JP2020525426A5 - - Google Patents
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- JP2020525426A5 JP2020525426A5 JP2019570461A JP2019570461A JP2020525426A5 JP 2020525426 A5 JP2020525426 A5 JP 2020525426A5 JP 2019570461 A JP2019570461 A JP 2019570461A JP 2019570461 A JP2019570461 A JP 2019570461A JP 2020525426 A5 JP2020525426 A5 JP 2020525426A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reducing agent
- reacting
- converting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](*)[C@@](CCC1C(C(C2)[C@@](C)(CCCC3)[C@]3C3*)C3=O)[C@@]1(C)[C@]2O Chemical compound C[C@](*)[C@@](CCC1C(C(C2)[C@@](C)(CCCC3)[C@]3C3*)C3=O)[C@@]1(C)[C@]2O 0.000 description 3
- HJIOHZIZYMNLRZ-LDCZGCDSSA-N CC[C@H]([C@H](C[C@@H](CC1)O)[C@@]1(C)C1C2C(CC[C@@H]3[C@H](C)CCC(O)=O)[C@H]3[C@H](C)C1)[C@H]2O Chemical compound CC[C@H]([C@H](C[C@@H](CC1)O)[C@@]1(C)C1C2C(CC[C@@H]3[C@H](C)CCC(O)=O)[C@H]3[C@H](C)C1)[C@H]2O HJIOHZIZYMNLRZ-LDCZGCDSSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762523937P | 2017-06-23 | 2017-06-23 | |
| US62/523,937 | 2017-06-23 | ||
| PCT/US2018/039148 WO2018237350A1 (en) | 2017-06-23 | 2018-06-22 | METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020525426A JP2020525426A (ja) | 2020-08-27 |
| JP2020525426A5 true JP2020525426A5 (https=) | 2021-07-26 |
| JP7224307B2 JP7224307B2 (ja) | 2023-02-17 |
Family
ID=64691408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570461A Active JP7224307B2 (ja) | 2017-06-23 | 2018-06-22 | 胆汁酸誘導体の調製のための方法及び中間体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11066437B2 (https=) |
| EP (1) | EP3642217A4 (https=) |
| JP (1) | JP7224307B2 (https=) |
| KR (2) | KR20250109791A (https=) |
| CN (1) | CN110945006A (https=) |
| AU (1) | AU2018288883B2 (https=) |
| BR (1) | BR112019027458A2 (https=) |
| CA (1) | CA3067219A1 (https=) |
| IL (3) | IL326587A (https=) |
| WO (1) | WO2018237350A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2848212C (en) | 2011-09-08 | 2022-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| PT2968369T (pt) | 2013-03-13 | 2018-12-05 | Sage Therapeutics Inc | Esteroides neuroativos e métodos para o seu uso |
| US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| HUE071964T2 (hu) | 2015-07-06 | 2025-10-28 | Sage Therapeutics Inc | Oxiszterolok és alkalmazási eljárásaik |
| EP3828194B1 (en) | 2015-07-06 | 2025-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CA2991311C (en) | 2015-07-06 | 2025-05-06 | Sage Therapeutics, Inc. | OXYSTEROLS AND THEIR METHODS OF USE |
| EP3981779A1 (en) * | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Farnesoid x receptor modulators |
| SMT202200300T1 (it) | 2016-04-01 | 2022-09-14 | Sage Therapeutics Inc | Ossisteroli e relativi metodi d'uso |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| ES2884071T3 (es) | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA |
| ES2935057T3 (es) | 2016-09-30 | 2023-03-01 | Sage Therapeutics Inc | C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA |
| RU2019115113A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| KR20230051723A (ko) | 2016-10-18 | 2023-04-18 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| US20230128984A1 (en) * | 2020-01-31 | 2023-04-27 | The Johns Hopkins University | Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases, including inflammatory bowel disease (ibd) |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| US12215127B2 (en) | 2020-04-17 | 2025-02-04 | Cornell University | Compositions and methods for profiling of gut microbiota-associated bile salt hydrolase (BSH) activity |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| CN112795615A (zh) * | 2021-02-03 | 2021-05-14 | 湖南醇康医药科技有限公司 | 一种诱变菌种以及微生物发酵制备熊去氧胆酸的方法 |
| WO2023288123A1 (en) * | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid |
| CN114045239B (zh) * | 2021-11-08 | 2023-09-29 | 浙江树人学院（浙江树人大学） | 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用 |
| US20250288600A1 (en) * | 2022-04-21 | 2025-09-18 | Intercept Pharmaceuticals, Inc. | Uses of farnesoid x receptor agonists |
| WO2024163640A2 (en) * | 2023-02-01 | 2024-08-08 | Intercept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of bile acid derivatives |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2403683A (en) * | 1942-04-25 | 1946-07-09 | Relchstein Tadeus | Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same |
| US2554882A (en) * | 1943-02-04 | 1951-05-29 | Reichstein Tadeus | 3-hydroxy-11-ketoetiocholanic acid and its esters |
| US3277121A (en) * | 1964-05-04 | 1966-10-04 | Canada Packers Ltd | Conversion of delta11-steroids to 11-oxygenated steroids |
| DE3040634A1 (de) * | 1980-10-29 | 1982-05-27 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von 3 (alpha) -hydroxy-5- (beta) -pregnan-11,20-dion |
| JPS58155098A (ja) * | 1982-03-09 | 1983-09-14 | Yakult Honsha Co Ltd | 微生物によるウルソデオキシコ−ル酸の製造法 |
| WO1990009394A2 (en) * | 1989-02-07 | 1990-08-23 | The Upjohn Company | Dehalogenation of organic compounds using tin or lead |
| DE10113257C1 (de) | 2001-03-19 | 2002-11-14 | Inst Mikrotechnik Mainz Gmbh | Elektrophoresevorrichtung und ihre Verwendung |
| ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| NZ734451A (en) * | 2012-06-19 | 2018-12-21 | Intercept Pharmaceuticals Inc | Preparation, uses and solid forms of obeticholic acid |
| CA2912139C (en) | 2013-05-14 | 2021-04-20 | Roberto Pellicciari | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
| WO2016073767A1 (en) | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
| JP2017535570A (ja) | 2014-11-26 | 2017-11-30 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法 |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
| MX2017010376A (es) | 2015-02-11 | 2017-12-20 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos. |
| CA2981503C (en) | 2015-03-31 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| CN108137643A (zh) * | 2015-08-07 | 2018-06-08 | 英特塞普特医药品公司 | 制备胆汁酸及其衍生物的方法 |
| EP3981779A1 (en) * | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Farnesoid x receptor modulators |
| CN107973834A (zh) | 2016-10-22 | 2018-05-01 | 合帕吉恩治疗公司 | 作为fxr/tgr5调节剂的胆酸衍生物 |
| WO2018081285A1 (en) | 2016-10-26 | 2018-05-03 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as fxr agonists and methods of use thereof |
-
2018
- 2018-06-22 JP JP2019570461A patent/JP7224307B2/ja active Active
- 2018-06-22 BR BR112019027458-8A patent/BR112019027458A2/pt unknown
- 2018-06-22 IL IL326587A patent/IL326587A/en unknown
- 2018-06-22 EP EP18821477.9A patent/EP3642217A4/en active Pending
- 2018-06-22 CN CN201880047896.5A patent/CN110945006A/zh active Pending
- 2018-06-22 AU AU2018288883A patent/AU2018288883B2/en active Active
- 2018-06-22 KR KR1020257022279A patent/KR20250109791A/ko active Pending
- 2018-06-22 KR KR1020207002009A patent/KR102831293B1/ko active Active
- 2018-06-22 CA CA3067219A patent/CA3067219A1/en active Pending
- 2018-06-22 IL IL271343A patent/IL271343B2/en unknown
- 2018-06-22 WO PCT/US2018/039148 patent/WO2018237350A1/en not_active Ceased
- 2018-06-22 US US16/016,486 patent/US11066437B2/en active Active
-
2021
- 2021-06-08 US US17/342,057 patent/US20220127302A1/en active Pending
-
2023
- 2023-07-13 IL IL304455A patent/IL304455B1/en unknown
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