JP2020517618A - Ｅｈｍｔ２阻害剤との併用療法 - Google Patents

Ｅｈｍｔ２阻害剤との併用療法 Download PDF

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JP2020517618A
JP2020517618A JP2019556647A JP2019556647A JP2020517618A JP 2020517618 A JP2020517618 A JP 2020517618A JP 2019556647 A JP2019556647 A JP 2019556647A JP 2019556647 A JP2019556647 A JP 2019556647A JP 2020517618 A JP2020517618 A JP 2020517618A
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inhibitor
halo
alkyl
optionally substituted
independently
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JP2020517618A5 (OSRAM
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ジョン エマーソン キャンベル，
ジョン エマーソン キャンベル，
ケネス ウィリアム ダンカン，
ケネス ウィリアム ダンカン，
マリア アレジャンドラ ライモンディ，
マリア アレジャンドラ ライモンディ，
クリスティーン クラウス，
クリスティーン クラウス，
エレイン ペネブレ，
エレイン ペネブレ，
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エピザイム，インコーポレイティド
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Publication of JP2020517618A5 publication Critical patent/JP2020517618A5/ja
Priority to JP2022184887A priority Critical patent/JP2023009301A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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  • Molecular Biology (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019556647A 2017-04-21 2018-04-20 Ｅｈｍｔ２阻害剤との併用療法 Withdrawn JP2020517618A (ja)

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US201762488679P 2017-04-21 2017-04-21
US62/488,679 2017-04-21
US201762574147P 2017-10-18 2017-10-18
US62/574,147 2017-10-18
PCT/US2018/028609 WO2018195450A1 (en) 2017-04-21 2018-04-20 Combination therapies with ehmt2 inhibitors

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US (2) US11672800B2 (OSRAM)
EP (1) EP3612181A4 (OSRAM)
JP (2) JP2020517618A (OSRAM)
CN (2) CN118021814A (OSRAM)
AU (1) AU2018254577B2 (OSRAM)
CA (1) CA3060416A1 (OSRAM)
WO (1) WO2018195450A1 (OSRAM)

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