JP2014532430A5 - - Google Patents

Download PDF

Info

Publication number
JP2014532430A5
JP2014532430A5 JP2014540177A JP2014540177A JP2014532430A5 JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5 JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5
Authority
JP
Japan
Prior art keywords
nucleic acid
binding
binding partner
acid complex
linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014540177A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014532430A (ja
JP6430253B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/063538 external-priority patent/WO2013067489A1/en
Publication of JP2014532430A publication Critical patent/JP2014532430A/ja
Publication of JP2014532430A5 publication Critical patent/JP2014532430A5/ja
Application granted granted Critical
Publication of JP6430253B2 publication Critical patent/JP6430253B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014540177A 2011-11-05 2012-11-05 相互作用を検出および測定するための核酸ベースのリンカー Active JP6430253B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161556194P 2011-11-05 2011-11-05
US61/556,194 2011-11-05
US201261666655P 2012-06-29 2012-06-29
US61/666,655 2012-06-29
PCT/US2012/063538 WO2013067489A1 (en) 2011-11-05 2012-11-05 Nucleic acid-based linkers for detecting and measuring interactions

Publications (3)

Publication Number Publication Date
JP2014532430A JP2014532430A (ja) 2014-12-08
JP2014532430A5 true JP2014532430A5 (enExample) 2015-12-24
JP6430253B2 JP6430253B2 (ja) 2018-11-28

Family

ID=48192891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014540177A Active JP6430253B2 (ja) 2011-11-05 2012-11-05 相互作用を検出および測定するための核酸ベースのリンカー

Country Status (3)

Country Link
US (2) US9914958B2 (enExample)
JP (1) JP6430253B2 (enExample)
WO (1) WO2013067489A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6430253B2 (ja) * 2011-11-05 2018-11-28 プレジデント アンド フェローズ オブ ハーバード カレッジ 相互作用を検出および測定するための核酸ベースのリンカー
US10876177B2 (en) 2013-07-10 2020-12-29 President And Fellows Of Harvard College Compositions and methods relating to nucleic acid-protein complexes
JP2017514467A (ja) * 2014-04-23 2017-06-08 チルドレンズ メディカル センター コーポレーション 核酸キャリパーを用いた高スループット構造決定
WO2016089588A1 (en) * 2014-12-06 2016-06-09 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
WO2016196824A1 (en) * 2015-06-02 2016-12-08 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
WO2017003950A2 (en) * 2015-06-27 2017-01-05 Children's Medical Center Corporation Compositions and methods for analyte detection using nanoswitches
EP3356547B1 (en) * 2015-10-01 2020-11-18 Dynamic Biosensors GmbH Method for detecting molecular interactions using an immobilized nucleic acid
US11713483B2 (en) 2016-02-09 2023-08-01 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
US10948401B2 (en) 2016-02-25 2021-03-16 President And Fellows Of Harvard College Spinning apparatus for measurement of characteristics relating to molecules
US11414694B2 (en) 2016-03-11 2022-08-16 Children's Medical Center Corporation Nucleic acid nanoswitch catenanes
WO2017165647A1 (en) * 2016-03-23 2017-09-28 Children's Medical Center Corporation Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods
WO2017165585A1 (en) 2016-03-23 2017-09-28 Children's Medical Center Corporation Systems and apparatus for detecting compounds in human biological samples
WO2017189794A1 (en) * 2016-04-27 2017-11-02 President And Fellows Of Harvard College Method of secure communication via nucleotide polymers
US10823699B2 (en) 2016-07-29 2020-11-03 Vital Biosciences, Inc. Gel electrophoresis diagnostic kit and methods of using the same
EP3494124B1 (en) 2016-08-02 2022-03-09 President and Fellows of Harvard College Crisscross cooperative self-assembly
WO2018106721A1 (en) * 2016-12-05 2018-06-14 Children's Medical Center Corporation Nucleic acid nanoswitch construction methods
US11353423B2 (en) 2016-12-23 2022-06-07 Vital Biosciences, Inc. Electrophoresis diagnostic methods and kits
US11591636B2 (en) 2017-11-20 2023-02-28 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
FR3075820B1 (fr) 2017-12-21 2022-12-30 Paris Sciences Lettres Quartier Latin Molecule d'adn double-brin pour la detection et la caracterisation des interactions moleculaires
US11561221B2 (en) * 2018-05-02 2023-01-24 Trustees Of Boston University Dynamic tracking of captured targets for enhanced digital biosensing
AU2019280712B2 (en) 2018-06-06 2025-11-20 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
EP3921438A2 (en) * 2019-02-04 2021-12-15 Akoya Biosciences, Inc. Analyte detection by selective labeling of biological samples
US12571802B2 (en) 2020-02-29 2026-03-10 President And Fellows Of Harvard College Nanoswitch caliper trains for high-throughput, high-resolution structural analysis of biomolecules
CN111549098B (zh) * 2020-06-16 2024-10-29 南开大学 测量人端粒精准长度的单分子力学方法
CN111721504B (zh) * 2020-06-17 2022-02-18 中国科学院物理研究所 在小力下测算磁镊高度转换系数的方法及应用
US20230407374A1 (en) * 2020-11-09 2023-12-21 Children's Medical Center Corporation Systems and methods for high throughput screening of molecular interactions
WO2023187759A1 (en) 2022-04-01 2023-10-05 Depixus SAS Methods of screening compounds
WO2025041065A1 (en) * 2023-08-21 2025-02-27 Depixus SAS Device for determining molecular interactions

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9114525D0 (en) * 1991-07-05 1991-08-21 Delnatte Sabine Homogeneous nucleic acids probe based tests and substances
JPH09500378A (ja) 1993-07-02 1997-01-14 リンクス セラピューティクス,インコーポレイティド 枝分れされそして複雑に結合された高分子構造体の集中的合成
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
AU4040097A (en) * 1996-07-12 1998-02-09 Tm Technologies, Inc. Signal amplification method
AU753191B2 (en) 1997-11-25 2002-10-10 Exact Sciences Corporation Devices and methods for detecting target molecules in biological samples
US20020177144A1 (en) 1997-12-30 2002-11-28 Jose Remacle Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc
US6143504A (en) * 1998-10-27 2000-11-07 Arch Development Corporation Methods and compositions for the diagnosis of fragile X syndrome
GB9827912D0 (en) * 1998-12-19 1999-02-10 Univ Manchester Detecting nucleic acids
JP3080951B1 (ja) 1999-03-04 2000-08-28 株式会社分子バイオホトニクス研究所 ウイルスを検出する方法
CA2453360A1 (en) 2001-07-11 2003-01-23 Applera Corporation Internal calibration standards for electrophoretic analyses
US20030143549A1 (en) 2002-01-29 2003-07-31 Eastman Kodak Company Method for DNA sequencing and gene identification
US7294513B2 (en) 2002-07-24 2007-11-13 Wyatt Technology Corporation Method and apparatus for characterizing solutions of small particles
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
AU2002952797A0 (en) 2002-11-20 2002-12-05 Bio-Molecular Holdings Pty Limited Centrifugal device and method using same
CA2897376A1 (en) * 2003-02-26 2004-09-10 Radoje T. Drmanac Modular system and probes for dna analysis
EP1816192B1 (en) 2004-10-15 2012-12-12 National Institute of Advanced Industrial Science and Technology LINKER FOR CONSTRUCTING mRNA-PUROMYCIN-PROTEIN CONJUGATE
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
CA2610027A1 (en) * 2005-05-26 2006-11-30 Ensemble Discovery Corporation Biodetection by nucleic acid-templated chemistry
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
WO2007056250A2 (en) 2005-11-04 2007-05-18 U.S. Genomics, Inc. Heterogeneous assay of analytes in solution using polymers
ATE525482T1 (de) 2005-12-23 2011-10-15 Nanostring Technologies Inc Nanoreporter und verfahren zu deren herstellung und verwendung
US8354227B2 (en) * 2006-02-03 2013-01-15 Columbia University In The City Of New York Binary deoxyribozyme probes for nucleic acid analysis
WO2007139849A2 (en) * 2006-05-25 2007-12-06 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Modified nucleic acid nanoarrays and uses therefor
US20090286694A1 (en) 2006-08-21 2009-11-19 Gafur Zainiev Nucleic acid array with releaseable nucleic acid probes
JP2008259453A (ja) * 2007-04-12 2008-10-30 Toyobo Co Ltd 核酸の検出方法
US8043810B2 (en) 2007-05-02 2011-10-25 Eagle Eye Research, Inc. Analyte detection using autocatalytic chain reactions
US8361299B2 (en) 2008-10-08 2013-01-29 Sage Science, Inc. Multichannel preparative electrophoresis system
WO2010051530A2 (en) 2008-10-31 2010-05-06 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
US8491454B2 (en) 2008-12-02 2013-07-23 President And Fellows Of Harvard College Spinning force apparatus
WO2011153211A1 (en) 2010-06-01 2011-12-08 President And Fellows Of Harvard College Apparatus for measurement of spinning forces relating to molecules
SG177395A1 (en) 2009-07-07 2012-02-28 Agency Science Tech & Res Methods of identifying a pair of binding partners
WO2011047087A2 (en) * 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011072133A1 (en) 2009-12-09 2011-06-16 William Marsh Rice University Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles
WO2012044387A2 (en) 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
JP6430253B2 (ja) * 2011-11-05 2018-11-28 プレジデント アンド フェローズ オブ ハーバード カレッジ 相互作用を検出および測定するための核酸ベースのリンカー
US9182334B2 (en) 2012-02-24 2015-11-10 Agilent Technologies, Inc. Method of determining thermodynamic and kinetic parameters from measured off rates
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2014011800A1 (en) 2012-07-10 2014-01-16 Pivot Bio, Inc. Methods for multipart, modular and scarless assembly of dna molecules
US10876177B2 (en) 2013-07-10 2020-12-29 President And Fellows Of Harvard College Compositions and methods relating to nucleic acid-protein complexes
US9333463B2 (en) 2013-07-26 2016-05-10 General Electric Company Devices and systems for elution of biomolecules
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US20150361422A1 (en) 2014-06-16 2015-12-17 Agilent Technologies, Inc. High throughput gene assembly in droplets
WO2016089588A1 (en) 2014-12-06 2016-06-09 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
WO2017003950A2 (en) 2015-06-27 2017-01-05 Children's Medical Center Corporation Compositions and methods for analyte detection using nanoswitches

Similar Documents

Publication Publication Date Title
Wang et al. Development of a SPR aptasensor containing oriented aptamer for direct capture and detection of tetracycline in multiple honey samples
JP6525872B2 (ja) 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること
JP2013507642A5 (enExample)
US10415034B2 (en) Method for the selection of aptamers for unbound targets
JP2008504842A5 (enExample)
JP2014513557A5 (enExample)
JP2012198225A5 (enExample)
Matochko et al. Next-generation sequencing of phage-displayed peptide libraries
US20180135043A1 (en) Nucleic acid complexes for screening barcoded compounds
JP2018512862A5 (enExample)
JPWO2017126646A1 (ja) 核酸アプタマーをスクリーニングするための方法
Pinto et al. Real-time apta-PCR for 20 000-fold improvement in detection limit
WO2014130793A1 (en) Epitope-polymer platform for detection of bacterial organisms
Sato et al. Bead-based padlock rolling circle amplification for single DNA molecule counting
JP2017026631A5 (enExample)
JP2021092576A (ja) 2個のリガンドと1個のレセプタとからなる高親和性錯体の特定方法と該方法を実行する装置及び該方法に用いられる自己集合型ケミカルライブラリ
JP6155251B2 (ja) 核酸の検出方法、そのキット及びその使用
US9644202B2 (en) Switchable aptamers
WO2016099999A1 (en) Analyte detection on a solid support by nucleic acid amplification coupled to an immunoassay
Lin et al. Electrochemical biosensor for detection of BCR/ABL fusion gene based on hairpin locked nucleic acids probe
Takashima et al. Kinetic study of DNA hybridization on DNA-modified gold nanoparticles with engineered nano-interfaces
JP2017529062A5 (enExample)
KR20120047767A (ko) 표적 폴리뉴클레오티드의 염기서열을 비특이적으로 연장하는 방법, 이를 위한 프라이머 조성물 및 표적 폴리뉴클레오티드 검출감도 향상용 키트
Chylewska et al. Modern approach to medical diagnostics-the use of separation techniques in microorganisms detection
Xiong et al. Ultrasensitive detection of Staphylococcal enterotoxin B in milk based on target-triggered assembly of the flower like nucleic acid nanostructure