JP2021518162A5 - - Google Patents
Info
- Publication number
- JP2021518162A5 JP2021518162A5 JP2020573082A JP2020573082A JP2021518162A5 JP 2021518162 A5 JP2021518162 A5 JP 2021518162A5 JP 2020573082 A JP2020573082 A JP 2020573082A JP 2020573082 A JP2020573082 A JP 2020573082A JP 2021518162 A5 JP2021518162 A5 JP 2021518162A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- modified
- immunoeffector
- seq
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024070727A JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643578P | 2018-03-15 | 2018-03-15 | |
| US201862643582P | 2018-03-15 | 2018-03-15 | |
| US62/643,582 | 2018-03-15 | ||
| US62/643,578 | 2018-03-15 | ||
| US201862692010P | 2018-06-29 | 2018-06-29 | |
| US201862692014P | 2018-06-29 | 2018-06-29 | |
| US62/692,014 | 2018-06-29 | ||
| US62/692,010 | 2018-06-29 | ||
| US201862714337P | 2018-08-03 | 2018-08-03 | |
| US201862714333P | 2018-08-03 | 2018-08-03 | |
| US62/714,337 | 2018-08-03 | ||
| US62/714,333 | 2018-08-03 | ||
| US201862768462P | 2018-11-16 | 2018-11-16 | |
| US201862768459P | 2018-11-16 | 2018-11-16 | |
| US201862768428P | 2018-11-16 | 2018-11-16 | |
| US201862768430P | 2018-11-16 | 2018-11-16 | |
| US62/768,462 | 2018-11-16 | ||
| US62/768,428 | 2018-11-16 | ||
| US62/768,430 | 2018-11-16 | ||
| US62/768,459 | 2018-11-16 | ||
| US201962804259P | 2019-02-12 | 2019-02-12 | |
| US62/804,259 | 2019-02-12 | ||
| PCT/US2019/022366 WO2019178422A1 (en) | 2018-03-15 | 2019-03-14 | Gene-regulating compositions and methods for improved immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024070727A Division JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021518162A JP2021518162A (ja) | 2021-08-02 |
| JP2021518162A5 true JP2021518162A5 (enExample) | 2022-03-18 |
Family
ID=67903888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573082A Pending JP2021518162A (ja) | 2018-03-15 | 2019-03-14 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| JP2024070727A Pending JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024070727A Pending JP2024091902A (ja) | 2018-03-15 | 2024-04-24 | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190284529A1 (enExample) |
| EP (1) | EP3765608A4 (enExample) |
| JP (2) | JP2021518162A (enExample) |
| KR (2) | KR20250174987A (enExample) |
| CN (1) | CN112041433A (enExample) |
| AU (2) | AU2019236205A1 (enExample) |
| BR (1) | BR112020018573A2 (enExample) |
| CA (1) | CA3093968A1 (enExample) |
| WO (1) | WO2019178422A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019178420A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| US20220081691A1 (en) * | 2018-08-07 | 2022-03-17 | Dana-Farber Cancer Institute, Inc | Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages |
| CN112840026B (zh) * | 2018-10-18 | 2025-01-14 | 施能康公司 | 抑制tigit基因表达的组合物和方法 |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| EP3917541A4 (en) * | 2019-01-28 | 2022-12-07 | Bar Ilan University | Combinations, nanoparticles and methods for controlling natural killer cell activation and function |
| CA3128823A1 (en) * | 2019-02-04 | 2020-08-13 | KSQ Therapeutics, Inc. | Combination gene targets for improved immunotherapy |
| EP3930731A4 (en) | 2019-02-26 | 2022-11-23 | Rambam Med-Tech Ltd. | CELLS AND METHODS FOR IMPROVED IMMUNOTHERAPY |
| US12188045B2 (en) | 2019-06-07 | 2025-01-07 | KSQ Therapeutics, Inc. | Guide RNA combinations and methods of use |
| CA3162896A1 (en) * | 2019-11-27 | 2021-06-03 | Board Of Regents, The University Of Texas System | Engineered t cells and tumor-infiltrating lymphocytes to overcome immunosuppression in the tumor microenvironment |
| CN114929853A (zh) * | 2019-11-27 | 2022-08-19 | 得克萨斯大学体系董事会 | 用于治疗胶质母细胞瘤和其他癌症的天然杀伤细胞免疫疗法 |
| AU2020395612A1 (en) * | 2019-12-04 | 2022-06-09 | Monash University | Methods of activating cytotoxic leukocytes using PTP1B and PTPN2 inhibitors |
| WO2021119555A2 (en) * | 2019-12-12 | 2021-06-17 | Kumquat Biosciences Inc. | Compositions and methods for potentiating immune response |
| EP4073242A4 (en) * | 2019-12-12 | 2024-01-03 | Kumquat Biosciences Inc. | Compositions and methods for potentiating immune activity |
| EP3845646A1 (en) * | 2019-12-30 | 2021-07-07 | Secarna Pharmaceuticals GmbH & Co. KG | Modified antisense oligonucleotide for inhibition of foxp3 expression |
| CN113151178B (zh) * | 2020-01-07 | 2022-09-09 | 清华大学 | 敲除Rc3h1基因和/或Zc3h12a基因的重组T细胞及其应用 |
| CN116948964A (zh) | 2020-11-19 | 2023-10-27 | 苏州沙砾生物科技有限公司 | 肿瘤浸润淋巴细胞的培养方法及其用途 |
| US20230364138A1 (en) * | 2020-11-23 | 2023-11-16 | City Of Hope | Engineered t cells for expression of chimeric anitgen receptors |
| AU2021392809A1 (en) * | 2020-12-03 | 2023-07-20 | Nkarta, Inc. | Methods of engineering immune cells for enhanced potency and persistence and uses of engineered cells in immunotherapy |
| WO2022186297A1 (ja) * | 2021-03-02 | 2022-09-09 | 花王株式会社 | アトピー性皮膚炎による皮膚痒みの症度悪化の検出方法 |
| JP2024518421A (ja) * | 2021-05-07 | 2024-05-01 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | キメラ抗原受容体(car)t細胞治療に関連する血清メタボロミクス |
| CN113234834A (zh) * | 2021-07-09 | 2021-08-10 | 北京泱深生物信息技术有限公司 | 一组用于胰腺癌预后的基因及其应用 |
| WO2023015213A1 (en) * | 2021-08-03 | 2023-02-09 | Spotlight Therapeutics | Ptpn2 specific guide rnas and uses thereof |
| US20240360410A1 (en) * | 2021-08-03 | 2024-10-31 | Suzhou Grit Biotechnology Co., Ltd. | Modified tumor infiltrating lymphocyte and use thereof |
| CN113430202A (zh) * | 2021-08-26 | 2021-09-24 | 山东兴瑞生物科技有限公司 | 一种具有高敲除率的人PD1基因sgRNA及含有该sgRNA的质粒、T细胞 |
| US20240390493A1 (en) * | 2021-09-29 | 2024-11-28 | The Johns Hopkins University | Methods and compositions to augment efficacy and reduce toxicity of non-engrafting, cd8-depleted allogenic donor lymphocyte infusions |
| IL311570A (en) | 2021-10-14 | 2024-05-01 | Arsenal Biosciences Inc | Immune cells with common expression chain and logic gate systems |
| GB202114871D0 (en) * | 2021-10-18 | 2021-12-01 | Ucl Business Ltd | Guide RNA and uses thereof |
| CN114134177B (zh) * | 2021-11-19 | 2022-11-08 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 敲除Setd5的小鼠模型和抵御急性T淋巴细胞白血病小鼠模型的构建方法和应用 |
| EP4471128A4 (en) * | 2022-01-29 | 2026-03-04 | Suzhou Grit Biotechnology Co Ltd | Modified tumor infiltrating lymphocyte and use thereof |
| WO2023184107A1 (en) * | 2022-03-28 | 2023-10-05 | Huigene Therapeutics Co., Ltd. | Crispr-cas13 system for treating mecp2-associated diseases |
| EP4260932A1 (en) | 2022-04-13 | 2023-10-18 | GEA Process Engineering A/S | Method and system for reducing water consumption in a membrane dealcoholization process |
| EP4276174A1 (en) * | 2022-05-09 | 2023-11-15 | Cellectis S.A. | Gene therapy for the treatment of activated pi3kinase delta syndrome type 1 (apds1) |
| CN119630792A (zh) * | 2022-08-24 | 2025-03-14 | 莱兰斯坦福初级大学评议会 | 用于原代免疫细胞工程化改造的多重化rna调节平台 |
| TW202417626A (zh) * | 2022-09-13 | 2024-05-01 | 美商亞森諾生物科學公司 | 具有共表現的tgfbr shrna之免疫細胞 |
| EP4382118B1 (en) * | 2022-12-07 | 2025-08-20 | Eberhard Karls Universität Tübingen, Medizinische Fakultät | Modified immune cell |
| JP2026507228A (ja) | 2023-03-03 | 2026-02-27 | アーセナル バイオサイエンシズ インコーポレイテッド | Psma及びca9を標的とするシステム |
| EP4720059A1 (en) | 2023-05-24 | 2026-04-08 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| KR102637929B1 (ko) * | 2023-08-07 | 2024-02-20 | 충남대학교 산학협력단 | 면역관문 억제제의 효능 예측용 pbrm1 유전자 마커및 이의 용도 |
| WO2025092690A1 (zh) * | 2023-10-30 | 2025-05-08 | 苏州沙砾生物科技有限公司 | 一种修饰的细胞及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2304124A1 (en) * | 1997-09-17 | 1999-03-25 | The Walter And Eliza Hall Institute Of Medical Research | Bci-2-like protein bim and methods of use thereof |
| US20160017286A1 (en) * | 2013-03-06 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Ikaros inhibition to augment adoptive t cell transfer |
| RU2725542C2 (ru) * | 2013-05-13 | 2020-07-02 | Селлектис | Способы конструирования высокоактивных т-клеток для иммунотерапии |
| US20170224731A1 (en) * | 2014-06-10 | 2017-08-10 | Monash University | Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer |
| US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US20170049709A1 (en) * | 2015-08-21 | 2017-02-23 | Pfizer Inc. | Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same |
-
2019
- 2019-03-14 CA CA3093968A patent/CA3093968A1/en active Pending
- 2019-03-14 WO PCT/US2019/022366 patent/WO2019178422A1/en not_active Ceased
- 2019-03-14 EP EP19768408.7A patent/EP3765608A4/en active Pending
- 2019-03-14 KR KR1020257039513A patent/KR20250174987A/ko active Pending
- 2019-03-14 CN CN201980019181.3A patent/CN112041433A/zh active Pending
- 2019-03-14 JP JP2020573082A patent/JP2021518162A/ja active Pending
- 2019-03-14 US US16/354,098 patent/US20190284529A1/en not_active Abandoned
- 2019-03-14 AU AU2019236205A patent/AU2019236205A1/en not_active Abandoned
- 2019-03-14 KR KR1020207026515A patent/KR20200133218A/ko not_active Ceased
- 2019-03-14 BR BR112020018573-6A patent/BR112020018573A2/pt unknown
-
2022
- 2022-08-25 US US17/822,183 patent/US20230088186A1/en active Pending
-
2024
- 2024-04-24 JP JP2024070727A patent/JP2024091902A/ja active Pending
-
2025
- 2025-09-02 AU AU2025226682A patent/AU2025226682A1/en active Pending
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