CL2020001272A1 - Emulsiones para el tratamiento de infecciones de mucosas. - Google Patents

Emulsiones para el tratamiento de infecciones de mucosas.

Info

Publication number
CL2020001272A1
CL2020001272A1 CL2020001272A CL2020001272A CL2020001272A1 CL 2020001272 A1 CL2020001272 A1 CL 2020001272A1 CL 2020001272 A CL2020001272 A CL 2020001272A CL 2020001272 A CL2020001272 A CL 2020001272A CL 2020001272 A1 CL2020001272 A1 CL 2020001272A1
Authority
CL
Chile
Prior art keywords
emulsion
phase
treatment
emulsions
mucosal infections
Prior art date
Application number
CL2020001272A
Other languages
English (en)
Spanish (es)
Inventor
Noe Marion
R Noe Christian
Original Assignee
Profem Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP17201651.1A external-priority patent/EP3482744A1/de
Priority claimed from EP17201650.3A external-priority patent/EP3482743A1/de
Application filed by Profem Gmbh filed Critical Profem Gmbh
Publication of CL2020001272A1 publication Critical patent/CL2020001272A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/665Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2020001272A 2017-11-14 2020-05-14 Emulsiones para el tratamiento de infecciones de mucosas. CL2020001272A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17201651.1A EP3482744A1 (de) 2017-11-14 2017-11-14 Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
EP17201650.3A EP3482743A1 (de) 2017-11-14 2017-11-14 Emulsionen zur behandlung von scheideninfektionen

Publications (1)

Publication Number Publication Date
CL2020001272A1 true CL2020001272A1 (es) 2020-10-30

Family

ID=64172522

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020001272A CL2020001272A1 (es) 2017-11-14 2020-05-14 Emulsiones para el tratamiento de infecciones de mucosas.
CL2020001273A CL2020001273A1 (es) 2017-11-14 2020-05-14 Emulsiones para el tratamiento tópico de infecciones dérmicas y de infecciones de mucosas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020001273A CL2020001273A1 (es) 2017-11-14 2020-05-14 Emulsiones para el tratamiento tópico de infecciones dérmicas y de infecciones de mucosas.

Country Status (19)

Country Link
US (3) US11779538B2 (https=)
EP (2) EP3709968B1 (https=)
JP (2) JP7419241B2 (https=)
KR (2) KR102657908B1 (https=)
CN (2) CN111601585B (https=)
AU (2) AU2018367116B2 (https=)
BR (2) BR112020009458A2 (https=)
CA (2) CA3082720A1 (https=)
CL (2) CL2020001272A1 (https=)
CY (1) CY1126752T1 (https=)
ES (2) ES2963977T3 (https=)
HR (2) HRP20231507T1 (https=)
HU (2) HUE065778T2 (https=)
IL (2) IL274630B2 (https=)
MX (2) MX2020005055A (https=)
PL (2) PL3709969T3 (https=)
RS (1) RS64869B1 (https=)
UA (2) UA126597C2 (https=)
WO (2) WO2019096857A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102657908B1 (ko) * 2017-11-14 2024-04-17 프로펨 게엠베하 점막 감염을 치료하기 위한 에멀젼
CN112691075B (zh) * 2020-12-31 2023-06-20 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏及其制备方法
JP2024509256A (ja) * 2021-03-09 2024-02-29 ジュリス ゲルマナス, ヒドロキシキノリン化合物および色素変性剤としての使用方法
CN113520993B (zh) * 2021-07-30 2022-07-29 海南海神同洲制药有限公司 一种低粘度硝酸舍他康唑乳膏的制备方法及其制备的产品
WO2024187210A1 (de) 2023-03-15 2024-09-19 Profem Gmbh Kombinationsarzneimittel zur behandlung und reduktion der rückfallraten vaginaler mykosen
CN117122561A (zh) * 2023-10-09 2023-11-28 江苏恒丰强生物技术有限公司 一种酮康唑纳米结构脂质载体凝胶及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017165A2 (en) 1993-12-23 1995-06-29 The Procter & Gamble Company Tissue moisturizing and antimicrobial compositions
EP0923937B1 (en) * 1997-12-08 2004-03-10 Council of Scientific and Industrial Research A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
GB0108082D0 (en) * 2001-03-30 2001-05-23 Novartis Consumer Health Sa Topical composition
US20070292355A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
EP2977043A3 (en) * 2003-08-25 2016-04-06 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
LT2018164T (lt) * 2006-05-12 2017-07-10 Christian Noe Vaistų derinių, apimančių priešgrybelinius agentus, naudojimas
WO2009028650A1 (ja) * 2007-08-29 2009-03-05 Yutoku Pharmaceutical Industries Co., Ltd. 乳化型外用剤およびその製造方法
DE102008034944B4 (de) 2008-07-26 2017-03-16 Arivine Pharma Ag Mikroemulsion
US9566256B2 (en) * 2008-09-22 2017-02-14 Biochemics, Inc. Transdermal drug delivery using an osmolyte and vasoactive agent
UA111147C2 (uk) * 2009-11-11 2016-04-11 Байєр Б.В. Способи та композиції для лікування або профілактики зовнішнього отиту
AT11910U1 (de) * 2010-03-31 2011-07-15 Helmut Dr Vockner Zusammensetzung enhaltend chlorhexidin, ein bisphosphonat und ein nsaid
EP2630952A1 (en) * 2012-02-23 2013-08-28 Novagali Pharma S.A. Self-preserved oil dispersions comprising boric acid
CN103655459A (zh) * 2013-12-19 2014-03-26 中国药科大学 一种多功能微乳凝胶制剂及其制备工艺
WO2016069952A1 (en) 2014-10-31 2016-05-06 Sreedhar Rao Rayudu Anti-acne composition and methods of use
US20170290810A1 (en) * 2016-04-08 2017-10-12 Imprimis Pharmaceuticals, Inc. Anti-fungal compositions for treating nails and methods for fabricating and using thereof
KR102657908B1 (ko) * 2017-11-14 2024-04-17 프로펨 게엠베하 점막 감염을 치료하기 위한 에멀젼

Also Published As

Publication number Publication date
CA3082727A1 (en) 2019-05-23
US20230414505A1 (en) 2023-12-28
KR20200087792A (ko) 2020-07-21
AU2018367122A1 (en) 2020-06-04
CY1126752T1 (el) 2026-02-25
CN111601585B (zh) 2023-10-13
PL3709969T3 (pl) 2024-02-19
US11266600B2 (en) 2022-03-08
UA126691C2 (uk) 2023-01-11
EP3709968A1 (de) 2020-09-23
EP3709969B1 (de) 2023-08-23
MX2020005055A (es) 2020-10-28
EP3709968C0 (de) 2023-08-23
HRP20231508T1 (hr) 2024-03-01
EP3709968B1 (de) 2023-08-23
WO2019096857A1 (de) 2019-05-23
US20200281852A1 (en) 2020-09-10
ES2963977T3 (es) 2024-04-03
KR102657908B1 (ko) 2024-04-17
US11779538B2 (en) 2023-10-10
AU2018367116A1 (en) 2020-06-04
US12377047B2 (en) 2025-08-05
IL274630A (en) 2020-06-30
HRP20231507T1 (hr) 2024-03-01
JP7419241B2 (ja) 2024-01-22
JP2021503002A (ja) 2021-02-04
JP7378409B2 (ja) 2023-11-13
IL274630B1 (en) 2025-01-01
IL274631A (en) 2020-06-30
KR20200089283A (ko) 2020-07-24
EP3709969C0 (de) 2023-08-23
BR112020009454A2 (pt) 2020-10-13
RS64869B1 (sr) 2023-12-29
CA3082720A1 (en) 2019-05-23
UA126597C2 (uk) 2022-11-02
AU2018367116B2 (en) 2025-07-03
EP3709969A1 (de) 2020-09-23
WO2019096863A1 (de) 2019-05-23
KR102658716B1 (ko) 2024-04-18
CN111629711B (zh) 2024-04-02
CL2020001273A1 (es) 2020-10-30
BR112020009458A2 (pt) 2020-10-27
JP2021503001A (ja) 2021-02-04
IL274630B2 (en) 2025-05-01
HUE064253T2 (hu) 2024-03-28
US20200281853A1 (en) 2020-09-10
MX2020005056A (es) 2020-10-28
CN111601585A (zh) 2020-08-28
CN111629711A (zh) 2020-09-04
HUE065778T2 (hu) 2024-06-28
ES2963980T3 (es) 2024-04-03
PL3709968T3 (pl) 2024-02-19

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