JP6928605B2 - Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 - Google Patents

Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 Download PDF

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JP6928605B2
JP6928605B2 JP2018525730A JP2018525730A JP6928605B2 JP 6928605 B2 JP6928605 B2 JP 6928605B2 JP 2018525730 A JP2018525730 A JP 2018525730A JP 2018525730 A JP2018525730 A JP 2018525730A JP 6928605 B2 JP6928605 B2 JP 6928605B2
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JP2018534314A (ja
JP2018534314A5 (enExample
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ジョン ジェームズ ウィンター−ホルト
ジョン ジェームズ ウィンター−ホルト
エドワード ジャイルズ マクアイヴァー
エドワード ジャイルズ マクアイヴァー
マーティン アンブラー
マーティン アンブラー
スティーヴン ルイス
スティーヴン ルイス
ジョアンヌ オズボーン
ジョアンヌ オズボーン
ケイリー ウェッブ−スミス
ケイリー ウェッブ−スミス
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LifeArc
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LifeArc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018525730A 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体 Active JP6928605B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1520500.8A GB201520500D0 (en) 2015-11-20 2015-11-20 Compounds
GB1520500.8 2015-11-20
PCT/GB2016/053580 WO2017085484A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors

Related Child Applications (1)

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JP2021019390A Division JP7181647B2 (ja) 2015-11-20 2021-02-09 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体

Publications (3)

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JP2018534314A JP2018534314A (ja) 2018-11-22
JP2018534314A5 JP2018534314A5 (enExample) 2019-12-26
JP6928605B2 true JP6928605B2 (ja) 2021-09-01

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JP2018525730A Active JP6928605B2 (ja) 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体
JP2021019390A Active JP7181647B2 (ja) 2015-11-20 2021-02-09 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体

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JP2021019390A Active JP7181647B2 (ja) 2015-11-20 2021-02-09 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体

Country Status (9)

Country Link
US (2) US10669284B2 (enExample)
EP (2) EP3939981B1 (enExample)
JP (2) JP6928605B2 (enExample)
CN (1) CN108495855B (enExample)
AU (1) AU2016355104B2 (enExample)
CA (2) CA3240011A1 (enExample)
ES (2) ES2981048T3 (enExample)
GB (1) GB201520500D0 (enExample)
WO (1) WO2017085484A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
ES2969988T3 (es) 2017-02-14 2024-05-23 Effector Therapeutics Inc Inhibidores de Mnk sustituidos con piperidina y métodos relacionados con los mismos
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
WO2020086713A1 (en) 2018-10-24 2020-04-30 Effector Therapeutics, Inc. Crystalline forms of mnk inhibitors
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用
AU2021300363A1 (en) * 2020-06-30 2023-02-09 4E Therapeutics, Inc. Pyridine-1,5-diones exhibiting MNK inhibition and their method of use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US20050165029A1 (en) * 2004-01-13 2005-07-28 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
EP1724268A4 (en) 2004-02-20 2010-04-21 Kirin Pharma Kk COMPOUNDS WITH TGF-BETA-HEMMENDER EFFECT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
JPWO2005095419A1 (ja) 2004-04-01 2008-02-21 武田薬品工業株式会社 チアゾロピリミジン誘導体
EP1773826A4 (en) 2004-07-02 2009-06-03 Exelixis Inc MODULATORS OF C-MET AND THEIR METHOD OF USE
US8633201B2 (en) * 2006-04-07 2014-01-21 Boehringer Ingelheim International Gmbh Thienopyrimidines having Mnk1/Mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008057402A2 (en) * 2006-11-02 2008-05-15 Cytovia, Inc. N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof
EP2219649A2 (en) * 2007-11-22 2010-08-25 Boehringer Ingelheim International Gmbh Use of mnk inhibitors for the treatment of alzheimer's disease
EP2331551B1 (en) * 2008-08-26 2016-06-29 Evotec International GmbH Thienopyrimidines for pharmaceutical compositions
UY33241A (es) * 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
JP5575274B2 (ja) * 2010-02-26 2014-08-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン
EP2539343B1 (en) * 2010-02-26 2015-12-30 Evotec International GmbH Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
CN102002044A (zh) * 2010-09-29 2011-04-06 中国药科大学 嘌呤-8-酮类及噻唑并嘧啶类衍生物及其制备方法和医药用途
ES2653419T3 (es) 2013-02-01 2018-02-07 Bayer Pharma Aktiengesellschaft Pirazolopirimidinilamino-indazoles sustituidos
US9675612B2 (en) 2013-03-06 2017-06-13 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
KR20160030239A (ko) * 2013-07-08 2016-03-16 바이엘 파마 악티엔게젤샤프트 치환된 피라졸로-피리딘아민

Also Published As

Publication number Publication date
US20200247822A1 (en) 2020-08-06
CA3003559C (en) 2024-09-10
CN108495855B (zh) 2022-05-31
JP2021073306A (ja) 2021-05-13
EP3939981A1 (en) 2022-01-19
AU2016355104A1 (en) 2018-05-24
US11136338B2 (en) 2021-10-05
JP2018534314A (ja) 2018-11-22
AU2016355104B2 (en) 2021-01-28
ES2893154T3 (es) 2022-02-08
ES2981048T3 (es) 2024-10-07
EP3377501B1 (en) 2021-08-18
US20180346483A1 (en) 2018-12-06
CA3003559A1 (en) 2017-05-26
CN108495855A (zh) 2018-09-04
US10669284B2 (en) 2020-06-02
GB201520500D0 (en) 2016-01-06
JP7181647B2 (ja) 2022-12-01
EP3939981B1 (en) 2024-04-03
EP3939981C0 (en) 2024-04-03
HK1253575A1 (en) 2019-06-21
WO2017085484A1 (en) 2017-05-26
CA3240011A1 (en) 2017-05-26
EP3377501A1 (en) 2018-09-26

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