CA3003559C - Fused thiazolopyrimidine derivatives as MNK inhibitors - Google Patents

Fused thiazolopyrimidine derivatives as MNK inhibitors

Info

Publication number
CA3003559C
CA3003559C CA3003559A CA3003559A CA3003559C CA 3003559 C CA3003559 C CA 3003559C CA 3003559 A CA3003559 A CA 3003559A CA 3003559 A CA3003559 A CA 3003559A CA 3003559 C CA3003559 C CA 3003559C
Authority
CA
Canada
Prior art keywords
nmr
mhz
ppm
pct
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3003559A
Other languages
English (en)
French (fr)
Other versions
CA3003559A1 (en
Inventor
Jon James WINTER-HOLT
Edward Giles McIver
Martin Ambler
Stephen Lewis
Joanne Osborne
Kayleigh Webb-Smith
Original Assignee
LifeArc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LifeArc filed Critical LifeArc
Priority to CA3240011A priority Critical patent/CA3240011A1/en
Publication of CA3003559A1 publication Critical patent/CA3003559A1/en
Application granted granted Critical
Publication of CA3003559C publication Critical patent/CA3003559C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3003559A 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as MNK inhibitors Active CA3003559C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3240011A CA3240011A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1520500.8A GB201520500D0 (en) 2015-11-20 2015-11-20 Compounds
GB1520500.8 2015-11-20
PCT/GB2016/053580 WO2017085484A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3240011A Division CA3240011A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Publications (2)

Publication Number Publication Date
CA3003559A1 CA3003559A1 (en) 2017-05-26
CA3003559C true CA3003559C (en) 2024-09-10

Family

ID=55133106

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3003559A Active CA3003559C (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as MNK inhibitors
CA3240011A Pending CA3240011A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3240011A Pending CA3240011A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Country Status (9)

Country Link
US (2) US10669284B2 (enExample)
EP (2) EP3939981B1 (enExample)
JP (2) JP6928605B2 (enExample)
CN (1) CN108495855B (enExample)
AU (1) AU2016355104B2 (enExample)
CA (2) CA3003559C (enExample)
ES (2) ES2893154T3 (enExample)
GB (1) GB201520500D0 (enExample)
WO (1) WO2017085484A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
PE20191349A1 (es) 2017-02-14 2019-09-30 Effector Therapeutics Inc Inhibidores de mnk sustituidos con piperidina y metodos relacionados con los mismos
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
CA3117169A1 (en) 2018-10-24 2020-04-30 Effector Therapeutics, Inc. Crystalline forms of mnk inhibitors
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用
MX2022016516A (es) * 2020-06-30 2023-03-28 4E Therapeutics Inc Piridina-1,5-dionas que exhiben inhibición de proteínas cinasas activadas por mitogenos que interaccionan con cinasas activadas (mnk) y su método de uso.
CN118146134A (zh) * 2024-02-07 2024-06-07 南方海洋科学与工程广东省实验室(湛江) 一种3-羟基吡咯烷衍生物及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
WO2005067546A2 (en) 2004-01-13 2005-07-28 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
TW200538120A (en) 2004-02-20 2005-12-01 Kirin Brewery Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same
US20080269238A1 (en) 2004-04-01 2008-10-30 Takeda Pharmaceutical Company Limited Thiazolopyrimidine Derivative
CA2572331A1 (en) 2004-07-02 2006-02-09 Exelixis, Inc. C-met modulators and method of use
WO2007115822A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnkl /mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008057402A2 (en) * 2006-11-02 2008-05-15 Cytovia, Inc. N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof
JP2011504474A (ja) * 2007-11-22 2011-02-10 ベーリンガー インゲルハイム インテルナツィオナール ゲゼルシャフト ミット ベシュレンクテル ハフツング アルツハイマー氏病を治療するためのＭｎｋインヒビターの使用
CN102186857A (zh) * 2008-08-26 2011-09-14 贝林格尔·英格海姆国际有限公司 用于药物组合物的噻吩并嘧啶
TW201141872A (en) * 2010-02-26 2011-12-01 Boehringer Ingelheim Int Cycloalkyl containing thienopyrimidines for pharmaceutical compositions
TW201141483A (en) * 2010-02-26 2011-12-01 Boehringer Ingelheim Int Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
UY33241A (es) * 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
CN102002044A (zh) * 2010-09-29 2011-04-06 中国药科大学 嘌呤-8-酮类及噻唑并嘧啶类衍生物及其制备方法和医药用途
HK1222173A1 (zh) 2013-02-01 2017-06-23 Bayer Pharma Aktiengesellschaft 取代的吡唑并嘧啶基氨基-吲唑类
US9675612B2 (en) 2013-03-06 2017-06-13 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
CN105531279A (zh) * 2013-07-08 2016-04-27 拜耳制药股份公司 取代的吡唑并吡啶胺

Also Published As

Publication number Publication date
JP6928605B2 (ja) 2021-09-01
EP3939981A1 (en) 2022-01-19
ES2893154T3 (es) 2022-02-08
CN108495855A (zh) 2018-09-04
HK1253575A1 (en) 2019-06-21
US20180346483A1 (en) 2018-12-06
US11136338B2 (en) 2021-10-05
AU2016355104B2 (en) 2021-01-28
CA3240011A1 (en) 2017-05-26
US10669284B2 (en) 2020-06-02
JP2018534314A (ja) 2018-11-22
US20200247822A1 (en) 2020-08-06
GB201520500D0 (en) 2016-01-06
AU2016355104A1 (en) 2018-05-24
CA3003559A1 (en) 2017-05-26
JP7181647B2 (ja) 2022-12-01
EP3377501B1 (en) 2021-08-18
WO2017085484A1 (en) 2017-05-26
CN108495855B (zh) 2022-05-31
EP3939981B1 (en) 2024-04-03
JP2021073306A (ja) 2021-05-13
ES2981048T3 (es) 2024-10-07
EP3377501A1 (en) 2018-09-26
EP3939981C0 (en) 2024-04-03

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