JP2022545159A5 - - Google Patents
Info
- Publication number
- JP2022545159A5 JP2022545159A5 JP2022503834A JP2022503834A JP2022545159A5 JP 2022545159 A5 JP2022545159 A5 JP 2022545159A5 JP 2022503834 A JP2022503834 A JP 2022503834A JP 2022503834 A JP2022503834 A JP 2022503834A JP 2022545159 A5 JP2022545159 A5 JP 2022545159A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- independently selected
- heterocyclyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2019/052358 WO2021032935A1 (en) | 2019-08-21 | 2019-08-21 | Enzyme inhibitors |
| GBPCT/GB2019/052358 | 2019-08-21 | ||
| PCT/GB2020/050334 WO2021032938A1 (en) | 2019-08-21 | 2020-02-13 | Enzyme inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022545159A JP2022545159A (ja) | 2022-10-26 |
| JP2022545159A5 true JP2022545159A5 (enExample) | 2023-02-20 |
Family
ID=67777358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022503834A Ceased JP2022545159A (ja) | 2019-08-21 | 2020-02-13 | 酵素阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220289727A1 (enExample) |
| EP (1) | EP4017850A1 (enExample) |
| JP (1) | JP2022545159A (enExample) |
| KR (1) | KR20220050925A (enExample) |
| CN (1) | CN114258392A (enExample) |
| AR (1) | AR118083A1 (enExample) |
| AU (1) | AU2020331720A1 (enExample) |
| BR (1) | BR112022001390A2 (enExample) |
| CA (1) | CA3148028A1 (enExample) |
| CO (1) | CO2022000270A2 (enExample) |
| IL (1) | IL289778A (enExample) |
| MX (1) | MX2022000811A (enExample) |
| PH (1) | PH12022550118A1 (enExample) |
| TW (1) | TW202115021A (enExample) |
| WO (2) | WO2021032935A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| CN114269430A (zh) * | 2019-08-21 | 2022-04-01 | 卡尔维斯塔制药有限公司 | 酶抑制剂 |
| WO2023205366A1 (en) | 2022-04-20 | 2023-10-26 | Carthronix, Inc. | Small molecule modulators of gp130 signaling pathways |
| CN119264065A (zh) * | 2023-07-05 | 2025-01-07 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| EP1177188B1 (en) * | 1999-05-12 | 2005-10-12 | Ortho-McNeil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| GB0518237D0 (en) * | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US8338437B2 (en) * | 2007-02-28 | 2012-12-25 | Methylgene Inc. | Amines as small molecule inhibitors |
| WO2009147188A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| EP2149552A1 (de) * | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| US9290485B2 (en) * | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| JP2013544831A (ja) * | 2010-12-03 | 2013-12-19 | アラーガン インコーポレイテッド | スフィンゴシン−１−リン酸（ｓ１ｐ）受容体モジュレーターとしての新規アゼチジン誘導体 |
| CN103415301A (zh) * | 2011-03-09 | 2013-11-27 | 德国杰特贝林生物制品有限公司 | 用于与包括与人造表面接触的医疗操作一起施用的fxii抑制剂 |
| US8404859B2 (en) * | 2011-03-16 | 2013-03-26 | Hoffmann-La Roche Inc. | Thiazole and thiophene compounds |
| US20120252853A1 (en) * | 2011-04-01 | 2012-10-04 | H. Lundbeck A/S | Positive allosteric modulators of nicotinic acetylcholine receptor |
| BR112013026341A2 (pt) * | 2011-04-13 | 2019-09-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, e, método para tratar, prevenir e/ou atrasar o início de uma doença ou patologia |
| JP5971657B2 (ja) * | 2011-04-20 | 2016-08-17 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素環誘導体 |
| US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| MX350717B (es) * | 2011-11-30 | 2017-09-14 | Hoffmann La Roche | Nuevos derivados biciclicos de dihidroisoquinolin-1-ona. |
| AR091022A1 (es) * | 2012-05-11 | 2014-12-30 | Abbvie Inc | Inhibidores del nampt |
| GB201300304D0 (en) * | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
| RU2712621C2 (ru) | 2013-05-23 | 2020-01-30 | Калвиста Фармасьютикалз Лимитед | Азотсодержащие гетероциклические производные, полезные в качестве ингибитора калликреина плазмы |
| HRP20221373T1 (hr) * | 2014-03-07 | 2023-01-06 | Biocryst Pharmaceuticals, Inc. | Supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi |
| US10772881B2 (en) * | 2017-02-27 | 2020-09-15 | Russell Dahl | Quinolines that modulate SERCA and their use for treating disease |
| GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| CN104592204B (zh) * | 2014-12-26 | 2017-05-17 | 华润赛科药业有限责任公司 | 达比加群衍生物及其制备方法和用途 |
| WO2017123518A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Aminotriazole immunomodulators for treating autoimmune diseases |
| GB201604647D0 (en) * | 2016-03-18 | 2016-05-04 | Mission Therapeutics Ltd | Novel compounds |
| EP3440082A1 (en) * | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| CA3025810A1 (en) * | 2016-05-23 | 2017-11-30 | Manish P. PONDA | Aminoacylindazole immunomodulators for treatment of autoimmune diseases |
| US10858319B2 (en) * | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
| WO2018093716A1 (en) | 2016-11-18 | 2018-05-24 | Merck Sharp & Dohme Corp. | FACTOR XIIa INHIBITORS |
| US10875851B2 (en) | 2016-11-18 | 2020-12-29 | Merck Sharp & Dohme Corp. | Factor XIIa inhibitors |
| CN111670034A (zh) | 2017-11-29 | 2020-09-15 | 洛克菲勒大学 | 用于治疗自身免疫性疾病的吡喃并吡唑类和吡唑并吡啶类免疫调节剂 |
| JP7627209B2 (ja) * | 2018-08-14 | 2025-02-05 | エピザイム，インコーポレイティド | 置換インドール及びその使用方法 |
| WO2021028645A1 (en) * | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| CN114269430A (zh) * | 2019-08-21 | 2022-04-01 | 卡尔维斯塔制药有限公司 | 酶抑制剂 |
-
2019
- 2019-08-21 EP EP19759702.4A patent/EP4017850A1/en not_active Withdrawn
- 2019-08-21 CN CN201980099443.1A patent/CN114258392A/zh active Pending
- 2019-08-21 WO PCT/GB2019/052358 patent/WO2021032935A1/en not_active Ceased
-
2020
- 2020-02-13 AR ARP200100397A patent/AR118083A1/es not_active Application Discontinuation
- 2020-02-13 WO PCT/GB2020/050334 patent/WO2021032938A1/en not_active Ceased
- 2020-02-13 JP JP2022503834A patent/JP2022545159A/ja not_active Ceased
- 2020-02-13 TW TW109104466A patent/TW202115021A/zh unknown
- 2020-02-13 US US17/634,593 patent/US20220289727A1/en not_active Abandoned
- 2020-02-13 AU AU2020331720A patent/AU2020331720A1/en active Pending
- 2020-02-13 KR KR1020227008854A patent/KR20220050925A/ko not_active Withdrawn
- 2020-02-13 MX MX2022000811A patent/MX2022000811A/es unknown
- 2020-02-13 CA CA3148028A patent/CA3148028A1/en active Pending
- 2020-02-13 BR BR112022001390A patent/BR112022001390A2/pt not_active Application Discontinuation
- 2020-02-13 PH PH1/2022/550118A patent/PH12022550118A1/en unknown
-
2022
- 2022-01-12 IL IL289778A patent/IL289778A/en unknown
- 2022-01-17 CO CONC2022/0000270A patent/CO2022000270A2/es unknown
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