JP2022188182A5 - - Google Patents
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- Publication number
- JP2022188182A5 JP2022188182A5 JP2022160139A JP2022160139A JP2022188182A5 JP 2022188182 A5 JP2022188182 A5 JP 2022188182A5 JP 2022160139 A JP2022160139 A JP 2022160139A JP 2022160139 A JP2022160139 A JP 2022160139A JP 2022188182 A5 JP2022188182 A5 JP 2022188182A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- amadoriase
- substituted
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 51
- 108010078123 amadoriase Proteins 0.000 claims 35
- 235000001014 amino acid Nutrition 0.000 claims 33
- 229940024606 amino acid Drugs 0.000 claims 33
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 22
- 239000004472 Lysine Substances 0.000 claims 22
- 239000004475 Arginine Chemical group 0.000 claims 20
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 20
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 18
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 239000004094 surface-active agent Substances 0.000 claims 9
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 8
- 238000002835 absorbance Methods 0.000 claims 8
- 235000013922 glutamic acid Nutrition 0.000 claims 8
- 239000004220 glutamic acid Substances 0.000 claims 8
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 8
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 4
- 102000017011 Glycated Hemoglobin A Human genes 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 4
- 235000009582 asparagine Nutrition 0.000 claims 4
- 229960001230 asparagine Drugs 0.000 claims 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 4
- 235000003704 aspartic acid Nutrition 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 4
- 239000003593 chromogenic compound Substances 0.000 claims 4
- 108091005995 glycated hemoglobin Proteins 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 241000736122 Parastagonospora nodorum Species 0.000 claims 3
- 108010006172 fructosyl-peptide oxidase Proteins 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical group CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Chemical group 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 229930182817 methionine Chemical group 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024157550A JP2024170623A (ja) | 2013-08-09 | 2024-09-11 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013167005 | 2013-08-09 | ||
| JP2013167005 | 2013-08-09 | ||
| JP2013221515 | 2013-10-24 | ||
| JP2013221515 | 2013-10-24 | ||
| JP2020003038A JP7158108B2 (ja) | 2013-08-09 | 2020-01-10 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020003038A Division JP7158108B2 (ja) | 2013-08-09 | 2020-01-10 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024157550A Division JP2024170623A (ja) | 2013-08-09 | 2024-09-11 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022188182A JP2022188182A (ja) | 2022-12-20 |
| JP2022188182A5 true JP2022188182A5 (enExample) | 2023-06-20 |
| JP7629429B2 JP7629429B2 (ja) | 2025-02-13 |
Family
ID=52461524
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530983A Active JP6682268B2 (ja) | 2013-08-09 | 2014-08-08 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
| JP2020003038A Active JP7158108B2 (ja) | 2013-08-09 | 2020-01-10 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
| JP2022160139A Active JP7629429B2 (ja) | 2013-08-09 | 2022-10-04 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
| JP2024157550A Pending JP2024170623A (ja) | 2013-08-09 | 2024-09-11 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530983A Active JP6682268B2 (ja) | 2013-08-09 | 2014-08-08 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
| JP2020003038A Active JP7158108B2 (ja) | 2013-08-09 | 2020-01-10 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024157550A Pending JP2024170623A (ja) | 2013-08-09 | 2024-09-11 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10619183B2 (enExample) |
| EP (2) | EP3031914B1 (enExample) |
| JP (4) | JP6682268B2 (enExample) |
| CN (2) | CN105473715B (enExample) |
| ES (1) | ES2848705T3 (enExample) |
| WO (1) | WO2015020200A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3031914B1 (en) * | 2013-08-09 | 2020-12-23 | Kikkoman Corporation | Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring hba1c using the same |
| KR102159807B1 (ko) * | 2014-10-24 | 2020-09-25 | 기꼬만 가부시키가이샤 | 디히드로게나아제 활성이 향상된 아마도리아제 |
| WO2016072520A1 (ja) * | 2014-11-07 | 2016-05-12 | キッコーマン株式会社 | アニオン性界面活性剤耐性が向上したアマドリアーゼ |
| KR102596402B1 (ko) * | 2016-04-22 | 2023-10-31 | 기꼬만 가부시키가이샤 | HbA1c 디히드로게나아제 |
| JP7352838B2 (ja) * | 2018-06-27 | 2023-09-29 | 東洋紡株式会社 | フルクトシルバリルヒスチジンオキシダーゼ活性を有するタンパク質 |
| JP7540890B2 (ja) * | 2020-01-10 | 2024-08-27 | キリンホールディングス株式会社 | 低毒性のポリマー粒子の製法 |
| EP4108678A4 (en) | 2020-02-21 | 2024-03-27 | Kikkoman Corporation | DEVICE FOR ASSESSING THE CONDITION OF A SAMPLE, SYSTEM THEREOF, METHOD FOR ASSESSING THE CONDITION OF A SAMPLE AND LACTATE DEHYDROGENASE USED THEREFOR |
| CN113773236B (zh) * | 2021-09-10 | 2023-03-14 | 上海奥威日化有限公司 | 用于制备烷基硫酸钠干燥物的前驱组合物 |
| WO2025018360A1 (ja) | 2023-07-19 | 2025-01-23 | 株式会社Provigate | フルクトシルアミノ酸オキシダーゼ、遺伝子、発現ベクター、糖化タンパク質センサ、糖化タンパク質の測定方法、及びフルクトシルアミノ酸オキシダーゼの製造方法 |
Family Cites Families (46)
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| JPS61280297A (ja) | 1985-06-04 | 1986-12-10 | Noda Sangyo Kagaku Kenkyusho | アマドリ化合物の定量法及びその定量用試薬 |
| JPH01127895A (ja) | 1987-11-04 | 1989-05-19 | Akutoronikusu Kk | 閉ループ管型熱伝達装置 |
| EP0567642A4 (en) * | 1991-01-14 | 1994-08-17 | Bior Inc | Process for producing (r)-malic acid, microbial maleate hydratase, and process for producing said hydratase |
| GB9116315D0 (en) | 1991-07-29 | 1991-09-11 | Genzyme Ltd | Assay |
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| DE69635503T2 (de) * | 1995-04-11 | 2006-08-17 | Arkray, Inc. | Fructosyl-Aminosäureoxidase und Verfahren zu deren Herstellung |
| WO1997013872A1 (en) | 1995-10-12 | 1997-04-17 | Kyoto Daiichi Kagaku Co., Ltd. | Method and assaying amodori compounds |
| JP3949854B2 (ja) | 1999-10-01 | 2007-07-25 | キッコーマン株式会社 | 糖化蛋白質の測定方法 |
| DE60143748D1 (de) | 2000-07-14 | 2011-02-10 | Arkray Inc | Verfahren zur selektiven bestimmung von glykosyliertem hämoglobin |
| EP2107123A3 (en) * | 2001-01-31 | 2010-01-06 | Asahi Kasei Pharma Corporation | Composition for assaying glycated proteins |
| JP4231668B2 (ja) | 2001-09-04 | 2009-03-04 | キッコーマン株式会社 | 新規なフルクトシルペプチドオキシダーゼ |
| US7291256B2 (en) * | 2002-09-12 | 2007-11-06 | Lifescan, Inc. | Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays |
| CN1701118A (zh) * | 2002-09-24 | 2005-11-23 | 爱科来株式会社 | 果糖基胺氧化酶 |
| JP4227820B2 (ja) | 2003-03-12 | 2009-02-18 | 旭化成ファーマ株式会社 | 新規な酵素 |
| JP4248900B2 (ja) | 2003-03-14 | 2009-04-02 | イチビキ株式会社 | 新規なフルクトシルアミンオキシダーゼをコードする遺伝子及びそれを用いての該フルクトシルアミンオキシダーゼの製造方法 |
| WO2004104203A1 (ja) | 2003-05-21 | 2004-12-02 | Asahi Kasei Pharma Corporation | ヘモグロビンA1c測定法およびそれに用いる酵素とその製造法 |
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| KR20060123751A (ko) * | 2003-11-19 | 2006-12-04 | 다이이치 가가쿠 야쿠힝 가부시키가이샤 | 헤모글로빈 함유 시료 중의 기질의 측정방법 |
| CN1957090A (zh) * | 2004-03-17 | 2007-05-02 | 第一化学药品株式会社 | 糖蛋白的测定方法 |
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| JP4798600B2 (ja) | 2005-05-30 | 2011-10-19 | キッコーマン株式会社 | フルクトシルペプチドオキシダ−ゼの安定化方法 |
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| CN101479383B (zh) | 2006-04-25 | 2013-10-02 | 龟甲万株式会社 | 具有优良的热稳定性的真核阿马道里酶、真核阿马道里酶的基因和重组dna，和生产具有优良的热稳定性的真核阿马道里酶的方法 |
| DE102006021401A1 (de) * | 2006-05-08 | 2007-12-13 | Henkel Kgaa | Amadoriasen in Wasch- und Reinigungsmitteln |
| ES2404059T3 (es) * | 2006-07-25 | 2013-05-23 | General Atomics | Procedimientos para analizar el porcentaje de hemoglobina glicada |
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| EP2354224B1 (en) | 2008-10-10 | 2018-02-14 | Toyobo Co., Ltd. | Novel protein having fructosyl valyl histidine oxidase activity and modified product thereof, and use of the protein or the modified product |
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| EP2281900A1 (en) * | 2009-08-03 | 2011-02-09 | Roche Diagnostics GmbH | Fructosyl peptidyl oxidase and sensor for assaying a glycated protein |
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| KR102070990B1 (ko) | 2010-08-06 | 2020-01-29 | 기꼬만 가부시키가이샤 | 기질 특이성이 개변된 아마드리아제 |
| BR112013001398A2 (pt) | 2010-08-11 | 2016-05-24 | Kyowa Medex Co Ltd | método, reagente e kit para medir hemoglobina glicada |
| WO2012043601A1 (ja) * | 2010-09-29 | 2012-04-05 | キッコーマン株式会社 | アマドリアーゼ改変体 |
| US20150132786A1 (en) | 2011-06-17 | 2015-05-14 | Haruyo Soya | Method for measuring glycosylated hemoglobin, measurement reagent, and measurement kit |
| WO2013010006A2 (en) * | 2011-07-12 | 2013-01-17 | Huawei Technologies Co., Ltd. | Seamless mobility schemes in named-data networking using multi-path routing and content caching |
| JP2013102736A (ja) * | 2011-11-15 | 2013-05-30 | Toyobo Co Ltd | 色素の安定性を改善した生化学分析用試験片 |
| WO2013100006A1 (ja) | 2011-12-28 | 2013-07-04 | キッコーマン株式会社 | 熱安定性が向上したアマドリアーゼ、その遺伝子および組換えｄｎａならびに熱安定性が向上したアマドリアーゼの製造法 |
| JP5779118B2 (ja) | 2012-02-16 | 2015-09-16 | Ntn株式会社 | 転がり接触部品、転がり軸受、自在継手およびそれらの製造方法 |
| US20130269351A1 (en) | 2012-04-17 | 2013-10-17 | General Electric Company | Micromixer assembly of a turbine system and method of assembly |
| EP3508577A3 (en) * | 2012-04-27 | 2019-09-04 | Kikkoman Corporation | Modified amadoriase capable of acting on fructosyl hexapeptide |
| EP3031914B1 (en) * | 2013-08-09 | 2020-12-23 | Kikkoman Corporation | Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring hba1c using the same |
-
2014
- 2014-08-08 EP EP14834684.4A patent/EP3031914B1/en active Active
- 2014-08-08 WO PCT/JP2014/071036 patent/WO2015020200A1/ja not_active Ceased
- 2014-08-08 CN CN201480044806.9A patent/CN105473715B/zh active Active
- 2014-08-08 JP JP2015530983A patent/JP6682268B2/ja active Active
- 2014-08-08 EP EP20187370.0A patent/EP3760717A1/en active Pending
- 2014-08-08 US US14/910,789 patent/US10619183B2/en active Active
- 2014-08-08 CN CN202010046578.6A patent/CN111398605B/zh active Active
- 2014-08-08 ES ES14834684T patent/ES2848705T3/es active Active
-
2020
- 2020-01-10 JP JP2020003038A patent/JP7158108B2/ja active Active
- 2020-03-27 US US16/832,712 patent/US11549134B2/en active Active
-
2022
- 2022-10-04 JP JP2022160139A patent/JP7629429B2/ja active Active
-
2024
- 2024-09-11 JP JP2024157550A patent/JP2024170623A/ja active Pending
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