JP2024091645A5 - - Google Patents

Download PDF

Info

Publication number
JP2024091645A5
JP2024091645A5 JP2024050083A JP2024050083A JP2024091645A5 JP 2024091645 A5 JP2024091645 A5 JP 2024091645A5 JP 2024050083 A JP2024050083 A JP 2024050083A JP 2024050083 A JP2024050083 A JP 2024050083A JP 2024091645 A5 JP2024091645 A5 JP 2024091645A5
Authority
JP
Japan
Prior art keywords
amino acid
seq
acid sequence
encoded
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2024050083A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024091645A (ja
JP7829610B2 (ja
Filing date
Publication date
Priority claimed from JP2019171818A external-priority patent/JP7627544B2/ja
Application filed filed Critical
Publication of JP2024091645A publication Critical patent/JP2024091645A/ja
Publication of JP2024091645A5 publication Critical patent/JP2024091645A5/ja
Application granted granted Critical
Publication of JP7829610B2 publication Critical patent/JP7829610B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2024050083A 2013-07-15 2024-03-26 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス Active JP7829610B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846460P 2013-07-15 2013-07-15
US61/846,460 2013-07-15
JP2019171818A JP7627544B2 (ja) 2013-07-15 2019-09-20 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2019171818A Division JP7627544B2 (ja) 2013-07-15 2019-09-20 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Publications (3)

Publication Number Publication Date
JP2024091645A JP2024091645A (ja) 2024-07-05
JP2024091645A5 true JP2024091645A5 (enExample) 2025-02-19
JP7829610B2 JP7829610B2 (ja) 2026-03-13

Family

ID=51257635

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016527046A Withdrawn JP2016524915A (ja) 2013-07-15 2014-07-15 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2019171818A Active JP7627544B2 (ja) 2013-07-15 2019-09-20 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2022016436A Active JP7691380B2 (ja) 2013-07-15 2022-02-04 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2024050083A Active JP7829610B2 (ja) 2013-07-15 2024-03-26 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2016527046A Withdrawn JP2016524915A (ja) 2013-07-15 2014-07-15 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2019171818A Active JP7627544B2 (ja) 2013-07-15 2019-09-20 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
JP2022016436A Active JP7691380B2 (ja) 2013-07-15 2022-02-04 Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス

Country Status (5)

Country Link
US (2) US9950057B2 (enExample)
EP (1) EP3022296B1 (enExample)
JP (4) JP2016524915A (enExample)
AU (2) AU2014290203B2 (enExample)
WO (1) WO2015009743A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009532352A (ja) 2006-03-31 2009-09-10 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ワクチンのための高力価組み換えインフルエンザ・ウィルス
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
JP2013507990A (ja) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
ES2655051T3 (es) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas
JP2016524915A (ja) 2013-07-15 2016-08-22 ウィスコンシン アルムニ リサーチ ファンデイション Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017007839A1 (en) * 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
JP2019510481A (ja) 2016-02-19 2019-04-18 ウィスコンシン アルムニ リサーチ ファンデイション ワクチン開発のための改善されたb型インフルエンザウイルス複製
WO2018201044A1 (en) 2017-04-27 2018-11-01 Mississippi State University Influenza virus vaccine and method of making
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
US11389523B2 (en) 2018-08-20 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
EP3888677A4 (en) * 2018-11-14 2022-08-17 Tokyo Metropolitan Institute of Medical Science DIS-DERIVED RECOMBINANT VACCINIA VIRUS WITH NOVEL INFLUENCE VIRUS-DERIVED HEMAGGLUTININ PROTEIN GENE
EP3914295A2 (en) 2019-01-23 2021-12-01 Yoshihiro Kawaoka Mutations that confer genetic stability to additional genes in influenza viruses
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
CN114929269A (zh) * 2019-05-01 2022-08-19 威斯康星校友研究基金会(Warf) 用于疫苗开发的改进的流感病毒复制
EP3980060A4 (en) * 2019-06-07 2023-04-12 Flugen, Inc. FLU VIRUS BACKBONE
WO2021041624A2 (en) 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
CN110551187B (zh) * 2019-09-23 2022-09-16 新乡学院 化学合成的h7n9禽流感病毒na蛋白胞外区抗原片段及制备方法和应用
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたnaを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
WO2022020469A1 (en) * 2020-07-21 2022-01-27 Flugen, Inc. Influenza virus backbone
CN116867512A (zh) * 2020-12-23 2023-10-10 佛罗里达州大学研究基金会 包装效率提高的用于心脏基因治疗的载体

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071618A (en) 1974-09-03 1978-01-31 Research Foundation For Microbial Diseases Of Osaka University Process for preparing virus disease live vaccines
JPS57136528A (en) 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
NZ219515A (en) 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5854037A (en) 1989-08-28 1998-12-29 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US5166057A (en) 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
DK0702085T4 (da) 1994-07-18 2010-04-06 Conzelmann Karl Klaus Prof Dr Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus
WO1996010400A1 (en) 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
AU3727895A (en) 1994-09-30 1996-04-26 St. Jude Children's Research Hospital Nucleic acid encoding mutant matrix proteins useful for attenuation or enhancement of influenza a virus
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
EP0780475B2 (en) 1995-08-09 2006-07-19 SCHWEIZ. SERUM- & IMPFINSTITUT BERN Process for the production of infectious negative-strand RNA viruses
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
US5994526A (en) 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
EP0912724B1 (en) 1996-07-15 2009-12-09 The Government of The United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
TW570803B (en) 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
DE69842165D1 (de) 1997-05-23 2011-04-21 Us Of America As Represented By The Secretary Of The Dept Of Health And Human Services Herstellung attenuierter parainfluenza-virus impfstoffe aus klonierten nukleotidsequenzen
EP0996717B1 (en) 1997-08-05 2005-12-07 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Immunoprotective influenza antigen and its use in vaccination
US6169175B1 (en) 1997-08-06 2001-01-02 Centers For Disease Control And Prevention Preparation and use of recombinant influenza A virus M2 construct vaccines
KR100281676B1 (ko) 1997-11-29 2001-04-02 신동권 신규한독감생백신바이러스
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
DK1820853T3 (da) 1999-04-06 2011-12-19 Wisconsin Alumni Res Found Rekombinant influenzavirus til vacciner og genterapi
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6686168B1 (en) 1999-11-04 2004-02-03 Zymogenetics, Inc. Cell surface display of proteins by recombinant host cells
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
CA2401117C (en) 2000-03-03 2010-06-29 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell
AU5533601A (en) 2000-04-14 2001-10-30 Wisconsin Alumni Res Found Viruses comprising mutation ion channel protein
AU5921101A (en) 2000-04-28 2001-11-12 St Jude Childrens Res Hospital Dna transfection system for the generation of infectious influenza virus
EP1201760A1 (en) 2000-10-30 2002-05-02 ARTEMIS Pharmaceuticals GmbH Influenza virus vector for human dendritic cells
EP1233059A1 (en) * 2001-02-09 2002-08-21 ARTEMIS Pharmaceuticals GmbH Influenza viruses with enhanced transcriptional and replicational capacities
EP1364006A2 (en) 2001-02-23 2003-11-26 Wisconsin Alumni Research Foundation Methods to identify mutant cells with altered sialic acid
DE10144906B4 (de) 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
EP3009507B1 (en) 2002-02-13 2020-06-24 Wisconsin Alumini Research Foundation Signal for packaging of influenza virus vectors
WO2003076462A1 (en) 2002-03-08 2003-09-18 Crucell Holland B.V. Use of recombinant trypsin for vaccine production
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
CN1678345B (zh) 2002-04-26 2013-09-11 米迪缪尼有限公司 制备流感病毒的多质粒系统
DK1520008T3 (da) 2002-07-09 2012-10-15 Baxter Int Medium frit for dyreprotein til dyrkning af celler
JP2007525175A (ja) 2003-04-23 2007-09-06 ウィスコンシン アルムニ リサーチ ファウンデイション 突然変異した膜タンパク質をその機能性の一部ウイルス
ES2593082T3 (es) 2003-05-28 2016-12-05 Wisconsin Alumni Research Foundation Virus de la gripe recombinantes a título elevado para vacunas y terapia génica
AU2004274860A1 (en) 2003-05-28 2005-03-31 Wisconsin Alumni Research Foundation Recombinant influenza vectors with a polII promoter and ribozymes
EP1633312A4 (en) 2003-06-16 2012-09-26 Medimmune Llc INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS
US7037707B2 (en) 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
EP1697521B1 (en) 2003-12-23 2010-06-02 MedImmune, LLC Multi plasmid system for the production of influenza virus
JP2005245302A (ja) 2004-03-04 2005-09-15 Kanazawa Univ Tlo Inc 組換えインフルエンザウイルスおよびそれを用いたワクチン
AU2005245943A1 (en) 2004-05-20 2005-12-01 Id Biomedical Corporation Process for the production of an influenza vaccine
RS51665B (sr) 2004-09-09 2011-10-31 Novartis Vaccines And Diagnostics Gmbh. Smanjenje potencijalnih jatrogenih rizika povezanih sa vakcinama protiv gripa
CN101103103A (zh) 2004-11-19 2008-01-09 威斯康星旧生研究基金会 具有串联转录单位的重组流感病毒载体
ES2526170T3 (es) 2004-12-23 2015-01-07 Medimmune, Llc Línea celular MDCK no tumorigénica para propagar virus
NZ556061A (en) 2004-12-24 2009-06-26 Solvay Biologicals Bv Rescue of influenza virus
ES2527503T3 (es) 2005-03-08 2015-01-26 Medimmune, Llc Virus influenza reordenantes
ES2402061T3 (es) 2005-10-17 2013-04-26 Medimmune, Llc Método de aumento de la replicación del virus influenza
PL2478916T3 (pl) 2006-01-27 2020-11-16 Seqirus UK Limited Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy
AU2012204138B2 (en) 2006-03-31 2014-02-06 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
AU2014202470B2 (en) 2006-03-31 2016-08-04 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
JP2009532352A (ja) 2006-03-31 2009-09-10 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ワクチンのための高力価組み換えインフルエンザ・ウィルス
EP2022849A4 (en) 2006-05-11 2010-10-06 Chemo Sero Therapeut Res Inst PROCESS FOR THE PROLIFERATION OF INFLUENZA VIRUS
US7507411B2 (en) 2006-06-23 2009-03-24 University Of Saskatchewan Attenuated influenza NS1 variants
CA2659267C (en) 2006-08-09 2016-12-13 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
AU2007347716B2 (en) 2006-09-15 2013-06-20 Medimmune, Llc MDCK cell lines supporting viral growth to high titers and bioreactor process using the same
JP2011506264A (ja) 2006-12-06 2011-03-03 ノバルティス アーゲー インフルエンザウイルスの4つの株に由来する抗原を含むワクチン
CA2690196A1 (en) 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
PT2185191E (pt) 2007-06-27 2012-11-27 Novartis Ag Vacinas contra a gripe com baixo teor de aditivos
US8591914B2 (en) 2008-07-11 2013-11-26 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
HRP20140597T1 (hr) 2009-07-16 2014-09-12 Crucell Holland B.V. Proizvodnja polio virusa u visokim titrima za proizvodnju cjepiva
JP2013507990A (ja) * 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス
GB0919117D0 (en) 2009-10-30 2009-12-16 Glaxosmithkline Biolog Sa Process
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
GB201011502D0 (en) 2010-07-08 2010-08-25 Glaxosmithkline Biolog Sa Novel process
WO2012033236A1 (ko) 2010-09-06 2012-03-15 에스케이케미칼 주식회사 무혈청 배양 및 부유 배양에 적응된 mdck 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법
CN106995802B (zh) 2011-06-24 2021-04-09 复尔健有限公司 流感病毒突变体及其用途
CN102304495A (zh) 2011-09-08 2012-01-04 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
CN105722976A (zh) 2013-06-06 2016-06-29 诺华股份有限公司 流感病毒重配
JP2016524915A (ja) 2013-07-15 2016-08-22 ウィスコンシン アルムニ リサーチ ファンデイション Mdck、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
JP2019510481A (ja) 2016-02-19 2019-04-18 ウィスコンシン アルムニ リサーチ ファンデイション ワクチン開発のための改善されたb型インフルエンザウイルス複製

Similar Documents

Publication Publication Date Title
EP1820853B1 (en) Recombinant influenza viruses for vaccines and gene therapy
US11701422B2 (en) Expression systems
US8715940B2 (en) Method of making recombinant influenza virus
JP2022172369A5 (enExample)
WO2022193553A1 (zh) 一种基于流感病毒载体的新型冠状病毒疫苗及其制备方法
HK40059786A (en) Expression system
HK1148778B (en) Recombinant influenza viruses for vaccines and gene therapy
AU2008201521A1 (en) Recombinant influenza viruses for vaccines and gene therapy