|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
JPH0832707B2
(ja)
|
1986-02-05 |
1996-03-29 |
富山化学工業株式会社 |
新規なセフアロスポリン類およびその塩
|
|
DK0495421T3
(da)
|
1991-01-15 |
1996-12-09 |
Alcon Lab Inc |
Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
ATE216247T1
(de)
|
1991-05-20 |
2002-05-15 |
Rhone Poulenc Rorer Internat H |
Aromatische oligomere verbindungen als imitatoren bioaktives makromoleküle
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
CA2249615A1
(en)
|
1996-04-03 |
1997-10-09 |
Robert Gomez |
Inhibitors of farnesyl-protein transferase
|
|
JP2000256286A
(ja)
|
1999-03-11 |
2000-09-19 |
Kaken Pharmaceut Co Ltd |
アルキルアミン誘導体
|
|
KR20020088406A
(ko)
|
1999-09-17 |
2002-11-27 |
애보트 게엠베하 운트 콤파니 카게 |
치료제로서의 피라졸로피리미딘
|
|
US6887870B1
(en)
|
1999-10-12 |
2005-05-03 |
Bristol-Myers Squibb Company |
Heterocyclic sodium/proton exchange inhibitors and method
|
|
AU2001273040A1
(en)
|
2000-06-27 |
2002-01-08 |
Du Pont Pharmaceuticals Company |
Factor xa inhibitors
|
|
BR0116493A
(pt)
|
2000-12-21 |
2003-09-30 |
Vertex Pharma |
Compostos de pirazol úteis como inibidores de proteìna cinase
|
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
|
MY139563A
(en)
|
2002-09-04 |
2009-10-30 |
Bristol Myers Squibb Co |
Heterocyclic aromatic compounds useful as growth hormone secretagogues
|
|
AU2004255913B2
(en)
|
2003-07-09 |
2007-10-11 |
Takeda Pharmaceutical Company Limited |
Organosilicon compounds and their use
|
|
EP1758579A1
(en)
|
2004-05-29 |
2007-03-07 |
7TM Pharma A/S |
Crth2 receptor ligands for medicinal uses
|
|
WO2006091898A2
(en)
|
2005-02-25 |
2006-08-31 |
Adenosine Therapeutics, Llc |
Pyrazolyl substituted xanthines
|
|
WO2007009236A1
(en)
|
2005-07-20 |
2007-01-25 |
Merck Frosst Canada Ltd. |
Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
|
|
US7728017B2
(en)
|
2005-11-30 |
2010-06-01 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-Met and uses thereof
|
|
EP1981519B1
(en)
|
2005-12-29 |
2017-12-27 |
Dyax Corp. |
Protease inhibition
|
|
EP1849781A1
(en)
|
2006-04-28 |
2007-10-31 |
Laboratorios del Dr. Esteve S.A. |
Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
|
|
EP2051707B1
(en)
|
2006-07-31 |
2013-07-17 |
Activesite Pharmaceuticals, Inc. |
Inhibitors of plasma kallikrein
|
|
EP1908762A2
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Organic compounds
|
|
EP1908471A1
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Tetrahydropyridines as renin inhibitors
|
|
WO2008059854A1
(en)
|
2006-11-16 |
2008-05-22 |
Astellas Pharma Inc. |
Piperidine derivatives or salts thereof
|
|
EP1974729A1
(en)
|
2007-03-28 |
2008-10-01 |
Santhera Pharmaceuticals (Schweiz) AG |
Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
|
|
CA2691987C
(en)
|
2007-06-12 |
2016-08-16 |
Achaogen, Inc. |
Antibacterial agents
|
|
CN101842098A
(zh)
|
2007-08-10 |
2010-09-22 |
基因实验室技术有限公司 |
用于治疗病毒感染的含氮的二环化学实体
|
|
KR100994115B1
(ko)
|
2008-08-18 |
2010-11-15 |
삼성모바일디스플레이주식회사 |
광효율 개선층을 구비한 유기 발광 소자
|
|
US20100160369A1
(en)
|
2008-12-04 |
2010-06-24 |
Exelixis, Inc. |
S1P1 Agonists and Methods of Making And Using
|
|
US20100204265A1
(en)
*
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
|
AU2010239188B2
(en)
|
2009-04-22 |
2016-03-31 |
Janssen Pharmaceutica Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
CA2760778A1
(en)
|
2009-05-13 |
2010-11-18 |
Amgen Inc. |
Heteroaryl compounds as pikk inhibitors
|
|
TW201109327A
(en)
|
2009-05-28 |
2011-03-16 |
Otsuka Pharma Co Ltd |
Heterocyclic compound
|
|
US8937150B2
(en)
|
2009-06-11 |
2015-01-20 |
Abbvie Inc. |
Anti-viral compounds
|
|
US9394279B2
(en)
|
2009-06-11 |
2016-07-19 |
Abbvie Inc. |
Anti-viral compounds
|
|
GB201007187D0
(en)
|
2010-04-29 |
2010-06-09 |
Iti Scotland Ltd |
Ubiquitination modulators
|
|
WO2012016133A2
(en)
|
2010-07-29 |
2012-02-02 |
President And Fellows Of Harvard College |
Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
|
|
US8927559B2
(en)
|
2010-10-11 |
2015-01-06 |
Merck Sharp & Dohme Corp. |
Quinazolinone-type compounds as CRTH2 antagonists
|
|
US9273028B2
(en)
|
2010-10-29 |
2016-03-01 |
Biogen Ma Inc. |
Heterocyclic tyrosine kinase inhibitors
|
|
JP2012111731A
(ja)
|
2010-11-26 |
2012-06-14 |
Otsuka Pharmaceut Co Ltd |
医薬
|
|
UY33801A
(es)
|
2010-12-13 |
2013-06-28 |
Array Biopharma Inc |
COMPUESTOS SUSTITUIDOS DE N-(1H-INDAZOL-4IL)IMIDAZO[1,2-a]PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III
|
|
TWI450891B
(zh)
|
2010-12-29 |
2014-09-01 |
Dev Center Biotechnology |
新穎微管蛋白抑制劑
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
EP2697196A1
(en)
|
2011-04-13 |
2014-02-19 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
BR112013026341A2
(pt)
|
2011-04-13 |
2019-09-24 |
Merck Sharp & Dohe Corp. |
composto, composição farmacêutica, e, método para tratar, prevenir e/ou atrasar o início de uma doença ou patologia
|
|
GB2494851A
(en)
|
2011-07-07 |
2013-03-27 |
Kalvista Pharmaceuticals Ltd |
Plasma kallikrein inhibitors
|
|
WO2013052526A1
(en)
|
2011-10-06 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
Triazolyl pde10 inhibitors
|
|
WO2013081094A1
(ja)
|
2011-11-30 |
2013-06-06 |
東レ株式会社 |
イミダゾ［１，２－ａ］ピリジン誘導体及びその医薬用途
|
|
MX352861B
(es)
|
2011-12-30 |
2017-12-13 |
Ptc Therapeutics Inc |
Compuestos para tratar la atrofia muscular espinal.
|
|
HRP20170411T1
(hr)
|
2012-03-02 |
2017-06-16 |
Genentech, Inc. |
Amido spirocilični amidni i sulfonamidni derivati
|
|
US20150182490A1
(en)
|
2012-06-26 |
2015-07-02 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
AR096393A1
(es)
|
2013-05-23 |
2015-12-30 |
Bayer Cropscience Ag |
Compuestos heterocíclicos pesticidas
|
|
HUE14755117T2
(hu)
|
2013-08-14 |
2018-12-28 |
Kalvista Pharmaceuticals Ltd |
Plazma-kallikrein inhibitorok
|
|
WO2015063093A1
(de)
|
2013-10-30 |
2015-05-07 |
Bayer Pharma Aktiengesellschaft |
Substituierte oxopyridin-derivate
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
US9624170B2
(en)
|
2013-12-26 |
2017-04-18 |
Takeda Pharmaceutical Company Limited |
4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors
|
|
US10266515B2
(en)
|
2013-12-30 |
2019-04-23 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
US9611252B2
(en)
|
2013-12-30 |
2017-04-04 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
EP3152206A1
(en)
|
2014-06-06 |
2017-04-12 |
Biogen MA Inc. |
Atx modulating agents
|
|
KR102286305B1
(ko)
|
2014-07-16 |
2021-08-09 |
라이프에스씨아이 파마슈티컬스, 인크. |
치료적 억제 화합물
|
|
US10913736B2
(en)
|
2014-08-22 |
2021-02-09 |
University Of Washington |
Specific inhibitors of methionyl-tRNA synthetase
|
|
GB201421083D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
Enzyme inhibitors
|
|
GB201421085D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
GB201421088D0
(en)
*
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
CN105777632A
(zh)
|
2015-01-09 |
2016-07-20 |
成都贝斯凯瑞生物科技有限公司 |
芳环并氮杂环衍生物及其应用
|
|
EP3578541B1
(en)
|
2015-04-17 |
2025-05-28 |
Corteva Agriscience LLC |
Compositions comprising molecules having pesticidal utility, and processes related thereto
|
|
WO2017001936A2
(en)
|
2015-07-01 |
2017-01-05 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2017001926A2
(en)
|
2015-07-01 |
2017-01-05 |
Lifesci Pharmaceuticals, Inc |
Therapeutic inhibitory compounds
|
|
WO2017098328A2
(en)
|
2015-12-11 |
2017-06-15 |
Lifesci Phamaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2017161028A1
(en)
|
2016-03-16 |
2017-09-21 |
Kura Oncology, Inc. |
Substituted inhibitors of menin-mll and methods of use
|
|
GB201609519D0
(en)
|
2016-05-31 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyr idin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
ME03794B
(me)
|
2016-05-31 |
2021-04-20 |
Kalvista Pharmaceuticals Ltd |
Derivati pirazola kao inhibitori kalikreina plazme
|
|
GB201609607D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
|
|
GB201609603D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
WO2018011628A1
(en)
|
2016-07-11 |
2018-01-18 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2018015818A2
(en)
|
2016-07-15 |
2018-01-25 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
JP2019529484A
(ja)
|
2016-09-29 |
2019-10-17 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤
|
|
US11111245B2
(en)
|
2017-02-01 |
2021-09-07 |
Aucentra Therapeutics Pty Ltd |
Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents
|
|
WO2018161033A1
(en)
|
2017-03-02 |
2018-09-07 |
Wright, Adrian |
Small molecule ire1-alpha inhibitors
|
|
CN110678466B
(zh)
|
2017-03-30 |
2023-01-31 |
豪夫迈·罗氏有限公司 |
作为hpk1抑制剂的二氮杂萘类
|
|
WO2018229543A2
(en)
|
2017-06-14 |
2018-12-20 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
CN111132972B
(zh)
|
2017-06-22 |
2024-07-12 |
克拉德夫制药有限公司 |
人sting的小分子调节剂
|
|
EP4494698A3
(en)
*
|
2017-08-04 |
2025-04-23 |
Takeda Pharmaceutical Company Limited |
Inhibitors of plasma kallikrein and uses thereof
|
|
GB201719881D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of plasma kallikrein inhibitor and salts thereof
|
|
GB201719882D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of a plasma kallikrein inhibitor and salts thereof
|
|
CN112135825A
(zh)
*
|
2018-03-13 |
2020-12-25 |
夏尔人类遗传性治疗公司 |
血浆激肽释放酶抑制剂及其用途
|
|
WO2021004535A1
(en)
|
2019-07-11 |
2021-01-14 |
Nanjing Zhengxiang Pharmaceuticals Co., Ltd. |
Cinnolines as inhibitors of hpk 1
|
|
WO2021055589A1
(en)
|
2019-09-18 |
2021-03-25 |
Shire Human Genetic Therapies, Inc. |
Heteroaryl plasma kallikrein inhibitors
|
|
CN114728962B
(zh)
|
2019-09-18 |
2025-09-19 |
武田药品工业有限公司 |
血浆激肽释放酶抑制剂及其用途
|
|
CN114605401B
(zh)
|
2020-04-28 |
2023-08-22 |
江南大学 |
一类含氧五元杂环化合物、合成方法、药物组合物及用途
|
|
EP4210694B1
(en)
|
2020-09-10 |
2025-10-15 |
Merck Sharp & Dohme LLC |
Plasma kallikrein inhibitors
|
|
WO2022197755A1
(en)
|
2021-03-17 |
2022-09-22 |
Shire Human Genetic Therapies, Inc. |
Imidazopyridinyl inhibitors of plasma kallikrein
|
|
US20240199613A1
(en)
|
2021-03-17 |
2024-06-20 |
Takeda Pharmaceutical Company Limited |
Polycyclic inhibitors of plasma kallikrein
|
|
US20240226106A1
(en)
|
2021-03-17 |
2024-07-11 |
Shire Human Genetic Therapies, Inc. |
Inhibitors of plasma kallikrein
|
|
EP4585265A3
(en)
|
2021-03-17 |
2025-10-15 |
Takeda Pharmaceutical Company Limited |
Heteroaryl inhibitors of plasma kallikrein
|
|
US20240382482A1
(en)
|
2021-03-17 |
2024-11-21 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors
|