JP7777519B2 - 血漿カリクレインインヒビター及びその使用 - Google Patents

血漿カリクレインインヒビター及びその使用

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Publication number
JP7777519B2
JP7777519B2 JP2022517386A JP2022517386A JP7777519B2 JP 7777519 B2 JP7777519 B2 JP 7777519B2 JP 2022517386 A JP2022517386 A JP 2022517386A JP 2022517386 A JP2022517386 A JP 2022517386A JP 7777519 B2 JP7777519 B2 JP 7777519B2
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JP
Japan
Prior art keywords
methyl
nitrogen
oxygen
pyridin
sulfur
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2022517386A
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English (en)
Japanese (ja)
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JP2022548696A (ja
JP2022548696A5 (enExample
Inventor
ニコラオス パパイオアヌー，
ジェレミー マーク トラビンス，
サラ ジョセリン フィンク，
ジョン マーク エラード，
アラステア レイ，
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of JP2022548696A publication Critical patent/JP2022548696A/ja
Publication of JP2022548696A5 publication Critical patent/JP2022548696A5/ja
Priority to JP2025147693A priority Critical patent/JP2025179190A/ja
Application granted granted Critical
Publication of JP7777519B2 publication Critical patent/JP7777519B2/ja
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022517386A 2019-09-18 2020-09-17 血漿カリクレインインヒビター及びその使用 Active JP7777519B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025147693A JP2025179190A (ja) 2019-09-18 2025-09-05 血漿カリクレインインヒビター及びその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962902353P 2019-09-18 2019-09-18
US62/902,353 2019-09-18
PCT/US2020/051293 WO2021055621A1 (en) 2019-09-18 2020-09-17 Plasma kallikrein inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025147693A Division JP2025179190A (ja) 2019-09-18 2025-09-05 血漿カリクレインインヒビター及びその使用

Publications (3)

Publication Number Publication Date
JP2022548696A JP2022548696A (ja) 2022-11-21
JP2022548696A5 JP2022548696A5 (enExample) 2023-09-26
JP7777519B2 true JP7777519B2 (ja) 2025-11-28

Family

ID=72717914

Family Applications (2)

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JP2022517386A Active JP7777519B2 (ja) 2019-09-18 2020-09-17 血漿カリクレインインヒビター及びその使用
JP2025147693A Pending JP2025179190A (ja) 2019-09-18 2025-09-05 血漿カリクレインインヒビター及びその使用

Family Applications After (1)

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JP2025147693A Pending JP2025179190A (ja) 2019-09-18 2025-09-05 血漿カリクレインインヒビター及びその使用

Country Status (10)

Country Link
US (2) US11787796B2 (enExample)
EP (2) EP4477220A3 (enExample)
JP (2) JP7777519B2 (enExample)
CN (1) CN114728962B (enExample)
DK (1) DK4031547T3 (enExample)
ES (1) ES2987744T3 (enExample)
FI (1) FI4031547T3 (enExample)
PL (1) PL4031547T3 (enExample)
PT (1) PT4031547T (enExample)
WO (1) WO2021055621A1 (enExample)

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CN112135825A (zh) * 2018-03-13 2020-12-25 夏尔人类遗传性治疗公司 血浆激肽释放酶抑制剂及其用途
CN114728962B (zh) 2019-09-18 2025-09-19 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
WO2021055589A1 (en) 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Heteroaryl plasma kallikrein inhibitors
KR20220119653A (ko) 2019-12-20 2022-08-30 테나야 테라퓨틱스, 인코포레이티드 플루오로알킬-옥사디아졸 및 이의 용도
TW202144331A (zh) * 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
TWI873290B (zh) 2020-02-13 2025-02-21 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
CN114262322B (zh) * 2020-09-16 2026-01-06 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
US20240252502A1 (en) 2021-05-04 2024-08-01 Tenaya Therapeutics, Inc. Hdac6 inhibitors for treatment of metabolic disease and hfpef
CN114907260A (zh) * 2022-05-27 2022-08-16 河南省科学院高新技术研究中心 一种利用离子液体制备4-溴甲基喹啉酮的方法
CA3262952A1 (en) * 2022-07-29 2024-02-01 Rezolute, Inc. PLASMA KALLICEREIN INHIBITORS
WO2024059186A1 (en) * 2022-09-15 2024-03-21 Takeda Pharmaceutical Company Limited N-((isoquinolin-6-yl)methyl)-1h-pyrazole-4-carboxamid derivatives as plasma kallikrein inhibitors for the treatment of hereditary angioedema
CN116041260A (zh) * 2022-12-26 2023-05-02 济南周行医药科技有限公司 一种发光检测试剂aps-5关键中间体的制备方法
CN118026889A (zh) * 2023-06-27 2024-05-14 甘肃博克斯生物技术有限公司 基于伯吉斯试剂脱水的水杨腈合成方法
CN119604497A (zh) * 2023-06-30 2025-03-11 远森制药（杭州）有限公司 杂芳族甲酰胺类化合物及其在医药上的应用
CN117659069A (zh) * 2023-12-05 2024-03-08 南通敏言生物医药科技有限公司 一种2-甲基-5-(4,4,5,5-四甲基-1,3,2-二氧硼杂环戊烷-2-基)喹啉的合成方法
WO2025160190A1 (en) * 2024-01-23 2025-07-31 Retune Pharma Inc. Therapeutic inhibitory compounds
WO2025159870A1 (en) * 2024-01-24 2025-07-31 Rezolute, Inc. Alkylated inhibitors of plasma kallikrein
WO2026008750A1 (en) 2024-07-05 2026-01-08 Syngenta Crop Protection Ag Novel carboxamide compounds
WO2026119962A1 (en) 2024-12-04 2026-06-11 Syngenta Crop Protection Ag Novel phenyl carboxamide compounds

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