JP2021518162A5 - - Google Patents
Info
- Publication number
- JP2021518162A5 JP2021518162A5 JP2020573082A JP2020573082A JP2021518162A5 JP 2021518162 A5 JP2021518162 A5 JP 2021518162A5 JP 2020573082 A JP2020573082 A JP 2020573082A JP 2020573082 A JP2020573082 A JP 2020573082A JP 2021518162 A5 JP2021518162 A5 JP 2021518162A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- modified
- immunoeffector
- seq
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024070727A JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643582P | 2018-03-15 | 2018-03-15 | |
| US201862643578P | 2018-03-15 | 2018-03-15 | |
| US62/643,578 | 2018-03-15 | ||
| US62/643,582 | 2018-03-15 | ||
| US201862692014P | 2018-06-29 | 2018-06-29 | |
| US201862692010P | 2018-06-29 | 2018-06-29 | |
| US62/692,010 | 2018-06-29 | ||
| US62/692,014 | 2018-06-29 | ||
| US201862714337P | 2018-08-03 | 2018-08-03 | |
| US201862714333P | 2018-08-03 | 2018-08-03 | |
| US62/714,337 | 2018-08-03 | ||
| US62/714,333 | 2018-08-03 | ||
| US201862768462P | 2018-11-16 | 2018-11-16 | |
| US201862768459P | 2018-11-16 | 2018-11-16 | |
| US201862768428P | 2018-11-16 | 2018-11-16 | |
| US201862768430P | 2018-11-16 | 2018-11-16 | |
| US62/768,459 | 2018-11-16 | ||
| US62/768,462 | 2018-11-16 | ||
| US62/768,430 | 2018-11-16 | ||
| US62/768,428 | 2018-11-16 | ||
| US201962804259P | 2019-02-12 | 2019-02-12 | |
| US62/804,259 | 2019-02-12 | ||
| PCT/US2019/022366 WO2019178422A1 (en) | 2018-03-15 | 2019-03-14 | Gene-regulating compositions and methods for improved immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024070727A Division JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021518162A JP2021518162A (ja) | 2021-08-02 |
| JP2021518162A5 true JP2021518162A5 (enExample) | 2022-03-18 |
Family
ID=67903888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573082A Pending JP2021518162A (ja) | 2018-03-15 | 2019-03-14 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| JP2024070727A Pending JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024070727A Pending JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190284529A1 (enExample) |
| EP (1) | EP3765608A4 (enExample) |
| JP (2) | JP2021518162A (enExample) |
| KR (2) | KR20200133218A (enExample) |
| CN (1) | CN112041433A (enExample) |
| AU (2) | AU2019236205A1 (enExample) |
| BR (1) | BR112020018573A2 (enExample) |
| CA (1) | CA3093968A1 (enExample) |
| WO (1) | WO2019178422A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112040986A (zh) | 2018-03-15 | 2020-12-04 | Ksq治疗公司 | 用于改进的免疫疗法的基因调控组合物和方法 |
| EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY |
| US20220081691A1 (en) * | 2018-08-07 | 2022-03-17 | Dana-Farber Cancer Institute, Inc | Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages |
| CN112840026B (zh) * | 2018-10-18 | 2025-01-14 | 施能康公司 | 抑制tigit基因表达的组合物和方法 |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| US20220096551A1 (en) * | 2019-01-28 | 2022-03-31 | Bar Ilan University | Combinations, nanoparticles and methods for controlling natural killer cell activation and function |
| SG11202108452WA (en) * | 2019-02-04 | 2021-09-29 | Ksq Therapeutics Inc | Combination gene targets for improved immunotherapy |
| WO2020174472A1 (en) * | 2019-02-26 | 2020-09-03 | Rambam Med-Tech Ltd. | Cells and methods for improved immunotherapy |
| US12188045B2 (en) | 2019-06-07 | 2025-01-07 | KSQ Therapeutics, Inc. | Guide RNA combinations and methods of use |
| JP2023503652A (ja) * | 2019-11-27 | 2023-01-31 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 腫瘍微小環境における免疫抑制に打ち勝つための操作されたt細胞及び腫瘍浸潤リンパ球 |
| CN114929853A (zh) * | 2019-11-27 | 2022-08-19 | 得克萨斯大学体系董事会 | 用于治疗胶质母细胞瘤和其他癌症的天然杀伤细胞免疫疗法 |
| AU2020395612A1 (en) * | 2019-12-04 | 2022-06-09 | Monash University | Methods of activating cytotoxic leukocytes using PTP1B and PTPN2 inhibitors |
| WO2021119555A2 (en) * | 2019-12-12 | 2021-06-17 | Kumquat Biosciences Inc. | Compositions and methods for potentiating immune response |
| AU2020401376A1 (en) * | 2019-12-12 | 2022-06-30 | Kumquat Biosciences Inc. | Compositions and methods for potentiating immune activity |
| EP3845646A1 (en) | 2019-12-30 | 2021-07-07 | Secarna Pharmaceuticals GmbH & Co. KG | Modified antisense oligonucleotide for inhibition of foxp3 expression |
| CN113151178B (zh) * | 2020-01-07 | 2022-09-09 | 清华大学 | 敲除Rc3h1基因和/或Zc3h12a基因的重组T细胞及其应用 |
| TWI895549B (zh) | 2020-11-19 | 2025-09-01 | 大陸商蘇州沙礫生物科技有限公司 | 腫瘤浸潤淋巴細胞的培養方法及其用途 |
| WO2022109498A1 (en) * | 2020-11-23 | 2022-05-27 | City Of Hope | Engineered t cells for expression of chimeric anitgen receptors |
| EP4255453A4 (en) * | 2020-12-03 | 2025-03-26 | Nkarta, Inc. | Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy |
| JP7847451B2 (ja) * | 2021-03-02 | 2026-04-17 | 花王株式会社 | アトピー性皮膚炎による皮膚痒みの症度悪化の検出方法 |
| KR20240006612A (ko) * | 2021-05-07 | 2024-01-15 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 (car) t-세포 요법에 관련된 혈청 대사체학 |
| CN113234834A (zh) * | 2021-07-09 | 2021-08-10 | 北京泱深生物信息技术有限公司 | 一组用于胰腺癌预后的基因及其应用 |
| US20240360410A1 (en) * | 2021-08-03 | 2024-10-31 | Suzhou Grit Biotechnology Co., Ltd. | Modified tumor infiltrating lymphocyte and use thereof |
| WO2023015213A1 (en) * | 2021-08-03 | 2023-02-09 | Spotlight Therapeutics | Ptpn2 specific guide rnas and uses thereof |
| CN113430202A (zh) * | 2021-08-26 | 2021-09-24 | 山东兴瑞生物科技有限公司 | 一种具有高敲除率的人PD1基因sgRNA及含有该sgRNA的质粒、T细胞 |
| JP2024536839A (ja) * | 2021-09-29 | 2024-10-08 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 非移植cd8除去同種ドナーリンパ球輸注の有効性を高め、毒性を低減する方法および組成物 |
| MX2024003887A (es) | 2021-10-14 | 2024-07-09 | Arsenal Biosciences Inc | Células inmunitarias que tienen arnch coespresados y sistemas de compuerta lógica. |
| GB202114871D0 (en) * | 2021-10-18 | 2021-12-01 | Ucl Business Ltd | Guide RNA and uses thereof |
| CN114134177B (zh) * | 2021-11-19 | 2022-11-08 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 敲除Setd5的小鼠模型和抵御急性T淋巴细胞白血病小鼠模型的构建方法和应用 |
| CN118401651A (zh) * | 2022-01-29 | 2024-07-26 | 苏州沙砾生物科技有限公司 | 一种修饰的肿瘤浸润淋巴细胞及其用途 |
| WO2023184107A1 (en) * | 2022-03-28 | 2023-10-05 | Huigene Therapeutics Co., Ltd. | Crispr-cas13 system for treating mecp2-associated diseases |
| EP4260932A1 (en) | 2022-04-13 | 2023-10-18 | GEA Process Engineering A/S | Method and system for reducing water consumption in a membrane dealcoholization process |
| EP4276174A1 (en) * | 2022-05-09 | 2023-11-15 | Cellectis S.A. | Gene therapy for the treatment of activated pi3kinase delta syndrome type 1 (apds1) |
| US20260053921A1 (en) * | 2022-08-24 | 2026-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | A multiplexed rna regulation platform for primary immune cell engineering |
| CR20250095A (es) * | 2022-09-13 | 2025-09-01 | Arsenal Biosciences Inc | Células inmunitarias que coexpresan arnhc de tgfbr |
| EP4382118B1 (en) * | 2022-12-07 | 2025-08-20 | Eberhard Karls Universität Tübingen, Medizinische Fakultät | Modified immune cell |
| TW202442689A (zh) | 2023-03-03 | 2024-11-01 | 美商亞森諾生物科學公司 | 靶向psma及ca9之系統 |
| WO2024243441A1 (en) | 2023-05-24 | 2024-11-28 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| KR102637929B1 (ko) * | 2023-08-07 | 2024-02-20 | 충남대학교 산학협력단 | 면역관문 억제제의 효능 예측용 pbrm1 유전자 마커및 이의 용도 |
| WO2025092690A1 (zh) * | 2023-10-30 | 2025-05-08 | 苏州沙砾生物科技有限公司 | 一种修饰的细胞及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7064193B1 (en) * | 1997-09-17 | 2006-06-20 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic molecules |
| WO2014138348A1 (en) * | 2013-03-06 | 2014-09-12 | The Trustees Of The University Of Pennsylvania | Iikaros inhibition to augment adoptive t cell transfer |
| CA2912375C (en) * | 2013-05-13 | 2023-03-14 | Cellectis | Methods for engineering highly active t cell for immunotherapy |
| JP2017524348A (ja) * | 2014-06-10 | 2017-08-31 | モナッシュ ユニバーシティ | 養子細胞移入のためのptpn2阻害を用いた白血球の産生方法 |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| BR112018003110A2 (pt) * | 2015-08-21 | 2018-09-25 | Pfizer | nanopartículas terapêuticas compreendendo um agente terapêutico e métodos de fabricação e uso dos mesmos |
-
2019
- 2019-03-14 WO PCT/US2019/022366 patent/WO2019178422A1/en not_active Ceased
- 2019-03-14 CN CN201980019181.3A patent/CN112041433A/zh active Pending
- 2019-03-14 KR KR1020207026515A patent/KR20200133218A/ko not_active Ceased
- 2019-03-14 EP EP19768408.7A patent/EP3765608A4/en active Pending
- 2019-03-14 BR BR112020018573-6A patent/BR112020018573A2/pt unknown
- 2019-03-14 US US16/354,098 patent/US20190284529A1/en not_active Abandoned
- 2019-03-14 AU AU2019236205A patent/AU2019236205A1/en not_active Abandoned
- 2019-03-14 JP JP2020573082A patent/JP2021518162A/ja active Pending
- 2019-03-14 KR KR1020257039513A patent/KR20250174987A/ko active Pending
- 2019-03-14 CA CA3093968A patent/CA3093968A1/en active Pending
-
2022
- 2022-08-25 US US17/822,183 patent/US20230088186A1/en active Pending
-
2024
- 2024-04-24 JP JP2024070727A patent/JP2024091902A/ja active Pending
-
2025
- 2025-09-02 AU AU2025226682A patent/AU2025226682A1/en active Pending
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