CA3082720A1 - Emulsions for treating mucosal infections - Google Patents

Emulsions for treating mucosal infections Download PDF

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Publication number
CA3082720A1
CA3082720A1 CA3082720A CA3082720A CA3082720A1 CA 3082720 A1 CA3082720 A1 CA 3082720A1 CA 3082720 A CA3082720 A CA 3082720A CA 3082720 A CA3082720 A CA 3082720A CA 3082720 A1 CA3082720 A1 CA 3082720A1
Authority
CA
Canada
Prior art keywords
emulsion
concentration
nsaid
weight percent
emulsion according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3082720A
Other languages
English (en)
French (fr)
Inventor
Marion Noe
Christian Noe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Profem GmbH
Original Assignee
Profem GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP17201651.1A external-priority patent/EP3482744A1/de
Priority claimed from EP17201650.3A external-priority patent/EP3482743A1/de
Application filed by Profem GmbH filed Critical Profem GmbH
Publication of CA3082720A1 publication Critical patent/CA3082720A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3082720A 2017-11-14 2018-11-14 Emulsions for treating mucosal infections Pending CA3082720A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17201651.1 2017-11-14
EP17201650.3 2017-11-14
EP17201651.1A EP3482744A1 (de) 2017-11-14 2017-11-14 Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
EP17201650.3A EP3482743A1 (de) 2017-11-14 2017-11-14 Emulsionen zur behandlung von scheideninfektionen
PCT/EP2018/081253 WO2019096857A1 (de) 2017-11-14 2018-11-14 Emulsionen zur behandlung von schleimhautinfektionen

Publications (1)

Publication Number Publication Date
CA3082720A1 true CA3082720A1 (en) 2019-05-23

Family

ID=64172522

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3082720A Pending CA3082720A1 (en) 2017-11-14 2018-11-14 Emulsions for treating mucosal infections
CA3082727A Pending CA3082727A1 (en) 2017-11-14 2018-11-14 Emulsions for the topical treatment of dermal and mucosal infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3082727A Pending CA3082727A1 (en) 2017-11-14 2018-11-14 Emulsions for the topical treatment of dermal and mucosal infections

Country Status (19)

Country Link
US (3) US11779538B2 (https=)
EP (2) EP3709968B1 (https=)
JP (2) JP7378409B2 (https=)
KR (2) KR102657908B1 (https=)
CN (2) CN111601585B (https=)
AU (2) AU2018367116B2 (https=)
BR (2) BR112020009454A2 (https=)
CA (2) CA3082720A1 (https=)
CL (2) CL2020001273A1 (https=)
CY (1) CY1126752T1 (https=)
ES (2) ES2963977T3 (https=)
HR (2) HRP20231507T1 (https=)
HU (2) HUE065778T2 (https=)
IL (2) IL274630B2 (https=)
MX (2) MX2020005056A (https=)
PL (2) PL3709969T3 (https=)
RS (1) RS64869B1 (https=)
UA (2) UA126691C2 (https=)
WO (2) WO2019096863A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020009454A2 (pt) * 2017-11-14 2020-10-13 Profem Gmbh emulsões para o tratamento de infecções da mucosa
CN112691075B (zh) * 2020-12-31 2023-06-20 海南海神同洲制药有限公司 一种硝酸舍他康唑乳膏及其制备方法
JP2024509256A (ja) * 2021-03-09 2024-02-29 ジュリス ゲルマナス， ヒドロキシキノリン化合物および色素変性剤としての使用方法
CN113520993B (zh) * 2021-07-30 2022-07-29 海南海神同洲制药有限公司 一种低粘度硝酸舍他康唑乳膏的制备方法及其制备的产品
WO2024187210A1 (de) 2023-03-15 2024-09-19 Profem Gmbh Kombinationsarzneimittel zur behandlung und reduktion der rückfallraten vaginaler mykosen
CN117122561A (zh) * 2023-10-09 2023-11-28 江苏恒丰强生物技术有限公司 一种酮康唑纳米结构脂质载体凝胶及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0735861A1 (en) 1993-12-23 1996-10-09 The Procter & Gamble Company Tissue moisturizing and antimicrobial compositions
EP0923937B1 (en) 1997-12-08 2004-03-10 Council of Scientific and Industrial Research A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
GB0108082D0 (en) * 2001-03-30 2001-05-23 Novartis Consumer Health Sa Topical composition
US20070292355A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
EP1663148A2 (en) * 2003-08-25 2006-06-07 Foamix Ltd. Penetrating pharmaceutical foam
EP2018164B1 (de) 2006-05-12 2017-03-01 Christian Noe Verwendung von kombinationspräparaten, umfassend antimykotika
WO2009028650A1 (ja) * 2007-08-29 2009-03-05 Yutoku Pharmaceutical Industries Co., Ltd. 乳化型外用剤およびその製造方法
DE102008034944B4 (de) * 2008-07-26 2017-03-16 Arivine Pharma Ag Mikroemulsion
MX349176B (es) * 2008-09-22 2017-07-14 Biochemics Inc Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
UA111147C2 (uk) 2009-11-11 2016-04-11 Байєр Б.В. Способи та композиції для лікування або профілактики зовнішнього отиту
AT11910U1 (de) * 2010-03-31 2011-07-15 Helmut Dr Vockner Zusammensetzung enhaltend chlorhexidin, ein bisphosphonat und ein nsaid
EP2630952A1 (en) * 2012-02-23 2013-08-28 Novagali Pharma S.A. Self-preserved oil dispersions comprising boric acid
CN103655459A (zh) * 2013-12-19 2014-03-26 中国药科大学 一种多功能微乳凝胶制剂及其制备工艺
US20160120797A1 (en) 2014-10-31 2016-05-05 Sreedhar Rao Rayudu Anti-acne composition and methods of use thereof
US20170290810A1 (en) * 2016-04-08 2017-10-12 Imprimis Pharmaceuticals, Inc. Anti-fungal compositions for treating nails and methods for fabricating and using thereof
BR112020009454A2 (pt) * 2017-11-14 2020-10-13 Profem Gmbh emulsões para o tratamento de infecções da mucosa

Also Published As

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IL274631A (en) 2020-06-30
IL274630B1 (en) 2025-01-01
CN111601585A (zh) 2020-08-28
CN111629711B (zh) 2024-04-02
US11779538B2 (en) 2023-10-10
BR112020009454A2 (pt) 2020-10-13
JP2021503002A (ja) 2021-02-04
MX2020005055A (es) 2020-10-28
JP2021503001A (ja) 2021-02-04
KR20200089283A (ko) 2020-07-24
US20200281853A1 (en) 2020-09-10
HUE065778T2 (hu) 2024-06-28
ES2963977T3 (es) 2024-04-03
WO2019096863A1 (de) 2019-05-23
EP3709968C0 (de) 2023-08-23
CA3082727A1 (en) 2019-05-23
ES2963980T3 (es) 2024-04-03
UA126597C2 (uk) 2022-11-02
EP3709968B1 (de) 2023-08-23
CN111601585B (zh) 2023-10-13
CL2020001272A1 (es) 2020-10-30
EP3709969A1 (de) 2020-09-23
US11266600B2 (en) 2022-03-08
MX2020005056A (es) 2020-10-28
EP3709969C0 (de) 2023-08-23
WO2019096857A1 (de) 2019-05-23
US12377047B2 (en) 2025-08-05
HUE064253T2 (hu) 2024-03-28
RS64869B1 (sr) 2023-12-29
KR102657908B1 (ko) 2024-04-17
PL3709969T3 (pl) 2024-02-19
CY1126752T1 (el) 2026-02-25
IL274630A (en) 2020-06-30
UA126691C2 (uk) 2023-01-11
HRP20231507T1 (hr) 2024-03-01
US20200281852A1 (en) 2020-09-10
IL274630B2 (en) 2025-05-01
KR20200087792A (ko) 2020-07-21
PL3709968T3 (pl) 2024-02-19
AU2018367116A1 (en) 2020-06-04
EP3709968A1 (de) 2020-09-23
AU2018367116B2 (en) 2025-07-03
AU2018367122A1 (en) 2020-06-04
BR112020009458A2 (pt) 2020-10-27
JP7419241B2 (ja) 2024-01-22
HRP20231508T1 (hr) 2024-03-01
US20230414505A1 (en) 2023-12-28
CL2020001273A1 (es) 2020-10-30
KR102658716B1 (ko) 2024-04-18
CN111629711A (zh) 2020-09-04
JP7378409B2 (ja) 2023-11-13
EP3709969B1 (de) 2023-08-23

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