CN101809706B - 大气压离子源性能增强方法 - Google Patents

大气压离子源性能增强方法 Download PDF

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Publication number
CN101809706B
CN101809706B CN200880100260.9A CN200880100260A CN101809706B CN 101809706 B CN101809706 B CN 101809706B CN 200880100260 A CN200880100260 A CN 200880100260A CN 101809706 B CN101809706 B CN 101809706B
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CN
China
Prior art keywords
electrospray
solution
acid
ion
electrolyte
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Expired - Fee Related
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CN200880100260.9A
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English (en)
Chinese (zh)
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CN101809706A (zh
Inventor
克雷格·M·怀特豪斯
托马斯·P·怀特
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Revvity Health Sciences Inc
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PerkinElmer Health Sciences Inc
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Publication of CN101809706A publication Critical patent/CN101809706A/zh
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation

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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN200880100260.9A 2007-06-01 2008-06-02 大气压离子源性能增强方法 Expired - Fee Related CN101809706B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93264407P 2007-06-01 2007-06-01
US60/932,644 2007-06-01
PCT/US2008/065513 WO2008151121A1 (en) 2007-06-01 2008-06-02 Atmospheric pressure ion source performance enhancement

Publications (2)

Publication Number Publication Date
CN101809706A CN101809706A (zh) 2010-08-18
CN101809706B true CN101809706B (zh) 2015-12-09

Family

ID=40094160

Family Applications (1)

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CN200880100260.9A Expired - Fee Related CN101809706B (zh) 2007-06-01 2008-06-02 大气压离子源性能增强方法

Country Status (6)

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US (2) US7800057B2 (enExample)
EP (1) EP2153455B1 (enExample)
JP (1) JP5613557B2 (enExample)
CN (1) CN101809706B (enExample)
CA (1) CA2692317C (enExample)
WO (1) WO2008151121A1 (enExample)

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US7872225B2 (en) * 2006-08-25 2011-01-18 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
USRE44887E1 (en) 2005-05-19 2014-05-13 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
JP5613557B2 (ja) * 2007-06-01 2014-10-22 パーキンエルマー ヘルス サイエンス インコーポレイテッドＰｅｒｋｉｎｅｌｍｅｒ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． 大気圧イオン源の性能強化
US7919746B2 (en) * 2007-10-16 2011-04-05 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
EP2387791A1 (en) * 2009-01-14 2011-11-23 Sociedad Europea De Analisis Diferencial De Movilidad S.L. Improved ionizer for vapor analysis decoupling the ionization region from the analyzer
US8063362B1 (en) * 2009-07-09 2011-11-22 The United States Of America As Represented By The Secretary Of The Air Force Ionic liquid membrane for air-to-vacuum sealing and ion transport
CN102221576B (zh) * 2010-04-15 2015-09-16 岛津分析技术研发（上海）有限公司 一种产生、分析离子的方法与装置
IL213522A (en) 2011-06-13 2016-07-31 Kramer Electronics Ltd Install a reversible electric cable extension
CN102568998B (zh) * 2011-12-22 2015-02-18 清华大学 一种非接触式交流电喷雾离子化装置及方法
US10481164B2 (en) * 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
TWI488216B (zh) * 2013-04-18 2015-06-11 Univ Nat Sun Yat Sen 多游離源的質譜游離裝置及質譜分析系統
CN103258711B (zh) * 2013-05-21 2015-07-08 中国科学院上海有机化学研究所 一种溶剂辅助电喷雾离子化装置及使用该装置实现电喷雾离子化的方法
TWI633100B (zh) * 2013-07-19 2018-08-21 半導體能源研究所股份有限公司 有機化合物、發光元件、顯示器模組、照明模組、發光裝置、顯示裝置、照明設備及電子裝置
CN103545166B (zh) * 2013-11-04 2016-01-27 清华大学深圳研究生院 便携式电喷雾离子源装置及质谱仪
JP6526656B2 (ja) * 2013-11-15 2019-06-05 スミスズ ディテクション モントリオール インコーポレイティド 同心ａｐｃｉ表面イオン化イオン源、イオンガイド及び使用方法
WO2015189548A1 (en) 2014-06-12 2015-12-17 Micromass Uk Limited Secondary electrospray ionization at reduced pressure
GB201410472D0 (en) * 2014-06-12 2014-07-30 Micromass Ltd Secondary electrospray ionization at reduced pressure
CN105632870B (zh) * 2014-10-28 2017-09-15 中国科学院大连化学物理研究所 一种用于质谱的大气压化学电离源
CN104616963B (zh) * 2015-01-30 2017-03-22 昆山禾信质谱技术有限公司 一种等离子体喷雾质谱电离源
JP6867392B2 (ja) * 2015-12-18 2021-04-28 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Ｅｓｉ動作中の放電を最小化するためのシステム
CN108700552B (zh) * 2016-03-09 2021-02-26 株式会社岛津制作所 质量分析装置以及使用该装置的生物试样的分析方法
JP6620896B2 (ja) * 2016-11-29 2019-12-18 株式会社島津製作所 イオン化装置及び質量分析装置

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EP0655769A1 (en) * 1993-11-17 1995-05-31 Hewlett-Packard Company Method and apparatus for preparing an electrospray ion source sample
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
US6504149B2 (en) * 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
EP1876442A3 (en) 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integrated monolithic microfabricated liquid chromatography system and method
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
FI19992070A7 (fi) * 1999-09-28 2001-03-29 Carbion Oy Uudet fukosyloidut oligosakkaridit ja menetelmä niiden valmistamiseksi
US6596988B2 (en) * 2000-01-18 2003-07-22 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
US6396057B1 (en) * 2000-04-18 2002-05-28 Waters Investments Limited Electrospray and other LC/MS interfaces
EP2479578A1 (en) * 2000-10-19 2012-07-25 Target Discovery, Inc. Mass defect labeling for the determination of oligomer sequences
US20060079002A1 (en) * 2002-06-07 2006-04-13 Bogdan Gologan System and method for landing of ions on a gas/liquid interface
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WO2004038752A2 (en) * 2002-10-21 2004-05-06 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Contiguous capillary electrospray sources and analytical device
US7232992B2 (en) * 2004-05-21 2007-06-19 Analytica Of Branford, Inc. Charged droplet sprayers
JP4773150B2 (ja) 2004-07-12 2011-09-14 住友化学株式会社 Ｅｓｉ用カチオン化剤及びそれを用いるｓｅｃ／ｅｓｉｍｓ測定方法
SE0402966D0 (sv) 2004-12-06 2004-12-06 Capture Device Ab A device, methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry
GB2423187B (en) * 2005-02-10 2010-10-27 Bruker Daltonik Gmbh Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
US7872225B2 (en) * 2006-08-25 2011-01-18 Perkinelmer Health Sciences, Inc. Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
JP5613557B2 (ja) * 2007-06-01 2014-10-22 パーキンエルマー ヘルス サイエンス インコーポレイテッドＰｅｒｋｉｎｅｌｍｅｒ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． 大気圧イオン源の性能強化
US7919746B2 (en) * 2007-10-16 2011-04-05 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement

Also Published As

Publication number Publication date
US20110006198A1 (en) 2011-01-13
CA2692317A1 (en) 2008-12-11
JP2010529435A (ja) 2010-08-26
AU2008259894A1 (en) 2008-12-11
EP2153455A1 (en) 2010-02-17
EP2153455A4 (en) 2012-12-05
WO2008151121A1 (en) 2008-12-11
US7800057B2 (en) 2010-09-21
CN101809706A (zh) 2010-08-18
US8525105B2 (en) 2013-09-03
JP5613557B2 (ja) 2014-10-22
CA2692317C (en) 2017-03-28
EP2153455B1 (en) 2020-04-29
US20090008547A1 (en) 2009-01-08

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Granted publication date: 20151209