KR102657908B1 - 점막 감염을 치료하기 위한 에멀젼 - Google Patents

점막 감염을 치료하기 위한 에멀젼 Download PDF

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Publication number
KR102657908B1
KR102657908B1 KR1020207016564A KR20207016564A KR102657908B1 KR 102657908 B1 KR102657908 B1 KR 102657908B1 KR 1020207016564 A KR1020207016564 A KR 1020207016564A KR 20207016564 A KR20207016564 A KR 20207016564A KR 102657908 B1 KR102657908 B1 KR 102657908B1
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emulsion
emulsion according
nsaid
concentration
vaginal
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Korean (ko)
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KR20200089283A (ko
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마리온 노이
크리스티안 알. 노이
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프로펨 게엠베하
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Priority claimed from EP17201651.1A external-priority patent/EP3482744A1/de
Priority claimed from EP17201650.3A external-priority patent/EP3482743A1/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207016564A 2017-11-14 2018-11-14 점막 감염을 치료하기 위한 에멀젼 Active KR102657908B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17201651.1 2017-11-14
EP17201650.3 2017-11-14
EP17201651.1A EP3482744A1 (de) 2017-11-14 2017-11-14 Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
EP17201650.3A EP3482743A1 (de) 2017-11-14 2017-11-14 Emulsionen zur behandlung von scheideninfektionen
PCT/EP2018/081253 WO2019096857A1 (de) 2017-11-14 2018-11-14 Emulsionen zur behandlung von schleimhautinfektionen

Publications (2)

Publication Number Publication Date
KR20200089283A KR20200089283A (ko) 2020-07-24
KR102657908B1 true KR102657908B1 (ko) 2024-04-17

Family

ID=64172522

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207016564A Active KR102657908B1 (ko) 2017-11-14 2018-11-14 점막 감염을 치료하기 위한 에멀젼
KR1020207016570A Active KR102658716B1 (ko) 2017-11-14 2018-11-14 피부 감염 및 점막 감염의 국소 치료를 위한 에멀젼

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207016570A Active KR102658716B1 (ko) 2017-11-14 2018-11-14 피부 감염 및 점막 감염의 국소 치료를 위한 에멀젼

Country Status (19)

Country Link
US (3) US11779538B2 (https=)
EP (2) EP3709968B1 (https=)
JP (2) JP7378409B2 (https=)
KR (2) KR102657908B1 (https=)
CN (2) CN111601585B (https=)
AU (2) AU2018367116B2 (https=)
BR (2) BR112020009454A2 (https=)
CA (2) CA3082720A1 (https=)
CL (2) CL2020001273A1 (https=)
CY (1) CY1126752T1 (https=)
ES (2) ES2963977T3 (https=)
HR (2) HRP20231507T1 (https=)
HU (2) HUE065778T2 (https=)
IL (2) IL274630B2 (https=)
MX (2) MX2020005056A (https=)
PL (2) PL3709969T3 (https=)
RS (1) RS64869B1 (https=)
UA (2) UA126691C2 (https=)
WO (2) WO2019096863A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020009454A2 (pt) * 2017-11-14 2020-10-13 Profem Gmbh emulsões para o tratamento de infecções da mucosa
CN112691075B (zh) * 2020-12-31 2023-06-20 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏及其制备方法
JP2024509256A (ja) * 2021-03-09 2024-02-29 ジュリス ゲルマナス， ヒドロキシキノリン化合物および色素変性剤としての使用方法
CN113520993B (zh) * 2021-07-30 2022-07-29 海南海神同洲制药有限公司 一种低粘度硝酸舍他康唑乳膏的制备方法及其制备的产品
WO2024187210A1 (de) 2023-03-15 2024-09-19 Profem Gmbh Kombinationsarzneimittel zur behandlung und reduktion der rückfallraten vaginaler mykosen
CN117122561A (zh) * 2023-10-09 2023-11-28 江苏恒丰强生物技术有限公司 一种酮康唑纳米结构脂质载体凝胶及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256238A1 (en) 2007-08-29 2010-10-07 Yutoku Pharmaceutical Industries Co., Ltd. Emulsion-type external preparation, and method for production thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0735861A1 (en) 1993-12-23 1996-10-09 The Procter & Gamble Company Tissue moisturizing and antimicrobial compositions
EP0923937B1 (en) 1997-12-08 2004-03-10 Council of Scientific and Industrial Research A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
GB0108082D0 (en) * 2001-03-30 2001-05-23 Novartis Consumer Health Sa Topical composition
US20070292355A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
EP1663148A2 (en) * 2003-08-25 2006-06-07 Foamix Ltd. Penetrating pharmaceutical foam
EP2018164B1 (de) 2006-05-12 2017-03-01 Christian Noe Verwendung von kombinationspräparaten, umfassend antimykotika
DE102008034944B4 (de) * 2008-07-26 2017-03-16 Arivine Pharma Ag Mikroemulsion
MX349176B (es) * 2008-09-22 2017-07-14 Biochemics Inc Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
UA111147C2 (uk) 2009-11-11 2016-04-11 Байєр Б.В. Способи та композиції для лікування або профілактики зовнішнього отиту
AT11910U1 (de) * 2010-03-31 2011-07-15 Helmut Dr Vockner Zusammensetzung enhaltend chlorhexidin, ein bisphosphonat und ein nsaid
EP2630952A1 (en) * 2012-02-23 2013-08-28 Novagali Pharma S.A. Self-preserved oil dispersions comprising boric acid
CN103655459A (zh) * 2013-12-19 2014-03-26 中国药科大学 一种多功能微乳凝胶制剂及其制备工艺
US20160120797A1 (en) 2014-10-31 2016-05-05 Sreedhar Rao Rayudu Anti-acne composition and methods of use thereof
US20170290810A1 (en) * 2016-04-08 2017-10-12 Imprimis Pharmaceuticals, Inc. Anti-fungal compositions for treating nails and methods for fabricating and using thereof
BR112020009454A2 (pt) * 2017-11-14 2020-10-13 Profem Gmbh emulsões para o tratamento de infecções da mucosa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256238A1 (en) 2007-08-29 2010-10-07 Yutoku Pharmaceutical Industries Co., Ltd. Emulsion-type external preparation, and method for production thereof

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IL274630B1 (en) 2025-01-01
CN111601585A (zh) 2020-08-28
CN111629711B (zh) 2024-04-02
US11779538B2 (en) 2023-10-10
BR112020009454A2 (pt) 2020-10-13
JP2021503002A (ja) 2021-02-04
MX2020005055A (es) 2020-10-28
JP2021503001A (ja) 2021-02-04
KR20200089283A (ko) 2020-07-24
US20200281853A1 (en) 2020-09-10
HUE065778T2 (hu) 2024-06-28
ES2963977T3 (es) 2024-04-03
WO2019096863A1 (de) 2019-05-23
EP3709968C0 (de) 2023-08-23
CA3082727A1 (en) 2019-05-23
CA3082720A1 (en) 2019-05-23
ES2963980T3 (es) 2024-04-03
UA126597C2 (uk) 2022-11-02
EP3709968B1 (de) 2023-08-23
CN111601585B (zh) 2023-10-13
CL2020001272A1 (es) 2020-10-30
EP3709969A1 (de) 2020-09-23
US11266600B2 (en) 2022-03-08
MX2020005056A (es) 2020-10-28
EP3709969C0 (de) 2023-08-23
WO2019096857A1 (de) 2019-05-23
US12377047B2 (en) 2025-08-05
HUE064253T2 (hu) 2024-03-28
RS64869B1 (sr) 2023-12-29
PL3709969T3 (pl) 2024-02-19
CY1126752T1 (el) 2026-02-25
IL274630A (en) 2020-06-30
UA126691C2 (uk) 2023-01-11
HRP20231507T1 (hr) 2024-03-01
US20200281852A1 (en) 2020-09-10
IL274630B2 (en) 2025-05-01
KR20200087792A (ko) 2020-07-21
PL3709968T3 (pl) 2024-02-19
AU2018367116A1 (en) 2020-06-04
EP3709968A1 (de) 2020-09-23
AU2018367116B2 (en) 2025-07-03
AU2018367122A1 (en) 2020-06-04
BR112020009458A2 (pt) 2020-10-27
JP7419241B2 (ja) 2024-01-22
HRP20231508T1 (hr) 2024-03-01
US20230414505A1 (en) 2023-12-28
CL2020001273A1 (es) 2020-10-30
KR102658716B1 (ko) 2024-04-18
CN111629711A (zh) 2020-09-04
JP7378409B2 (ja) 2023-11-13
EP3709969B1 (de) 2023-08-23

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