BR112019024892A2 - Derivados de piridoquinazolina úteis como inibidores de proteína quinase - Google Patents

Derivados de piridoquinazolina úteis como inibidores de proteína quinase Download PDF

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Publication number
BR112019024892A2
BR112019024892A2 BR112019024892-7A BR112019024892A BR112019024892A2 BR 112019024892 A2 BR112019024892 A2 BR 112019024892A2 BR 112019024892 A BR112019024892 A BR 112019024892A BR 112019024892 A2 BR112019024892 A2 BR 112019024892A2
Authority
BR
Brazil
Prior art keywords
protein kinase
kinase inhibitors
piridoquinazoline
derivatives useful
diseases
Prior art date
Application number
BR112019024892-7A
Other languages
English (en)
Inventor
Kurz Guido
Camacho Gómez Juan
Original Assignee
Oncostellae, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncostellae, S.L. filed Critical Oncostellae, S.L.
Publication of BR112019024892A2 publication Critical patent/BR112019024892A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/082—Arrangement or mounting of control or safety devices on ranges, e.g. control panels, illumination
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/087—Arrangement or mounting of control or safety devices of electric circuits regulating heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a presente invenção se refere a novos derivados de 11-oxo-11h-pirido[2,1-b] quinazolina-6-carboxamida como potentes inibidores da proteína quinase, a composições farmacêuticas contendo os mesmos e ao uso dos referidos compostos para a fabricação de um fármaco para o tratamento de doenças ou doenças patológicas que podem ser melhoradas pela inibição da proteína quinase.
BR112019024892-7A 2017-06-01 2018-05-31 Derivados de piridoquinazolina úteis como inibidores de proteína quinase BR112019024892A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP201730759 2017-06-01
ES201730759 2017-06-01
PCT/ES2018/070396 WO2018220252A1 (es) 2017-06-01 2018-05-31 Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa

Publications (1)

Publication Number Publication Date
BR112019024892A2 true BR112019024892A2 (pt) 2020-06-16

Family

ID=61569288

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019024892-7A BR112019024892A2 (pt) 2017-06-01 2018-05-31 Derivados de piridoquinazolina úteis como inibidores de proteína quinase

Country Status (22)

Country Link
US (1) US11021479B2 (pt)
EP (1) EP3632912B1 (pt)
JP (1) JP7110335B2 (pt)
KR (1) KR102629854B1 (pt)
CN (1) CN111247143B (pt)
AU (1) AU2018278283B2 (pt)
BR (1) BR112019024892A2 (pt)
CA (1) CA3066009A1 (pt)
CY (1) CY1124087T1 (pt)
DK (1) DK3632912T3 (pt)
EA (1) EA037384B1 (pt)
ES (1) ES2881960T3 (pt)
HR (1) HRP20210814T1 (pt)
HU (1) HUE054792T2 (pt)
LT (1) LT3632912T (pt)
MX (1) MX2019014436A (pt)
PL (1) PL3632912T3 (pt)
PT (1) PT3632912T (pt)
RS (1) RS61833B1 (pt)
SI (1) SI3632912T1 (pt)
WO (1) WO2018220252A1 (pt)
ZA (1) ZA201908372B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11978921B2 (en) 2020-01-31 2024-05-07 Lg Energy Solution, Ltd. Method of manufacturing separator-composite electrode comprising multilayer-structured inorganic layer and separator-composite electrode manufactured thereby

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551460A (en) 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
ES2176800T3 (es) 1996-11-26 2002-12-01 American Cyanamid Co Derivados hetero-biaril-piridoquinazolinona como agentes anticancerosos.
EP1684762A4 (en) 2003-11-13 2009-06-17 Ambit Biosciences Corp UREA DERIVATIVES AS MODULATORS OF KINASE
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009320683B2 (en) 2008-11-28 2012-07-19 Kowa Company, Ltd. Pyridine-3-carboxyamide derivative
ES2833459T3 (es) * 2014-03-20 2021-06-15 Univ Johns Hopkins Compuestos que inhiben la ARN polimerasa, composiciones que incluyen dichos compuestos y su uso

Also Published As

Publication number Publication date
CN111247143B (zh) 2022-07-05
MX2019014436A (es) 2020-02-10
WO2018220252A1 (es) 2018-12-06
LT3632912T (lt) 2021-06-10
KR102629854B1 (ko) 2024-01-25
EP3632912A1 (en) 2020-04-08
US11021479B2 (en) 2021-06-01
DK3632912T3 (da) 2021-05-10
PT3632912T (pt) 2021-06-02
HUE054792T2 (hu) 2021-09-28
CN111247143A (zh) 2020-06-05
CA3066009A1 (en) 2018-12-06
HRP20210814T1 (hr) 2021-06-25
EA201992793A1 (ru) 2020-03-26
EP3632912B1 (en) 2021-03-17
PL3632912T3 (pl) 2021-09-06
JP2020521817A (ja) 2020-07-27
US20200148676A1 (en) 2020-05-14
ZA201908372B (en) 2021-04-28
JP7110335B2 (ja) 2022-08-01
RS61833B1 (sr) 2021-06-30
AU2018278283B2 (en) 2021-06-17
CY1124087T1 (el) 2022-05-27
AU2018278283A1 (en) 2019-12-19
EA037384B1 (ru) 2021-03-23
ES2881960T3 (es) 2021-11-30
KR20200011990A (ko) 2020-02-04
SI3632912T1 (sl) 2021-08-31

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Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]