-10-14 | Advion Biosciences, Inc. | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
| FI19992070A7 (fi) * | 1999-09-28 | 2001-03-29 | Carbion Oy | Uudet fukosyloidut oligosakkaridit ja menetelmä niiden valmistamiseksi |
| AU2001229633A1 (en) * | 2000-01-18 | 2001-07-31 | Advion Biosciences, Inc. | Separation media, multiple electrospray nozzle system and method |
| US6396057B1 (en) * | 2000-04-18 | 2002-05-28 | Waters Investments Limited | Electrospray and other LC/MS interfaces |
| US20040209251A1 (en) * | 2000-10-19 | 2004-10-21 | Schneider Luke V | Methods for determining protein and peptide terminal sequences |
| US20060079002A1 (en) | 2002-06-07 | 2006-04-13 | Bogdan Gologan | System and method for landing of ions on a gas/liquid interface |
| US7041516B2 (en) * | 2002-10-10 | 2006-05-09 | Lsi Logic Corporation | Multi chip module assembly |
| WO2004038752A2 (en) * | 2002-10-21 | 2004-05-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Contiguous capillary electrospray sources and analytical device |
| WO2005114691A2 (en) | 2004-05-21 | 2005-12-01 | Whitehouse Craig M | Charged droplet sprayers |
| JP4773150B2 (ja) | 2004-07-12 | 2011-09-14 | 住友化学株式会社 | Ｅｓｉ用カチオン化剤及びそれを用いるｓｅｃ／ｅｓｉｍｓ測定方法 |
| SE0402966D0 (sv) | 2004-12-06 | 2004-12-06 | Capture Device Ab | A device, methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry |
| US7385192B2 (en) * | 2005-02-10 | 2008-06-10 | Bruker Daltonik, Gmbh | Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis |
| US20060255261A1 (en) | 2005-04-04 | 2006-11-16 | Craig Whitehouse | Atmospheric pressure ion source for mass spectrometry |
| US7872225B2 (en) | 2006-08-25 | 2011-01-18 | Perkinelmer Health Sciences, Inc. | Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry |
| WO2008151121A1 (en) * | 2007-06-01 | 2008-12-11 | Analytica Of Branford, Inc. | Atmospheric pressure ion source performance enhancement |
| US20090095899A1 (en) * | 2007-10-16 | 2009-04-16 | Whitehouse Craig M | Atmospheric pressure ion source performance enhancement |
-
2008
- 2008-06-02 WO PCT/US2008/065513 patent/WO2008151121A1/en not_active Ceased
- 2008-06-02 JP JP2010510550A patent/JP5613557B2/ja not_active Expired - Fee Related
- 2008-06-02 CA CA2692317A patent/CA2692317C/en active Active
- 2008-06-02 US US12/131,486 patent/US7800057B2/en not_active Expired - Fee Related
- 2008-06-02 EP EP08769970.8A patent/EP2153455B1/en active Active
- 2008-06-02 CN CN200880100260.9A patent/CN101809706B/zh not_active Expired - Fee Related
-
2010
- 2010-09-10 US US12/879,532 patent/US8525105B2/en not_active Expired - Fee Related
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