JP2014532430A5 - - Google Patents
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- Publication number
- JP2014532430A5 JP2014532430A5 JP2014540177A JP2014540177A JP2014532430A5 JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5 JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- binding
- binding partner
- acid complex
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 57
- 150000007523 nucleic acids Chemical class 0.000 claims 57
- 102000039446 nucleic acids Human genes 0.000 claims 57
- 108091034117 Oligonucleotide Proteins 0.000 claims 42
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 15
- 238000000034 method Methods 0.000 claims 8
- 238000010494 dissociation reaction Methods 0.000 claims 6
- 230000005593 dissociations Effects 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 5
- 238000004630 atomic force microscopy Methods 0.000 claims 4
- 238000001502 gel electrophoresis Methods 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000000799 fluorescence microscopy Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000000386 microscopy Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000012576 optical tweezer Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556194P | 2011-11-05 | 2011-11-05 | |
| US61/556,194 | 2011-11-05 | ||
| US201261666655P | 2012-06-29 | 2012-06-29 | |
| US61/666,655 | 2012-06-29 | ||
| PCT/US2012/063538 WO2013067489A1 (en) | 2011-11-05 | 2012-11-05 | Nucleic acid-based linkers for detecting and measuring interactions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532430A JP2014532430A (ja) | 2014-12-08 |
| JP2014532430A5 true JP2014532430A5 (enExample) | 2015-12-24 |
| JP6430253B2 JP6430253B2 (ja) | 2018-11-28 |
Family
ID=48192891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540177A Active JP6430253B2 (ja) | 2011-11-05 | 2012-11-05 | 相互作用を検出および測定するための核酸ベースのリンカー |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US9914958B2 (enExample) |
| JP (1) | JP6430253B2 (enExample) |
| WO (1) | WO2013067489A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9914958B2 (en) * | 2011-11-05 | 2018-03-13 | President And Fellows Of Harvard College | Nucleic acid-based linkers for detecting and measuring interactions |
| CA2917435A1 (en) | 2013-07-10 | 2015-01-15 | Children's Medical Center Corporation | Compositions and methods relating to nucleic acid-protein complexes |
| WO2015164602A2 (en) | 2014-04-23 | 2015-10-29 | Children's Medical Center Corporation | High-throughput structure determination using nucleic acid calipers |
| WO2016089588A1 (en) * | 2014-12-06 | 2016-06-09 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| WO2016196824A1 (en) * | 2015-06-02 | 2016-12-08 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
| WO2017003950A2 (en) * | 2015-06-27 | 2017-01-05 | Children's Medical Center Corporation | Compositions and methods for analyte detection using nanoswitches |
| US10822637B2 (en) * | 2015-10-01 | 2020-11-03 | Dynamic Biosensors Gmbh | Method for detecting molecular interactions using an immobilized nucleic acid |
| US11713483B2 (en) | 2016-02-09 | 2023-08-01 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
| WO2017147398A1 (en) | 2016-02-25 | 2017-08-31 | Children's Medical Center Corporation | Spinning apparatus for measurement of characteristics relating to molecules |
| EP3426598B1 (en) | 2016-03-11 | 2021-07-28 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| US12123869B2 (en) * | 2016-03-23 | 2024-10-22 | Children's Medical Center Corporation | Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods |
| US10919037B2 (en) | 2016-03-23 | 2021-02-16 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
| WO2017189794A1 (en) * | 2016-04-27 | 2017-11-02 | President And Fellows Of Harvard College | Method of secure communication via nucleotide polymers |
| WO2018023088A1 (en) | 2016-07-29 | 2018-02-01 | Confer Health, Inc. | Gel electrophoresis diagnostic kit and methods of using the same |
| EP4071159B1 (en) | 2016-08-02 | 2023-12-13 | President and Fellows of Harvard College | Crisscross cooperative self-assembly |
| WO2018106721A1 (en) * | 2016-12-05 | 2018-06-14 | Children's Medical Center Corporation | Nucleic acid nanoswitch construction methods |
| WO2018119437A2 (en) | 2016-12-23 | 2018-06-28 | Confer Health, Inc. | Electrophoresis diagnostic methods and kits |
| US11591636B2 (en) | 2017-11-20 | 2023-02-28 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
| FR3075820B1 (fr) | 2017-12-21 | 2022-12-30 | Paris Sciences Lettres Quartier Latin | Molecule d'adn double-brin pour la detection et la caracterisation des interactions moleculaires |
| US11561221B2 (en) * | 2018-05-02 | 2023-01-24 | Trustees Of Boston University | Dynamic tracking of captured targets for enhanced digital biosensing |
| AU2019280712B2 (en) | 2018-06-06 | 2025-11-20 | The Regents Of The University Of California | Methods of producing nucleic acid libraries and compositions and kits for practicing same |
| EP3921438A2 (en) * | 2019-02-04 | 2021-12-15 | Akoya Biosciences, Inc. | Analyte detection by selective labeling of biological samples |
| CN111549098B (zh) * | 2020-06-16 | 2024-10-29 | 南开大学 | 测量人端粒精准长度的单分子力学方法 |
| CN111721504B (zh) * | 2020-06-17 | 2022-02-18 | 中国科学院物理研究所 | 在小力下测算磁镊高度转换系数的方法及应用 |
| CN119563035A (zh) | 2022-04-01 | 2025-03-04 | 德皮克萨斯股份有限公司 | 筛选化合物的方法 |
| WO2025041065A1 (en) * | 2023-08-21 | 2025-02-27 | Depixus SAS | Device for determining molecular interactions |
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|---|---|---|---|---|
| GB9114525D0 (en) | 1991-07-05 | 1991-08-21 | Delnatte Sabine | Homogeneous nucleic acids probe based tests and substances |
| WO1995001365A1 (en) | 1993-07-02 | 1995-01-12 | Lynx Therapeutics, Inc. | Synthesis of branched nucleic acids |
| US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| WO1998002580A2 (en) * | 1996-07-12 | 1998-01-22 | Tm Technologies, Inc. | Signal amplification method |
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| WO2016089588A1 (en) | 2014-12-06 | 2016-06-09 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| WO2017003950A2 (en) | 2015-06-27 | 2017-01-05 | Children's Medical Center Corporation | Compositions and methods for analyte detection using nanoswitches |
-
2012
- 2012-11-05 US US14/356,282 patent/US9914958B2/en active Active
- 2012-11-05 JP JP2014540177A patent/JP6430253B2/ja active Active
- 2012-11-05 WO PCT/US2012/063538 patent/WO2013067489A1/en not_active Ceased
-
2018
- 2018-02-05 US US15/888,941 patent/US20180291434A1/en not_active Abandoned
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