JP7110335B2 - プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 - Google Patents

プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 Download PDF

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Publication number
JP7110335B2
JP7110335B2 JP2020516962A JP2020516962A JP7110335B2 JP 7110335 B2 JP7110335 B2 JP 7110335B2 JP 2020516962 A JP2020516962 A JP 2020516962A JP 2020516962 A JP2020516962 A JP 2020516962A JP 7110335 B2 JP7110335 B2 JP 7110335B2
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Japan
Prior art keywords
oxo
pyrido
quinazoline
carboxamide
branched
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JP2020516962A
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Japanese (ja)
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JP2020521817A5 (enExample
JP2020521817A (ja
Inventor
グイド、クルツ
フアン、カマチョ、ゴメス
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Oncostellae SL
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Oncostellae SL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/082—Arrangement or mounting of control or safety devices on ranges, e.g. control panels, illumination
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/087—Arrangement or mounting of control or safety devices of electric circuits regulating heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020516962A 2017-06-01 2018-05-31 プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 Active JP7110335B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201730759 2017-06-01
ESP201730759 2017-06-01
PCT/ES2018/070396 WO2018220252A1 (es) 2017-06-01 2018-05-31 Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa

Publications (3)

Publication Number Publication Date
JP2020521817A JP2020521817A (ja) 2020-07-27
JP2020521817A5 JP2020521817A5 (enExample) 2021-07-26
JP7110335B2 true JP7110335B2 (ja) 2022-08-01

Family

ID=61569288

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020516962A Active JP7110335B2 (ja) 2017-06-01 2018-05-31 プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体

Country Status (22)

Country Link
US (1) US11021479B2 (enExample)
EP (1) EP3632912B1 (enExample)
JP (1) JP7110335B2 (enExample)
KR (1) KR102629854B1 (enExample)
CN (1) CN111247143B (enExample)
AU (1) AU2018278283B2 (enExample)
CA (1) CA3066009A1 (enExample)
CY (1) CY1124087T1 (enExample)
DK (1) DK3632912T3 (enExample)
EA (1) EA037384B1 (enExample)
ES (1) ES2881960T3 (enExample)
HR (1) HRP20210814T1 (enExample)
HU (1) HUE054792T2 (enExample)
LT (1) LT3632912T (enExample)
MX (1) MX385475B (enExample)
PL (1) PL3632912T3 (enExample)
PT (1) PT3632912T (enExample)
RS (1) RS61833B1 (enExample)
SI (1) SI3632912T1 (enExample)
SM (1) SMT202100312T1 (enExample)
WO (1) WO2018220252A1 (enExample)
ZA (1) ZA201908372B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7525609B2 (ja) 2020-01-31 2024-07-30 エルジー エナジー ソリューション リミテッド 多層構造の無機物層を含む分離膜一体型電極の製造方法及びそれによる分離膜一体型電極

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001507341A (ja) 1996-11-26 2001-06-05 アメリカン・サイアナミド・カンパニー 抗癌薬としてのヘテロ−ビアリール−ピリドキナゾリノン誘導体
JP2007512255A (ja) 2003-11-13 2007-05-17 アンビット バイオサイエンシス コーポレーション キナーゼ調節因子としての尿素誘導体
WO2015143293A1 (en) 2014-03-20 2015-09-24 The Johns Hopkins University Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551460A (en) 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009320683B2 (en) 2008-11-28 2012-07-19 Kowa Company, Ltd. Pyridine-3-carboxyamide derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001507341A (ja) 1996-11-26 2001-06-05 アメリカン・サイアナミド・カンパニー 抗癌薬としてのヘテロ−ビアリール−ピリドキナゾリノン誘導体
JP2007512255A (ja) 2003-11-13 2007-05-17 アンビット バイオサイエンシス コーポレーション キナーゼ調節因子としての尿素誘導体
WO2015143293A1 (en) 2014-03-20 2015-09-24 The Johns Hopkins University Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Also Published As

Publication number Publication date
RS61833B1 (sr) 2021-06-30
PL3632912T3 (pl) 2021-09-06
KR20200011990A (ko) 2020-02-04
SI3632912T1 (sl) 2021-08-31
EP3632912A1 (en) 2020-04-08
AU2018278283B2 (en) 2021-06-17
CY1124087T1 (el) 2022-05-27
LT3632912T (lt) 2021-06-10
CN111247143A (zh) 2020-06-05
AU2018278283A1 (en) 2019-12-19
ES2881960T3 (es) 2021-11-30
HRP20210814T1 (hr) 2021-06-25
BR112019024892A2 (pt) 2020-06-16
CN111247143B (zh) 2022-07-05
SMT202100312T1 (it) 2021-07-12
US20200148676A1 (en) 2020-05-14
CA3066009A1 (en) 2018-12-06
DK3632912T3 (da) 2021-05-10
US11021479B2 (en) 2021-06-01
JP2020521817A (ja) 2020-07-27
HUE054792T2 (hu) 2021-09-28
MX385475B (es) 2025-03-18
EA201992793A1 (ru) 2020-03-26
MX2019014436A (es) 2020-02-10
ZA201908372B (en) 2021-04-28
PT3632912T (pt) 2021-06-02
EP3632912B1 (en) 2021-03-17
KR102629854B1 (ko) 2024-01-25
WO2018220252A1 (es) 2018-12-06
EA037384B1 (ru) 2021-03-23

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