JP2021072816A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021072816A5 JP2021072816A5 JP2021006893A JP2021006893A JP2021072816A5 JP 2021072816 A5 JP2021072816 A5 JP 2021072816A5 JP 2021006893 A JP2021006893 A JP 2021006893A JP 2021006893 A JP2021006893 A JP 2021006893A JP 2021072816 A5 JP2021072816 A5 JP 2021072816A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- template nucleic
- nucleic acid
- nucleotides
- primed template
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 42
- 125000003729 nucleotide group Chemical group 0.000 claims 42
- 238000000034 method Methods 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 13
- 230000000295 complement effect Effects 0.000 claims 5
- 230000002441 reversible effect Effects 0.000 claims 5
- 238000010348 incorporation Methods 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375379P | 2016-08-15 | 2016-08-15 | |
| US62/375,379 | 2016-08-15 | ||
| US201762447319P | 2017-01-17 | 2017-01-17 | |
| US62/447,319 | 2017-01-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508256A Division JP6828140B2 (ja) | 2016-08-15 | 2017-08-15 | 核酸をシーケンシングするための方法及びシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021072816A JP2021072816A (ja) | 2021-05-13 |
| JP2021072816A5 true JP2021072816A5 (enExample) | 2021-07-26 |
| JP7198295B2 JP7198295B2 (ja) | 2022-12-28 |
Family
ID=59772700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508256A Active JP6828140B2 (ja) | 2016-08-15 | 2017-08-15 | 核酸をシーケンシングするための方法及びシステム |
| JP2021006893A Active JP7198295B2 (ja) | 2016-08-15 | 2021-01-20 | 核酸をシーケンシングするための方法及びシステム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508256A Active JP6828140B2 (ja) | 2016-08-15 | 2017-08-15 | 核酸をシーケンシングするための方法及びシステム |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10443098B2 (enExample) |
| EP (2) | EP4039824A1 (enExample) |
| JP (2) | JP6828140B2 (enExample) |
| KR (1) | KR102230444B1 (enExample) |
| CN (2) | CN109844136A (enExample) |
| AU (1) | AU2017313718B2 (enExample) |
| WO (1) | WO2018035134A1 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11859171B2 (en) | 2013-04-17 | 2024-01-02 | Agency For Science, Technology And Research | Method for generating extended sequence reads |
| US10077470B2 (en) * | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| CN109072297B (zh) * | 2016-04-22 | 2022-09-13 | 加利福尼亚太平洋生物科学股份有限公司 | 使用增强的核苷酸特异性三元复合物形成检测的核酸测序方法和系统 |
| EP4039824A1 (en) * | 2016-08-15 | 2022-08-10 | Pacific Biosciences of California, Inc. | Method and system for sequencing nucleic acids |
| EP4575499A3 (en) | 2017-01-04 | 2025-07-09 | MGI Tech Co., Ltd. | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
| AU2018210944B2 (en) * | 2017-01-20 | 2021-07-22 | Pacific Biosciences Of California, Inc. | Process for cognate nucleotide detection in a nucleic acid sequencing workflow |
| US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| WO2019018366A1 (en) | 2017-07-18 | 2019-01-24 | Omniome, Inc. | METHOD OF CHEMICAL MODIFICATION OF PLASTIC SURFACES |
| WO2019035897A1 (en) | 2017-08-15 | 2019-02-21 | Omniome, Inc. | SCANNING APPARATUS AND METHODS USEFUL FOR DETECTION OF CHEMICAL OR BIOLOGICAL ANALYTES |
| AU2018353136B2 (en) | 2017-10-19 | 2022-05-19 | Pacific Biosciences Of California, Inc. | Simultaneous background reduction and complex stabilization in binding assay workflows |
| KR20200139671A (ko) | 2018-02-06 | 2020-12-14 | 옴니옴 인코포레이티드 | 핵산 프라이머 연장을 위한 조성물 및 기술 |
| WO2019161253A1 (en) | 2018-02-16 | 2019-08-22 | Ultima Genomics, Inc. | Methods for sequencing with single frequency detection |
| EP3775259A4 (en) * | 2018-03-26 | 2022-01-05 | Ultima Genomics, Inc. | Methods of sequencing nucleic acid molecules |
| AU2019255987A1 (en) | 2018-04-19 | 2020-12-10 | Pacific Biosciences Of California, Inc. | Improving accuracy of base calls in nucleic acid sequencing methods |
| WO2019209426A1 (en) | 2018-04-26 | 2019-10-31 | Omniome, Inc. | Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes |
| WO2019231568A1 (en) * | 2018-05-31 | 2019-12-05 | Omniome, Inc. | Increased signal to noise in nucleic acid sequencing |
| US11180794B2 (en) | 2018-05-31 | 2021-11-23 | Omniome, Inc. | Methods and compositions for capping nucleic acids |
| WO2020023362A1 (en) | 2018-07-24 | 2020-01-30 | Omniome, Inc. | Serial formation of ternary complex species |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| GB2574746B (en) * | 2018-09-17 | 2020-06-03 | Omniome Inc | Engineered polymerases for improved sequencing |
| US10704094B1 (en) | 2018-11-14 | 2020-07-07 | Element Biosciences, Inc. | Multipart reagents having increased avidity for polymerase binding |
| US10768173B1 (en) | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US20240011086A1 (en) * | 2018-11-15 | 2024-01-11 | Omniome, Inc. | Electronic detection of nucleic acid structure |
| WO2020117653A1 (en) | 2018-12-04 | 2020-06-11 | Omniome, Inc. | Mixed-phase fluids for nucleic acid sequencing and other analytical assays |
| CN113227348B (zh) | 2018-12-20 | 2025-05-27 | 加利福尼亚太平洋生物科学股份有限公司 | 用于分析核酸和其他分析物的温度控制 |
| WO2020167574A1 (en) | 2019-02-14 | 2020-08-20 | Omniome, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
| US11680950B2 (en) | 2019-02-20 | 2023-06-20 | Pacific Biosciences Of California, Inc. | Scanning apparatus and methods for detecting chemical and biological analytes |
| WO2020181129A1 (en) * | 2019-03-07 | 2020-09-10 | The Trustees Of Columbia University In The City Of New York | High accuracy nanopore-based single molecule sequencing by synthesis with tagged nucleotides |
| WO2020206114A1 (en) * | 2019-04-02 | 2020-10-08 | The Trustees Of Columbia University In The City Of New York | Sequencing by synthesis with energy transfer dye pairs |
| US12391929B2 (en) | 2019-05-24 | 2025-08-19 | Element Biosciences, Inc. | Polymerase-nucleotide conjugates for sequencing by trapping |
| WO2020252186A1 (en) | 2019-06-11 | 2020-12-17 | Omniome, Inc. | Calibrated focus sensing |
| US10656368B1 (en) | 2019-07-24 | 2020-05-19 | Omniome, Inc. | Method and system for biological imaging using a wide field objective lens |
| US11180520B2 (en) * | 2019-09-10 | 2021-11-23 | Omniome, Inc. | Reversible modifications of nucleotides |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| CN118186063A (zh) | 2019-10-18 | 2024-06-14 | 加利福尼亚太平洋生物科学股份有限公司 | 用于对核酸加帽的方法和组合物 |
| WO2021092431A1 (en) | 2019-11-08 | 2021-05-14 | Omniome, Inc. | Engineered polymerases for improved sequencing by binding |
| DE202019106694U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
| CN115243792A (zh) | 2020-02-04 | 2022-10-25 | 加利福尼亚太平洋生物科学股份有限公司 | 流通池及其制造和使用方法 |
| AU2021230282A1 (en) | 2020-03-03 | 2022-09-22 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
| US20230183798A1 (en) | 2020-05-05 | 2023-06-15 | Pacific Biosciences Of California, Inc. | Compositions and methods for modifying polymerase-nucleic acid complexes |
| US12505571B2 (en) | 2020-08-31 | 2025-12-23 | Element Biosciences, Inc. | Primary analysis in next generation sequencing |
| US12371743B2 (en) | 2022-03-04 | 2025-07-29 | Element Biosciences, Inc. | Double-stranded splint adaptors and methods of use |
| US12469162B2 (en) | 2020-08-31 | 2025-11-11 | Element Biosciences, Inc. | Primary analysis in next generation sequencing |
| US12359193B2 (en) | 2022-03-04 | 2025-07-15 | Element Biosciences, Inc. | Single-stranded splint strands and methods of use |
| US11200446B1 (en) | 2020-08-31 | 2021-12-14 | Element Biosciences, Inc. | Single-pass primary analysis |
| CN115812103A (zh) * | 2020-11-06 | 2023-03-17 | 伊鲁米纳公司 | 使用寡核苷酸检测混合物中的材料 |
| CA3204784A1 (en) | 2021-01-13 | 2022-07-21 | Alex Nemiroski | Surface structuring with colloidal assembly |
| CN117858959A (zh) | 2021-05-10 | 2024-04-09 | 加利福尼亚太平洋生物科学股份有限公司 | 滚环扩增期间的dna扩增缓冲液补充 |
| EP4337786A1 (en) | 2021-05-10 | 2024-03-20 | Pacific Biosciences of California, Inc. | Single-molecule seeding and amplification on a surface |
| US11859241B2 (en) | 2021-06-17 | 2024-01-02 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| US11236388B1 (en) | 2021-06-17 | 2022-02-01 | Element Biosciences, Inc. | Compositions and methods for pairwise sequencing |
| JP2024522795A (ja) | 2021-06-18 | 2024-06-21 | エレメント バイオサイエンシズ,インコーポレイティド | 操作されたポリメラーゼ |
| CN115710599A (zh) * | 2021-08-23 | 2023-02-24 | 深圳华大智造科技股份有限公司 | 去除核苷酸修饰缺陷的方法、试剂盒及在测序中的应用 |
| WO2023081485A1 (en) | 2021-11-08 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Stepwise sequencing of a polynucleotide with a homogenous reaction mixture |
| EP4532751A1 (en) | 2022-06-03 | 2025-04-09 | Element Biosciences, Inc. | Compositions and methods for reducing base call errors by removing deaminated nucleotides from a nucleic acid library |
| WO2023240093A1 (en) | 2022-06-06 | 2023-12-14 | Element Biosciences, Inc. | Methods for assembling and reading nucleic acid sequences from mixed populations |
| CN119923478A (zh) | 2022-07-05 | 2025-05-02 | 元素生物科学公司 | 使用双链夹板衔接子的无pcr文库制备以及使用方法 |
| WO2024015962A1 (en) | 2022-07-15 | 2024-01-18 | Pacific Biosciences Of California, Inc. | Blocked asymmetric hairpin adaptors |
| EP4573213A1 (en) | 2022-08-15 | 2025-06-25 | Element Biosciences, Inc. | Spatially resolved surface capture of nucleic acids |
| WO2024040058A1 (en) | 2022-08-15 | 2024-02-22 | Element Biosciences, Inc. | Methods for preparing nucleic acid nanostructures using compaction oligonucleotides |
| JP2025530259A (ja) | 2022-09-12 | 2025-09-11 | エレメント バイオサイエンシズ,インコーポレイティド | ユニバーサル長スプリント鎖を有する二本鎖スプリントアダプター及び使用方法 |
| EP4630490A2 (en) | 2022-12-07 | 2025-10-15 | Element Biosciences, Inc. | Water soluble cyanine derivatives and their use in methods of sequencing of nucleic acids |
| CN121712907A (zh) | 2023-01-27 | 2026-03-20 | 元素生物科学公司 | 用于使用基于酶的试剂对模板分子的多个区进行测序的组合物和方法 |
| CN116287167B (zh) * | 2023-02-20 | 2024-06-25 | 深圳市大道测序生物科技有限公司 | 核酸分子的测序方法 |
| CN116559427A (zh) * | 2023-03-13 | 2023-08-08 | 浙江大学 | 一种基于cmos无透镜成像的侧向流动免疫检测芯片及制备方法、装置及使用方法 |
| WO2024216163A1 (en) | 2023-04-13 | 2024-10-17 | Esbiolab Llc | Methods and compositions for nucleic acid sequencing using predominantly unlabeled nucleotides |
| WO2024216159A1 (en) | 2023-04-13 | 2024-10-17 | Esbiolab Llc | Methods and compositions for nucleic acid sequencing using labeled nucleotides |
| WO2025010160A1 (en) | 2023-07-06 | 2025-01-09 | Pacific Biosciences Of California, Inc. | Methods and compositions for stabilizing concatemers |
| AU2024298639A1 (en) | 2023-07-24 | 2026-01-29 | Element Biosciences, Inc. | On-support circularization and amplification for generating immobilized nucleic acid concatemer molecules |
| AU2024301610A1 (en) | 2023-07-26 | 2026-02-26 | Element Biosciences, Inc. | Dna sequencing systems and use thereof |
| WO2025062341A1 (en) | 2023-09-20 | 2025-03-27 | Element Biosciences, Inc. | Solid-state and configurable optical test targets and flow cell devices |
| WO2025120579A1 (en) | 2023-12-07 | 2025-06-12 | Element Biosciences, Inc. | Compositions and methods for sequencing multiple regions of a template molecule using read-capping nucleotide analogs |
| WO2025137268A1 (en) | 2023-12-20 | 2025-06-26 | Pacific Biosciences Of California, Inc. | Methods and compositions for reducing gc bias |
| WO2025147442A1 (en) * | 2024-01-02 | 2025-07-10 | Grail, Inc. | Rapid bisulfite conversion and recovery of nucleic acid molecules |
| WO2025163526A1 (en) | 2024-01-30 | 2025-08-07 | Element Biosciences, Inc. | Method for improving nucleic acid sequencing quality by eliminating nucleic acids with deaminated bases from library and method for sequencing in which complexes of primers, polymerases and labelled probes are bound to concatemers |
| WO2025165512A1 (en) | 2024-02-02 | 2025-08-07 | Element Biosciences, Inc. | Amplification-free probe complexes for detection of target analytes |
| WO2025191535A1 (en) | 2024-03-15 | 2025-09-18 | Element Biosciences, Inc. | Partially double-stranded splint adaptors and methods of use |
| WO2025196650A1 (en) | 2024-03-19 | 2025-09-25 | Element Biosciences, Inc. | Flow cell devices and use thereof |
| WO2025196727A1 (en) | 2024-03-22 | 2025-09-25 | Element Biosciences, Inc. | Macromolecular multivalent conjugates and related uses |
| WO2025196731A1 (en) | 2024-03-22 | 2025-09-25 | Element Biosciences, Inc. | Polymeric multivalent conjugates and related uses |
| WO2025212655A1 (en) | 2024-04-02 | 2025-10-09 | Element Biosciences, Inc. | Multiple priming for on-support nucleic acid amplification |
| WO2025212654A1 (en) | 2024-04-02 | 2025-10-09 | Element Biosciences, Inc. | Library molecule titration for tunable surface density in polony sequencing |
| WO2025235016A1 (en) | 2024-05-07 | 2025-11-13 | Element Biosciences, Inc. | Sequencing method with spatial flexibility |
| WO2025235623A1 (en) | 2024-05-08 | 2025-11-13 | Esbiolab, Llc | Methods and systems for nucleic acid sequencing using an error-buffered coding scheme |
| WO2025240909A1 (en) | 2024-05-17 | 2025-11-20 | Element Biosciences, Inc. | Hybridization-based capture and enrichment of target nucleic acid sequences |
| WO2026039088A2 (en) | 2024-06-03 | 2026-02-19 | Esbiolab, Llc | Excitation and detection methods for analyzing biomolecules |
| CN121409161A (zh) * | 2025-12-29 | 2026-01-27 | 西安交通大学 | 一种衬层及润滑膜厚度同步超声测量方法及系统 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910880D0 (en) | 1989-05-11 | 1989-06-28 | Amersham Int Plc | Sequencing method |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| EP0450060A1 (en) | 1989-10-26 | 1991-10-09 | Sri International | Dna sequencing |
| US5614365A (en) | 1994-10-17 | 1997-03-25 | President & Fellow Of Harvard College | DNA polymerase having modified nucleotide binding site for DNA sequencing |
| US6165765A (en) | 1995-10-18 | 2000-12-26 | Shanghai Institute Of Biochemistry, Chinese Academy Of Sciences | DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides |
| US6828094B2 (en) | 1996-12-20 | 2004-12-07 | Roche Diagnostics Gmbh | Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application |
| ATE225858T1 (de) | 1997-07-28 | 2002-10-15 | Medical Biosystems Ltd | Sequenzanalyse von nukleinsäuren |
| US6248539B1 (en) | 1997-09-05 | 2001-06-19 | The Scripps Research Institute | Porous semiconductor-based optical interferometric sensor |
| DE69940430D1 (de) | 1998-06-24 | 2009-04-02 | Illumina Inc | Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel |
| NO986133D0 (no) | 1998-12-23 | 1998-12-23 | Preben Lexow | FremgangsmÕte for DNA-sekvensering |
| US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US6982146B1 (en) | 1999-08-30 | 2006-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | High speed parallel molecular nucleic acid sequencing |
| WO2001016375A2 (en) | 1999-08-30 | 2001-03-08 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High speed parallel molecular nucleic acid sequencing |
| US6908736B1 (en) | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
| GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
| US20030064366A1 (en) | 2000-07-07 | 2003-04-03 | Susan Hardin | Real-time sequence determination |
| US6664079B2 (en) | 2000-10-06 | 2003-12-16 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| AU2002241803A1 (en) | 2000-10-20 | 2002-06-18 | The Board Of Trustees Of The Leland Stanford Junior University | Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample |
| US7371562B2 (en) | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| GB2398383B (en) * | 2003-02-12 | 2005-03-09 | Global Genomics Ab | Method and means for nucleic acid sequencing |
| DE602004021235D1 (de) | 2003-02-21 | 2009-07-09 | Geneform Technologies Ltd | Verfahren, kits und reagenzien zur nukleinsäuresequenzierung |
| GB0317343D0 (en) | 2003-07-24 | 2003-08-27 | Medical Biosystems Ltd | Polynucleotide sequencing |
| WO2005019476A1 (en) * | 2003-08-20 | 2005-03-03 | Applera Corporation | Polymerase compositions |
| WO2005065814A1 (en) | 2004-01-07 | 2005-07-21 | Solexa Limited | Modified molecular arrays |
| US8071755B2 (en) | 2004-05-25 | 2011-12-06 | Helicos Biosciences Corporation | Nucleotide analogs |
| AU2005254984B2 (en) | 2004-06-10 | 2008-10-16 | Ge Healthcare Bio-Sciences Corp. | Method for nucleic acid analysis |
| US7264934B2 (en) | 2004-06-10 | 2007-09-04 | Ge Healthcare Bio-Sciences Corp. | Rapid parallel nucleic acid analysis |
| GB0413082D0 (en) | 2004-06-11 | 2004-07-14 | Medical Biosystems Ltd | Method |
| EP1790202A4 (en) | 2004-09-17 | 2013-02-20 | Pacific Biosciences California | APPARATUS AND METHOD FOR ANALYZING MOLECULES |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7544794B1 (en) | 2005-03-11 | 2009-06-09 | Steven Albert Benner | Method for sequencing DNA and RNA by synthesis |
| US7449297B2 (en) | 2005-04-14 | 2008-11-11 | Euclid Diagnostics Llc | Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays |
| US20070009925A1 (en) | 2005-05-05 | 2007-01-11 | Applera Corporation | Genomic dna sequencing methods and kits |
| US8192930B2 (en) * | 2006-02-08 | 2012-06-05 | Illumina Cambridge Limited | Method for sequencing a polynucleotide template |
| CA2648149A1 (en) | 2006-03-31 | 2007-11-01 | Solexa, Inc. | Systems and devices for sequence by synthesis analysis |
| US7883869B2 (en) | 2006-12-01 | 2011-02-08 | The Trustees Of Columbia University In The City Of New York | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators |
| US7678894B2 (en) | 2007-05-18 | 2010-03-16 | Helicos Biosciences Corporation | Nucleotide analogs |
| CN101434988B (zh) | 2007-11-16 | 2013-05-01 | 深圳华因康基因科技有限公司 | 一种高通量寡核苷酸测序方法 |
| WO2009097368A2 (en) | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| US8652781B2 (en) | 2008-02-12 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Cognate sampling kinetics |
| US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| CA2720046C (en) | 2008-03-31 | 2018-07-24 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
| US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
| EP2274446B1 (en) | 2008-03-31 | 2015-09-09 | Pacific Biosciences of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| GB2461026B (en) * | 2008-06-16 | 2011-03-09 | Plc Diagnostics Inc | System and method for nucleic acids sequencing by phased synthesis |
| US20100092960A1 (en) | 2008-07-25 | 2010-04-15 | Pacific Biosciences Of California, Inc. | Helicase-assisted sequencing with molecular beacons |
| TWI408888B (zh) * | 2008-08-07 | 2013-09-11 | Ind Tech Res Inst | 超音波線性馬達 |
| CN102317471A (zh) | 2008-12-11 | 2012-01-11 | 加利福尼亚大学董事会 | 用于单个dna分子的直接测序的方法和系统 |
| EP2379748A4 (en) | 2008-12-23 | 2012-08-29 | Illumina Inc | MULTIBASE RELEASE FOR LONG READINGS IN SEQUENCING BY SYNTHESIS PROTOCOLS |
| US20100255487A1 (en) | 2009-03-27 | 2010-10-07 | Life Technologies Corporation | Methods and apparatus for single molecule sequencing using energy transfer detection |
| US8034923B1 (en) | 2009-03-27 | 2011-10-11 | Steven Albert Benner | Reagents for reversibly terminating primer extension |
| US20120156728A1 (en) * | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| US8632975B2 (en) * | 2009-06-05 | 2014-01-21 | Life Technologies Corporation | Nucleotide transient binding for sequencing methods |
| WO2011038241A1 (en) | 2009-09-25 | 2011-03-31 | President And Fellows Of Harvard College | Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides |
| US8911972B2 (en) | 2009-12-16 | 2014-12-16 | Pacific Biosciences Of California, Inc. | Sequencing methods using enzyme conformation |
| US8603741B2 (en) | 2010-02-18 | 2013-12-10 | Pacific Biosciences Of California, Inc. | Single molecule sequencing with two distinct chemistry steps |
| WO2011159942A1 (en) | 2010-06-18 | 2011-12-22 | Illumina, Inc. | Conformational probes and methods for sequencing nucleic acids |
| US8986930B2 (en) | 2010-07-12 | 2015-03-24 | Pacific Biosciences Of California, Inc. | Sequencing reactions with alkali metal cations for pulse width control |
| BE1019015A5 (nl) * | 2010-12-13 | 2012-01-10 | Luxafoil | Energiewerende kunststoffolie. |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| EP2714935B1 (en) | 2011-05-27 | 2017-03-15 | Genapsys Inc. | Systems and methods for genetic and biological analysis |
| US20150087537A1 (en) | 2011-08-31 | 2015-03-26 | Life Technologies Corporation | Methods, Systems, Computer Readable Media, and Kits for Sample Identification |
| MX342195B (es) | 2011-09-13 | 2016-09-20 | Lasergen Inc | Nucleótidos de terminación de rápida fotodescomposición 5-metoxi, 3' -oh no bloqueados y métodos para secuenciación de ácido nucleico. |
| CA3104322C (en) | 2011-09-23 | 2023-06-13 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
| US9279154B2 (en) | 2011-12-21 | 2016-03-08 | Illumina, Inc. | Apparatus and methods for kinetic analysis and determination of nucleic acid sequences |
| CN102634586B (zh) | 2012-04-27 | 2013-10-30 | 东南大学 | 一种两核苷酸实时合成dna解码测序方法 |
| ES2683707T3 (es) | 2012-05-02 | 2018-09-27 | Ibis Biosciences, Inc. | Secuenciación de ADN |
| GB201301178D0 (en) | 2013-01-23 | 2013-03-06 | Dynamic Biosensors Gmbh | Method for sequencing a template nucleic acid immobilized on a substrate |
| DK3553175T3 (da) | 2013-03-13 | 2021-08-23 | Illumina Inc | Fremgangsmåde til fremstilling af et nukleinsyresekvenseringsbibliotek |
| EP2971071B1 (en) | 2013-03-15 | 2018-02-28 | Illumina, Inc. | Enzyme-linked nucleotides |
| US8808989B1 (en) | 2013-04-02 | 2014-08-19 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acids |
| EP3241913B1 (en) | 2013-07-03 | 2019-02-20 | Illumina, Inc. | System for sequencing by orthogonal synthesis |
| CN105980578B (zh) | 2013-12-16 | 2020-02-14 | 深圳华大智造科技有限公司 | 用于使用机器学习进行dna测序的碱基判定器 |
| US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| CN107849605B (zh) * | 2015-07-21 | 2021-08-20 | 欧姆尼欧美公司 | 核酸测序方法和系统 |
| WO2017087724A1 (en) | 2015-11-17 | 2017-05-26 | Omniome, Inc. | Methods for determining sequence profiles |
| CN109072297B (zh) * | 2016-04-22 | 2022-09-13 | 加利福尼亚太平洋生物科学股份有限公司 | 使用增强的核苷酸特异性三元复合物形成检测的核酸测序方法和系统 |
| CA3021769C (en) | 2016-04-29 | 2021-11-23 | Omniome, Inc. | Sequencing method employing ternary complex destabilization to identify cognate nucleotides |
| KR102231977B1 (ko) * | 2016-04-29 | 2021-03-24 | 옴니옴 인코포레이티드 | 핵산 서열의 결정 방법 |
| EP4039824A1 (en) | 2016-08-15 | 2022-08-10 | Pacific Biosciences of California, Inc. | Method and system for sequencing nucleic acids |
| US9951385B1 (en) | 2017-04-25 | 2018-04-24 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
-
2017
- 2017-08-15 EP EP21206020.6A patent/EP4039824A1/en not_active Withdrawn
- 2017-08-15 EP EP17761630.7A patent/EP3497236B1/en active Active
- 2017-08-15 US US15/677,870 patent/US10443098B2/en active Active
- 2017-08-15 JP JP2019508256A patent/JP6828140B2/ja active Active
- 2017-08-15 WO PCT/US2017/046976 patent/WO2018035134A1/en not_active Ceased
- 2017-08-15 AU AU2017313718A patent/AU2017313718B2/en active Active
- 2017-08-15 KR KR1020197007695A patent/KR102230444B1/ko active Active
- 2017-08-15 CN CN201780063633.9A patent/CN109844136A/zh active Pending
- 2017-08-15 CN CN202311235787.5A patent/CN117385014A/zh active Pending
- 2017-10-04 US US15/724,570 patent/US10246744B2/en active Active
-
2019
- 2019-09-13 US US16/570,873 patent/US11168364B2/en active Active
-
2021
- 2021-01-20 JP JP2021006893A patent/JP7198295B2/ja active Active
- 2021-10-06 US US17/495,739 patent/US20220162690A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021072816A5 (enExample) | ||
| JP7569404B2 (ja) | 酵素不要及び増幅不要の配列決定 | |
| Shendure et al. | Overview of DNA sequencing strategies | |
| US7378242B2 (en) | DNA sequence detection by limited primer extension | |
| EP0953056B1 (en) | Nucleic acid sequencing with solid phase capturable terminators | |
| JP2019526225A5 (enExample) | ||
| JP2018522543A5 (enExample) | ||
| IL255446B2 (en) | Field-effect apparatus and methods for sequencing nucelic acids | |
| JP2009521223A5 (enExample) | ||
| JP2017520580A5 (enExample) | ||
| CA2582809A1 (en) | Replica amplification of nucleic acid arrays | |
| JP2006517798A (ja) | 核酸配列用の方法及び手段 | |
| JPWO2019209426A5 (enExample) | ||
| JP2005000174A5 (enExample) | ||
| US11946096B2 (en) | Methods for estimating cluster numbers | |
| JP2017533709A5 (enExample) | ||
| US11359236B2 (en) | DNA sequencing | |
| JP2009517052A5 (enExample) | ||
| EP3520221A1 (en) | Efficient clustering of noisy polynucleotide sequence reads | |
| JP2017505120A (ja) | Ngsシステム用の対照及びそれを用いる方法 | |
| US20240002913A1 (en) | Systems and methods for multiplexed analyte detection using antibody-oligonucleotide conjugates | |
| JP2021509814A5 (enExample) | ||
| US20250231172A1 (en) | Single molecule multi-molecular trace methods and systems | |
| JP2019502374A5 (enExample) | ||
| JPH05219995A (ja) | ヌクレオチドの配列の決定方法 |