JP2020522691A5 - - Google Patents
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- JP2020522691A5 JP2020522691A5 JP2019566134A JP2019566134A JP2020522691A5 JP 2020522691 A5 JP2020522691 A5 JP 2020522691A5 JP 2019566134 A JP2019566134 A JP 2019566134A JP 2019566134 A JP2019566134 A JP 2019566134A JP 2020522691 A5 JP2020522691 A5 JP 2020522691A5
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- antibody
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- cancer
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- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 238000000034 method Methods 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 27
- 102000036639 antigens Human genes 0.000 claims 27
- 108091007433 antigens Proteins 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 27
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 239000003112 inhibitor Substances 0.000 claims 17
- 239000005557 antagonist Substances 0.000 claims 16
- 201000011510 cancer Diseases 0.000 claims 15
- 102000017578 LAG3 Human genes 0.000 claims 13
- 101150030213 Lag3 gene Proteins 0.000 claims 13
- 238000011282 treatment Methods 0.000 claims 13
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 11
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 11
- 230000037361 pathway Effects 0.000 claims 11
- 238000009169 immunotherapy Methods 0.000 claims 6
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 5
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 4
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 4
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 4
- 229940125563 LAG3 inhibitor Drugs 0.000 claims 4
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 229940124060 PD-1 antagonist Drugs 0.000 claims 2
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- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
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- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
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- 101150013553 CD40 gene Proteins 0.000 claims 1
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- 101710093674 Cyclic nucleotide-gated cation channel beta-1 Proteins 0.000 claims 1
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- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
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- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010052178 Lymphocytic lymphoma Diseases 0.000 claims 1
- 229940125568 MGD013 Drugs 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
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- 229940123387 PVRIG antagonist Drugs 0.000 claims 1
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- 206010061538 Pituitary tumour benign Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010036524 Precursor B-lymphoblastic lymphomas Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 229940125566 REGN3767 Drugs 0.000 claims 1
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- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
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- 229940125564 Sym022 Drugs 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 208000020982 T-lymphoblastic lymphoma Diseases 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 229940125567 TSR-033 Drugs 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102100025946 Transforming growth factor beta activator LRRC32 Human genes 0.000 claims 1
- 101710169732 Transforming growth factor beta activator LRRC32 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
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- 208000011654 childhood malignant neoplasm Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000011284 combination treatment Methods 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000003236 esophagogastric junction Anatomy 0.000 claims 1
- 229940124981 favezelimab Drugs 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
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- 210000004392 genitalia Anatomy 0.000 claims 1
- 238000003881 globally optimized alternating phase rectangular pulse Methods 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229940121569 ieramilimab Drugs 0.000 claims 1
- 210000004969 inflammatory cell Anatomy 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000020984 malignant renal pelvis neoplasm Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003101 oviduct Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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- 229960002621 pembrolizumab Drugs 0.000 claims 1
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- 201000006037 primary mediastinal B-cell lymphoma Diseases 0.000 claims 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023111620A JP2023139047A (ja) | 2017-05-30 | 2023-07-06 | Ｌａｇ－３陽性腫瘍の処置 |
| JP2025097456A JP2025134762A (ja) | 2017-05-30 | 2025-06-11 | Ｌａｇ－３陽性腫瘍の処置 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762512648P | 2017-05-30 | 2017-05-30 | |
| US62/512,648 | 2017-05-30 | ||
| US201762513813P | 2017-06-01 | 2017-06-01 | |
| US62/513,813 | 2017-06-01 | ||
| US201762555176P | 2017-09-07 | 2017-09-07 | |
| US62/555,176 | 2017-09-07 | ||
| US201762582178P | 2017-11-06 | 2017-11-06 | |
| US62/582,178 | 2017-11-06 | ||
| PCT/US2018/035134 WO2018222718A1 (en) | 2017-05-30 | 2018-05-30 | Treatment of lag-3 positive tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023111620A Division JP2023139047A (ja) | 2017-05-30 | 2023-07-06 | Ｌａｇ－３陽性腫瘍の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020522691A JP2020522691A (ja) | 2020-07-30 |
| JP2020522691A5 true JP2020522691A5 (cg-RX-API-DMAC7.html) | 2021-07-26 |
Family
ID=62778996
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566134A Pending JP2020522691A (ja) | 2017-05-30 | 2018-05-30 | Ｌａｇ−３陽性腫瘍の処置 |
| JP2023111620A Pending JP2023139047A (ja) | 2017-05-30 | 2023-07-06 | Ｌａｇ－３陽性腫瘍の処置 |
| JP2025097456A Pending JP2025134762A (ja) | 2017-05-30 | 2025-06-11 | Ｌａｇ－３陽性腫瘍の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023111620A Pending JP2023139047A (ja) | 2017-05-30 | 2023-07-06 | Ｌａｇ－３陽性腫瘍の処置 |
| JP2025097456A Pending JP2025134762A (ja) | 2017-05-30 | 2025-06-11 | Ｌａｇ－３陽性腫瘍の処置 |
Country Status (22)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS64268B1 (sr) * | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| UY36032A (es) | 2014-03-14 | 2015-10-30 | Novartis Ag | Moléculas de anticuerpo que se unen a lag-3 y usos de las mismas |
| TWI843168B (zh) | 2016-10-11 | 2024-05-21 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| MX2019012076A (es) | 2017-05-30 | 2019-12-09 | Bristol Myers Squibb Co | Composiciones que comprenden un anticuerpo anti gen-3 de activacion del linfocito (lag-3) o un anticuerpo anti-lag-3 y un anticuerpo anti muerte celular programada 1 (pd-1) o anti ligando 1 de muerte celular programada (pd-l1). |
| DK3631454T3 (da) | 2017-05-30 | 2023-12-04 | Bristol Myers Squibb Co | Behandling af lag-3 positive tumorer |
| WO2019018730A1 (en) * | 2017-07-20 | 2019-01-24 | Novartis Ag | DOSAGE REGIMES FOR ANTI-LAG3 ANTIBODIES AND USES THEREOF |
| CA3107660A1 (en) * | 2018-07-26 | 2020-01-30 | Bristol-Myers Squibb Company | Lag-3 combination therapy for the treatment of cancer |
| US20210403557A1 (en) * | 2018-11-05 | 2021-12-30 | Merck Sharp & Dohme Corp. | Dosing regimen of anti-tigit antibody for treatment of cancer |
| MX2021005394A (es) | 2018-11-07 | 2021-07-06 | Merck Sharp & Dohme Llc | Co-formulaciones de anticuerpos anti-gen de activacion de linfocitos 3 (anti-lag3) y anticuerpos anti-muerte programada-1 (anti-pd-1). |
| BR112021022831A2 (pt) * | 2019-05-14 | 2022-01-18 | F Star Therapeutics Ltd | Regimes de dosagem para a administração de um anticorpo biespecífico lag-3/pd-l1 |
| WO2021030156A1 (en) * | 2019-08-09 | 2021-02-18 | The Regents Of The University Of California | Compositions and methods for diagnosis and treatment of bladder cancer |
| US20220348653A1 (en) * | 2019-09-22 | 2022-11-03 | Bristol-Myers Squibb Company | Quantitative Spatial Profiling for LAG-3 Antagonist Therapy |
| CN114630679A (zh) * | 2019-10-25 | 2022-06-14 | 第一三共株式会社 | 抗garp抗体和免疫调节剂的组合 |
| CN115942973A (zh) * | 2019-11-08 | 2023-04-07 | 百时美施贵宝公司 | 用于黑色素瘤的lag-3拮抗剂疗法 |
| CN113616788A (zh) * | 2020-05-08 | 2021-11-09 | 勤浩医药（苏州）有限公司 | 抗lag-3抗体与shp-2抑制剂联合治疗肿瘤的用途 |
| EP4157879A4 (en) * | 2020-05-27 | 2024-06-19 | Agilent Technologies, Inc. | Anti-human lag-3 antibodies and their use in immunohistochemistry (ihc) |
| CA3193421A1 (en) * | 2020-08-28 | 2022-03-03 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
| WO2023051621A1 (zh) * | 2021-09-29 | 2023-04-06 | 中山康方生物医药有限公司 | 抗lag3抗体、药物组合物及用途 |
| CN114869877B (zh) * | 2022-01-26 | 2024-05-31 | 兰州大学 | 一种小分子化合物及其作为lag3蛋白抑制剂的应用 |
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| CN115942973A (zh) | 2019-11-08 | 2023-04-07 | 百时美施贵宝公司 | 用于黑色素瘤的lag-3拮抗剂疗法 |
| CA3193421A1 (en) | 2020-08-28 | 2022-03-03 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
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2018
- 2018-05-30 DK DK18735009.5T patent/DK3631454T3/da active
- 2018-05-30 ES ES18735009T patent/ES2965352T3/es active Active
- 2018-05-30 EP EP18735009.5A patent/EP3631454B1/en active Active
- 2018-05-30 JP JP2019566134A patent/JP2020522691A/ja active Pending
- 2018-05-30 KR KR1020247032471A patent/KR20240146108A/ko not_active Ceased
- 2018-05-30 EP EP23196582.3A patent/EP4306542A3/en not_active Withdrawn
- 2018-05-30 CN CN201880036546.9A patent/CN110720039A/zh active Pending
- 2018-05-30 CA CA3060984A patent/CA3060984A1/en active Pending
- 2018-05-30 RS RS20231032A patent/RS64787B1/sr unknown
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- 2018-05-30 AU AU2018277824A patent/AU2018277824A1/en not_active Abandoned
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- 2018-05-30 PL PL18735009.5T patent/PL3631454T3/pl unknown
- 2018-05-30 BR BR112019020610-8A patent/BR112019020610A2/pt unknown
- 2018-05-30 SI SI201831006T patent/SI3631454T1/sl unknown
- 2018-05-30 HU HUE18735009A patent/HUE065242T2/hu unknown
- 2018-05-30 KR KR1020197038189A patent/KR102713203B1/ko active Active
- 2018-05-30 WO PCT/US2018/035134 patent/WO2018222718A1/en not_active Ceased
- 2018-05-30 US US16/616,574 patent/US11807686B2/en active Active
- 2018-05-30 HR HRP20231457TT patent/HRP20231457T1/hr unknown
- 2018-05-30 PT PT187350095T patent/PT3631454T/pt unknown
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- 2018-05-30 LT LTEPPCT/US2018/035134T patent/LT3631454T/lt unknown
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2019
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2023
- 2023-07-06 JP JP2023111620A patent/JP2023139047A/ja active Pending
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2024
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2025
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