KR102629854B1 - 단백질 키나제 저해제로서 유용한 피리도퀴나졸린 유도체 - Google Patents
단백질 키나제 저해제로서 유용한 피리도퀴나졸린 유도체 Download PDFInfo
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- KR102629854B1 KR102629854B1 KR1020197038842A KR20197038842A KR102629854B1 KR 102629854 B1 KR102629854 B1 KR 102629854B1 KR 1020197038842 A KR1020197038842 A KR 1020197038842A KR 20197038842 A KR20197038842 A KR 20197038842A KR 102629854 B1 KR102629854 B1 KR 102629854B1
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- South Korea
- Prior art keywords
- pyrido
- oxo
- quinazoline
- carboxamide
- branched
- Prior art date
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- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 2
- 239000003909 protein kinase inhibitor Substances 0.000 title description 2
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 10
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- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 4
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- 239000011737 fluorine Substances 0.000 claims description 4
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- XSKMMXUMCQXLDO-UHFFFAOYSA-N 2-cyclopropyl-N-(3-methyloxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1C(COCC1)C)=O XSKMMXUMCQXLDO-UHFFFAOYSA-N 0.000 claims description 3
- MTDAHYCAQCESTK-UHFFFAOYSA-N 2-cyclopropyl-N-(4,4-difluorocyclohexyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCC(CC1)(F)F)=O MTDAHYCAQCESTK-UHFFFAOYSA-N 0.000 claims description 3
- FVODTXIMSAHXIU-UHFFFAOYSA-N 2-cyclopropyl-N-(oxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCOCC1)=O FVODTXIMSAHXIU-UHFFFAOYSA-N 0.000 claims description 3
- XWTSGDSYCDKUNY-RTBURBONSA-N 2-cyclopropyl-N-[(1R,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@@H](CCCC1)O)=O XWTSGDSYCDKUNY-RTBURBONSA-N 0.000 claims description 3
- XWTSGDSYCDKUNY-MOPGFXCFSA-N 2-cyclopropyl-N-[(1R,2S)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@H](CCCC1)O)=O XWTSGDSYCDKUNY-MOPGFXCFSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
- F24C7/00—Stoves or ranges heated by electric energy
- F24C7/08—Arrangement or mounting of control or safety devices
- F24C7/082—Arrangement or mounting of control or safety devices on ranges, e.g. control panels, illumination
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
- F24C7/00—Stoves or ranges heated by electric energy
- F24C7/08—Arrangement or mounting of control or safety devices
- F24C7/087—Arrangement or mounting of control or safety devices of electric circuits regulating heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201730759 | 2017-06-01 | ||
| ES201730759 | 2017-06-01 | ||
| PCT/ES2018/070396 WO2018220252A1 (es) | 2017-06-01 | 2018-05-31 | Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200011990A KR20200011990A (ko) | 2020-02-04 |
| KR102629854B1 true KR102629854B1 (ko) | 2024-01-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197038842A Active KR102629854B1 (ko) | 2017-06-01 | 2018-05-31 | 단백질 키나제 저해제로서 유용한 피리도퀴나졸린 유도체 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11021479B2 (enExample) |
| EP (1) | EP3632912B1 (enExample) |
| JP (1) | JP7110335B2 (enExample) |
| KR (1) | KR102629854B1 (enExample) |
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| WO1998023617A1 (en) | 1996-11-26 | 1998-06-04 | American Cyanamid Company | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents |
| WO2015143293A1 (en) | 2014-03-20 | 2015-09-24 | The Johns Hopkins University | Compounds which inhibit rna polymerase, compositions including such compounds, and their use |
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| US4551460A (en) | 1982-05-10 | 1985-11-05 | Hoffmann-La Roche Inc. | Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis |
| US20050171172A1 (en) * | 2003-11-13 | 2005-08-04 | Ambit Biosciences Corporation | Amide derivatives as PDGFR modulators |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| KR101361027B1 (ko) | 2008-11-28 | 2014-02-11 | 코와 가부시키가이샤 | 피리딘-3-카르복시아미드 유도체 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998023617A1 (en) | 1996-11-26 | 1998-06-04 | American Cyanamid Company | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents |
| WO2015143293A1 (en) | 2014-03-20 | 2015-09-24 | The Johns Hopkins University | Compounds which inhibit rna polymerase, compositions including such compounds, and their use |
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| HUE054792T2 (hu) | 2021-09-28 |
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| WO2018220252A1 (es) | 2018-12-06 |
| AU2018278283A1 (en) | 2019-12-19 |
| BR112019024892A2 (pt) | 2020-06-16 |
| ZA201908372B (en) | 2021-04-28 |
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