JP2012233922A5 - - Google Patents

Info

Publication number

JP2012233922A5

JP2012233922A5 JP2012186627A JP2012186627A JP2012233922A5 JP 2012233922 A5 JP2012233922 A5 JP 2012233922A5 JP 2012186627 A JP2012186627 A JP 2012186627A JP 2012186627 A JP2012186627 A JP 2012186627A JP 2012233922 A5 JP2012233922 A5 JP 2012233922A5

Authority

JP

Japan

Prior art keywords

protease

amino acid

glycated

hemoglobin

oxidant

Prior art date

2012-08-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 45
• 108091005804 Peptidases Proteins 0.000 claims 40
• 239000004365 Protease Substances 0.000 claims 40
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 40
• 235000019419 proteases Nutrition 0.000 claims 40
• 239000007800 oxidant agent Substances 0.000 claims 32
• 150000001413 amino acids Chemical class 0.000 claims 21
• 102000001554 Hemoglobins Human genes 0.000 claims 20
• 108010054147 Hemoglobins Proteins 0.000 claims 20
• 230000001590 oxidative effect Effects 0.000 claims 20
• 108010078123 amadoriase Proteins 0.000 claims 19
• 102000017011 Glycated Hemoglobin A Human genes 0.000 claims 18
• -1 N-carboxymethylaminocarbonyl Chemical group 0.000 claims 16
• 210000004369 blood Anatomy 0.000 claims 14
• 239000008280 blood Substances 0.000 claims 14
• 239000012139 lysis buffer Substances 0.000 claims 13
• 239000012634 fragment Substances 0.000 claims 12
• 102000003992 Peroxidases Human genes 0.000 claims 11
• 108040007629 peroxidase activity proteins Proteins 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 108091005995 glycated hemoglobin Proteins 0.000 claims 10
• 108010014663 Glycated Hemoglobin A Proteins 0.000 claims 8
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 8
• 125000003831 tetrazolyl group Chemical group 0.000 claims 8
• 102000004169 proteins and genes Human genes 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 7
• 239000000126 substance Substances 0.000 claims 6
• 241000228212 Aspergillus Species 0.000 claims 4
• 108090000145 Bacillolysin Proteins 0.000 claims 4
• 241000193830 Bacillus <bacterium> Species 0.000 claims 4
• 241000283690 Bos taurus Species 0.000 claims 4
• 108010067770 Endopeptidase K Proteins 0.000 claims 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
• 108010001336 Horseradish Peroxidase Proteins 0.000 claims 4
• 102000035092 Neutral proteases Human genes 0.000 claims 4
• 108091005507 Neutral proteases Proteins 0.000 claims 4
• 108010059712 Pronase Proteins 0.000 claims 4
• 108090000787 Subtilisin Proteins 0.000 claims 4
• 108090001109 Thermolysin Proteins 0.000 claims 4
• 238000011088 calibration curve Methods 0.000 claims 4
• 238000004040 coloring Methods 0.000 claims 4
• NKLCNNUWBJBICK-UHFFFAOYSA-N dess–martin periodinane Chemical group C1=CC=C2I(OC(=O)C)(OC(C)=O)(OC(C)=O)OC(=O)C2=C1 NKLCNNUWBJBICK-UHFFFAOYSA-N 0.000 claims 4
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 239000000463 material Substances 0.000 claims 4
• 229950000688 phenothiazine Drugs 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 229910052708 sodium Inorganic materials 0.000 claims 4
• 239000011734 sodium Substances 0.000 claims 4
• SMBKJPHMYWYRDF-UHFFFAOYSA-M sodium 4-[2-(2,4-dinitrophenyl)-3-(4-iodophenyl)-1,3-dihydrotetrazol-3-ium-5-yl]benzene-1,3-disulfonate Chemical group [Na+].[O-][N+](=O)C1=CC([N+](=O)[O-])=CC=C1N1[NH+](C=2C=CC(I)=CC=2)N=C(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)N1 SMBKJPHMYWYRDF-UHFFFAOYSA-M 0.000 claims 4
• 210000000601 blood cell Anatomy 0.000 claims 3
• 125000006303 iodophenyl group Chemical group 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 239000004471 Glycine Substances 0.000 claims 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
• GHAZCVNUKKZTLG-UHFFFAOYSA-N N-ethyl-succinimide Natural products CCN1C(=O)CCC1=O GHAZCVNUKKZTLG-UHFFFAOYSA-N 0.000 claims 2
• HDFGOPSGAURCEO-UHFFFAOYSA-N N-ethylmaleimide Chemical compound CCN1C(=O)C=CC1=O HDFGOPSGAURCEO-UHFFFAOYSA-N 0.000 claims 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
• 239000003638 chemical reducing agent Substances 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 210000003743 erythrocyte Anatomy 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 238000005259 measurement Methods 0.000 claims 2
• 239000004474 valine Substances 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 239000000872 buffer Substances 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1