WO2012070893A3 - 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법 - Google Patents

코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법 Download PDF

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WO2012070893A3
WO2012070893A3 PCT/KR2011/009031 KR2011009031W WO2012070893A3 WO 2012070893 A3 WO2012070893 A3 WO 2012070893A3 KR 2011009031 W KR2011009031 W KR 2011009031W WO 2012070893 A3 WO2012070893 A3 WO 2012070893A3
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nanogap
manufacturing
core
single nanoparticle
nanoparticles
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PCT/KR2011/009031
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English (en)
French (fr)
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WO2012070893A2 (ko
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서영덕
남좌민
임동권
전기석
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한국화학연구원
서울대학교 산학협력단
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Priority to EP11843138.6A priority Critical patent/EP2645104B1/en
Priority to CN201180061979.8A priority patent/CN103403546B/zh
Priority to JP2013540896A priority patent/JP5813128B2/ja
Priority to US13/989,709 priority patent/US9482618B2/en
Priority to CA2819052A priority patent/CA2819052C/en
Publication of WO2012070893A2 publication Critical patent/WO2012070893A2/ko
Publication of WO2012070893A3 publication Critical patent/WO2012070893A3/ko
Priority to IL226549A priority patent/IL226549B/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 나노갭에 의한 플라즈몬 커플링(plasomonic coupling)에 의한 매우 높은 신호 증폭의 효과 및 높은 재현성을 가지고 있어 라만 분석에 유용하게 사용될 수 있는, 코어(core) 및 상기 코어를 둘러싼 쉘(shell)을 포함하고, 상기 코어와 쉘 사이에 나노갭이 형성된 나노입자 및 이의 제조방법을 제공한다. 또한, 상기 나노입자를 이용한 분석물을 검출하는 방법 및 상기 나노입자를 포함하는 분석물 검출용 키트를 제공하기 위한 것이다.
PCT/KR2011/009031 2010-11-24 2011-11-24 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법 WO2012070893A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP11843138.6A EP2645104B1 (en) 2010-11-24 2011-11-24 Single nanoparticle having a nanogap between a core material and a shell material, and preparation method thereof
CN201180061979.8A CN103403546B (zh) 2010-11-24 2011-11-24 核材和壳材之间形成有纳米间隙的单个纳米粒子及其制备方法
JP2013540896A JP5813128B2 (ja) 2010-11-24 2011-11-24 コア物質とシェル物質との間にナノギャップを有する単一ナノ粒子およびその調製方法
US13/989,709 US9482618B2 (en) 2010-11-24 2011-11-24 Single nanoparticle having a nanogap between a core material and a shell material, and preparation method thereof
CA2819052A CA2819052C (en) 2010-11-24 2011-11-24 Single nanoparticle having a nanogap between a core material and a shell material, and preparation method thereof
IL226549A IL226549B (en) 2010-11-24 2013-05-23 A single nanoparticle with a nanospace between a core material and a shell material and a method for its production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0117527 2010-11-24
KR1020100117527A KR101352342B1 (ko) 2010-11-24 2010-11-24 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법

Publications (2)

Publication Number Publication Date
WO2012070893A2 WO2012070893A2 (ko) 2012-05-31
WO2012070893A3 true WO2012070893A3 (ko) 2012-09-27

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PCT/KR2011/009031 WO2012070893A2 (ko) 2010-11-24 2011-11-24 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법

Country Status (8)

Country Link
US (1) US9482618B2 (ko)
EP (1) EP2645104B1 (ko)
JP (1) JP5813128B2 (ko)
KR (1) KR101352342B1 (ko)
CN (1) CN103403546B (ko)
CA (1) CA2819052C (ko)
IL (1) IL226549B (ko)
WO (1) WO2012070893A2 (ko)

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CN103403546B (zh) 2015-07-08
WO2012070893A2 (ko) 2012-05-31
US9482618B2 (en) 2016-11-01
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CA2819052C (en) 2017-06-27
EP2645104A4 (en) 2017-12-27
KR101352342B1 (ko) 2014-02-17
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