GB201520500D0 - Compounds - Google Patents

Compounds

Info

Publication number
GB201520500D0
GB201520500D0 GBGB1520500.8A GB201520500A GB201520500D0 GB 201520500 D0 GB201520500 D0 GB 201520500D0 GB 201520500 A GB201520500 A GB 201520500A GB 201520500 D0 GB201520500 D0 GB 201520500D0
Authority
GB
United Kingdom
Prior art keywords
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1520500.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeArc
Original Assignee
Medical Research Council Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council Technology filed Critical Medical Research Council Technology
Priority to GBGB1520500.8A priority Critical patent/GB201520500D0/en
Publication of GB201520500D0 publication Critical patent/GB201520500D0/en
Priority to CN201680079581.XA priority patent/CN108495855B/zh
Priority to ES21190890T priority patent/ES2981048T3/es
Priority to CA3003559A priority patent/CA3003559C/en
Priority to JP2018525730A priority patent/JP6928605B2/ja
Priority to AU2016355104A priority patent/AU2016355104B2/en
Priority to EP21190890.0A priority patent/EP3939981B1/en
Priority to ES16801016T priority patent/ES2893154T3/es
Priority to CA3240011A priority patent/CA3240011A1/en
Priority to EP16801016.3A priority patent/EP3377501B1/en
Priority to US15/776,536 priority patent/US10669284B2/en
Priority to HK18112780.9A priority patent/HK1253575B/en
Priority to PCT/GB2016/053580 priority patent/WO2017085484A1/en
Priority to US16/855,701 priority patent/US11136338B2/en
Priority to JP2021019390A priority patent/JP7181647B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB1520500.8A 2015-11-20 2015-11-20 Compounds Ceased GB201520500D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB1520500.8A GB201520500D0 (en) 2015-11-20 2015-11-20 Compounds
PCT/GB2016/053580 WO2017085484A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors
EP21190890.0A EP3939981B1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors
CA3240011A CA3240011A1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors
CA3003559A CA3003559C (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as MNK inhibitors
JP2018525730A JP6928605B2 (ja) 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体
AU2016355104A AU2016355104B2 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as MNKs inhibitors
CN201680079581.XA CN108495855B (zh) 2015-11-20 2016-11-16 作为mnk抑制剂的稠合噻唑并嘧啶衍生物
ES16801016T ES2893154T3 (es) 2015-11-20 2016-11-16 Derivados de tiazolopirimidina fusionados como inhibidores de MNKs
ES21190890T ES2981048T3 (es) 2015-11-20 2016-11-16 Derivados de tiazolopirimidina fusionados como inhibidores de mnk
EP16801016.3A EP3377501B1 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors
US15/776,536 US10669284B2 (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as MNKS inhibitors
HK18112780.9A HK1253575B (en) 2015-11-20 2016-11-16 Fused thiazolopyrimidine derivatives as mnks inhibitors
US16/855,701 US11136338B2 (en) 2015-11-20 2020-04-22 Fused thiazolopyrimidine derivatives as MNKs inhibitors
JP2021019390A JP7181647B2 (ja) 2015-11-20 2021-02-09 Ｍｎｋ阻害剤としての縮合チアゾロピリミジン誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1520500.8A GB201520500D0 (en) 2015-11-20 2015-11-20 Compounds

Publications (1)

Publication Number Publication Date
GB201520500D0 true GB201520500D0 (en) 2016-01-06

Family

ID=55133106

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1520500.8A Ceased GB201520500D0 (en) 2015-11-20 2015-11-20 Compounds

Country Status (9)

Country Link
US (2) US10669284B2 (enExample)
EP (2) EP3377501B1 (enExample)
JP (2) JP6928605B2 (enExample)
CN (1) CN108495855B (enExample)
AU (1) AU2016355104B2 (enExample)
CA (2) CA3003559C (enExample)
ES (2) ES2981048T3 (enExample)
GB (1) GB201520500D0 (enExample)
WO (1) WO2017085484A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
MX394700B (es) 2017-02-14 2025-03-24 Effector Therapeutics Inc Inhibidores de mnk sustituidos con piperidina y métodos relacionados con los mismos.
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
KR20210102211A (ko) 2018-10-24 2021-08-19 이펙터 테라퓨틱스, 인크. Mnk 억제제의 결정질 형태
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用
AU2021300363A1 (en) * 2020-06-30 2023-02-09 4E Therapeutics, Inc. Pyridine-1,5-diones exhibiting MNK inhibition and their method of use
CN118146134A (zh) * 2024-02-07 2024-06-07 南方海洋科学与工程广东省实验室(湛江) 一种3-羟基吡咯烷衍生物及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
WO2005069865A2 (en) 2004-01-13 2005-08-04 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
EP1724268A4 (en) 2004-02-20 2010-04-21 Kirin Pharma Kk COMPOUNDS WITH TGF-BETA-HEMMENDER EFFECT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
US20080269238A1 (en) 2004-04-01 2008-10-30 Takeda Pharmaceutical Company Limited Thiazolopyrimidine Derivative
EP1773826A4 (en) 2004-07-02 2009-06-03 Exelixis Inc MODULATORS OF C-MET AND THEIR METHOD OF USE
EP2004656B1 (en) 2006-04-07 2013-07-10 Boehringer Ingelheim International GmbH Thienopyrimidines having mnk1 /mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008057402A2 (en) * 2006-11-02 2008-05-15 Cytovia, Inc. N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof
WO2009065596A2 (en) * 2007-11-22 2009-05-28 Develogen Aktiengesellschaft Use of mnk inhibitors for the treatment of alzheimer's disease
AU2009286734A1 (en) * 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
UY33245A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas
US8754079B2 (en) 2010-02-26 2014-06-17 Boehringer Ingelheim International Gmbh Cycloalkyl containing thienopyrimidines for pharmaceutical compositions
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
CN102002044A (zh) * 2010-09-29 2011-04-06 中国药科大学 嘌呤-8-酮类及噻唑并嘧啶类衍生物及其制备方法和医药用途
US9556181B2 (en) 2013-02-01 2017-01-31 Bayer Pharma Aktiengesellschaft Substituted pyrazolopyrimidinylamino-indazoles
US9675612B2 (en) 2013-03-06 2017-06-13 Bayer Pharma Aktiengesellschaft Substituted thiazolopyrimidines
AP2016009025A0 (en) * 2013-07-08 2016-02-29 Bayer Pharma AG Substituted pyrazolo-pyridinamines

Also Published As

Publication number Publication date
AU2016355104B2 (en) 2021-01-28
JP2018534314A (ja) 2018-11-22
HK1253575A1 (en) 2019-06-21
JP2021073306A (ja) 2021-05-13
ES2981048T3 (es) 2024-10-07
US10669284B2 (en) 2020-06-02
CA3003559A1 (en) 2017-05-26
JP6928605B2 (ja) 2021-09-01
EP3939981A1 (en) 2022-01-19
AU2016355104A1 (en) 2018-05-24
US20200247822A1 (en) 2020-08-06
EP3939981C0 (en) 2024-04-03
US20180346483A1 (en) 2018-12-06
ES2893154T3 (es) 2022-02-08
JP7181647B2 (ja) 2022-12-01
EP3377501B1 (en) 2021-08-18
CN108495855B (zh) 2022-05-31
WO2017085484A1 (en) 2017-05-26
US11136338B2 (en) 2021-10-05
EP3939981B1 (en) 2024-04-03
CN108495855A (zh) 2018-09-04
CA3003559C (en) 2024-09-10
CA3240011A1 (en) 2017-05-26
EP3377501A1 (en) 2018-09-26

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)