JP2021503002A5 - - Google Patents
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- JP2021503002A5 JP2021503002A5 JP2020544155A JP2020544155A JP2021503002A5 JP 2021503002 A5 JP2021503002 A5 JP 2021503002A5 JP 2020544155 A JP2020544155 A JP 2020544155A JP 2020544155 A JP2020544155 A JP 2020544155A JP 2021503002 A5 JP2021503002 A5 JP 2021503002A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion according
- emulsion
- weight
- infection
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000839 emulsion Substances 0.000 claims 33
- 208000015181 infectious disease Diseases 0.000 claims 16
- 230000000699 topical effect Effects 0.000 claims 7
- 208000035473 Communicable disease Diseases 0.000 claims 6
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 229940121375 antifungal agent Drugs 0.000 claims 4
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- NCEHACHJIXJSPD-FQEVSTJZSA-N (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethoxy)phenyl]pyridin-2-yl]propan-2-ol Chemical compound O[C@@](Cn1cnnn1)(c2ccc(F)cc2F)C(F)(F)c3ccc(cn3)c4ccc(OC(F)(F)F)cc4 NCEHACHJIXJSPD-FQEVSTJZSA-N 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 206010065764 Mucosal infection Diseases 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 239000003429 antifungal agent Substances 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 229960001259 diclofenac Drugs 0.000 claims 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims 2
- 229960000564 nitrofurantoin Drugs 0.000 claims 2
- IDUYJRXRDSPPRC-NRFANRHFSA-N oteseconazole Chemical compound C([C@](O)(C=1C(=CC(F)=CC=1)F)C(F)(F)C=1N=CC(=CC=1)C=1C=CC(OCC(F)(F)F)=CC=1)N1C=NN=N1 IDUYJRXRDSPPRC-NRFANRHFSA-N 0.000 claims 2
- 210000003899 penis Anatomy 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 229940070115 quilseconazole Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- 206010040872 skin infection Diseases 0.000 claims 2
- 210000003708 urethra Anatomy 0.000 claims 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims 1
- ZCJYUTQZBAIHBS-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 ZCJYUTQZBAIHBS-UHFFFAOYSA-N 0.000 claims 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 1
- TXASKRGBMHFMPT-UHFFFAOYSA-O 1-methoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium-2-ol Chemical compound C1=[N+](C)C2=C3C=C4OCOC4=CC3=CC=C2C2=C1C(OC)=C(O)C=C2 TXASKRGBMHFMPT-UHFFFAOYSA-O 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims 1
- JLGKQTAYUIMGRK-UHFFFAOYSA-N 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 JLGKQTAYUIMGRK-UHFFFAOYSA-N 0.000 claims 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000207201 Gardnerella vaginalis Species 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000555676 Malassezia Species 0.000 claims 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- 241000605861 Prevotella Species 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 150000003851 azoles Chemical class 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 229960002206 bifonazole Drugs 0.000 claims 1
- -1 boriconazole Chemical compound 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960002227 clindamycin Drugs 0.000 claims 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 229940047766 co-trimoxazole Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 229960003428 dexibuprofen Drugs 0.000 claims 1
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical compound CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 229960001274 fenticonazole Drugs 0.000 claims 1
- 229960004884 fluconazole Drugs 0.000 claims 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
- 229960000308 fosfomycin Drugs 0.000 claims 1
- YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- BODYFEUFKHPRCK-ZCZMVWJSSA-N ibrexafungerp Chemical compound N1([C@@H]2C[C@@]34COC[C@]([C@H]2OC[C@](C)(N)C(C)(C)C)(C)[C@@H]3CC[C@@H]2[C@@]3(C)CC[C@]([C@H]([C@]3(C)CC=C24)C(O)=O)(C)[C@H](C)C(C)C)N=CN=C1C1=CC=NC=C1 BODYFEUFKHPRCK-ZCZMVWJSSA-N 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- 229960004849 isoconazole Drugs 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- OXROWJKCGCOJDO-JLHYYAGUSA-N lornoxicam Chemical compound O=C1C=2SC(Cl)=CC=2S(=O)(=O)N(C)\C1=C(\O)NC1=CC=CC=N1 OXROWJKCGCOJDO-JLHYYAGUSA-N 0.000 claims 1
- 229960002202 lornoxicam Drugs 0.000 claims 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 claims 1
- 229960003464 mefenamic acid Drugs 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 229960002509 miconazole Drugs 0.000 claims 1
- 239000013081 microcrystal Substances 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 229960000349 nitrofural Drugs 0.000 claims 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims 1
- 229960005131 nitroxoline Drugs 0.000 claims 1
- RJIWZDNTCBHXAL-UHFFFAOYSA-N nitroxoline Chemical compound C1=CN=C2C(O)=CC=C([N+]([O-])=O)C2=C1 RJIWZDNTCBHXAL-UHFFFAOYSA-N 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229950004864 olamine Drugs 0.000 claims 1
- 229950011629 oteseconazole Drugs 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 229960001589 posaconazole Drugs 0.000 claims 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 1
- 229960005429 sertaconazole Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 claims 1
- 229960004306 sulfadiazine Drugs 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
- 229960004214 tioconazole Drugs 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 1
- 229960001082 trimethoprim Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17201651.1 | 2017-11-14 | ||
| EP17201650.3 | 2017-11-14 | ||
| EP17201651.1A EP3482744A1 (de) | 2017-11-14 | 2017-11-14 | Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen |
| EP17201650.3A EP3482743A1 (de) | 2017-11-14 | 2017-11-14 | Emulsionen zur behandlung von scheideninfektionen |
| PCT/EP2018/081264 WO2019096863A1 (de) | 2017-11-14 | 2018-11-14 | Emulsionen zur topischen behandlung von dermalen infektionen und schleimhautinfektionen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021503002A JP2021503002A (ja) | 2021-02-04 |
| JP2021503002A5 true JP2021503002A5 (https=) | 2021-12-23 |
| JP7378409B2 JP7378409B2 (ja) | 2023-11-13 |
Family
ID=64172522
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544155A Active JP7378409B2 (ja) | 2017-11-14 | 2018-11-14 | 皮膚および粘膜感染症の局所治療用エマルション |
| JP2020544154A Active JP7419241B2 (ja) | 2017-11-14 | 2018-11-14 | 粘膜感染症治療用エマルション |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544154A Active JP7419241B2 (ja) | 2017-11-14 | 2018-11-14 | 粘膜感染症治療用エマルション |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11779538B2 (https=) |
| EP (2) | EP3709968B1 (https=) |
| JP (2) | JP7378409B2 (https=) |
| KR (2) | KR102657908B1 (https=) |
| CN (2) | CN111601585B (https=) |
| AU (2) | AU2018367116B2 (https=) |
| BR (2) | BR112020009454A2 (https=) |
| CA (2) | CA3082720A1 (https=) |
| CL (2) | CL2020001273A1 (https=) |
| CY (1) | CY1126752T1 (https=) |
| ES (2) | ES2963977T3 (https=) |
| HR (2) | HRP20231507T1 (https=) |
| HU (2) | HUE065778T2 (https=) |
| IL (2) | IL274630B2 (https=) |
| MX (2) | MX2020005056A (https=) |
| PL (2) | PL3709969T3 (https=) |
| RS (1) | RS64869B1 (https=) |
| UA (2) | UA126691C2 (https=) |
| WO (2) | WO2019096863A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020009454A2 (pt) * | 2017-11-14 | 2020-10-13 | Profem Gmbh | emulsões para o tratamento de infecções da mucosa |
| CN112691075B (zh) * | 2020-12-31 | 2023-06-20 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑乳膏及其制备方法 |
| JP2024509256A (ja) * | 2021-03-09 | 2024-02-29 | ジュリス ゲルマナス， | ヒドロキシキノリン化合物および色素変性剤としての使用方法 |
| CN113520993B (zh) * | 2021-07-30 | 2022-07-29 | 海南海神同洲制药有限公司 | 一种低粘度硝酸舍他康唑乳膏的制备方法及其制备的产品 |
| WO2024187210A1 (de) | 2023-03-15 | 2024-09-19 | Profem Gmbh | Kombinationsarzneimittel zur behandlung und reduktion der rückfallraten vaginaler mykosen |
| CN117122561A (zh) * | 2023-10-09 | 2023-11-28 | 江苏恒丰强生物技术有限公司 | 一种酮康唑纳米结构脂质载体凝胶及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0735861A1 (en) | 1993-12-23 | 1996-10-09 | The Procter & Gamble Company | Tissue moisturizing and antimicrobial compositions |
| EP0923937B1 (en) | 1997-12-08 | 2004-03-10 | Council of Scientific and Industrial Research | A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders |
| IL142037A0 (en) * | 2001-03-15 | 2002-03-10 | Agis Ind 1983 Ltd | Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug |
| GB0108082D0 (en) * | 2001-03-30 | 2001-05-23 | Novartis Consumer Health Sa | Topical composition |
| US20070292355A1 (en) | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
| EP1663148A2 (en) * | 2003-08-25 | 2006-06-07 | Foamix Ltd. | Penetrating pharmaceutical foam |
| EP2018164B1 (de) | 2006-05-12 | 2017-03-01 | Christian Noe | Verwendung von kombinationspräparaten, umfassend antimykotika |
| WO2009028650A1 (ja) * | 2007-08-29 | 2009-03-05 | Yutoku Pharmaceutical Industries Co., Ltd. | 乳化型外用剤およびその製造方法 |
| DE102008034944B4 (de) * | 2008-07-26 | 2017-03-16 | Arivine Pharma Ag | Mikroemulsion |
| MX349176B (es) * | 2008-09-22 | 2017-07-14 | Biochemics Inc | Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo. |
| UA111147C2 (uk) | 2009-11-11 | 2016-04-11 | Байєр Б.В. | Способи та композиції для лікування або профілактики зовнішнього отиту |
| AT11910U1 (de) * | 2010-03-31 | 2011-07-15 | Helmut Dr Vockner | Zusammensetzung enhaltend chlorhexidin, ein bisphosphonat und ein nsaid |
| EP2630952A1 (en) * | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
| CN103655459A (zh) * | 2013-12-19 | 2014-03-26 | 中国药科大学 | 一种多功能微乳凝胶制剂及其制备工艺 |
| US20160120797A1 (en) | 2014-10-31 | 2016-05-05 | Sreedhar Rao Rayudu | Anti-acne composition and methods of use thereof |
| US20170290810A1 (en) * | 2016-04-08 | 2017-10-12 | Imprimis Pharmaceuticals, Inc. | Anti-fungal compositions for treating nails and methods for fabricating and using thereof |
| BR112020009454A2 (pt) * | 2017-11-14 | 2020-10-13 | Profem Gmbh | emulsões para o tratamento de infecções da mucosa |
-
2018
- 2018-11-14 BR BR112020009454-4A patent/BR112020009454A2/pt active Search and Examination
- 2018-11-14 HU HUE18799567A patent/HUE065778T2/hu unknown
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