AU2018278283B2 - Pyridoquinazoline derivatives useful as protein kinase inhibitors - Google Patents

Pyridoquinazoline derivatives useful as protein kinase inhibitors Download PDF

Info

Publication number
AU2018278283B2
AU2018278283B2 AU2018278283A AU2018278283A AU2018278283B2 AU 2018278283 B2 AU2018278283 B2 AU 2018278283B2 AU 2018278283 A AU2018278283 A AU 2018278283A AU 2018278283 A AU2018278283 A AU 2018278283A AU 2018278283 B2 AU2018278283 B2 AU 2018278283B2
Authority
AU
Australia
Prior art keywords
pyrido
quinazoline
oxo
carboxamide
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018278283A
Other languages
English (en)
Other versions
AU2018278283A1 (en
Inventor
Juan CAMACHO GÓMEZ
Guido Kurz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncostellae SL
Original Assignee
Oncostellae SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncostellae SL filed Critical Oncostellae SL
Publication of AU2018278283A1 publication Critical patent/AU2018278283A1/en
Application granted granted Critical
Publication of AU2018278283B2 publication Critical patent/AU2018278283B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/082—Arrangement or mounting of control or safety devices on ranges, e.g. control panels, illumination
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24C—DOMESTIC STOVES OR RANGES ; DETAILS OF DOMESTIC STOVES OR RANGES, OF GENERAL APPLICATION
    • F24C7/00—Stoves or ranges heated by electric energy
    • F24C7/08—Arrangement or mounting of control or safety devices
    • F24C7/087—Arrangement or mounting of control or safety devices of electric circuits regulating heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018278283A 2017-06-01 2018-05-31 Pyridoquinazoline derivatives useful as protein kinase inhibitors Active AU2018278283B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP201730759 2017-06-01
ES201730759 2017-06-01
PCT/ES2018/070396 WO2018220252A1 (es) 2017-06-01 2018-05-31 Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa

Publications (2)

Publication Number Publication Date
AU2018278283A1 AU2018278283A1 (en) 2019-12-19
AU2018278283B2 true AU2018278283B2 (en) 2021-06-17

Family

ID=61569288

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018278283A Active AU2018278283B2 (en) 2017-06-01 2018-05-31 Pyridoquinazoline derivatives useful as protein kinase inhibitors

Country Status (22)

Country Link
US (1) US11021479B2 (enExample)
EP (1) EP3632912B1 (enExample)
JP (1) JP7110335B2 (enExample)
KR (1) KR102629854B1 (enExample)
CN (1) CN111247143B (enExample)
AU (1) AU2018278283B2 (enExample)
CA (1) CA3066009A1 (enExample)
CY (1) CY1124087T1 (enExample)
DK (1) DK3632912T3 (enExample)
EA (1) EA037384B1 (enExample)
ES (1) ES2881960T3 (enExample)
HR (1) HRP20210814T1 (enExample)
HU (1) HUE054792T2 (enExample)
LT (1) LT3632912T (enExample)
MX (1) MX385475B (enExample)
PL (1) PL3632912T3 (enExample)
PT (1) PT3632912T (enExample)
RS (1) RS61833B1 (enExample)
SI (1) SI3632912T1 (enExample)
SM (1) SMT202100312T1 (enExample)
WO (1) WO2018220252A1 (enExample)
ZA (1) ZA201908372B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7525609B2 (ja) 2020-01-31 2024-07-30 エルジー エナジー ソリューション リミテッド 多層構造の無機物層を含む分離膜一体型電極の製造方法及びそれによる分離膜一体型電極

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023617A1 (en) * 1996-11-26 1998-06-04 American Cyanamid Company Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents
WO2015143293A1 (en) * 2014-03-20 2015-09-24 The Johns Hopkins University Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551460A (en) 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US20050171172A1 (en) * 2003-11-13 2005-08-04 Ambit Biosciences Corporation Amide derivatives as PDGFR modulators
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
KR101361027B1 (ko) 2008-11-28 2014-02-11 코와 가부시키가이샤 피리딘-3-카르복시아미드 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023617A1 (en) * 1996-11-26 1998-06-04 American Cyanamid Company Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents
WO2015143293A1 (en) * 2014-03-20 2015-09-24 The Johns Hopkins University Compounds which inhibit rna polymerase, compositions including such compounds, and their use

Also Published As

Publication number Publication date
RS61833B1 (sr) 2021-06-30
EA201992793A1 (ru) 2020-03-26
EA037384B1 (ru) 2021-03-23
HRP20210814T1 (hr) 2021-06-25
CA3066009A1 (en) 2018-12-06
CN111247143B (zh) 2022-07-05
SMT202100312T1 (it) 2021-07-12
EP3632912B1 (en) 2021-03-17
JP7110335B2 (ja) 2022-08-01
ES2881960T3 (es) 2021-11-30
JP2020521817A (ja) 2020-07-27
MX385475B (es) 2025-03-18
CN111247143A (zh) 2020-06-05
US20200148676A1 (en) 2020-05-14
US11021479B2 (en) 2021-06-01
DK3632912T3 (da) 2021-05-10
MX2019014436A (es) 2020-02-10
KR20200011990A (ko) 2020-02-04
SI3632912T1 (sl) 2021-08-31
KR102629854B1 (ko) 2024-01-25
CY1124087T1 (el) 2022-05-27
PL3632912T3 (pl) 2021-09-06
LT3632912T (lt) 2021-06-10
PT3632912T (pt) 2021-06-02
HUE054792T2 (hu) 2021-09-28
EP3632912A1 (en) 2020-04-08
WO2018220252A1 (es) 2018-12-06
AU2018278283A1 (en) 2019-12-19
BR112019024892A2 (pt) 2020-06-16
ZA201908372B (en) 2021-04-28

Similar Documents

Publication Publication Date Title
TW202144345A (zh) Ｋｒａｓ突變蛋白抑制劑
CN109983016B (zh) 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
WO2018121228A1 (zh) 一种具有axl抑制活性的化合物及其制备和应用
WO2019029629A1 (en) SUBSTITUTED PYRAZOLOPYRIMIDINES FOR USE AS KINASE INHIBITORS
CN115160309B (zh) Krasg12c突变蛋白杂环类抑制剂的制备及其应用
WO2020156479A1 (zh) 环丙烯并苯并呋喃取代的氮杂芳基化合物、其中间体、制备方法及应用
EP4293029B1 (en) Azaheteroaryl compound, preparation method therefor, and application thereof
AU2018278283B2 (en) Pyridoquinazoline derivatives useful as protein kinase inhibitors
CN110078730A (zh) 作为pi3k/mtor抑制剂的喹啉取代的稠合喹啉化合物
JP2018513214A (ja) 新規なキナーゼ阻害剤の調製と使用
WO2025218831A2 (zh) 具有ptpn2/ptpn1抑制活性的噻二唑烷酮衍生物及其制备方法和应用
KR102606167B1 (ko) 불소 함유 치환 벤조티오펜 화합물, 그의 약학적 조성물 및 응용
JP2024507747A (ja) Ｒｉｐ２キナーゼ阻害剤としてのヘテロアリール化合物、その組成物及び用途
AU2018278284A1 (en) Carboxylic acid derivatives of pyridoquinazolines useful as protein kinase inhibitors
CN115703799B (zh) 氮杂芳基化合物、其制备方法及应用
BR112019024892B1 (pt) Inibidores da proteína quinase
CN116768886A (zh) N-(4-(1H-吡咯并[2,3-b]吡啶-5-基)苯基)酰胺衍生物及制备与用途
CN114426541A (zh) 氮杂芳基化合物及其用途
CN115340499A (zh) Bcl-xl抑制剂及其用途

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)