JP2018534314A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018534314A5 JP2018534314A5 JP2018525730A JP2018525730A JP2018534314A5 JP 2018534314 A5 JP2018534314 A5 JP 2018534314A5 JP 2018525730 A JP2018525730 A JP 2018525730A JP 2018525730 A JP2018525730 A JP 2018525730A JP 2018534314 A5 JP2018534314 A5 JP 2018534314A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- heterocycloalkyl
- groups
- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520500.8A GB201520500D0 (en) | 2015-11-20 | 2015-11-20 | Compounds |
| GB1520500.8 | 2015-11-20 | ||
| PCT/GB2016/053580 WO2017085484A1 (en) | 2015-11-20 | 2016-11-16 | Fused thiazolopyrimidine derivatives as mnks inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019390A Division JP7181647B2 (ja) | 2015-11-20 | 2021-02-09 | Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534314A JP2018534314A (ja) | 2018-11-22 |
| JP2018534314A5 true JP2018534314A5 (enExample) | 2019-12-26 |
| JP6928605B2 JP6928605B2 (ja) | 2021-09-01 |
Family
ID=55133106
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525730A Expired - Fee Related JP6928605B2 (ja) | 2015-11-20 | 2016-11-16 | Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 |
| JP2021019390A Expired - Fee Related JP7181647B2 (ja) | 2015-11-20 | 2021-02-09 | Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019390A Expired - Fee Related JP7181647B2 (ja) | 2015-11-20 | 2021-02-09 | Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10669284B2 (enExample) |
| EP (2) | EP3939981B1 (enExample) |
| JP (2) | JP6928605B2 (enExample) |
| CN (1) | CN108495855B (enExample) |
| AU (1) | AU2016355104B2 (enExample) |
| CA (2) | CA3240011A1 (enExample) |
| ES (2) | ES2981048T3 (enExample) |
| GB (1) | GB201520500D0 (enExample) |
| WO (1) | WO2017085484A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| DK3582776T3 (da) | 2017-02-14 | 2024-01-08 | Effector Therapeutics Inc | Piperidinsubstituerede mnk-hæmmere og dertil relaterede fremgangsmåder |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| EP3870178A4 (en) | 2018-10-24 | 2022-08-03 | Effector Therapeutics Inc. | Crystalline forms of mnk inhibitors |
| CN110903286B (zh) * | 2019-12-16 | 2021-09-24 | 沈阳药科大学 | 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用 |
| WO2022006331A2 (en) * | 2020-06-30 | 2022-01-06 | 4E Therapeutics, Inc. | Pyridine-1,5-diones exhibitng mnk inhibition and their method of use |
| CN118146134B (zh) * | 2024-02-07 | 2026-07-07 | 南方海洋科学与工程广东省实验室(湛江) | 一种3-羟基吡咯烷衍生物及其制备方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US20050153989A1 (en) | 2004-01-13 | 2005-07-14 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| TW200538120A (en) | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
| JPWO2005095419A1 (ja) | 2004-04-01 | 2008-02-21 | 武田薬品工業株式会社 | チアゾロピリミジン誘導体 |
| CA2572331A1 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
| CA2651898A1 (en) | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| WO2008057402A2 (en) * | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| CA2706203A1 (en) * | 2007-11-22 | 2009-05-28 | Boehringer Ingelheim International Gmbh | Use of mnk inhibitors for the treatment of alzheimer's disease |
| BRPI0918971A2 (pt) * | 2008-08-26 | 2015-12-01 | Boehringer Ingelheim Int | tienopirimidinas para composições farmacêuticas |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| ES2562959T3 (es) * | 2010-02-26 | 2016-03-09 | Evotec International Gmbh | Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas |
| MX2012009735A (es) | 2010-02-26 | 2012-09-12 | Boehringer Ingelheim Int | 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas. |
| CN102002044A (zh) * | 2010-09-29 | 2011-04-06 | 中国药科大学 | 嘌呤-8-酮类及噻唑并嘧啶类衍生物及其制备方法和医药用途 |
| US9556181B2 (en) | 2013-02-01 | 2017-01-31 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
| HK1220972A1 (zh) | 2013-03-06 | 2017-05-19 | Bayer Pharma Aktiengesellschaft | 取代的噻唑并嘧啶 |
| CN105531279A (zh) * | 2013-07-08 | 2016-04-27 | 拜耳制药股份公司 | 取代的吡唑并吡啶胺 |
-
2015
- 2015-11-20 GB GBGB1520500.8A patent/GB201520500D0/en not_active Ceased
-
2016
- 2016-11-16 CA CA3240011A patent/CA3240011A1/en active Pending
- 2016-11-16 EP EP21190890.0A patent/EP3939981B1/en active Active
- 2016-11-16 ES ES21190890T patent/ES2981048T3/es active Active
- 2016-11-16 JP JP2018525730A patent/JP6928605B2/ja not_active Expired - Fee Related
- 2016-11-16 EP EP16801016.3A patent/EP3377501B1/en active Active
- 2016-11-16 CA CA3003559A patent/CA3003559C/en active Active
- 2016-11-16 WO PCT/GB2016/053580 patent/WO2017085484A1/en not_active Ceased
- 2016-11-16 AU AU2016355104A patent/AU2016355104B2/en not_active Ceased
- 2016-11-16 CN CN201680079581.XA patent/CN108495855B/zh not_active Expired - Fee Related
- 2016-11-16 US US15/776,536 patent/US10669284B2/en active Active
- 2016-11-16 ES ES16801016T patent/ES2893154T3/es active Active
-
2020
- 2020-04-22 US US16/855,701 patent/US11136338B2/en not_active Expired - Fee Related
-
2021
- 2021-02-09 JP JP2021019390A patent/JP7181647B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513110A5 (enExample) | ||
| JP2016530283A5 (enExample) | ||
| CY1124680T1 (el) | Παραγωγα 8-[6-[3-(αμινο)προποξυ]-3-πυριδυλο]-1-ισοπροπυλο-ιμιδαζο[4,5-c]κινολιν-2-ονης ως εκλεκτiκοι ρυθμιστες κινασης μεταλλαγμενης αταξιας τελαγγειεκτασιας (atm) για τη θεραπευτικη αγωγη του καρκινου | |
| JP2014139226A5 (enExample) | ||
| CN109568312A (zh) | 用于治疗癌症的化合物 | |
| JP2014503567A5 (enExample) | ||
| JP2014518544A5 (enExample) | ||
| JP2018533611A5 (enExample) | ||
| WO2017221100A1 (en) | Imidazopyrimidine compounds useful for the treatment of cancer | |
| RU2015124002A (ru) | Соединения, применяемые в качестве ингибиторов индоламин-2,3-диоксигеназы | |
| JP2019524883A5 (enExample) | ||
| JP2016525135A5 (enExample) | ||
| JP2016525076A5 (enExample) | ||
| HRP20171248T1 (hr) | Amino-supstituirani imidazopiridazini | |
| JP2014521725A5 (enExample) | ||
| JP2016522232A5 (enExample) | ||
| JP2015520143A5 (enExample) | ||
| JP2014505735A5 (enExample) | ||
| RU2018104702A (ru) | Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ | |
| RU2016134751A (ru) | Соединения | |
| JP2016523270A5 (enExample) | ||
| JP2014193925A5 (enExample) | ||
| JP2017504635A5 (enExample) | ||
| MX387207B (es) | Inhibidores de proteína quinasa, método de preparación y su uso médico. | |
| JP2017520613A5 (enExample) |