JP2022172369A5 - - Google Patents

Download PDF

Info

Publication number
JP2022172369A5
JP2022172369A5 JP2022144599A JP2022144599A JP2022172369A5 JP 2022172369 A5 JP2022172369 A5 JP 2022172369A5 JP 2022144599 A JP2022144599 A JP 2022144599A JP 2022144599 A JP2022144599 A JP 2022144599A JP 2022172369 A5 JP2022172369 A5 JP 2022172369A5
Authority
JP
Japan
Prior art keywords
residue
influenza virus
vector
virus
operably linked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022144599A
Other languages
English (en)
Japanese (ja)
Other versions
JP7575012B2 (ja
JP2022172369A (ja
Filing date
Publication date
Priority claimed from JP2020523276A external-priority patent/JP2021500891A/ja
Application filed filed Critical
Publication of JP2022172369A publication Critical patent/JP2022172369A/ja
Publication of JP2022172369A5 publication Critical patent/JP2022172369A5/ja
Priority to JP2024176620A priority Critical patent/JP2024177515A/ja
Application granted granted Critical
Publication of JP7575012B2 publication Critical patent/JP7575012B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022144599A 2017-10-25 2022-09-12 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス Active JP7575012B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024176620A JP2024177515A (ja) 2017-10-25 2024-10-08 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762577049P 2017-10-25 2017-10-25
US62/577,049 2017-10-25
US201862633400P 2018-02-21 2018-02-21
US62/633,400 2018-02-21
JP2020523276A JP2021500891A (ja) 2017-10-25 2018-10-25 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス
PCT/US2018/057576 WO2019084310A1 (en) 2017-10-25 2018-10-25 HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2020523276A Division JP2021500891A (ja) 2017-10-25 2018-10-25 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024176620A Division JP2024177515A (ja) 2017-10-25 2024-10-08 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Publications (3)

Publication Number Publication Date
JP2022172369A JP2022172369A (ja) 2022-11-15
JP2022172369A5 true JP2022172369A5 (enExample) 2022-11-22
JP7575012B2 JP7575012B2 (ja) 2024-10-29

Family

ID=64270970

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020523276A Pending JP2021500891A (ja) 2017-10-25 2018-10-25 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス
JP2022144599A Active JP7575012B2 (ja) 2017-10-25 2022-09-12 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス
JP2024176620A Pending JP2024177515A (ja) 2017-10-25 2024-10-08 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2020523276A Pending JP2021500891A (ja) 2017-10-25 2018-10-25 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024176620A Pending JP2024177515A (ja) 2017-10-25 2024-10-08 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス

Country Status (4)

Country Link
US (3) US11197926B2 (enExample)
EP (1) EP3700562A1 (enExample)
JP (3) JP2021500891A (enExample)
WO (1) WO2019084310A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
WO2013032942A1 (en) 2011-08-26 2013-03-07 Yoshihiro Kawaoka Influenza viruses with mutant pb2 gene segment as live attenuated vaccines
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
EP3417056A1 (en) 2016-02-19 2018-12-26 Wisconsin Alumni Research Foundation (WARF) Improved influenza b virus replication for vaccine development
JP2021500891A (ja) 2017-10-25 2021-01-14 ウィスコンシン アルムニ リサーチ ファンデイション 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
WO2021041624A2 (en) * 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたnaを有する組換えインフルエンザウイルス
JP2023521946A (ja) * 2020-03-06 2023-05-26 ユニバーシティ オブ ワシントン 操作されたインフルエンザノイラミニダーゼ抗原
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4927290B1 (enExample) 1969-08-05 1974-07-16
US4071618A (en) 1974-09-03 1978-01-31 Research Foundation For Microbial Diseases Of Osaka University Process for preparing virus disease live vaccines
JPS57136528A (en) 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
NZ219515A (en) 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5786199A (en) 1989-08-28 1998-07-28 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US6001634A (en) 1989-08-28 1999-12-14 Palese; Peter Recombinant negative strand RNA viruses
US5854037A (en) 1989-08-28 1998-12-29 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US5166057A (en) 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
JP3484215B2 (ja) 1994-01-27 2004-01-06 花王株式会社 チャイニーズハムスター卵巣細胞変異株
US5750394A (en) 1994-05-20 1998-05-12 The Mount Sinai Medical Center Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
CA2149197A1 (en) 1994-06-17 1995-12-18 Irene Popiel Production of an efficacious toxoplasma gondii bradyzoite vaccine in tissue culture
ATE257175T1 (de) 1994-07-18 2004-01-15 Conzelmann Karl Klaus Prof Dr Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus
EP0700991A1 (en) 1994-09-12 1996-03-13 Bayer Corporation Commercial scale concentrated preharvest tissue culture produced live T. Gondii bradyzoite and products and processes
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
EP0704533A1 (en) 1994-09-30 1996-04-03 Bayer Ag An attenuated vaccination virus, a method to make the virus and a pharmaceutical compositions comprising the virus
WO1996010631A1 (en) 1994-09-30 1996-04-11 St. Jude Children's Research Hospital Nucleic acid encoding mutant matrix proteins useful for attenuation or enhancement of influenza a virus
WO1996010400A1 (en) 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
US6843996B1 (en) 1995-06-05 2005-01-18 Medimmune Vaccines, Inc. Immunogenic composition comprising an influenza virus with a temperature sensitive PB2 mutation
ATE181112T1 (de) 1995-08-09 1999-06-15 Schweiz Serum & Impfinst Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US5994526A (en) 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
CN101012454B (zh) 1996-07-15 2011-11-16 美国政府健康及人类服务部 从克隆的核苷酸序列制备减毒呼吸道合胞病毒疫苗的方法
US6271011B1 (en) 1996-10-15 2001-08-07 The University Of Georgia Research Foundation, Inc. Pasteurella neuraminidase coding sequences and diagnostic methods
TW570803B (en) 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
AU7471098A (en) 1997-04-30 1998-11-24 Mount Sinai School Of Medicine Of The City University Of New York, The Recombinant influenza viruses expressing tumor-associated antigens as antitum or agents
AU7797798A (en) 1997-05-23 1998-12-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
ES2255181T3 (es) 1997-08-05 2006-06-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Antigeno inmunoprotector contra la gripe y su uso en vacunacion.
US6169175B1 (en) 1997-08-06 2001-01-02 Centers For Disease Control And Prevention Preparation and use of recombinant influenza A virus M2 construct vaccines
US20020010143A1 (en) 1997-09-26 2002-01-24 Miguel S. Barbosa Compositions and methods for the treatment of human cytomegalovirus infection
KR100281676B1 (ko) 1997-11-29 2001-04-02 신동권 신규한독감생백신바이러스
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
US6270958B1 (en) 1998-10-29 2001-08-07 Washington University Detection of negative-strand RNA viruses
ATE332364T1 (de) 1999-02-22 2006-07-15 Transgene Sa Verfahren zur gewinnung von purifizierter virenzuammensetzung
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
EP2910629B1 (en) 1999-04-06 2018-09-19 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
DE122008000056I1 (de) 1999-07-14 2009-04-09 Sinai School Medicine In vitro-rekonstitution von segmentierten negativstrang-rna-viren
EP1222299A1 (en) 1999-10-01 2002-07-17 Genovo, Incorporated Production of recombinant aav using adenovirus comprising aav rep/cap genes
US6686168B1 (en) 1999-11-04 2004-02-03 Zymogenetics, Inc. Cell surface display of proteins by recombinant host cells
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US20020009436A1 (en) 1999-12-30 2002-01-24 Doyle Ron J. Methods and compositions for inhibiting adhesion by microorganisms
AU2001236042B9 (en) 2000-03-03 2006-06-29 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell
AU5533601A (en) 2000-04-14 2001-10-30 Wisconsin Alumni Res Found Viruses comprising mutation ion channel protein
CN101580849B (zh) 2000-04-28 2012-11-21 圣朱德儿童研究医院 用于产生感染性流感病毒的dna转染系统
US6358733B1 (en) 2000-05-19 2002-03-19 Apolife, Inc. Expression of heterologous multi-domain proteins in yeast
US20040241139A1 (en) 2000-07-20 2004-12-02 Gerd Hobom Recombinant influenza viruses with bicistronic vRNAs coding for two genes in tandem arrangement
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
EP1201760A1 (en) 2000-10-30 2002-05-02 ARTEMIS Pharmaceuticals GmbH Influenza virus vector for human dendritic cells
ES2327719T3 (es) 2001-01-18 2009-11-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Complejos de proteina oligomerica recombinante con potencial inmunogenico mejorado.
EP1233059A1 (en) 2001-02-09 2002-08-21 ARTEMIS Pharmaceuticals GmbH Influenza viruses with enhanced transcriptional and replicational capacities
US7176021B2 (en) 2001-02-23 2007-02-13 Wisconsin Alumni Research Foundation Mutant cells with altered sialic acid
DE10144906B4 (de) 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US7682618B2 (en) 2001-11-07 2010-03-23 The United States Of America As Represented By The Secretary Of The Army Generation of virus-like particles and use as panfilovirus vaccine
CA2465895C (en) 2001-11-07 2012-10-02 U.S. Army Medical Research Institute Of Infectious Diseases Department Of The Army Generation of virus-like particles and demonstration of lipid rafts as sites of filovirus entry and budding
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US7211378B2 (en) 2002-01-31 2007-05-01 Wisconsin Alumni Research Foundation Filovirus vectors and noninfectious filovirus-based particles
CA2816242C (en) 2002-02-13 2019-01-08 Wisconsin Alumni Research Foundation Signal for packaging of influenza virus vectors
EP1572910B1 (en) 2002-02-13 2015-12-02 Wisconsin Alumni Research Foundation Signal for packaging of influenza virus vectors
AU2002239151A1 (en) 2002-03-08 2003-09-22 Crucell Holland B.V. Use of recombinant trypsin for vaccine production
FR2837497A1 (fr) 2002-03-22 2003-09-26 Univ Nantes Procede de production de vecteurs lentiviraux a haut titre
DK1499348T3 (en) 2002-04-26 2015-01-05 Medimmune Llc PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
US9045727B2 (en) 2002-05-17 2015-06-02 Emory University Virus-like particles, methods of preparation, and immunogenic compositions
US20060088909A1 (en) 2002-05-17 2006-04-27 Compans Richard W Virus-like particles, methods of preparation, and immunogenic compositions
EP2287288B1 (en) 2002-07-09 2012-11-07 Baxter International Inc. Animal protein free media for cultivation of cells
US6875433B2 (en) 2002-08-23 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
US20040242518A1 (en) 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
US20040142322A1 (en) 2002-10-07 2004-07-22 Schering Corporation Continuous non-radioactive polymerase assay
CA2522081C (en) 2003-04-23 2013-01-29 Wisconsin Alumni Research Foundation Recombinant influenza viruses holding a mutation in a transmembrane protein gene
CN1829799A (zh) 2003-05-28 2006-09-06 威斯康星旧生研究基金会 含polii启动子和核酶的重组流感载体
KR100908757B1 (ko) 2003-05-28 2009-07-22 위스콘신 얼럼나이 리서어치 화운데이션 백신 및 유전자 요법을 위한 고 역가 재조합 인플루엔자바이러스
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US20060240515A1 (en) 2003-07-21 2006-10-26 Dimitrov Dimiter S Soluble fragments of the SARS-CoV spike glycoprotein
US7037707B2 (en) 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
US7279275B2 (en) 2003-11-03 2007-10-09 Washington University Methods and compositions for detection of segmented negative strand RNA viruses
ES2345492T3 (es) 2003-12-23 2010-09-24 Medimmune, Llc Sistema multiplasmido para la produccion del virus de la gripe.
JP2005245302A (ja) 2004-03-04 2005-09-15 Kanazawa Univ Tlo Inc 組換えインフルエンザウイルスおよびそれを用いたワクチン
US20060099609A1 (en) 2004-04-13 2006-05-11 Sina Bavari Activation of natural killer (NK) cells and methods of use
WO2005113758A1 (en) 2004-05-20 2005-12-01 Id Biomedical Corporation Process for the production of an influenza vaccine
ATE489965T1 (de) 2004-09-09 2010-12-15 Novartis Vaccines & Diagnostic Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen
US20080292658A1 (en) 2004-11-11 2008-11-27 Emmie De Wit Defective Influenza Virus Particles
KR20070086344A (ko) 2004-11-19 2007-08-27 위스콘신 얼럼나이 리서어치 화운데이션 탠덤 전사 유닛을 갖는 재조합 인플루엔자 벡터
US7670837B2 (en) 2004-12-23 2010-03-02 Medimmune, Llc Non-tumorigenic MDCK cell line for propagating viruses
BRPI0518568A2 (pt) 2004-12-24 2008-11-25 Solvay Pharm Bv mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico
EP1856271A4 (en) 2005-03-08 2009-11-18 Medimmune Vaccines Inc INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS
EP1877088B1 (en) 2005-04-11 2014-12-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Vaccine against pandemic strains of influenza viruses
FR2887958B1 (fr) 2005-07-01 2007-10-12 Prospection Et D Inv S Techniq Dispositif de reglage de commande de vanne pour appareil de fixation a gaz et l'appareil comportant le dispositif
NL1030161C2 (nl) 2005-10-11 2007-04-12 Matthijs Dirk Meulenbelt Presentatie-inrichting.
US8354114B2 (en) 2005-10-17 2013-01-15 Medimmune, Llc Multi plasmid system for the production of influenza virus
US20110027314A1 (en) 2006-01-27 2011-02-03 Novartis Vaccines And Diagnostics Gmbh & Co. Kg Influenza Vaccines Containing Hemagglutinin and Matrix Proteins
AU2012204138B2 (en) 2006-03-31 2014-02-06 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
AU2014202470B2 (en) 2006-03-31 2016-08-04 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
EP2010557B1 (en) 2006-03-31 2014-02-26 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
US7883844B2 (en) 2006-05-11 2011-02-08 Juridical Foundation The Chemosero-Therapeutic Research Institute Method for propagating influenza virus
US20090017444A1 (en) 2006-06-09 2009-01-15 Wisconsin Alumni Research Foundation Screening method for modulators of viral transcription or replication
US7507411B2 (en) 2006-06-23 2009-03-24 University Of Saskatchewan Attenuated influenza NS1 variants
EP2049662A4 (en) 2006-07-21 2009-12-30 Medimmune Llc METHODS AND COMPOSITIONS FOR INCREASING REPLICATION CAPACITY OF A FLU VIRUS
AU2007286161B2 (en) 2006-08-09 2013-05-02 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US20080286850A1 (en) 2006-09-15 2008-11-20 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
CN101553252A (zh) 2006-12-06 2009-10-07 诺华有限公司 包含来自于四株流感病毒的抗原的疫苗
WO2009008921A2 (en) 2007-03-28 2009-01-15 Yoshihiro Kawaoka Influenza b viruses with reduced sensitivity to neuraminidase inhibitors
JP4880750B2 (ja) 2007-04-16 2012-02-22 ビ−エイイ− システムズ パブリック リミテッド カンパニ− 腐食センサ
US8597661B2 (en) 2007-05-04 2013-12-03 Wisconsin Alumni Research Foundation Neuraminidase-deficient live influenza vaccines
WO2008156681A2 (en) 2007-06-14 2008-12-24 Yoshihiro Kawaoka Adenoviral vectors for influenza virus production
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
CA2690196A1 (en) 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
WO2008155681A1 (en) 2007-06-21 2008-12-24 Nds Limited Power saving device
EP2048237A1 (en) 2007-10-05 2009-04-15 Avir Green Hills Biotechnology Research Development Trade Ag Replication deficient Influenza virus for the expression of heterologous sequences
SG182957A1 (en) 2007-06-27 2012-08-30 Novartis Ag Low-additive influenza vaccines
WO2009014919A2 (en) 2007-07-13 2009-01-29 Iowa State University Research Foundation, Inc. H2n3 influenza a viruses and methods of use
EP2215231A4 (en) 2007-10-15 2010-12-01 Univ Queensland EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE
WO2009128867A2 (en) 2008-01-07 2009-10-22 Warf - Wisconsin Alumni Research Foundation Recombinant biologically contained filovirus
EP2296701A1 (en) 2008-06-11 2011-03-23 Flugen, Inc. Cell-based systems for producing influenza vaccines
BRPI0915487A2 (pt) 2008-07-11 2017-06-27 Medimmune Inc hemaglutina de nfluenza e variantes de neuraminidase
JP5852883B2 (ja) 2008-08-08 2016-02-03 タケダ ワクチン,インコーポレイテッド 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子
WO2010053573A2 (en) 2008-11-07 2010-05-14 Yoshihiro Kawaoka Screen for inhibitors of filovirus and uses therefor
KR101548790B1 (ko) 2009-07-16 2015-08-31 크루셀 홀란드 비.브이. 백신 제조를 위한 고역가 폴리오바이러스의 제조
WO2011014504A1 (en) 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
EP2459585B1 (en) 2009-07-30 2024-09-04 Icahn School of Medicine at Mount Sinai Influenza viruses and uses thereof
US8507247B2 (en) 2009-08-11 2013-08-13 Wisconsin Alumni Research Foundation Influenza A virus with attenuating mutations in NS2 protein
US9109013B2 (en) 2009-10-26 2015-08-18 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
GB0919117D0 (en) 2009-10-30 2009-12-16 Glaxosmithkline Biolog Sa Process
KR101740019B1 (ko) 2009-11-10 2017-05-26 주식회사 팬택 무선통신시스템에서 시스템 정보 송수신 방법 및 그를 이용한 시스템 정보 송신장치와 수신장치
AU2010321710B2 (en) 2009-11-23 2013-03-07 Wm. Wrigley Jr. Company Gum bases, chewing gums based thereupon, and methods for making the same
WO2011087839A1 (en) 2009-12-22 2011-07-21 Baxter International Inc. Vaccine to influenza a virus
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
MX340735B (es) 2010-04-09 2016-07-22 Univ Utrecht Holding Bv Proteinas multimericas recombinantes de la influenza.
EP2560680B1 (en) 2010-04-16 2018-11-28 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Chimpanzee adenoviral vector-based filovirus vaccines
GB201011502D0 (en) 2010-07-08 2010-08-25 Glaxosmithkline Biolog Sa Novel process
US9534042B2 (en) 2010-09-03 2017-01-03 Fujita Health University Influenza virus-neutralizing antibody and screening method therefor
WO2012033236A1 (ko) 2010-09-06 2012-03-15 에스케이케미칼 주식회사 무혈청 배양 및 부유 배양에 적응된 mdck 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법
HUE027649T2 (en) 2010-10-07 2016-10-28 Ac Immune Sa Antibodies recognising phospho-tau
CN107267459A (zh) 2011-01-06 2017-10-20 约翰·霍普金斯大学 在哺乳动物细胞中产生具有延长的循环半衰期的重组糖蛋白的方法
DK3447131T3 (da) 2011-06-24 2021-09-13 Flugen Inc Influenza a-virusmutanter
WO2013032942A1 (en) 2011-08-26 2013-03-07 Yoshihiro Kawaoka Influenza viruses with mutant pb2 gene segment as live attenuated vaccines
CN102304495A (zh) 2011-09-08 2012-01-04 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
AU2013205478B9 (en) 2012-03-02 2014-11-20 Seqirus UK Limited Influenza virus reassortment
JP2015527296A (ja) 2012-03-26 2015-09-17 アメリカ合衆国 哺乳動物細胞へのパッケージングされたrnaの新規の送達
WO2014078674A1 (en) 2012-11-16 2014-05-22 Medimmune, Llc Swine influenza hemagglutinin and neuraminidase variants
JP6568514B2 (ja) 2013-03-15 2019-08-28 エーシー イミューン エス.エー. 抗タウ抗体及び使用方法
CA2914604A1 (en) 2013-06-06 2014-12-11 Novartis Ag Influenza virus reassortment
EP3022296B1 (en) 2013-07-15 2022-12-28 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
CN106661569B (zh) 2014-03-04 2020-09-11 西格马—奥尔德里奇有限责任公司 抗病毒细胞及其用途
WO2015142671A2 (en) 2014-03-17 2015-09-24 Flugen, Inc. Influenza virus vectors and uses therefor
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
WO2016034678A2 (en) 2014-09-03 2016-03-10 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
CN106999566B (zh) 2014-10-03 2022-01-28 麻省理工学院 结合埃博拉病毒糖蛋白的抗体及其用途
TWI710573B (zh) 2015-01-26 2020-11-21 美商再生元醫藥公司 抗伊波拉病毒醣蛋白之人類抗體
US10429386B2 (en) 2015-03-10 2019-10-01 The Regents Of The University Of California Antibodies to the surface of Toxoplasma gondii oocysts and methods of use thereof
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
HK1254344A1 (zh) 2015-06-26 2019-07-19 Seqirus UK Limited 抗原匹配的流感疫苗
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
US20170121391A1 (en) 2015-07-07 2017-05-04 Wisconsin Alumni Research Foundation (Warf) Potent glycoprotein antibody as a therapeutic against ebola virus
JP2018530314A (ja) 2015-08-28 2018-10-18 ウィスコンシン アルムニ リサーチ ファンデイション ウイルス様粒子からの感染性インフルエンザウイルスの生成
CN105296356A (zh) 2015-12-02 2016-02-03 河南农业大学 一种刚地弓形虫卵囊的制备、纯化及保存方法
US10063211B2 (en) 2016-02-03 2018-08-28 Qualcomm Incorporated Compact bypass and decoupling structure for millimeter-wave circuits
EP3417056A1 (en) 2016-02-19 2018-12-26 Wisconsin Alumni Research Foundation (WARF) Improved influenza b virus replication for vaccine development
JP2018064493A (ja) 2016-10-19 2018-04-26 京都府公立大学法人 Mdck細胞を用いたインフルエンザウイルスの増殖方法
JP2021500891A (ja) 2017-10-25 2021-01-14 ウィスコンシン アルムニ リサーチ ファンデイション 卵における複製のための安定化されたhaを有する組換えインフルエンザウイルス
WO2019241579A1 (en) 2018-06-13 2019-12-19 Wisconsin Alumni Research Foundation Toxoplasma gondii vaccine
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
CN113423421A (zh) 2018-09-21 2021-09-21 内布拉斯加大学董事会 制备和使用通用中心化流感疫苗基因的方法
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US20220249652A1 (en) 2019-06-26 2022-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus neuraminidase and uses thereof
WO2021041624A2 (en) 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたnaを有する組換えインフルエンザウイルス
US10953089B1 (en) 2020-01-27 2021-03-23 Novavax, Inc. Coronavirus vaccine formulations
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
WO2021242597A1 (en) 2020-05-23 2021-12-02 Wisconsin Alumni Research Foundation ("Warf") Ace2 expressing influenza virus
WO2022245888A1 (en) 2021-05-19 2022-11-24 Modernatx, Inc. Seasonal flu rna vaccines and methods of use
US20230321217A1 (en) 2021-09-28 2023-10-12 Yoshihiro Kawaoka Compositions comprising complexes displaying antigens and methods of using the compositions
WO2023125889A1 (en) 2021-12-31 2023-07-06 Suzhou Abogen Biosciences Co., Ltd. Quadrivalent mrna vaccines for influenza viruses
WO2023164556A2 (en) 2022-02-23 2023-08-31 Wisconsin Alumni Research Foundation Broadly protective influenza b virus vaccines
WO2024015510A1 (en) 2022-07-13 2024-01-18 Wisconsin Alumni Research Foundation ("Warf") Sars-cov-2 lacking the envelope protein as an attenuated vaccine virus against covid-19
US20240238403A1 (en) 2022-11-16 2024-07-18 Wisconsin Alumni Research Foundation Influenza virus replication for vaccine development
WO2024197167A1 (en) 2023-03-21 2024-09-26 Wisconsin Alumni Research Foundation A cold-adapted, live attenuated sars-cov-2 vaccine

Similar Documents

Publication Publication Date Title
JP2022172369A5 (enExample)
US20240075125A1 (en) Expression systems
JP2024177515A5 (enExample)
JP5438065B2 (ja) 突然変異した膜タンパク質をコードするウイルス
ES2668018T3 (es) Virus quiméricos de la enfermedad de Newcastle que presentan proteínas de superficie no naturales y sus usos
JP2024091645A5 (enExample)
CN113423421A (zh) 制备和使用通用中心化流感疫苗基因的方法
JP2007525175A5 (enExample)
TWI396741B (zh) 非洲綠猴腎細胞培養之流感病毒及疫苗
EP4247420A1 (en) Influenza virus encoding a truncated ns1 protein and a sars-cov receptor binding domain
CN103316357B (zh) 携带rsv基因的重组流感病毒嵌合疫苗及其制备方法
RU2556833C2 (ru) Аттенуированный холодоадаптированный штамм вируса гриппа а/рr/8/59/m2 (h1n1), предназначенный для получения вакцинных штаммов вируса гриппа в качестве донора аттенуации, вакцинные штаммы вируса гриппа а/59/м2/калифорния/66/2211 (н2n2) и а/59/м2/токио/67/22111 (н2n2)
KR102182987B1 (ko) 재조합 인플루엔자 a 바이러스 h5n1주 및 이를 포함하는 고병원성 인플루엔자 a 바이러스 백신 조성물
CN101454023B (zh) 干扰缺损病毒
KIM Mechanisms for the enhancement of influenza B virus vaccine antigen yield
Gambaryan et al. Mutations in hemagglutinin and polymerase alter the virulence of pandemic A (H1N1) influenza virus
RU2839428C2 (ru) Антиген для универсальной рекомбинантной вакцины против вируса гриппа птиц и человека
CN102174090B (zh) 一种猪源a型流感病毒头部蛋白及其制备方法和应用
JP2012525134A5 (enExample)
HK40059786A (en) Expression system
CN102174089B (zh) 一种禽流感病毒头部蛋白及其制备方法和应用
CN114980921A (zh) 新型初免-加强流感疫苗
Cai Live-attenuated vaccines against influenza viruses and role of NS1 in host response
HK1127731B (en) Chimeric viruses presenting non-native surface proteins and uses thereof
JPWO2021209199A5 (enExample)