DK1358458T3 - Massedefektmærkning til bestemmelse af oligomersekvenser - Google Patents
Massedefektmærkning til bestemmelse af oligomersekvenserInfo
- Publication number
- DK1358458T3 DK1358458T3 DK01270150.4T DK01270150T DK1358458T3 DK 1358458 T3 DK1358458 T3 DK 1358458T3 DK 01270150 T DK01270150 T DK 01270150T DK 1358458 T3 DK1358458 T3 DK 1358458T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- molecules
- mass
- useful
- mass defect
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24239800P | 2000-10-19 | 2000-10-19 | |
US24216500P | 2000-10-19 | 2000-10-19 | |
PCT/US2001/049951 WO2002066952A2 (en) | 2000-10-19 | 2001-10-19 | Mass defect labeling for the determination of oligomer sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1358458T3 true DK1358458T3 (da) | 2012-06-18 |
Family
ID=26934884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01270150.4T DK1358458T3 (da) | 2000-10-19 | 2001-10-19 | Massedefektmærkning til bestemmelse af oligomersekvenser |
Country Status (13)
Country | Link |
---|---|
US (4) | US6962818B2 (da) |
EP (3) | EP1430436A2 (da) |
JP (3) | JP4259869B2 (da) |
AT (1) | ATE552348T1 (da) |
AU (2) | AU2002246744B2 (da) |
CA (2) | CA2426580C (da) |
DK (1) | DK1358458T3 (da) |
ES (1) | ES2385335T3 (da) |
IL (5) | IL155518A0 (da) |
IS (1) | IS6781A (da) |
NO (1) | NO20033632L (da) |
PT (1) | PT1358458E (da) |
WO (2) | WO2002066952A2 (da) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379971B1 (en) | 1998-02-24 | 2002-04-30 | Target Discovery, Inc. | Methods for sequencing proteins |
US6764817B1 (en) | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US6716636B1 (en) | 1999-04-20 | 2004-04-06 | Target Discovery, Inc. | Methods for sequencing proteins |
CA2370539C (en) | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
AU8356201A (en) * | 2000-08-11 | 2002-02-25 | Agilix Corp | Ultra-sensitive detection systems |
DK1358458T3 (da) | 2000-10-19 | 2012-06-18 | Target Discovery Inc | Massedefektmærkning til bestemmelse af oligomersekvenser |
US20030078739A1 (en) * | 2001-10-05 | 2003-04-24 | Surromed, Inc. | Feature list extraction from data sets such as spectra |
CA2466861A1 (en) * | 2001-11-06 | 2003-07-10 | Agilix Corporation | Sensitive coded detection systems |
ITMI20020396A1 (it) * | 2002-02-27 | 2003-08-27 | Gian Luigi Gianfranceschi | Procedimento per la determinazione automatica della composizione e/o della sequenza di un polimero |
CA2486456C (en) * | 2002-05-20 | 2012-07-17 | Massachusetts Institute Of Technology | Method for sequence determination using nmr |
US20040172200A1 (en) * | 2002-11-22 | 2004-09-02 | Kearney Paul Edward | Constellation mapping and uses thereof |
JP3817523B2 (ja) * | 2003-02-14 | 2006-09-06 | 株式会社日立製作所 | 質量分析データ解析システム |
JP4532874B2 (ja) * | 2003-10-07 | 2010-08-25 | キヤノン株式会社 | 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法 |
US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
GB0329554D0 (en) * | 2003-12-22 | 2004-01-28 | Micromass Ltd | Mass spectrometer |
US7248360B2 (en) * | 2004-04-02 | 2007-07-24 | Ppd Biomarker Discovery Sciences, Llc | Polychronic laser scanning system and method of use |
JP4393270B2 (ja) * | 2004-05-21 | 2010-01-06 | 株式会社日立ハイテクノロジーズ | 質量分析装置および異性体分析方法 |
WO2006050130A2 (en) * | 2004-10-29 | 2006-05-11 | Target Discovery, Inc. | Glycan analysis using deuterated glucose |
EP1851551A2 (en) * | 2005-02-03 | 2007-11-07 | Perkinelmer Las, Inc. | Ultra-sensitive detection systems using multidimension signals |
US7429729B2 (en) * | 2005-05-27 | 2008-09-30 | Ionwerks, Inc. | Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection |
EP1982349B1 (en) * | 2006-02-07 | 2018-07-25 | DH Technologies Development Pte. Ltd. | Chemical noise reduction for mass spectrometry |
EP1991694B1 (en) * | 2006-02-13 | 2016-04-13 | Fluidigm Canada Inc. | Element-tagged oligonucleotide gene expression analysis |
WO2007095378A2 (en) * | 2006-02-15 | 2007-08-23 | University Of Virginia Patent Foundation | Mass tagging for quantitative analysis of biomolecules using 13c labeled phenylisocyanate |
DE102006035577A1 (de) * | 2006-07-27 | 2008-01-31 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Röntgendichtes Konjugat |
US7838303B2 (en) * | 2006-07-27 | 2010-11-23 | Agilent Technologies, Inc. | Peptide derivatization method to increase fragmentation information from MS/MS spectra |
CA2692317C (en) * | 2007-06-01 | 2017-03-28 | Perkinelmer Health Sciences, Inc. | Atmospheric pressure ion source performance enhancement |
US7820963B2 (en) | 2007-08-06 | 2010-10-26 | Metabolic Alayses, Inc. | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
US8536520B2 (en) | 2007-08-06 | 2013-09-17 | Iroa Technologies Llc | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
US7820964B2 (en) * | 2007-08-06 | 2010-10-26 | Metabolic Analyses, Inc | Method for generation and use of stable isotope patterns in mass spectral data |
US8969251B2 (en) | 2007-10-02 | 2015-03-03 | Methabolic Analyses, Inc. | Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms |
US7919746B2 (en) * | 2007-10-16 | 2011-04-05 | Perkinelmer Health Sciences, Inc. | Atmospheric pressure ion source performance enhancement |
CN102203292B (zh) * | 2008-10-29 | 2014-06-25 | 南克森制药公司 | 通过质谱分析法测序核酸分子 |
SG178073A1 (en) | 2009-07-22 | 2012-03-29 | Agency Science Tech & Res | Differentiation of isobaric amino acids and other species |
US8153961B2 (en) * | 2009-08-31 | 2012-04-10 | Thermo Finnigan Llc | Methods for acquisition and deductive analysis of mixed fragment peptide mass spectra |
PL390797A1 (pl) | 2010-03-22 | 2011-09-26 | Instytut Chemii Bioorganicznej Polskiej Akademii Nauk | Biblioteka kombinatoryczna, sposób otrzymywania biblioteki kombinatorycznej, sposób identyfikacji sekwencji, sposób sekwencjonowania elementów kombinatorycznych bibliotek oligonukleotydów i/lub analogów oligonukleotydów, zastosowanie łącznika do tworzenia bibliotek kombinatorycznych oraz zestaw do identyfikacji sekwencji |
TW201207383A (en) * | 2010-06-16 | 2012-02-16 | Abbott Lab | Comparison of protein samples |
US9405884B2 (en) | 2010-06-16 | 2016-08-02 | Abbvie Inc. | Methods and systems for the analysis of protein samples |
US9046525B2 (en) * | 2010-07-30 | 2015-06-02 | California Institute Of Technology | Method of determining the oligomeric state of a protein complex |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
WO2012137804A1 (ja) * | 2011-04-04 | 2012-10-11 | 株式会社Jclバイオアッセイ | オリゴヌクレオチドの配列決定法 |
US9097724B2 (en) | 2011-12-30 | 2015-08-04 | Dh Technologies Development Pte. Ltd. | Systems and methods for sequencing peptides by mass spectrometry |
EP3050074B1 (en) * | 2013-09-23 | 2020-08-26 | Micromass UK Limited | Peak assessment for mass spectrometers |
JP2015121500A (ja) * | 2013-12-25 | 2015-07-02 | 株式会社島津製作所 | 質量分析方法及び質量分析装置 |
US9837255B2 (en) * | 2014-07-18 | 2017-12-05 | Thermo Finnigan Llc | Methods for mass spectrometry of mixtures of protein or polypeptides using proton transfer reaction |
EP3193352A1 (en) | 2016-01-14 | 2017-07-19 | Thermo Finnigan LLC | Methods for mass spectrometric based characterization of biological molecules |
EP3193174B1 (en) | 2016-01-14 | 2018-11-07 | Thermo Finnigan LLC | Methods for top-down multiplexed mass spectral analysis of mixtures of proteins or polypeptides |
CN111164422B (zh) * | 2017-08-07 | 2023-05-02 | 新加坡科技研究局 | 从液相色谱-质谱(lc-ms)数据中快速分析和鉴定脂质 |
US20190172553A1 (en) * | 2017-11-08 | 2019-06-06 | Koninklijke Philips N.V. | Using k-mers for rapid quality control of sequencing data without alignment |
WO2019232520A1 (en) * | 2018-06-01 | 2019-12-05 | Cerno Bioscience Llc | Mass spectral analysis of large molecules |
AU2019320814A1 (en) * | 2018-08-17 | 2021-02-18 | Regeneron Pharmaceuticals, Inc. | Methods for de novo protein sequencing |
KR102648650B1 (ko) * | 2018-10-25 | 2024-03-15 | 주식회사 엘지화학 | 고분자 말단기 분석 방법 |
CN113552204A (zh) * | 2020-04-02 | 2021-10-26 | 株式会社岛津制作所 | 质谱分析方法和质谱系统 |
JP7249980B2 (ja) | 2020-10-26 | 2023-03-31 | 日本電子株式会社 | マススペクトル処理装置及び方法 |
CN112505328B (zh) * | 2020-11-02 | 2024-02-13 | 武汉金开瑞生物工程有限公司 | 一种同位素标记试剂盒和标记方法 |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
US4830010A (en) * | 1986-04-04 | 1989-05-16 | Marshall Barry J | Methods for the diagnosis of gastrointestinal disorders |
US4842701A (en) * | 1987-04-06 | 1989-06-27 | Battelle Memorial Institute | Combined electrophoretic-separation and electrospray method and system |
US4994155A (en) * | 1988-12-09 | 1991-02-19 | Learonal, Inc. | High speed tin, lead or tin/lead alloy electroplating |
US5174962A (en) * | 1988-06-20 | 1992-12-29 | Genomyx, Inc. | Apparatus for determining DNA sequences by mass spectrometry |
US4994165A (en) | 1989-02-16 | 1991-02-19 | Cornell Research Foundation, Inc. | Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry |
CA1340966C (en) * | 1989-05-19 | 2000-04-18 | Thomas R. Covey | Method of protein analysis |
US5100778A (en) | 1989-10-03 | 1992-03-31 | Monsanto Company | Oligosaccharide sequencing |
WO1992019768A1 (en) * | 1991-05-07 | 1992-11-12 | Oxford Glycosystems Limited | Sequencing of oligosaccharides |
DE69229914T2 (de) * | 1991-05-21 | 2000-04-20 | Analytica Of Brandford Inc | Verfahren und Apparat zur Verbesserung der Sprühionisation von gelösten Stoffen |
DE69322077T2 (de) | 1992-03-25 | 1999-04-08 | Depomed Inc | Auf hydroxyethylzellulose basierende oralen arzneidosisformen mit verzoegerter wirkstoffabgabe |
DE69318559D1 (de) * | 1992-07-24 | 1998-06-18 | Us Health | Peptide brauchbar als microsequezierungsstandard und verfahren zu ihrer anwendung |
US5470753A (en) * | 1992-09-03 | 1995-11-28 | Selectide Corporation | Peptide sequencing using mass spectrometry |
US5674698A (en) | 1992-09-14 | 1997-10-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
WO1994016101A2 (en) | 1993-01-07 | 1994-07-21 | Koester Hubert | Dna sequencing by mass spectrometry |
US6194144B1 (en) * | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
GB9310467D0 (en) | 1993-05-20 | 1993-07-07 | Oxford Glycosystems Ltd | Glycoconjugates |
US5386832A (en) * | 1993-06-11 | 1995-02-07 | New England Deaconess Hospital | Liver function breath test using aromatic amino acids |
US5503805A (en) | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5538897A (en) * | 1994-03-14 | 1996-07-23 | University Of Washington | Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases |
DE4415480C2 (de) * | 1994-05-02 | 1999-09-02 | Bruker Daltonik Gmbh | Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI) |
JP3415682B2 (ja) * | 1994-08-10 | 2003-06-09 | 株式会社日立製作所 | キャピラリー電気泳動・質量分析計 |
US5856082A (en) * | 1994-08-31 | 1999-01-05 | University Of British Columbia | Devices and methods for characterizing proteins and peptides |
US5766891A (en) * | 1994-12-19 | 1998-06-16 | Sloan-Kettering Institute For Cancer Research | Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase |
US6127134A (en) | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
US5827659A (en) * | 1995-05-19 | 1998-10-27 | Perseptive Biosystems, Inc. | Methods and apparatus for sequencing polymers using mass spectrometry |
US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
US6004770A (en) * | 1995-06-07 | 1999-12-21 | Arizona State University Board Of Regents | Sample presentation apparatus for mass spectrometry |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US6027890A (en) | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
US5722642A (en) * | 1996-02-16 | 1998-03-03 | Bradshaw; Terry L. | Standing privacy fence with a deployable bench |
US5800784A (en) | 1996-07-09 | 1998-09-01 | Horn; Marcus J. | Chemical sample treatment system and cassette, and methods for effecting multistep treatment process |
IL130885A (en) | 1997-01-15 | 2005-05-17 | Xzillion Gmbh & Co Kg | Hybridisation probes comprising a base sequence cleavably linked to a mass label and uses thereof |
US5953653A (en) | 1997-01-28 | 1999-09-14 | Mediaone Group, Inc. | Method and system for preventing mobile roaming fraud |
GB9710582D0 (en) | 1997-05-22 | 1997-07-16 | Oxford Glycosciences Uk Ltd | A method for de novo peptide sequence determination |
WO1999014375A2 (en) | 1997-09-19 | 1999-03-25 | Genetrace Systems, Inc. | Dna typing by mass spectrometry with polymorphic dna repeat markers |
GB9823646D0 (en) * | 1997-12-19 | 1998-12-23 | Brax Genomics Ltd | Compounds for mass spectrometry |
US6379971B1 (en) * | 1998-02-24 | 2002-04-30 | Target Discovery, Inc. | Methods for sequencing proteins |
US6428956B1 (en) * | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
US5995989A (en) * | 1998-04-24 | 1999-11-30 | Eg&G Instruments, Inc. | Method and apparatus for compression and filtering of data associated with spectrometry |
US6359111B1 (en) * | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
JP3345401B2 (ja) | 1998-08-25 | 2002-11-18 | ユニバーシティ オブ ワシントン | 複合した混合物中のタンパク質またはタンパク質機能の迅速定量分析 |
US6277644B1 (en) * | 1999-03-22 | 2001-08-21 | Beckman Coulter, Inc. | Method for compositional tag sequencing |
US6677114B1 (en) | 1999-04-20 | 2004-01-13 | Target Discovery, Inc. | Polypeptide fingerprinting methods and bioinformatics database system |
JP4723725B2 (ja) | 1999-04-20 | 2011-07-13 | ターゲット ディスカバリー, インコーポレイテッド | 代謝経路を分析するための方法 |
US6391649B1 (en) * | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
US6699846B2 (en) | 2000-03-17 | 2004-03-02 | Corixa Corporation | Mono- and disaccharides for the treatment of nitric oxide related disorders |
DK1358458T3 (da) | 2000-10-19 | 2012-06-18 | Target Discovery Inc | Massedefektmærkning til bestemmelse af oligomersekvenser |
CA2427747A1 (en) | 2000-10-30 | 2002-05-10 | Kalobios, Inc. | Affinity maturation by competitive selection |
US6875668B2 (en) | 2000-11-03 | 2005-04-05 | Advanced Micro Devices, Inc. | Notched gate structure fabrication |
US6713577B2 (en) * | 2000-11-07 | 2004-03-30 | Symyx Technologies, Inc. | Substituted pyridyl amine catalysts and processes for polymerizing and polymers |
WO2002042733A2 (en) | 2000-11-16 | 2002-05-30 | Ciphergen Biosystems, Inc. | Method for analyzing mass spectra |
EP2335660B1 (en) | 2001-01-18 | 2018-03-28 | The Regents of The University of California | Minimally invasive glaucoma surgical instrument |
WO2002062436A2 (en) | 2001-02-06 | 2002-08-15 | Electronic Arts Inc. | Integration of real-time data into a gaming application |
US7074534B2 (en) | 2002-07-10 | 2006-07-11 | E. I. Du Pont De Nemours And Company | Polymeric charge transport compositions and electronic devices made with such compositions |
JP2005533102A (ja) | 2002-07-12 | 2005-11-04 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 微小器官によって生物学的プロセスを誘発する方法と装置 |
JP4116351B2 (ja) | 2002-07-16 | 2008-07-09 | ジヤトコ株式会社 | 車両の制御装置 |
GB0216571D0 (en) | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
US20050147985A1 (en) * | 2004-01-05 | 2005-07-07 | Applera Corporation | Mixtures of isobarically labeled analytes and fragments ions derived therefrom |
JP2005241161A (ja) | 2004-02-27 | 2005-09-08 | Fujita Corp | 変流量変更時の消費エネルギー算出方法および省エネルギー診断方法 |
-
2001
- 2001-10-19 DK DK01270150.4T patent/DK1358458T3/da active
- 2001-10-19 EP EP01994337A patent/EP1430436A2/en not_active Ceased
- 2001-10-19 PT PT01270150T patent/PT1358458E/pt unknown
- 2001-10-19 CA CA2426580A patent/CA2426580C/en not_active Expired - Fee Related
- 2001-10-19 EP EP01270150A patent/EP1358458B1/en not_active Expired - Lifetime
- 2001-10-19 AT AT01270150T patent/ATE552348T1/de active
- 2001-10-19 CA CA000000001A patent/CA2425798A1/en not_active Abandoned
- 2001-10-19 EP EP12152952A patent/EP2479578A1/en not_active Withdrawn
- 2001-10-19 AU AU2002246744A patent/AU2002246744B2/en not_active Ceased
- 2001-10-19 JP JP2002561757A patent/JP4259869B2/ja not_active Expired - Fee Related
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