JP6401056B2 - フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ - Google Patents

フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ Download PDF

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JP6401056B2
JP6401056B2 JP2014512732A JP2014512732A JP6401056B2 JP 6401056 B2 JP6401056 B2 JP 6401056B2 JP 2014512732 A JP2014512732 A JP 2014512732A JP 2014512732 A JP2014512732 A JP 2014512732A JP 6401056 B2 JP6401056 B2 JP 6401056B2
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amino acid
seq
acid sequence
amadoriase
position corresponding
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JPWO2013162035A1 (ja
Inventor
敦 一柳
敦 一柳
陽介 鉞
陽介 鉞
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Kikkoman Corp
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Kikkoman Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/9065—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5)
    • G01N2333/90672—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3) in general

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014512732A 2012-04-27 2013-04-26 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ Active JP6401056B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014512732A JP6401056B2 (ja) 2012-04-27 2013-04-26 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012102771 2012-04-27
JP2012102771 2012-04-27
PCT/JP2013/062508 WO2013162035A1 (ja) 2012-04-27 2013-04-26 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
JP2014512732A JP6401056B2 (ja) 2012-04-27 2013-04-26 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ

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JP2018166687A Division JP6726243B2 (ja) 2012-04-27 2018-09-06 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ

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JPWO2013162035A1 JPWO2013162035A1 (ja) 2015-12-24
JP6401056B2 true JP6401056B2 (ja) 2018-10-03

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JP2018166687A Active JP6726243B2 (ja) 2012-04-27 2018-09-06 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ

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US (1) US10767211B2 (enExample)
EP (2) EP3508577A3 (enExample)
JP (2) JP6401056B2 (enExample)
WO (1) WO2013162035A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018153202A (ja) * 2018-06-28 2018-10-04 キッコーマン株式会社 改変アマドリアーゼ

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3508577A3 (en) * 2012-04-27 2019-09-04 Kikkoman Corporation Modified amadoriase capable of acting on fructosyl hexapeptide
JP6363327B2 (ja) * 2013-03-25 2018-07-25 キッコーマン株式会社 改変アマドリアーゼ
JP6328115B2 (ja) * 2013-07-09 2018-05-23 協和メデックス株式会社 糖化ヘキサペプチドオキシダーゼとその利用
EP3031914B1 (en) * 2013-08-09 2020-12-23 Kikkoman Corporation Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring hba1c using the same
WO2015060431A1 (ja) * 2013-10-25 2015-04-30 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
EP3061819B1 (en) * 2013-10-25 2023-05-24 Kikkoman Corporation HEMOGLOBIN A1c MEASUREMENT METHOD AND MEASUREMENT KIT
KR102159807B1 (ko) * 2014-10-24 2020-09-25 기꼬만 가부시키가이샤 디히드로게나아제 활성이 향상된 아마도리아제
WO2016072520A1 (ja) * 2014-11-07 2016-05-12 キッコーマン株式会社 アニオン性界面活性剤耐性が向上したアマドリアーゼ
JP6764219B2 (ja) * 2014-12-26 2020-09-30 キッコーマン株式会社 グッド緩衝液に対して安定なアマドリアーゼ
EP3279323B1 (en) * 2015-04-03 2023-03-08 Kikkoman Corporation Amadoriase having improved specific activity
KR102596402B1 (ko) 2016-04-22 2023-10-31 기꼬만 가부시키가이샤 HbA1c 디히드로게나아제
JP7458703B2 (ja) 2016-07-13 2024-04-01 キッコーマン株式会社 反応促進剤
US11168349B2 (en) 2016-07-29 2021-11-09 Hitachi Chemical Diagnostics Systems Co., Ltd. Method for measuring glycated hemoglobin
WO2019045052A1 (ja) 2017-08-31 2019-03-07 キッコーマン株式会社 糖化ヘモグロビンオキシダーゼ改変体及び測定方法
CN112143825B (zh) * 2020-09-28 2021-08-03 华南农业大学 一种区分检测花生黑腐病菌和花生基腐病菌的双重pcr检测引物及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018153202A (ja) * 2018-06-28 2018-10-04 キッコーマン株式会社 改変アマドリアーゼ

Also Published As

Publication number Publication date
EP3508577A2 (en) 2019-07-10
EP2843050B1 (en) 2019-03-13
EP2843050A1 (en) 2015-03-04
JP2018186837A (ja) 2018-11-29
US10767211B2 (en) 2020-09-08
EP3508577A3 (en) 2019-09-04
US20150118700A1 (en) 2015-04-30
EP2843050A4 (en) 2016-03-02
JP6726243B2 (ja) 2020-07-22
JPWO2013162035A1 (ja) 2015-12-24
WO2013162035A1 (ja) 2013-10-31

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