JP2018186837A5 - - Google Patents
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- JP2018186837A5 JP2018186837A5 JP2018166687A JP2018166687A JP2018186837A5 JP 2018186837 A5 JP2018186837 A5 JP 2018186837A5 JP 2018166687 A JP2018166687 A JP 2018166687A JP 2018166687 A JP2018166687 A JP 2018166687A JP 2018186837 A5 JP2018186837 A5 JP 2018186837A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- leucine
- histidine
- isoleucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 96
- 235000001014 amino acid Nutrition 0.000 claims 78
- 229940024606 amino acid Drugs 0.000 claims 73
- 150000001413 amino acids Chemical class 0.000 claims 72
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 63
- 235000005772 leucine Nutrition 0.000 claims 63
- 229960003136 leucine Drugs 0.000 claims 63
- 125000003275 alpha amino acid group Chemical group 0.000 claims 61
- 108010078123 amadoriase Proteins 0.000 claims 57
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 56
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 53
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 53
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 53
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 53
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 53
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 53
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 53
- 235000018417 cysteine Nutrition 0.000 claims 53
- 229960002433 cysteine Drugs 0.000 claims 53
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 53
- 235000014705 isoleucine Nutrition 0.000 claims 53
- 229960000310 isoleucine Drugs 0.000 claims 53
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 53
- 235000006109 methionine Nutrition 0.000 claims 53
- 229930182817 methionine Natural products 0.000 claims 53
- 229960004452 methionine Drugs 0.000 claims 53
- 235000013930 proline Nutrition 0.000 claims 53
- 229960002429 proline Drugs 0.000 claims 53
- 229960004799 tryptophan Drugs 0.000 claims 53
- 235000014393 valine Nutrition 0.000 claims 53
- 229960004295 valine Drugs 0.000 claims 53
- 239000004474 valine Substances 0.000 claims 53
- 239000004471 Glycine Substances 0.000 claims 52
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 52
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 52
- 229960002449 glycine Drugs 0.000 claims 52
- 235000002374 tyrosine Nutrition 0.000 claims 52
- 229960004441 tyrosine Drugs 0.000 claims 52
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 52
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 51
- 235000008729 phenylalanine Nutrition 0.000 claims 51
- 229960005190 phenylalanine Drugs 0.000 claims 51
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 51
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 49
- 235000014304 histidine Nutrition 0.000 claims 48
- 229960002885 histidine Drugs 0.000 claims 48
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Chemical group OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 48
- 239000004472 Lysine Chemical group 0.000 claims 47
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 47
- 235000018977 lysine Nutrition 0.000 claims 47
- 229960003646 lysine Drugs 0.000 claims 47
- 239000004475 Arginine Substances 0.000 claims 44
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 44
- 235000009697 arginine Nutrition 0.000 claims 44
- 229960003121 arginine Drugs 0.000 claims 44
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 44
- 235000004400 serine Nutrition 0.000 claims 44
- 229960001153 serine Drugs 0.000 claims 44
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 43
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 43
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 43
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 43
- 235000009582 asparagine Nutrition 0.000 claims 43
- 229960001230 asparagine Drugs 0.000 claims 43
- 235000004554 glutamine Nutrition 0.000 claims 43
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 43
- 229960002743 glutamine Drugs 0.000 claims 43
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 42
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 42
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 42
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 42
- 239000004473 Threonine Substances 0.000 claims 42
- 235000008521 threonine Nutrition 0.000 claims 42
- 229960002898 threonine Drugs 0.000 claims 42
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 40
- 235000004279 alanine Nutrition 0.000 claims 34
- 229960003767 alanine Drugs 0.000 claims 34
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 33
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 25
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 25
- 235000013922 glutamic acid Nutrition 0.000 claims 25
- 229960002989 glutamic acid Drugs 0.000 claims 25
- 239000004220 glutamic acid Substances 0.000 claims 25
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 24
- 235000003704 aspartic acid Nutrition 0.000 claims 24
- 229960005261 aspartic acid Drugs 0.000 claims 24
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 24
- 230000000694 effects Effects 0.000 claims 15
- -1 α-fructosyl Chemical group 0.000 claims 13
- 230000009257 reactivity Effects 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 9
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 8
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 2
- 241000235035 Debaryomyces Species 0.000 claims 2
- 241000228138 Emericella Species 0.000 claims 2
- 241000223609 Microascus Species 0.000 claims 2
- 241000228143 Penicillium Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 241000868613 Achaetomium sp. Species 0.000 claims 1
- 241000589158 Agrobacterium Species 0.000 claims 1
- 241000171738 Arthrinium Species 0.000 claims 1
- 241000186063 Arthrobacter Species 0.000 claims 1
- 241000228257 Aspergillus sp. Species 0.000 claims 1
- 241000221955 Chaetomium Species 0.000 claims 1
- 241001327444 Coniochaeta Species 0.000 claims 1
- 241001340163 Coniochaetidium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000223208 Curvularia Species 0.000 claims 1
- 241001149959 Fusarium sp. Species 0.000 claims 1
- 241001149562 Gelasinospora Species 0.000 claims 1
- 241000228456 Leptosphaeria Species 0.000 claims 1
- 241000124176 Neocosmospora Species 0.000 claims 1
- 241000190509 Ophiobolus Species 0.000 claims 1
- 241000228168 Penicillium sp. Species 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 241000555275 Phaeosphaeria Species 0.000 claims 1
- 241001136503 Pleospora Species 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 241000812330 Pyrenochaeta Species 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241001494489 Thielavia Species 0.000 claims 1
- 241000266300 Ulocladium Species 0.000 claims 1
- BNQVUHQWZGTIBX-IUCAKERBSA-N Val-His Chemical compound CC(C)[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC1=CN=CN1 BNQVUHQWZGTIBX-IUCAKERBSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012102771 | 2012-04-27 | ||
| JP2012102771 | 2012-04-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Division JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018186837A JP2018186837A (ja) | 2018-11-29 |
| JP2018186837A5 true JP2018186837A5 (enExample) | 2019-06-27 |
| JP6726243B2 JP6726243B2 (ja) | 2020-07-22 |
Family
ID=49483330
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Active JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
| JP2018166687A Active JP6726243B2 (ja) | 2012-04-27 | 2018-09-06 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Active JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10767211B2 (enExample) |
| EP (2) | EP2843050B1 (enExample) |
| JP (2) | JP6401056B2 (enExample) |
| WO (1) | WO2013162035A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2843050B1 (en) * | 2012-04-27 | 2019-03-13 | Kikkoman Corporation | Modified amadoriase capable of acting on fructosyl hexapeptide |
| JP6363327B2 (ja) * | 2013-03-25 | 2018-07-25 | キッコーマン株式会社 | 改変アマドリアーゼ |
| CN105431533B (zh) * | 2013-07-09 | 2019-06-28 | 协和梅迪克斯株式会社 | 糖化六肽氧化酶及其用途 |
| CN111398605B (zh) * | 2013-08-09 | 2024-04-05 | 龟甲万株式会社 | 糖化血红蛋白测定用组合物 |
| EP3061829B1 (en) * | 2013-10-25 | 2021-09-22 | Kikkoman Corporation | METHOD FOR MEASUREMENT OF HbA1c USING AMADORIASE THAT REACTS WITH GLYCATED PEPTIDE |
| KR102390390B1 (ko) * | 2013-10-25 | 2022-04-25 | 기꼬만 가부시키가이샤 | 헤모글로빈 A1c의 측정 방법 및 측정 키트 |
| KR102159807B1 (ko) * | 2014-10-24 | 2020-09-25 | 기꼬만 가부시키가이샤 | 디히드로게나아제 활성이 향상된 아마도리아제 |
| JP7094655B2 (ja) * | 2014-11-07 | 2022-07-04 | キッコーマン株式会社 | アニオン性界面活性剤耐性が向上したアマドリアーゼ |
| JP6764219B2 (ja) * | 2014-12-26 | 2020-09-30 | キッコーマン株式会社 | グッド緩衝液に対して安定なアマドリアーゼ |
| EP3279323B1 (en) * | 2015-04-03 | 2023-03-08 | Kikkoman Corporation | Amadoriase having improved specific activity |
| US11111517B2 (en) | 2016-04-22 | 2021-09-07 | Kikkoman Corporation | HbA1c dehydrogenase |
| US11384381B2 (en) | 2016-07-13 | 2022-07-12 | Kikkoman Corporation | Reaction accelerating agent |
| CN109563534B (zh) | 2016-07-29 | 2022-02-11 | 日立化成诊断系统株式会社 | 糖化血红蛋白的测定方法 |
| EP3677681A4 (en) | 2017-08-31 | 2021-07-14 | Kikkoman Corporation | GLYCATED HEMOGLOBIN OXIDASE VARIANT AND MEASURING METHOD |
| JP6818718B2 (ja) * | 2018-06-28 | 2021-01-20 | キッコーマン株式会社 | 改変アマドリアーゼ |
| CN112143825B (zh) * | 2020-09-28 | 2021-08-03 | 华南农业大学 | 一种区分检测花生黑腐病菌和花生基腐病菌的双重pcr检测引物及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280297A (ja) | 1985-06-04 | 1986-12-10 | Noda Sangyo Kagaku Kenkyusho | アマドリ化合物の定量法及びその定量用試薬 |
| GB9116315D0 (en) | 1991-07-29 | 1991-09-11 | Genzyme Ltd | Assay |
| WO1997013872A1 (en) | 1995-10-12 | 1997-04-17 | Kyoto Daiichi Kagaku Co., Ltd. | Method and assaying amodori compounds |
| US6767701B1 (en) * | 1998-10-26 | 2004-07-27 | Novozymes A/S | Methods of constructing and screening a DNA library of interest in filamentous fungal cells |
| JP3949854B2 (ja) | 1999-10-01 | 2007-07-25 | キッコーマン株式会社 | 糖化蛋白質の測定方法 |
| JP4231668B2 (ja) | 2001-09-04 | 2009-03-04 | キッコーマン株式会社 | 新規なフルクトシルペプチドオキシダーゼ |
| US7393549B2 (en) | 2002-10-23 | 2008-07-01 | Daiichi Pure Chemicals Co., Ltd. | Defructosylation method |
| JP4227820B2 (ja) | 2003-03-12 | 2009-02-18 | 旭化成ファーマ株式会社 | 新規な酵素 |
| JP4248900B2 (ja) | 2003-03-14 | 2009-04-02 | イチビキ株式会社 | 新規なフルクトシルアミンオキシダーゼをコードする遺伝子及びそれを用いての該フルクトシルアミンオキシダーゼの製造方法 |
| EP1626088B1 (en) * | 2003-05-21 | 2010-12-01 | Asahi Kasei Pharma Corporation | Method of measuring glycolated hemoglobin a1c, enzyme to be used therefor and process for producing the same |
| JP2005110657A (ja) | 2003-09-18 | 2005-04-28 | Kikkoman Corp | α−糖化ジペプチドの製造法及びα−糖化ジペプチドの測定法 |
| US7951553B2 (en) | 2003-11-19 | 2011-05-31 | Sekisui Medical Co., Ltd. | Method of assaying glycated protein |
| JP5074386B2 (ja) | 2006-04-25 | 2012-11-14 | キッコーマン株式会社 | 熱安定性に優れた真核型アマドリアーゼ、その遺伝子及び組換え体ｄｎａ、並びに熱安定性に優れた真核型アマドリアーゼの製造法 |
| DE602006011374D1 (de) | 2006-08-07 | 2010-02-04 | St Microelectronics Srl | Steuereinrichtung für eine leistungsfaktor-korrektureinrichtung in schaltnetzteilen |
| JP5442432B2 (ja) | 2007-03-05 | 2014-03-12 | キッコーマン株式会社 | 糖化ヘキサペプチドの測定方法 |
| JP5243878B2 (ja) | 2008-08-04 | 2013-07-24 | 東洋紡株式会社 | フルクトシルバリルヒスチジン測定用酵素、およびその利用法 |
| JP5350762B2 (ja) | 2008-08-04 | 2013-11-27 | 東洋紡株式会社 | フルクトシルアミノ酸オキシダーゼ、およびその利用法 |
| CA2739881A1 (en) | 2008-10-09 | 2010-04-15 | Kyowa Medex Co., Ltd. | Novel fructosyl peptide oxidase |
| EP2354224B1 (en) | 2008-10-10 | 2018-02-14 | Toyobo Co., Ltd. | Novel protein having fructosyl valyl histidine oxidase activity and modified product thereof, and use of the protein or the modified product |
| JP5476021B2 (ja) * | 2008-10-17 | 2014-04-23 | 東洋紡株式会社 | フルクトシルアミノ酸オキシダーゼ改変体およびその利用 |
| EP2287295A1 (en) * | 2009-08-03 | 2011-02-23 | Roche Diagnostics GmbH | Mutant Fructosyl amino acid oxidase |
| EP2281900A1 (en) | 2009-08-03 | 2011-02-09 | Roche Diagnostics GmbH | Fructosyl peptidyl oxidase and sensor for assaying a glycated protein |
| JP5927771B2 (ja) | 2010-04-09 | 2016-06-01 | 東洋紡株式会社 | ヘモグロビンＡ１ｃの測定方法 |
| WO2012018094A1 (ja) | 2010-08-06 | 2012-02-09 | キッコーマン株式会社 | 基質特異性が改変されたアマドリアーゼ |
| EP2843050B1 (en) * | 2012-04-27 | 2019-03-13 | Kikkoman Corporation | Modified amadoriase capable of acting on fructosyl hexapeptide |
-
2013
- 2013-04-26 EP EP13781492.7A patent/EP2843050B1/en active Active
- 2013-04-26 US US14/396,855 patent/US10767211B2/en active Active
- 2013-04-26 WO PCT/JP2013/062508 patent/WO2013162035A1/ja not_active Ceased
- 2013-04-26 JP JP2014512732A patent/JP6401056B2/ja active Active
- 2013-04-26 EP EP19154807.2A patent/EP3508577A3/en active Pending
-
2018
- 2018-09-06 JP JP2018166687A patent/JP6726243B2/ja active Active
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