JP2021169481A5 - - Google Patents
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- JP2021169481A5 JP2021169481A5 JP2021113423A JP2021113423A JP2021169481A5 JP 2021169481 A5 JP2021169481 A5 JP 2021169481A5 JP 2021113423 A JP2021113423 A JP 2021113423A JP 2021113423 A JP2021113423 A JP 2021113423A JP 2021169481 A5 JP2021169481 A5 JP 2021169481A5
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- Prior art keywords
- inhibitor
- pharmaceutical composition
- inhibitors
- pharmaceutically acceptable
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- Prior art date
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- 239000003112 inhibitor Substances 0.000 claims 9
- -1 niltamide Chemical compound 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 2
- 208000027747 Kennedy disease Diseases 0.000 claims 2
- 108010000817 Leuprolide Proteins 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 2
- 229960004338 leuprorelin Drugs 0.000 claims 2
- 229960001156 mitoxantrone Drugs 0.000 claims 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 1
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 1
- 229940123877 Aurora kinase inhibitor Drugs 0.000 claims 1
- 239000012664 BCL-2-inhibitor Substances 0.000 claims 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims 1
- 108010037003 Buserelin Proteins 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 108010069236 Goserelin Proteins 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 101100520074 Oryza sativa subsp. japonica PIK-1 gene Proteins 0.000 claims 1
- 239000012661 PARP inhibitor Substances 0.000 claims 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 229940124674 VEGF-R inhibitor Drugs 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 102000001307 androgen receptors Human genes 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 239000003719 aurora kinase inhibitor Substances 0.000 claims 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
- 229960000997 bicalutamide Drugs 0.000 claims 1
- 229960002719 buserelin Drugs 0.000 claims 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims 1
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 claims 1
- 229960003843 cyproterone Drugs 0.000 claims 1
- 229960003901 dacarbazine Drugs 0.000 claims 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims 1
- 229960000452 diethylstilbestrol Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229960001842 estramustine Drugs 0.000 claims 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 1
- 229960004039 finasteride Drugs 0.000 claims 1
- 229960002074 flutamide Drugs 0.000 claims 1
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims 1
- 229960003690 goserelin acetate Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 claims 1
- 229960002193 histrelin Drugs 0.000 claims 1
- 108700020746 histrelin Proteins 0.000 claims 1
- 229960002899 hydroxyprogesterone Drugs 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims 1
- 229960004296 megestrol acetate Drugs 0.000 claims 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims 1
- BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 1
- 229940046231 pamidronate Drugs 0.000 claims 1
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 1
- 229960005079 pemetrexed Drugs 0.000 claims 1
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 239000003197 protein kinase B inhibitor Substances 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Claims (9)
- 請求項1に記載の薬学的に許容可能な塩と薬学的に許容可能な担体を含む、医薬組成物。
- 患者における前立腺癌の治療に用いられるものである、請求項2に記載の医薬組成物。
- 有効量の追加的抗癌剤の使用をさらに含む、請求項3に記載の医薬組成物。
- 追加的抗癌剤がエストラムスチン、ドセタキセル、ケトコナゾール、ゴセレリン酢酸塩、ヒストレリン、トリプトレリン、ブセレリン、シプロテロン、フルタミド、ビカルタミド、ニルタミド、パミドロネート、ゾレドロネート、ミトキサントロン、ペメトレキセド、イピリムマブ、ボリノスタット、エトポシド、ゲムシタビン、ドキソルビシン、ビンクリスチン、テモゾロミド、カペシタビン、イリノテカン、タモキシフェン、アナストラゾール、エキセメスタン、レトロゾール、ジエチルスチルベストロール、エストラジオール、エストロゲン、ベバシズマブ、ロイプロリド酢酸塩、トリプトレリンパモ酸塩、メドロキシプロゲステロン酢酸塩、ヒドロキシプロゲステロンカプリル酸塩、ラロキシフェン、メゲストロール酢酸塩、カルボプラチン、シスプラチン、ダカルバジン、メトトレキサート、ビンブラスチン、ビノレルビン、トポテカン、フィナステリド、アルゾキシフェン、フルベストラント、プレドニゾン、またはエンザルタミドである、請求項4に記載の医薬組成物。
- 追加的抗癌剤がドセタキセル、ミトキサントロン、エストラムスチン、またはロイプロリド酢酸塩である、請求項5に記載の医薬組成物。
- 追加的抗癌剤がFLT-3阻害剤、アンドロゲン受容体阻害剤、VEGFR阻害剤、EGFR TK阻害剤、オーロラキナーゼ阻害剤、PIK-1阻害剤、Bcl-2阻害剤、HDAC阻害剤、c-MET阻害剤、PARP阻害剤、Cdk阻害剤、抗HGF抗体、IGFR-TK阻害剤、PI3キナーゼ阻害剤、AKT阻害剤、JAK/STAT阻害剤、チェックポイント-1阻害剤、チェックポイント-2阻害剤、焦点接着キナーゼ阻害剤、Mapキナーゼキナーゼ阻害剤、またはVEGFトラップ抗体である、請求項4に記載の医薬組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662406888P | 2016-10-11 | 2016-10-11 | |
US62/406,888 | 2016-10-11 | ||
US201762528385P | 2017-07-03 | 2017-07-03 | |
US62/528,385 | 2017-07-03 | ||
JP2020032037A JP6972210B2 (ja) | 2016-10-11 | 2020-02-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020032037A Division JP6972210B2 (ja) | 2016-10-11 | 2020-02-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021169481A JP2021169481A (ja) | 2021-10-28 |
JP2021169481A5 true JP2021169481A5 (ja) | 2022-03-16 |
JP7178532B2 JP7178532B2 (ja) | 2022-11-28 |
Family
ID=61830620
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019519731A Active JP7009466B2 (ja) | 2016-10-11 | 2017-10-11 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2020032037A Active JP6972210B2 (ja) | 2016-10-11 | 2020-02-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2021113423A Active JP7178532B2 (ja) | 2016-10-11 | 2021-07-08 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2021198476A Active JP7203936B2 (ja) | 2016-10-11 | 2021-12-07 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2022210062A Pending JP2023036887A (ja) | 2016-10-11 | 2022-12-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019519731A Active JP7009466B2 (ja) | 2016-10-11 | 2017-10-11 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2020032037A Active JP6972210B2 (ja) | 2016-10-11 | 2020-02-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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JP2021198476A Active JP7203936B2 (ja) | 2016-10-11 | 2021-12-07 | アンドロゲン受容体の標的分解のための化合物および方法 |
JP2022210062A Pending JP2023036887A (ja) | 2016-10-11 | 2022-12-27 | アンドロゲン受容体の標的分解のための化合物および方法 |
Country Status (22)
Country | Link |
---|---|
US (7) | US10584101B2 (ja) |
EP (2) | EP3660004B1 (ja) |
JP (5) | JP7009466B2 (ja) |
KR (2) | KR102173463B1 (ja) |
CN (2) | CN110506039A (ja) |
AU (5) | AU2017341723B2 (ja) |
CA (1) | CA3038979A1 (ja) |
CO (1) | CO2019003642A2 (ja) |
CY (1) | CY1126053T1 (ja) |
DK (1) | DK3660004T3 (ja) |
ES (1) | ES2945224T3 (ja) |
FI (1) | FI3660004T3 (ja) |
HR (1) | HRP20230414T1 (ja) |
HU (1) | HUE061847T2 (ja) |
IL (3) | IL283761B2 (ja) |
LT (1) | LT3660004T (ja) |
MX (3) | MX2019004278A (ja) |
PL (1) | PL3660004T3 (ja) |
PT (1) | PT3660004T (ja) |
RS (1) | RS64208B1 (ja) |
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Families Citing this family (155)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
US11352351B2 (en) | 2015-01-20 | 2022-06-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
EP3302482A4 (en) | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS CONTAINING BROMODOMAIN |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
EP3454856A4 (en) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
TWI739887B (zh) | 2016-08-19 | 2021-09-21 | 英屬開曼群島商百濟神州有限公司 | 使用包含btk抑制劑的組合產品治療癌症 |
US20180072711A1 (en) | 2016-09-15 | 2018-03-15 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
KR102173463B1 (ko) | 2016-10-11 | 2020-11-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적 분해용 화합물 및 방법 |
AU2017367872B2 (en) | 2016-11-01 | 2022-03-31 | Arvinas, Inc. | Tau-protein targeting protacs and associated methods of use |
LT3689868T (lt) | 2016-12-01 | 2023-12-27 | Arvinas Operations, Inc. | Tetrahidronaftaleno ir tetrahidroizochinolino dariniai kaip estrogenų receptorių destruktoriai |
US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
US10994015B2 (en) | 2016-12-23 | 2021-05-04 | Arvinas Operations, Inc. | EGFR proteolysis targeting chimeric molecules and associated methods of use |
WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
BR112019012878A2 (pt) | 2016-12-23 | 2019-11-26 | Arvinas Operations Inc | compostos e métodos para a degradação alvo de polipeptídos de fibrossarcoma rapidamente acelerados |
US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
CN117551089A (zh) | 2017-01-26 | 2024-02-13 | 阿尔维纳斯运营股份有限公司 | 雌激素受体蛋白水解调节剂及相关使用方法 |
WO2018237026A1 (en) | 2017-06-20 | 2018-12-27 | C4 Therapeutics, Inc. | N / O-LINKED DEGRONS AND DEGRONIMERS FOR DEGRADATION OF PROTEINS |
CN110799543A (zh) | 2017-06-26 | 2020-02-14 | 百济神州有限公司 | 肝细胞癌的免疫治疗 |
AU2018301335B2 (en) | 2017-07-10 | 2022-09-15 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
EP3679026A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Glutarimide |
CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
WO2019043208A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
WO2019099868A2 (en) | 2017-11-16 | 2019-05-23 | C4 Therapeutics, Inc. | Degraders and degrons for targeted protein degradation |
WO2019099926A1 (en) | 2017-11-17 | 2019-05-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
WO2019148055A1 (en) | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
US11028088B2 (en) | 2018-03-10 | 2021-06-08 | Yale University | Modulators of BTK proteolysis and methods of use |
WO2019191112A1 (en) | 2018-03-26 | 2019-10-03 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
AU2019249231B2 (en) | 2018-04-04 | 2022-04-21 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
KR102548191B1 (ko) * | 2018-04-09 | 2023-06-28 | 상하이테크 유니버시티 | 표적 단백질 분해 화합물, 이의 항종양 응용, 이의 중간체 및 중간체의 응용 |
WO2019199816A1 (en) * | 2018-04-13 | 2019-10-17 | Arvinas Operations, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
EP3781156A4 (en) | 2018-04-16 | 2022-05-18 | C4 Therapeutics, Inc. | SPIROCYCLIC COMPOUNDS |
CA3096404A1 (en) | 2018-04-23 | 2019-10-31 | Celgene Corporation | Substituted 4-aminoisoindoline-1,3-dione compounds and their use for treating lymphoma |
EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
WO2020012334A1 (en) | 2018-07-10 | 2020-01-16 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases |
AU2019301679A1 (en) | 2018-07-11 | 2021-01-28 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
WO2020023851A1 (en) | 2018-07-26 | 2020-01-30 | Yale University | Bifunctional substitued pyrimidines as modulators of fak proteolyse |
JPWO2020027225A1 (ja) | 2018-07-31 | 2021-11-11 | ファイメクス株式会社 | 複素環化合物 |
JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのe3ユビキチンリガーゼ結合活性を有するキメラ(protac)化合物を標的とし、アルファ-シヌクレインタンパク質を標的とするタンパク質分解 |
US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
EP3846800A4 (en) | 2018-09-04 | 2022-08-24 | C4 Therapeutics, Inc. | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 |
CN113423701A (zh) * | 2018-11-13 | 2021-09-21 | 拜欧斯瑞克斯公司 | 取代的异吲哚啉酮 |
SG11202106506WA (en) | 2018-12-19 | 2021-07-29 | Celgene Corp | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
AU2019403207A1 (en) | 2018-12-19 | 2021-07-15 | Celgene Corporation | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
CN113453679A (zh) | 2018-12-20 | 2021-09-28 | C4医药公司 | 靶向蛋白降解 |
WO2020142228A1 (en) * | 2019-01-03 | 2020-07-09 | The Regents Of The University Of Michigan | Androgen receptor protein degraders |
US11547759B2 (en) | 2019-01-30 | 2023-01-10 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
EP3917916A4 (en) * | 2019-01-30 | 2022-12-14 | Montelino Therapeutics, Inc. | BIFUNCTIONAL COMPOUNDS AND METHODS FOR TARGETING ANDROGEN RECEPTOR UBIQUITINATION |
US20220144807A1 (en) * | 2019-02-15 | 2022-05-12 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
KR20210129672A (ko) * | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 치환된 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체 및 이의 용도 |
JP2022521746A (ja) * | 2019-02-25 | 2022-04-12 | 上海科技大学 | グルタルイミド骨格に基づく硫黄含有化合物及びその応用 |
CN113891891A (zh) * | 2019-03-05 | 2022-01-04 | 戒毒及精神健康中心 | Ampa受体信号转导的调节剂 |
MX2021011242A (es) | 2019-03-21 | 2022-01-19 | Codiak Biosciences Inc | Conjugados de vesícula extracelular y usos de estos. |
US20220387906A1 (en) | 2019-03-21 | 2022-12-08 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
CN111747924B (zh) * | 2019-03-29 | 2023-11-10 | 华东师范大学 | 一类来那度胺/泊马度胺类似物及其应用 |
TW202102497A (zh) | 2019-03-29 | 2021-01-16 | 瑞典商阿斯特捷利康公司 | 化合物及它們在治療癌症中之用途 |
WO2020214555A1 (en) | 2019-04-16 | 2020-10-22 | Northwestern University | Bifunctional compounds comprising apcin-a and their use in the treatment of cancer |
JP2022529339A (ja) | 2019-04-18 | 2022-06-21 | ヒノバ ファーマシューティカルズ インコーポレイテッド | アンドロゲン受容体を標的に分解する二官能性キメラ複素環式化合物及びその使用 |
AU2020274113A1 (en) | 2019-05-14 | 2021-11-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
JP2022533147A (ja) * | 2019-05-17 | 2022-07-21 | ヒノバ ファーマシューティカルズ インコーポレイテッド | 芳香族アミン類のar及びbetを標的とするタンパク質分解キメラ化合物及び使用 |
JP2022534426A (ja) | 2019-05-31 | 2022-07-29 | イケナ オンコロジー, インコーポレイテッド | Tead阻害剤およびその使用 |
TWI762939B (zh) | 2019-05-31 | 2022-05-01 | 大陸商海思科醫藥集團股份有限公司 | Btk抑制劑環衍生物及其製備方法和藥學上的應用 |
US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
WO2021011913A1 (en) | 2019-07-17 | 2021-01-21 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
CN114521196A (zh) * | 2019-09-16 | 2022-05-20 | 诺华股份有限公司 | 双官能团降解剂及其使用方法 |
AU2020348849A1 (en) * | 2019-09-19 | 2022-04-07 | The Regents Of The University Of Michigan | Spirocyclic androgen receptor protein degraders |
KR20220079883A (ko) * | 2019-09-23 | 2022-06-14 | 액큐타 바이오테크놀로지 인코포레이티드 | 안드로겐 수용체 분해 활성을 갖는 신규한 치환된 퀴놀린-8-탄소수소 유도체 및 이의 용도 |
JP2022552006A (ja) | 2019-10-17 | 2022-12-14 | アルヴィナス・オペレーションズ・インコーポレイテッド | Bcl6標的化部分に連結されたe3ユビキチンリガーゼ結合部分を含有する二官能性分子 |
CA3158411A1 (en) * | 2019-10-22 | 2021-04-29 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
CN110790750B (zh) * | 2019-11-07 | 2021-09-21 | 郑州大学 | 一种邻苯二甲酰亚胺类选择性雄激素受体降解剂及其制备方法和用途 |
CN110746400B (zh) * | 2019-11-07 | 2021-12-17 | 郑州大学 | 一种靶向雄激素受体的荧光探针及其制备方法 |
WO2021097046A1 (en) | 2019-11-13 | 2021-05-20 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
AU2020387392A1 (en) | 2019-11-19 | 2022-07-14 | Bristol-Myers Squibb Company | Compounds useful as inhibitors of Helios protein |
AU2020404956A1 (en) * | 2019-12-17 | 2022-07-07 | Orionis Biosciences, Inc. | Compounds modulating protein recruitment and/or degradation |
AU2020410514A1 (en) | 2019-12-18 | 2022-06-30 | Novartis Ag | 3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
EP4077309A1 (en) | 2019-12-19 | 2022-10-26 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
MX2022007885A (es) * | 2019-12-23 | 2022-09-19 | Shanghai Jemincare Pharmaceuticals Co Ltd | Metodo y aplicacion de preparacion de compuesto como agente de degradacion de proteinas. |
KR20220145366A (ko) * | 2020-02-25 | 2022-10-28 | 상하이테크 유니버시티 | 글루타르이미드 골격을 기초로 하는 화합물 및 그 응용 |
CN113387930B (zh) * | 2020-03-11 | 2022-07-12 | 苏州开拓药业股份有限公司 | 一种双官能化合物及其制备方法和用途 |
CN113582974B (zh) * | 2020-04-30 | 2022-05-17 | 江西济民可信集团有限公司 | 一类作为蛋白降解剂的化合物及其制备方法和医药用途 |
CA3181782A1 (en) * | 2020-05-09 | 2021-11-18 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same |
WO2021231431A1 (en) | 2020-05-12 | 2021-11-18 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
WO2021231927A1 (en) * | 2020-05-14 | 2021-11-18 | The Regents Of The University Of Michigan | Androgen receptor protein degraders with a tricyclic cereblon ligand |
WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
CA3186981A1 (en) | 2020-06-12 | 2021-12-16 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Phthalazinone compound, and preparation method therefor and medical use thereof |
CN113896711A (zh) * | 2020-07-06 | 2022-01-07 | 北京诺诚健华医药科技有限公司 | 杂环类免疫调节剂 |
WO2022011205A1 (en) * | 2020-07-10 | 2022-01-13 | The Regents Of The University Of Michigan | Androgen receptor protein degraders |
WO2022011204A1 (en) * | 2020-07-10 | 2022-01-13 | The Regents Of The University Of Michigan | Small molecule androgen receptor protein degraders |
US20230302014A1 (en) * | 2020-08-04 | 2023-09-28 | Oric Pharmaceuticals, Inc. | Uses of glucocorticoid receptor (gr) antagonist and androgen receptor (ar) degrader combinations |
CN114133379B (zh) * | 2020-09-04 | 2024-02-13 | 南京奥瑞药业有限公司 | 一种杂环化合物、其制备方法、中间体、组合物以及应用 |
CN114163444B (zh) * | 2020-09-11 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 一种用于雄激素受体蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
CN114181277A (zh) * | 2020-09-15 | 2022-03-15 | 江苏恒瑞医药股份有限公司 | 一种用于雄激素受体蛋白靶向降解的嵌合体化合物、其制备方法及其在医药上的应用 |
WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
MX2023004545A (es) * | 2020-10-21 | 2023-07-05 | Arvinas Operations Inc | Compuestos y métodos para la degradación dirigida de la proteína del receptor de andrógenos. |
KR20230117577A (ko) | 2020-11-06 | 2023-08-08 | 프렐루드 테라퓨틱스, 인코포레이티드 | Brm을 표적으로 하는 화합물 및 연관된 사용 방법 |
EP4240733A1 (en) * | 2020-11-06 | 2023-09-13 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor and associated methods of use |
WO2022111526A1 (zh) * | 2020-11-25 | 2022-06-02 | 四川海思科制药有限公司 | 一种苯环衍生物及其组合物和药学上的应用 |
CN114262319B (zh) * | 2020-12-01 | 2023-05-05 | 南昌奥瑞药业有限公司 | 一类双功能分子、其制备方法及其应用 |
WO2022120355A1 (en) * | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead degraders and uses thereof |
IL303231A (en) | 2020-12-11 | 2023-07-01 | Arvinas Operations Inc | Prostate cancer treatment methods |
WO2022152821A1 (en) | 2021-01-13 | 2022-07-21 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
US20240166647A1 (en) * | 2021-03-03 | 2024-05-23 | The Regents Of The University Of Michigan | Cereblon Ligands |
WO2022187419A1 (en) * | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Small molecule degraders of androgen receptor |
TWI807697B (zh) * | 2021-03-17 | 2023-07-01 | 大陸商南京明德新藥研發有限公司 | 呋喃稠環取代的戊二醯亞胺類化合物 |
IL305933A (en) * | 2021-03-19 | 2023-11-01 | Arvinas Operations Inc | Indazole-based compounds and related methods of use |
AU2022246058A1 (en) | 2021-03-23 | 2023-10-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
TW202304881A (zh) | 2021-04-06 | 2023-02-01 | 美商必治妥美雅史谷比公司 | 經吡啶基取代之側氧基異吲哚啉化合物 |
EP4323352A1 (en) | 2021-04-16 | 2024-02-21 | Arvinas Operations, Inc. | Modulators of bcl6 proteolysis and associated methods of use |
CA3209633A1 (en) * | 2021-04-29 | 2022-11-03 | Tinghu Zhang | Phthalimido cereblon complex binders and transcription factor degraders and methods of use |
AU2022269568A1 (en) | 2021-05-03 | 2023-11-16 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
AR125768A1 (es) | 2021-05-05 | 2023-08-09 | Biogen Ma Inc | Compuestos para la degradación dirigida de la tirosina cinasa de bruton |
WO2022251588A1 (en) * | 2021-05-27 | 2022-12-01 | Halda Therapeutics Opco, Inc. | Heterobifunctional compounds and methods of treating disease |
CA3223447A1 (en) | 2021-06-25 | 2022-12-29 | Korea Research Institute Of Chemical Technology | Novel bifunctional heterocyclic compound having btk degradation function via ubiquitin proteasome pathway, and use thereof |
UY39844A (es) | 2021-07-07 | 2023-01-31 | Biogen Ma Inc | Compuestos para la degradación selectiva de las proteínas irak4 |
WO2023283372A1 (en) | 2021-07-07 | 2023-01-12 | Biogen Ma Inc. | Compounds for targeting degradation of irak4 proteins |
IL309666A (en) | 2021-07-09 | 2024-02-01 | Plexium Inc | Aryl compounds and pharmaceutical preparations that modulate IKZF2 |
CA3226118A1 (en) | 2021-08-18 | 2023-02-23 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
WO2023025268A1 (zh) * | 2021-08-27 | 2023-03-02 | 苏州晶云药物科技股份有限公司 | 哒嗪甲酰胺类化合物的晶型及其制备方法 |
WO2023034411A1 (en) | 2021-09-01 | 2023-03-09 | Oerth Bio Llc | Compositions and methods for targeted degradation of proteins in a plant cell |
CN115772210A (zh) * | 2021-09-08 | 2023-03-10 | 苏州开拓药业股份有限公司 | 硫代乙内酰脲化合物或其药用盐的无定形物、晶体、药物组合物、制备方法和用途 |
CN113861186B (zh) * | 2021-09-10 | 2023-08-25 | 浙江师范大学 | 基于异恶唑取代苯甲酰胺类衍生物及抗前列腺癌药物应用 |
US11981672B2 (en) | 2021-09-13 | 2024-05-14 | Montelino Therapeutics Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
WO2023039604A1 (en) * | 2021-09-13 | 2023-03-16 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
WO2023039602A1 (en) * | 2021-09-13 | 2023-03-16 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
CN113620931B (zh) * | 2021-09-13 | 2023-06-09 | 中国海洋大学 | 一种雄激素受体抑制剂及其用途 |
WO2023063351A1 (ja) | 2021-10-15 | 2023-04-20 | 国立大学法人筑波大学 | 情報処理装置、情報処理方法およびプログラム |
CN116003418A (zh) * | 2021-10-22 | 2023-04-25 | 标新生物医药科技(上海)有限公司 | Crbn e3连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用 |
CA3239071A1 (en) * | 2021-11-25 | 2023-06-01 | Fanglong Yang | Chimeric compound for targeted degradation of androgen receptor protein, preparation method therefor, and medical use thereof |
CN115894450B (zh) * | 2021-11-30 | 2023-09-12 | 山东如至生物医药科技有限公司 | 一种新型多环类化合物及其组合物和用途 |
WO2023104155A1 (zh) * | 2021-12-08 | 2023-06-15 | 标新生物医药科技(上海)有限公司 | E3泛素连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用 |
TW202346281A (zh) | 2022-01-21 | 2023-12-01 | 瑞典商阿斯特捷利康公司 | 化合物以及它們在治療癌症中之用途 |
WO2023143427A1 (zh) * | 2022-01-27 | 2023-08-03 | 杭州领业医药科技有限公司 | Arv-110的晶型及其制备方法和用途 |
KR20230140396A (ko) | 2022-03-23 | 2023-10-06 | 주식회사 대웅테라퓨틱스 | 핵 수용체의 저해 또는 분해를 유도하는 신규 화합물 |
WO2023180388A1 (en) | 2022-03-24 | 2023-09-28 | Glaxosmithkline Intellectual Property Development Limited | 2,4-dioxotetrahydropyrimidinyl derivatives as degrons in protacs |
WO2023193760A1 (en) * | 2022-04-06 | 2023-10-12 | Cullgen (Shanghai) , Inc. | Compounds and methods of treating cancers |
WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
WO2023205481A1 (en) | 2022-04-21 | 2023-10-26 | Arvinas Operations, Inc. | A combination for use in treating prostate cancer comprising arv-100 and abiraterone |
WO2023239750A1 (en) * | 2022-06-06 | 2023-12-14 | C4 Therapeutics, Inc. | Bicyclic-substituted glutarimide cereblon binders |
WO2023242598A1 (en) * | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Bifunctional molecules for targeted protein degradation |
TW202404976A (zh) * | 2022-06-30 | 2024-02-01 | 安宏生醫股份有限公司 | 雙官能基化合物及包含該雙官能基化合物之醫藥組成物,及其用於製備治療雄激素受體相關疾病之藥物的用途 |
US20240067632A1 (en) * | 2022-06-30 | 2024-02-29 | Bristol-Myers Squibb Company | WEE1 Degrading Compounds and Uses Thereof |
WO2024012570A1 (zh) * | 2022-07-15 | 2024-01-18 | 西藏海思科制药有限公司 | 一种含氮杂环衍生物及其组合物和药学上的应用 |
US20240033249A1 (en) * | 2022-07-20 | 2024-02-01 | The Regents Of The University Of California | Drug Implants Containing Darolutamide and Methods of Use Thereof |
CN115475164B (zh) * | 2022-08-22 | 2024-06-04 | 西安交通大学 | 一种可降解PDGFR-β的蛋白降解靶向嵌合体及其制备方法和应用 |
WO2024050016A1 (en) | 2022-08-31 | 2024-03-07 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
WO2024054952A1 (en) * | 2022-09-08 | 2024-03-14 | Halda Therapeutics Opco, Inc. | Heterobifunctional compounds and methods of treating disease |
WO2024054954A1 (en) * | 2022-09-08 | 2024-03-14 | Halda Therapeutics Opco, Inc. | Heterobifunctional compounds and methods of treating disease |
WO2024055994A1 (zh) * | 2022-09-14 | 2024-03-21 | 南京明德新药研发有限公司 | 萘并呋喃取代的戊二酰亚胺类化合物的晶型、制备方法及其应用 |
WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
WO2024102810A1 (en) | 2022-11-08 | 2024-05-16 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1226974A (en) * | 1916-06-06 | 1917-05-22 | August H Jahn | Cut-out for gas-engines. |
US1818885A (en) * | 1930-05-31 | 1931-08-11 | Pettibone Mulliken Company | Split-switch structure |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
CZ295762B6 (cs) | 1996-07-24 | 2005-10-12 | Celgene Corporation | 2,6-Dioxopiperidiny, jejich soli a optické izomery, farmaceutické kompozice obsahující tyto sloučeniny a léčiva pro snížení hladiny TNFalfa obsahující tyto sloučeniny |
US6670348B1 (en) | 1997-05-14 | 2003-12-30 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
BR9813769A (pt) | 1997-12-17 | 2000-10-10 | Merck & Co Inc | Composto, composição farmacêutica, e, processos para fabricar a mesma, para evocar um efeito antagonizante do receptor da integrina em um mamìfero em necessidade deste, para tratar ou prevenir uma condição mediada pelo antagonismo de um receptor da integrina em um mamìfero em necessidade deste, para inibir a reabsorção óssea em um mamìfero em necessidade deste, e para tratar o desenvolvimento tumoral em um mamìfero em necessidade deste. |
US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
JP2002543129A (ja) | 1999-05-05 | 2002-12-17 | メルク エンド カムパニー インコーポレーテッド | 抗微生物剤としての新規なプロリン類 |
WO2002000617A2 (en) | 2000-06-28 | 2002-01-03 | Bristol-Myers Squibb Company | Selective androgen receptor modulators and methods for their identification, design and use |
WO2002020740A2 (en) | 2000-09-08 | 2002-03-14 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
US7208157B2 (en) | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
RU2298554C2 (ru) | 2000-09-19 | 2007-05-10 | Бристол-Маерс Сквибб Компани | Конденсированные гетероциклические сукцинимидные соединения |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
EP1360205A1 (en) | 2001-02-16 | 2003-11-12 | E.I. Dupont De Nemours And Company | Angiogenesis-inhibitory tripeptides, compositions and their methods of use |
HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
EP1405621B1 (en) | 2001-06-20 | 2011-05-11 | Takeda Pharmaceutical Company Limited | Method of manufacturing tablet |
DE60231989D1 (de) | 2001-08-06 | 2009-05-28 | Childrens Medical Center | Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga |
US7030141B2 (en) | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
NZ538617A (en) | 2002-08-30 | 2005-12-23 | Eisai Co Ltd | Azaarene derivatives |
WO2006006065A1 (en) | 2004-07-08 | 2006-01-19 | Warner-Lambert Company Llc | Androgen modulators |
CN100383139C (zh) | 2005-04-07 | 2008-04-23 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的哌啶-2,6-二酮衍生物 |
WO2006113942A2 (en) | 2005-04-20 | 2006-10-26 | Schering Corporation | Method of inhibiting cathepsin activity |
UA91560C2 (ru) | 2005-08-31 | 2010-08-10 | Селджин Корпорэйшн | Соединения ряда изоиндолимидов, их композиция и применение |
KR20080095895A (ko) | 2006-03-03 | 2008-10-29 | 노파르티스 아게 | N―포르밀 히드록실아민 화합물 |
US8110594B2 (en) | 2006-03-29 | 2012-02-07 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
WO2008011392A2 (en) | 2006-07-20 | 2008-01-24 | Ligand Pharmacueticals Incorporated | Proline urea ccr1 antagonists for the treatment of autoimmune diseases or inflammation |
CL2007002513A1 (es) | 2006-08-30 | 2008-04-04 | Celgene Corp Soc Organizada Ba | Compuestos derivados de isoindolina sustituidos, compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento y prevencion de enfermedades tales como cancer, dolor, degeneracion macular, entre otras. |
RU2448101C2 (ru) | 2006-08-30 | 2012-04-20 | Селджин Корпорейшн | 5-замещенные изоиндолиновые соединения |
US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
US8987233B2 (en) | 2006-11-03 | 2015-03-24 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
CN101808693A (zh) | 2007-07-25 | 2010-08-18 | 百时美施贵宝公司 | 三嗪激酶抑制剂 |
KR20100051808A (ko) | 2007-07-31 | 2010-05-18 | 앤드로사이언스 코포레이션 | 안드로겐 수용체 분해 강화제를 포함한 조성물 및 탈모와 피부질환의 예방 또는 치료 방법 |
KR101696938B1 (ko) | 2008-10-29 | 2017-01-16 | 셀진 코포레이션 | 암의 치료에 사용하기 위한 이소인돌린 화합물 |
WO2010141805A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
US9163330B2 (en) | 2009-07-13 | 2015-10-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
LT3202460T (lt) * | 2010-02-11 | 2019-10-10 | Celgene Corporation | Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus |
CN103153335A (zh) | 2010-06-30 | 2013-06-12 | 布兰代斯大学 | 小分子靶定的蛋白质降解 |
CN103261169A (zh) | 2010-09-24 | 2013-08-21 | 密歇根大学董事会 | 脱泛素酶抑制剂及其应用方法 |
CN103502275A (zh) | 2010-12-07 | 2014-01-08 | 耶鲁大学 | 融合蛋白的小分子疏水性标记和引起的其降解 |
US20140243282A1 (en) | 2010-12-31 | 2014-08-28 | Satish Reddy Kallam | Methods and compositions for designing novel conjugate therapeutics |
MX360611B (es) | 2011-04-21 | 2018-11-09 | Orion Corp | Carboxamidas que modulan el receptor de andrógeno. |
EP2702410A2 (en) | 2011-04-29 | 2014-03-05 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
WO2013106646A2 (en) * | 2012-01-12 | 2013-07-18 | Yale University | Compounds and methods for the inhibition of vcb e3 ubiquitin ligase |
EP3608317A1 (en) * | 2012-01-12 | 2020-02-12 | Yale University | Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase |
US20140079636A1 (en) * | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
US20150119435A1 (en) | 2012-05-11 | 2015-04-30 | Yale University | Compounds useful for promoting protein degradation and methods using same |
EP2874997A4 (en) | 2012-07-19 | 2016-01-06 | Univ Drexel | NEW SIGMA RECEPTOR LIGANDS AND METHOD FOR REGULATING CELLULAR PROTEIN HOMEOSTASIS THEREWITH |
GB201311910D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel Compounds |
NL2011274C2 (en) | 2013-08-06 | 2015-02-09 | Illumicare Ip B V 51 | Groundbreaking platform technology for specific binding to necrotic cells. |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
WO2015038649A1 (en) * | 2013-09-10 | 2015-03-19 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
IN2014MU00303A (ja) | 2014-01-28 | 2015-09-11 | Cipla Ltd | |
WO2015134464A2 (en) * | 2014-03-03 | 2015-09-11 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
US20160058872A1 (en) | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
KR102320082B1 (ko) | 2014-04-14 | 2021-10-29 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법 |
TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
US20160022642A1 (en) | 2014-07-25 | 2016-01-28 | Yale University | Compounds Useful for Promoting Protein Degradation and Methods Using Same |
US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
EP3616686B8 (en) | 2014-11-21 | 2021-06-23 | Biohaven Pharmaceutical Holding Company Ltd. | Sublingual formulation of riluzole |
US9845291B2 (en) * | 2014-12-18 | 2017-12-19 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
EP3256470B1 (en) | 2014-12-23 | 2023-07-26 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
US11352351B2 (en) | 2015-01-20 | 2022-06-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
GB201504314D0 (en) | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
MX2017011919A (es) | 2015-03-18 | 2018-05-22 | Arvinas Inc | Compuestos y metodos para la degradacion mejorada de proteinas especificas. |
GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
EP3302572B8 (en) * | 2015-06-04 | 2021-03-24 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
EP3302482A4 (en) * | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
WO2017007612A1 (en) * | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
BR112017028394A2 (pt) * | 2015-07-10 | 2018-08-28 | Arvinas Inc | composto, composição, e, métodos para induzir a degradação de uma proteína-alvo em uma célula e para tratar um estado doente ou uma condição doente. |
US20170037004A1 (en) | 2015-07-13 | 2017-02-09 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS CONTAINING BROMODOMAIN |
WO2017079267A1 (en) | 2015-11-02 | 2017-05-11 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
KR101859074B1 (ko) | 2016-01-28 | 2018-05-18 | 이화여자대학교 산학협력단 | 신규한 글라이신 아미드 화합물 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 포함하는 소듐 채널 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
US10807977B2 (en) | 2016-04-21 | 2020-10-20 | Bioventures, Llc | Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof |
AU2017254711B2 (en) * | 2016-04-22 | 2021-01-21 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of CDK8 inhibitors with E3 ligase ligand and methods of use |
AU2017254708B2 (en) * | 2016-04-22 | 2021-09-16 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 4/6 (CDK4/6) by conjugation of CDK4/6 inhibitors with E3 ligase ligand and methods of use |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
WO2017197056A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
US20180072711A1 (en) | 2016-09-15 | 2018-03-15 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
KR102173463B1 (ko) * | 2016-10-11 | 2020-11-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적 분해용 화합물 및 방법 |
EP3544957B1 (en) | 2016-11-22 | 2024-05-29 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use |
FR3064633B1 (fr) | 2017-03-28 | 2019-04-12 | Ecole Polytechnique | Nouveaux composes de type dithiospirocetals et leur utilisation |
AU2018261331C1 (en) | 2017-05-01 | 2022-08-04 | Spg Therapeutics, Inc. | Tripartite androgen receptor eliminators, methods and uses thereof |
KR102119465B1 (ko) | 2017-09-20 | 2020-06-08 | (주)아모레퍼시픽 | 트리메톡시 페닐 화합물 및 그를 포함하는 발모 또는 육모 촉진용 조성물 |
WO2020047487A1 (en) | 2018-08-31 | 2020-03-05 | The Regents Of The University Of California | Methods for treating cancer with rorgamma inhibitors and statins |
JP2022529339A (ja) | 2019-04-18 | 2022-06-21 | ヒノバ ファーマシューティカルズ インコーポレイテッド | アンドロゲン受容体を標的に分解する二官能性キメラ複素環式化合物及びその使用 |
WO2021061642A1 (en) | 2019-09-23 | 2021-04-01 | Accutar Biotechnology Inc. | Novel ureas having androgen receptor degradation activity and uses thereof |
CA3158411A1 (en) * | 2019-10-22 | 2021-04-29 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
CA3181782A1 (en) * | 2020-05-09 | 2021-11-18 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same |
WO2021231431A1 (en) | 2020-05-12 | 2021-11-18 | Arvinas Operations, Inc. | Methods of treating prostate cancer |
MX2023004545A (es) * | 2020-10-21 | 2023-07-05 | Arvinas Operations Inc | Compuestos y métodos para la degradación dirigida de la proteína del receptor de andrógenos. |
IL303231A (en) * | 2020-12-11 | 2023-07-01 | Arvinas Operations Inc | Prostate cancer treatment methods |
WO2023205481A1 (en) | 2022-04-21 | 2023-10-26 | Arvinas Operations, Inc. | A combination for use in treating prostate cancer comprising arv-100 and abiraterone |
-
2017
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- 2017-10-11 CN CN201780076646.XA patent/CN110506039A/zh active Pending
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- 2020-08-28 US US17/006,193 patent/US20210040044A1/en not_active Abandoned
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2021
- 2021-06-30 AU AU2021204556A patent/AU2021204556B2/en active Active
- 2021-07-08 JP JP2021113423A patent/JP7178532B2/ja active Active
- 2021-11-30 AU AU2021277645A patent/AU2021277645B2/en active Active
- 2021-12-01 US US17/539,679 patent/US11952347B2/en active Active
- 2021-12-07 JP JP2021198476A patent/JP7203936B2/ja active Active
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2022
- 2022-12-27 JP JP2022210062A patent/JP2023036887A/ja active Pending
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2023
- 2023-05-22 CY CY20231100243T patent/CY1126053T1/el unknown
- 2023-06-22 US US18/213,055 patent/US20230331681A1/en active Pending
- 2023-08-18 AU AU2023216887A patent/AU2023216887A1/en active Pending
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