JP2020521817A5 - - Google Patents
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- Publication number
- JP2020521817A5 JP2020521817A5 JP2020516962A JP2020516962A JP2020521817A5 JP 2020521817 A5 JP2020521817 A5 JP 2020521817A5 JP 2020516962 A JP2020516962 A JP 2020516962A JP 2020516962 A JP2020516962 A JP 2020516962A JP 2020521817 A5 JP2020521817 A5 JP 2020521817A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- quinazoline
- carboxamide
- oxo
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000004384 Alopecia Diseases 0.000 claims 3
- 208000019838 Blood disease Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 208000014951 hematologic disease Diseases 0.000 claims 3
- 208000018706 hematopoietic system disease Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 2
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- JXPVWJOKXDUSLJ-JKSUJKDBSA-N 2-bromo-N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@@H](CCCC1)O)=O JXPVWJOKXDUSLJ-JKSUJKDBSA-N 0.000 claims 1
- RQUOUHPZMZVZGL-UHFFFAOYSA-N 2-bromo-N-cyclohexyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCCC1)=O RQUOUHPZMZVZGL-UHFFFAOYSA-N 0.000 claims 1
- GHBYQVNMUFILIA-UHFFFAOYSA-N 2-bromo-N-cyclopentyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCC1)=O GHBYQVNMUFILIA-UHFFFAOYSA-N 0.000 claims 1
- NYWQWNVWBKDBBS-UHFFFAOYSA-N 2-cyano-N-cyclohexyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C(#N)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCCC1)=O NYWQWNVWBKDBBS-UHFFFAOYSA-N 0.000 claims 1
- LVHASCJIJRLCRT-UHFFFAOYSA-N 2-cyclopropyl-11-oxo-N-(oxolan-3-yl)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1COCC1)=O LVHASCJIJRLCRT-UHFFFAOYSA-N 0.000 claims 1
- QREIFIKQJUGJBT-UHFFFAOYSA-N 2-cyclopropyl-N-(1-methylpiperidin-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCN(CC1)C)=O QREIFIKQJUGJBT-UHFFFAOYSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-UHFFFAOYSA-N 2-cyclopropyl-N-(2-hydroxycyclohexyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1C(CCCC1)O)=O XWTSGDSYCDKUNY-UHFFFAOYSA-N 0.000 claims 1
- XSKMMXUMCQXLDO-UHFFFAOYSA-N 2-cyclopropyl-N-(3-methyloxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1C(COCC1)C)=O XSKMMXUMCQXLDO-UHFFFAOYSA-N 0.000 claims 1
- MTDAHYCAQCESTK-UHFFFAOYSA-N 2-cyclopropyl-N-(4,4-difluorocyclohexyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCC(CC1)(F)F)=O MTDAHYCAQCESTK-UHFFFAOYSA-N 0.000 claims 1
- FVODTXIMSAHXIU-UHFFFAOYSA-N 2-cyclopropyl-N-(oxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCOCC1)=O FVODTXIMSAHXIU-UHFFFAOYSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-RTBURBONSA-N 2-cyclopropyl-N-[(1R,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@@H](CCCC1)O)=O XWTSGDSYCDKUNY-RTBURBONSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-MOPGFXCFSA-N 2-cyclopropyl-N-[(1R,2S)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@H](CCCC1)O)=O XWTSGDSYCDKUNY-MOPGFXCFSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-RBUKOAKNSA-N 2-cyclopropyl-N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@@H](CCCC1)O)=O XWTSGDSYCDKUNY-RBUKOAKNSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-OALUTQOASA-N 2-cyclopropyl-N-[(1S,2S)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@H](CCCC1)O)=O XWTSGDSYCDKUNY-OALUTQOASA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 claims 1
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 claims 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 1
- CEXAGGOVTBATNW-UHFFFAOYSA-N N-(4,4-difluorocyclohexyl)-2-fluoro-8-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound FC1(CCC(CC1)NC(=O)C1=CC(=CN2C1=NC1=CC=C(C=C1C2=O)F)C)F CEXAGGOVTBATNW-UHFFFAOYSA-N 0.000 claims 1
- QXOHLSLHTKNUBT-LEWJYISDSA-N N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound O[C@H]1[C@H](CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 QXOHLSLHTKNUBT-LEWJYISDSA-N 0.000 claims 1
- CWDONLQVGHHKDP-LEWJYISDSA-N N-[(1S,2R)-2-hydroxycyclohexyl]-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound O[C@H]1[C@H](CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C CWDONLQVGHHKDP-LEWJYISDSA-N 0.000 claims 1
- BUQVOMJSBHFNOL-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-(trifluoromethoxy)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)OC(F)(F)F BUQVOMJSBHFNOL-UHFFFAOYSA-N 0.000 claims 1
- FJBTUIMJJJCNRZ-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-(trifluoromethyl)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C(F)(F)F FJBTUIMJJJCNRZ-UHFFFAOYSA-N 0.000 claims 1
- IYQDXNGDJCBVDZ-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-phenylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=CC=C1 IYQDXNGDJCBVDZ-UHFFFAOYSA-N 0.000 claims 1
- GUWULDWWZFEBMG-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 GUWULDWWZFEBMG-UHFFFAOYSA-N 0.000 claims 1
- IKOANHRJTRKQAF-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-thiophen-2-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C=1SC=CC=1 IKOANHRJTRKQAF-UHFFFAOYSA-N 0.000 claims 1
- GESCXFZABJFAKQ-UHFFFAOYSA-N N-cyclohexyl-2-(4-fluorophenyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=C(C=C1)F GESCXFZABJFAKQ-UHFFFAOYSA-N 0.000 claims 1
- HWPLAPKOYVXNOJ-UHFFFAOYSA-N N-cyclohexyl-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C HWPLAPKOYVXNOJ-UHFFFAOYSA-N 0.000 claims 1
- FYQHQBSVPAYETJ-UHFFFAOYSA-N N-cyclohexyl-2-cyclopropyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1 FYQHQBSVPAYETJ-UHFFFAOYSA-N 0.000 claims 1
- AUKKKXYRYHJYGX-UHFFFAOYSA-N N-cyclohexyl-2-cyclopropyl-8-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC(=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1)C AUKKKXYRYHJYGX-UHFFFAOYSA-N 0.000 claims 1
- ANUBZHMGCRHWQV-UHFFFAOYSA-N N-cyclohexyl-2-hydroxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)O ANUBZHMGCRHWQV-UHFFFAOYSA-N 0.000 claims 1
- JAEARRRCUGRDJR-UHFFFAOYSA-N N-cyclohexyl-2-methoxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)OC JAEARRRCUGRDJR-UHFFFAOYSA-N 0.000 claims 1
- VHIYDUCRIGCKTQ-UHFFFAOYSA-N N-cyclohexyl-2-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C VHIYDUCRIGCKTQ-UHFFFAOYSA-N 0.000 claims 1
- XAFMNQLWPHEYRJ-UHFFFAOYSA-N N-cyclohexyl-2-morpholin-4-yl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCOCC1 XAFMNQLWPHEYRJ-UHFFFAOYSA-N 0.000 claims 1
- VZKBWAZISLJGJE-UHFFFAOYSA-N N-cyclopentyl-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 VZKBWAZISLJGJE-UHFFFAOYSA-N 0.000 claims 1
- QRWVAHABHPOCIO-UHFFFAOYSA-N N-cyclopentyl-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C QRWVAHABHPOCIO-UHFFFAOYSA-N 0.000 claims 1
- QDEFFAKLENOJFJ-UHFFFAOYSA-N N-cyclopentyl-2-cyclopropyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1 QDEFFAKLENOJFJ-UHFFFAOYSA-N 0.000 claims 1
- MYPLVFXZZARGCE-UHFFFAOYSA-N N-cyclopentyl-2-hydroxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)O MYPLVFXZZARGCE-UHFFFAOYSA-N 0.000 claims 1
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 claims 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201730759 | 2017-06-01 | ||
| ESP201730759 | 2017-06-01 | ||
| PCT/ES2018/070396 WO2018220252A1 (es) | 2017-06-01 | 2018-05-31 | Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521817A JP2020521817A (ja) | 2020-07-27 |
| JP2020521817A5 true JP2020521817A5 (enExample) | 2021-07-26 |
| JP7110335B2 JP7110335B2 (ja) | 2022-08-01 |
Family
ID=61569288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516962A Active JP7110335B2 (ja) | 2017-06-01 | 2018-05-31 | プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11021479B2 (enExample) |
| EP (1) | EP3632912B1 (enExample) |
| JP (1) | JP7110335B2 (enExample) |
| KR (1) | KR102629854B1 (enExample) |
| CN (1) | CN111247143B (enExample) |
| AU (1) | AU2018278283B2 (enExample) |
| CY (1) | CY1124087T1 (enExample) |
| DK (1) | DK3632912T3 (enExample) |
| EA (1) | EA037384B1 (enExample) |
| ES (1) | ES2881960T3 (enExample) |
| HR (1) | HRP20210814T1 (enExample) |
| HU (1) | HUE054792T2 (enExample) |
| LT (1) | LT3632912T (enExample) |
| MX (1) | MX385475B (enExample) |
| PL (1) | PL3632912T3 (enExample) |
| PT (1) | PT3632912T (enExample) |
| RS (1) | RS61833B1 (enExample) |
| SI (1) | SI3632912T1 (enExample) |
| SM (1) | SMT202100312T1 (enExample) |
| WO (1) | WO2018220252A1 (enExample) |
| ZA (1) | ZA201908372B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11978921B2 (en) | 2020-01-31 | 2024-05-07 | Lg Energy Solution, Ltd. | Method of manufacturing separator-composite electrode comprising multilayer-structured inorganic layer and separator-composite electrode manufactured thereby |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551460A (en) | 1982-05-10 | 1985-11-05 | Hoffmann-La Roche Inc. | Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis |
| WO1998023617A1 (en) | 1996-11-26 | 1998-06-04 | American Cyanamid Company | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents |
| WO2005048953A2 (en) | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Amide derivatives as kinase modulators |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| KR101361027B1 (ko) | 2008-11-28 | 2014-02-11 | 코와 가부시키가이샤 | 피리딘-3-카르복시아미드 유도체 |
| EP3778600A1 (en) | 2014-03-20 | 2021-02-17 | The Johns Hopkins University | Compounds which inhibit rna polymerase, compositions including such compounds, and their use |
-
2018
- 2018-05-31 RS RS20210545A patent/RS61833B1/sr unknown
- 2018-05-31 SM SM20210312T patent/SMT202100312T1/it unknown
- 2018-05-31 AU AU2018278283A patent/AU2018278283B2/en active Active
- 2018-05-31 LT LTEP18759146.6T patent/LT3632912T/lt unknown
- 2018-05-31 WO PCT/ES2018/070396 patent/WO2018220252A1/es not_active Ceased
- 2018-05-31 MX MX2019014436A patent/MX385475B/es unknown
- 2018-05-31 CN CN201880048531.4A patent/CN111247143B/zh active Active
- 2018-05-31 JP JP2020516962A patent/JP7110335B2/ja active Active
- 2018-05-31 DK DK18759146.6T patent/DK3632912T3/da active
- 2018-05-31 KR KR1020197038842A patent/KR102629854B1/ko active Active
- 2018-05-31 EP EP18759146.6A patent/EP3632912B1/en active Active
- 2018-05-31 EA EA201992793A patent/EA037384B1/ru unknown
- 2018-05-31 PL PL18759146T patent/PL3632912T3/pl unknown
- 2018-05-31 HR HRP20210814TT patent/HRP20210814T1/hr unknown
- 2018-05-31 SI SI201830289T patent/SI3632912T1/sl unknown
- 2018-05-31 HU HUE18759146A patent/HUE054792T2/hu unknown
- 2018-05-31 US US16/615,867 patent/US11021479B2/en active Active
- 2018-05-31 ES ES18759146T patent/ES2881960T3/es active Active
- 2018-05-31 PT PT187591466T patent/PT3632912T/pt unknown
-
2019
- 2019-12-13 ZA ZA2019/08372A patent/ZA201908372B/en unknown
-
2021
- 2021-05-20 CY CY20211100437T patent/CY1124087T1/el unknown
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