|
US30985A
(en)
|
|
1860-12-18 |
|
Thomas l |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU651596B2
(en)
|
1990-06-05 |
1994-07-28 |
Immunex Corporation |
Type II interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
JP2938569B2
(ja)
|
1990-08-29 |
1999-08-23 |
ジェンファーム インターナショナル，インコーポレイティド |
異種免疫グロブリンを作る方法及びトランスジェニックマウス
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
AU2249592A
(en)
|
1991-06-14 |
1993-01-12 |
Dnx Corporation |
Production of human hemoglobin in transgenic pigs
|
|
DE69224906T2
(de)
|
1991-07-08 |
1998-10-29 |
Univ Massachusetts |
Thermotropes flüssig-kristallines segment-blockcopolymer
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
SG48760A1
(en)
|
1992-07-24 |
2003-03-18 |
Abgenix Inc |
Generation of xenogenetic antibodies
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
ES2301183T3
(es)
|
1996-12-03 |
2008-06-16 |
Amgen Fremont Inc. |
Anticuerpo completamente humano que se une al receptor del egfr.
|
|
US6878687B1
(en)
|
1997-03-07 |
2005-04-12 |
Human Genome Sciences, Inc. |
Protein HMAAD57
|
|
WO1998039446A2
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
70 human secreted proteins
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
EP1090118A2
(en)
|
1998-06-26 |
2001-04-11 |
Incyte Pharmaceuticals, Inc. |
Human signal peptide-containing proteins
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
AUPQ873300A0
(en)
|
2000-07-12 |
2000-08-03 |
Medvet Science Pty. Ltd. |
A binding motif of a receptor (2)
|
|
PT2857516T
(pt)
|
2000-04-11 |
2017-08-28 |
Genentech Inc |
Anticorpos multivalentes e utilizações dos mesmos
|
|
US7858094B2
(en)
|
2000-12-08 |
2010-12-28 |
Geneprint Corporation |
TREM-1 splice variant for use in modifying immune responses
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2342376C
(en)
|
2001-03-20 |
2013-11-12 |
Marco Colonna |
A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8231878B2
(en)
|
2001-03-20 |
2012-07-31 |
Cosmo Research & Development S.P.A. |
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
|
JP4317010B2
(ja)
|
2001-07-25 |
2009-08-19 |
ピーディーエル バイオファーマ，インコーポレイティド |
ＩｇＧ抗体の安定な凍結乾燥医薬製剤
|
|
EP2316485A1
(en)
|
2001-10-12 |
2011-05-04 |
Schering Corporation |
Use of bispecific antibodies to regulate immune responses
|
|
WO2003080667A2
(en)
|
2002-03-22 |
2003-10-02 |
Bioxell S.P.A. |
A novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
EP1508340A4
(en)
|
2002-05-24 |
2009-07-01 |
Takeda Pharmaceutical |
MEANS FOR IMPROVING INSULIN RESISTANCE
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
GB0401730D0
(en)
|
2004-01-27 |
2004-03-03 |
Bioxell Spa |
Diagnosis method
|
|
CN102139106B
(zh)
|
2004-05-27 |
2014-10-08 |
克鲁塞尔荷兰公司 |
能中和狂犬病病毒的结合分子及其应用
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
US8101345B1
(en)
|
2005-03-25 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Proinflammatory nucleic acids
|
|
KR20060135280A
(ko)
|
2005-06-24 |
2006-12-29 |
전남대학교산학협력단 |
선천성 면역에 관여하는 트렘-2의 클로닝
|
|
EP1959969A2
(en)
|
2005-07-01 |
2008-08-27 |
The Johns Hopkins University |
Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
|
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
|
SG170750A1
(en)
|
2006-03-17 |
2011-05-30 |
Biogen Idec Inc |
Stabilized polypeptide compositions
|
|
DE202006007499U1
(de)
|
2006-05-11 |
2007-01-11 |
Osaka University |
Verwendung einer Zusammensetzung, die Plexin-A1-DAP12-Interaktion inhibiert, zur Behandlung von Entzündungs-, Autoimmun- oder Knochenresorptionserkrankungen
|
|
MX380352B
(es)
|
2006-06-12 |
2025-03-12 |
Aptevo Res & Development Llc |
Proteinas de union multivalentes monocatenarias con funcion efectora.
|
|
CA2551163A1
(en)
|
2006-07-17 |
2008-01-17 |
Boehringer Ingelheim International Gmbh |
Methods for treating inflammatory, autoimmune or bone resorption diseases
|
|
US7553936B2
(en)
|
2006-12-04 |
2009-06-30 |
The United States of America as represented by Secretary Department of Health and Human Services |
Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
|
|
EP2121750A2
(en)
|
2007-01-16 |
2009-11-25 |
Wyeth |
Inflammation treatment, detection and monitoring via trem-1
|
|
US8280711B2
(en)
|
2007-03-12 |
2012-10-02 |
ESBATech, an Alcon Biomedical Research Unit, LLC. |
Sequence based engineering and optimization of single chain antibodies
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
WO2009000099A2
(en)
|
2007-06-25 |
2008-12-31 |
Esbatech Ag |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
GR1007327B
(el)
|
2007-08-08 |
2011-06-27 |
Ευαγγελος Γιαμαρελλος-Μπουρμπουλης |
Ο διαλυτος υποδοχεας ενεργοποιησης των μυελοκυτταρων (strem-1) ως δεικτης αποτελεσματικοτητας της θεραπειας του πεπτικου ελκους
|
|
MX2010002683A
(es)
|
2007-09-14 |
2010-03-26 |
Amgen Inc |
Poblaciones de anticuerpos homogeneos.
|
|
TW200918553A
(en)
*
|
2007-09-18 |
2009-05-01 |
Amgen Inc |
Human GM-CSF antigen binding proteins
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
KR100960684B1
(ko)
|
2008-02-22 |
2010-05-31 |
전남대학교산학협력단 |
Ｇａ733-2 발현 억제제로서의 ｔｒｅｍ-2 유전자, 및 이를포함하는 형질전환 동물 및 이의 사용방법
|
|
US20110256213A1
(en)
|
2008-10-15 |
2011-10-20 |
The Board Of Trustees Of The University Of Illinois |
Phospholipid micellar and liposomal compositions and uses thereof
|
|
EP2424976B1
(en)
|
2009-04-28 |
2013-07-31 |
Life & Brain GmbH |
Method for obtaining human microglial precursor cells from pluripotent stem cells
|
|
WO2010132370A2
(en)
|
2009-05-11 |
2010-11-18 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Soluble tlt-1 for the treatment and diagnosis of sepsis
|
|
EP2711018A1
(en)
|
2009-06-22 |
2014-03-26 |
MedImmune, LLC |
Engineered Fc regions for site-specific conjugation
|
|
WO2011047097A2
(en)
|
2009-10-13 |
2011-04-21 |
Sigalov Alexander B |
Inhibition of trem receptor signaling with peptide variants
|
|
CN102038698A
(zh)
|
2009-10-14 |
2011-05-04 |
山东绿叶天然药物研究开发有限公司 |
莫诺苷的新用途
|
|
JO3244B1
(ar)
*
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
WO2011056997A1
(en)
*
|
2009-11-04 |
2011-05-12 |
Fabrus Llc |
Methods for affinity maturation-based antibody optimization
|
|
CN102127168A
(zh)
|
2010-01-19 |
2011-07-20 |
中国人民解放军第二军医大学 |
一种髓样细胞表达激发受体-1的重组融合蛋白及其应用
|
|
KR20110086460A
(ko)
|
2010-01-22 |
2011-07-28 |
한국교원대학교산학협력단 |
수용성 수용체 라이브러리 및 이를 이용한 사이토카인 발현 조절 유전자의 스크리닝 방법
|
|
HRP20201081T1
(hr)
|
2010-04-08 |
2021-01-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Inhibitorni peptidi porijeklom od trem-sličnog transkripta 1 (tlt-1) i njihove uporabe
|
|
CA2798120A1
(en)
|
2010-04-30 |
2011-11-03 |
Paul P. Tamburini |
Antibodies having reduced immunogenicity in a human
|
|
WO2012016333A1
(en)
|
2010-08-06 |
2012-02-09 |
University Health Network |
Biomarkers for malaria
|
|
US20130130354A1
(en)
|
2010-09-28 |
2013-05-23 |
CTI Salud S.A. |
Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
|
|
WO2012088302A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
UY33826A
(es)
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión con dominios trivariables y sus usos
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
CA2829628A1
(en)
|
2011-03-11 |
2012-09-20 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
KR20120112973A
(ko)
|
2011-04-04 |
2012-10-12 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 예방 또는 치료용 조성물
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
WO2013055958A1
(en)
|
2011-10-11 |
2013-04-18 |
Genentech, Inc. |
Improved assembly of bispecific antibodies
|
|
SG10201601746TA
(en)
|
2011-10-21 |
2016-04-28 |
Stemgenics Inc |
Functionalized nanoparticles for intracellular delivery of biologically active molecules
|
|
WO2013063702A1
(en)
|
2011-11-04 |
2013-05-10 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
EP2776061B1
(en)
|
2011-11-07 |
2019-08-14 |
MedImmune, LLC |
Multispecific and multivalent binding proteins and uses thereof
|
|
CA3111357A1
(en)
|
2011-12-23 |
2013-06-27 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
TWI450727B
(zh)
|
2011-12-29 |
2014-09-01 |
Ind Tech Res Inst |
抗人類輸鐵蛋白受體的單域抗體與其應用
|
|
CN102517287B
(zh)
|
2012-01-10 |
2013-09-11 |
广西大学 |
抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用
|
|
KR20130114951A
(ko)
|
2012-04-10 |
2013-10-21 |
한양대학교 산학협력단 |
폴리감마글루탐산을 포함하는 Ｔｈ17 매개성 질환 예방 또는 치료용 조성물
|
|
HRP20200875T8
(hr)
|
2012-09-07 |
2021-04-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Inhibitorni peptidi porijeklom od aktivirajućeg receptora eksprimiranog na mijeloidnim stanicama-1 (trem-1)-sličnog transkripta 1 (tlt-1) i nihove upotrebe
|
|
CN107892719B
(zh)
*
|
2012-10-04 |
2022-01-14 |
达纳－法伯癌症研究所公司 |
人单克隆抗-pd-l1抗体和使用方法
|
|
EP2912058A1
(en)
|
2012-10-23 |
2015-09-02 |
The Board of Regents of The University of Texas System |
Antibodies with engineered igg fc domains
|
|
WO2014074942A1
(en)
|
2012-11-08 |
2014-05-15 |
Illumina, Inc. |
Risk variants of alzheimer's disease
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9066928B1
(en)
*
|
2012-12-04 |
2015-06-30 |
University Of Kentucky Research Foundation |
Method, composition, and kit useful for treatment of alzheimer's disease
|
|
US9546203B2
(en)
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
|
IL242088B2
(en)
|
2013-05-20 |
2023-12-01 |
Genentech Inc |
Anti-transferrin receptor antibodies and methods of use
|
|
KR20150010326A
(ko)
|
2013-07-19 |
2015-01-28 |
전남대학교산학협력단 |
비만 및 제 2형 당뇨 또는 지방간의 예방 또는 치료용 바이아릴아마이드를 포함한 유도체 화합물
|
|
KR101402921B1
(ko)
|
2013-08-28 |
2014-06-02 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 치료를 위한 레스베라톨 유도체의 이용
|
|
CA2825821A1
(en)
|
2013-08-28 |
2015-02-28 |
Chiesi Farmaceutici S.P.A. |
1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis
|
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
|
CN103555829B
(zh)
|
2013-10-12 |
2015-10-21 |
厦门人瑞生物医药科技有限公司 |
一种检测trem2基因r47h突变的探针、试剂盒和方法
|
|
US20160327572A1
(en)
|
2014-01-06 |
2016-11-10 |
Children's Medical Center Corporation |
Biomarkers for Dementia and Dementia Related Neurological Disorders
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
CN103866041A
(zh)
|
2014-04-04 |
2014-06-18 |
厦门大学 |
帕金森病和脑白质疏松症的突变检测试剂盒及其检测方法
|
|
SI3129406T1
(sl)
|
2014-04-11 |
2019-04-30 |
Medimmune, Llc |
Konjugirane spojine, ki vsebujejo cisteinsko konstruirana protitelesa
|
|
CN105218669A
(zh)
|
2014-06-10 |
2016-01-06 |
河北翰林生物科技有限公司 |
制备抗人r47h-trem2突变体的人单克隆抗体的方法
|
|
WO2016004389A2
(en)
|
2014-07-03 |
2016-01-07 |
Abbvie Inc. |
Monovalent binding proteins
|
|
SI3172232T1
(sl)
|
2014-07-17 |
2024-05-31 |
Novo Nordisk A/S |
Na mesto usmerjena mutageneza protiteles TREM-1 za zmanjšanje viskoznosti
|
|
MX2017001531A
(es)
|
2014-08-08 |
2017-05-15 |
Alector Llc |
Anticuerpos anti-trem2 y metodos de uso de los mismos.
|
|
KR101756417B1
(ko)
|
2014-08-21 |
2017-07-10 |
한국유나이티드제약 주식회사 |
금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물
|
|
US10428143B2
(en)
|
2014-09-28 |
2019-10-01 |
The Regents Of The University Of California |
Modulation of stimulatory and non-stimulatory myeloid cells
|
|
WO2016064895A1
(en)
|
2014-10-20 |
2016-04-28 |
The Brigham And Women's Hospital, Inc. |
Targeting apolipoprotein e (apoe) in neurologic disease
|
|
US10081792B2
(en)
|
2014-12-31 |
2018-09-25 |
Wisconsin Alumni Research Foundation |
Derivation of human microglia from pluripotent stem cells
|
|
PT3283508T
(pt)
|
2015-04-17 |
2021-06-21 |
Alpine Immune Sciences Inc |
Proteínas imuno modulatórias com afinidades afináveis
|
|
CA2986431C
(en)
|
2015-05-18 |
2020-04-14 |
Synaptec Development Llc |
Galantamine clearance of amyloid.beta.
|
|
AU2016276981B2
(en)
|
2015-06-12 |
2022-10-06 |
Alector Llc |
Anti-CD33 antibodies and methods of use thereof
|
|
WO2016201389A2
(en)
|
2015-06-12 |
2016-12-15 |
Alector Llc |
Anti-cd33 antibodies and methods of use thereof
|
|
WO2017007712A1
(en)
|
2015-07-04 |
2017-01-12 |
Emory University |
Use of trem-1 inhibitors for treatment, elimination and eradication of hiv-1 infection
|
|
WO2017011342A1
(en)
|
2015-07-10 |
2017-01-19 |
Abbvie Inc. |
Igm-or-ige-modified binding proteins and uses thereof
|
|
SI3328419T1
(sl)
*
|
2015-07-30 |
2021-11-30 |
Macrogenics, Inc. |
PD-1-vezavne molekule in postopki uporabe le-teh
|
|
WO2017040301A1
(en)
|
2015-08-28 |
2017-03-09 |
Alector Llc |
Anti-siglec-7 antibodies and methods of use thereof
|
|
WO2017058866A1
(en)
|
2015-09-28 |
2017-04-06 |
Precision Immune, Inc. |
Anti-trem2 antibodies and uses thereof
|
|
JP7725185B2
(ja)
|
2015-10-06 |
2025-08-19 |
アレクトル エルエルシー |
抗ｔｒｅｍ２抗体及びその使用方法
|
|
KR20180084817A
(ko)
|
2015-10-29 |
2018-07-25 |
알렉터 엘엘씨 |
항-siglec-9 항체 및 이의 이용 방법
|
|
US20170218058A1
(en)
|
2016-01-28 |
2017-08-03 |
Alector, LLC |
Anti-apoe4 antigen-binding proteins and methods of use thereof
|
|
EP3442543A4
(en)
|
2016-02-11 |
2020-01-22 |
The Johns Hopkins University |
COMPOSITIONS AND METHODS FOR NEUROGENESIS
|
|
US11066456B2
(en)
|
2016-02-25 |
2021-07-20 |
Washington University |
Compositions comprising TREM2 and methods of use thereof
|
|
US11472877B2
(en)
|
2016-03-04 |
2022-10-18 |
Alector Llc |
Anti-TREM1 antibodies and methods of use thereof
|
|
US10875919B2
(en)
|
2016-04-26 |
2020-12-29 |
Alector Llc |
Chimeric receptors and methods of use thereof
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
US11944665B2
(en)
|
2016-06-01 |
2024-04-02 |
University Of Virginia Patent Foundation |
Methods and compositions for modulating lymphatic vessels in the central nervous system
|
|
US10941200B2
(en)
|
2016-07-22 |
2021-03-09 |
Deutsches Zentrum Für Neurodegenerative Erkrankungen Ev |
TREM2 cleavage modulators and uses thereof
|
|
CN106244682B
(zh)
|
2016-07-29 |
2019-11-26 |
中山大学 |
Trem-2基因在鉴别猪对蓝耳病毒易感性中的应用
|
|
CN106636330B
(zh)
|
2016-09-21 |
2017-12-15 |
郁金泰 |
阿尔茨海默病的诊断和治疗药物
|
|
WO2018071898A1
(en)
|
2016-10-14 |
2018-04-19 |
Children's Medical Center Corporation |
Compositions and methods for treating diseases and disorders of the central nervous system
|
|
CA3044684A1
(en)
|
2016-12-09 |
2018-06-14 |
Alector Llc |
Anti-sirp-alpha antibodies and methods of use thereof
|
|
JP2020515813A
(ja)
|
2016-12-23 |
2020-05-28 |
ジェナボン バイオファーマシューティカルズ エルエルシー |
アルツハイマー病の診断および治療においてｇｍ６を使用する方法
|
|
US20190343882A1
(en)
|
2017-01-12 |
2019-11-14 |
Duke University |
Compositions and Methods for the Treatment of Demyelinating Conditions
|
|
EP3570883A2
(en)
|
2017-01-17 |
2019-11-27 |
Yeda Research and Development Co. Ltd |
Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
|
|
WO2018136598A1
(en)
|
2017-01-18 |
2018-07-26 |
Evelo Biosciences, Inc. |
Methods of treating cancer
|
|
US20190336615A1
(en)
|
2017-01-27 |
2019-11-07 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
US10143187B2
(en)
|
2017-02-17 |
2018-12-04 |
Denali Therapeutics Inc. |
Transferrin receptor transgenic models
|
|
WO2018157014A1
(en)
|
2017-02-24 |
2018-08-30 |
Duke University |
Metabolic biomarkers for the identification and characterization of alzheimer's disease
|
|
EP3589293A4
(en)
|
2017-02-28 |
2020-12-16 |
The Regents of the University of California |
DIFFERENTIATION AND USE OF HUMAN MICROGLIA-TYPE CELLS FROM PLURIPOTENT STEM CELLS AND HEMATOPOIETIC PROGENITORS
|
|
US11957115B2
(en)
|
2017-03-21 |
2024-04-16 |
The Jackson Laboratory |
Genetically modified mouse expressing human APOE4 and mouse Trem2 p.R47H and methods of use thereof
|
|
KR101936249B1
(ko)
|
2017-04-04 |
2019-01-08 |
경희대학교 산학협력단 |
쿠마타케닌을 포함하는 암의 예방, 개선 또는 치료용 조성물
|
|
JOP20190248A1
(ar)
|
2017-04-21 |
2019-10-20 |
Amgen Inc |
بروتينات ربط مولد ضد trem2 واستخداماته
|
|
US20180318379A1
(en)
|
2017-05-01 |
2018-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of triggering receptor expressed on myeloid cells 1 (trem1) to treat central nervous system disorders
|
|
US11359014B2
(en)
|
2017-05-16 |
2022-06-14 |
Alector Llc |
Anti-siglec-5 antibodies and methods of use thereof
|
|
CA3065999A1
(en)
|
2017-05-24 |
2018-11-29 |
Nanosomix, Inc. |
Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders
|
|
US11149094B2
(en)
|
2017-06-05 |
2021-10-19 |
Janssen Biotech, Inc. |
Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations
|
|
CN111148761B
(zh)
|
2017-06-25 |
2024-02-13 |
西雅图免疫公司 |
多特异性抗体及其制备和使用方法
|
|
US20190008812A1
(en)
|
2017-07-07 |
2019-01-10 |
Washington University |
Methods for treating microglial dysfunction
|
|
CN109206503A
(zh)
|
2017-07-07 |
2019-01-15 |
厦门大学 |
一种蛋白用于制备防治阿尔茨海默病药物的用途
|
|
WO2019016784A1
(en)
|
2017-07-21 |
2019-01-24 |
Universidade De Coimbra |
ANTI-NUCLEOLIN ANTIBODIES
|
|
AU2018307877A1
(en)
|
2017-07-27 |
2020-01-02 |
Novartis Ag |
Sheddase resistant TREM2 variants
|
|
RS64419B1
(sr)
|
2017-08-03 |
2023-09-29 |
Alector Llc |
Anti-trem2 antitela i postupci za njihovu upotrebu
|
|
CN110662765B
(zh)
|
2017-08-03 |
2023-09-29 |
艾利妥 |
抗cd33抗体及其使用方法
|
|
JP7267280B2
(ja)
|
2017-08-08 |
2023-05-01 |
パイオニア イミュノセラピューティクス インコーポレイテッド |
Ｔｒｅｍ１を発現する骨髄細胞を無能化させるための組成物および方法
|
|
US20200277373A1
(en)
|
2017-09-14 |
2020-09-03 |
Denali Therapeutics Inc. |
Anti-trem2 antibodies and methods of use thereof
|
|
US11364303B2
(en)
|
2017-09-29 |
2022-06-21 |
Pfizer Inc. |
Cysteine engineered antibody drug conjugates
|
|
US12276670B2
(en)
|
2017-09-29 |
2025-04-15 |
The General Hospital Corporation |
Methods for identifying and treating adrenomyeloneuropathy (AMN)
|
|
KR102709597B1
(ko)
|
2017-10-03 |
2024-09-26 |
프리베일 테라퓨틱스, 인크. |
리소좀 장애를 위한 유전자 요법
|
|
US20210186917A1
(en)
|
2017-10-17 |
2021-06-24 |
The Translational Genomics Research Institute |
Trem2 agonists for the stimulation of microglia and methods of identification
|
|
US10597462B1
(en)
|
2017-11-08 |
2020-03-24 |
University Of Puerto Rico |
Anti-TLT-1 antibody and uses thereof
|
|
US11530258B2
(en)
|
2017-11-15 |
2022-12-20 |
UNIVERSITé LAVAL |
Use of SRSF3 agents for the treatment and/or prevention of neurological conditions, cancer, bacterial infections or viral infections
|
|
CN109837330A
(zh)
|
2017-11-28 |
2019-06-04 |
上海中优精准医疗科技股份有限公司 |
一种检测trem2基因多态性的探针及方法
|
|
EP3723803A4
(en)
|
2017-12-12 |
2021-09-15 |
Pionyr Immunotherapeutics, Inc. |
ANTI-TREM2 ANTIBODIES AND RELATED PROCEDURES
|
|
US11470827B2
(en)
|
2017-12-12 |
2022-10-18 |
Alector Llc |
Transgenic mice expressing human TREM proteins and methods of use thereof
|
|
US11472874B2
(en)
|
2018-01-31 |
2022-10-18 |
Alector Llc |
Anti-MS4A4A antibodies and methods of use thereof
|
|
WO2019161080A1
(en)
|
2018-02-14 |
2019-08-22 |
Yale University |
Compositions for modulation of a trem or treml protein and methods of use
|
|
NL2020520B1
(en)
|
2018-03-02 |
2019-09-12 |
Labo Bio Medical Invest B V |
Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
|
|
US12201619B2
(en)
|
2018-03-22 |
2025-01-21 |
Nsc Therapeutics Gmbh |
Compounds and methods for use in the treatment of microglia-mediated disorders
|
|
EA202092302A1
(ru)
|
2018-04-02 |
2021-02-02 |
Бристол-Майерс Сквибб Компани |
Антитела к trem-1 и их применения
|
|
WO2019199776A1
(en)
|
2018-04-09 |
2019-10-17 |
The General Hospital Corporation |
Combination therapies for the treatment of amyotropic lateral sclerosis and related disorders
|
|
CR20200566A
(es)
|
2018-05-25 |
2021-02-19 |
Alector Llc |
Anticuerpos anti-sirpa y metodos de utilización de los mismos
|
|
JP7382970B2
(ja)
|
2018-06-08 |
2023-11-17 |
アレクトル エルエルシー |
抗Ｓｉｇｌｅｃ－７抗体及びその使用方法
|
|
CN108752482B
(zh)
|
2018-06-12 |
2019-04-30 |
南京卡提医学科技有限公司 |
携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用
|
|
WO2019246483A1
(en)
|
2018-06-21 |
2019-12-26 |
The Jackson Laboratory |
Genetically modified mouse models of alzheimer's disease
|
|
CA3099176A1
(en)
|
2018-06-29 |
2020-01-02 |
Alector Llc |
Anti-sirp-beta1 antibodies and methods of use thereof
|
|
US11278575B2
(en)
|
2018-07-12 |
2022-03-22 |
Duke University |
Compositions and methods for the treatment of demyelinating conditions
|
|
CN112601552A
(zh)
|
2018-07-12 |
2021-04-02 |
科尔沃斯制药股份有限公司 |
用于检测和治疗具有腺苷途径激活的癌症的方法
|
|
WO2020018461A1
(en)
|
2018-07-16 |
2020-01-23 |
The University Of Virginia Patent Foundation |
Compositions and methods of diagnosis and treatment for neurological diseases
|
|
CN109112214A
(zh)
|
2018-07-27 |
2019-01-01 |
复旦大学附属中山医院 |
模式识别受体trem2在肝癌预后和治疗中的应用
|
|
EA202190183A1
(ru)
|
2018-07-27 |
2021-05-18 |
Алектор Ллс |
Антитела к siglec-5 и способы их применения
|
|
AU2019331018A1
(en)
|
2018-08-31 |
2021-03-11 |
Alector Llc |
Anti-cd33 antibodies and methods of use thereof
|
|
US20220218652A1
(en)
|
2018-09-05 |
2022-07-14 |
The General Hospital Corporation |
Methods of treating cytokine release syndrome
|
|
CA3111569A1
(en)
|
2018-09-11 |
2020-03-19 |
Washington University |
Anti-trem-2 agonist antibodies
|
|
WO2020056114A1
(en)
|
2018-09-12 |
2020-03-19 |
Board Of Regents Of The University Of Nebraska |
Antimicrobial compositions and methods
|
|
KR102831552B1
(ko)
|
2018-09-28 |
2025-07-08 |
이노트렘 |
항염 요법에 반응할 수 있는 대상체를 식별하기 위한 가용성 trem-1 수준의 용도
|
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
|
KR102096282B1
(ko)
|
2018-10-15 |
2020-04-02 |
재단법인대구경북과학기술원 |
재조합 베큘로바이러스를 이용한 인간 ｔｒｅｍ２ 세포막 단백질의 효율적인 정제방법
|
|
KR102156165B1
(ko)
|
2018-10-29 |
2020-09-15 |
재단법인대구경북과학기술원 |
인간 ｔｒｅｍ２ 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도
|
|
CN111135185A
(zh)
|
2018-11-02 |
2020-05-12 |
杭州星鳌生物科技有限公司 |
天然免疫激活通过调控髓系细胞触发受体trem2抑制大脑神经慢性炎症
|
|
EP3876956A4
(en)
|
2018-11-08 |
2022-12-28 |
The Regents of The University of California |
SYSTEMS AND METHODS FOR TARGETING CANCER CELLS
|
|
MA54296A
(fr)
|
2018-11-26 |
2021-10-06 |
Denali Therapeutics Inc |
Procédés de traitement du métabolisme lipidique dérégulé
|
|
US12351629B2
(en)
|
2018-12-10 |
2025-07-08 |
Mor Research Applications Ltd. |
TREM2 antibodies and uses thereof
|
|
WO2020132230A2
(en)
|
2018-12-20 |
2020-06-25 |
Genentech, Inc. |
Modified antibody fcs and methods of use
|
|
CN113543808A
(zh)
|
2019-01-04 |
2021-10-22 |
特瑞奥制药公司 |
多特异性蛋白质分子及其用途
|
|
CN109646668B
(zh)
|
2019-01-04 |
2019-10-18 |
厦门大学 |
一种多肽用于制备防治阿尔茨海默病药物的用途
|
|
EP3911363A1
(en)
|
2019-01-14 |
2021-11-24 |
University of Virginia Patent Foundation |
Use of integrin inhibitors for treatment or prevention of a neurological immunity disorder and/or nervous system injury
|
|
US20220104468A1
(en)
|
2019-01-22 |
2022-04-07 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
|
WO2020154348A1
(en)
|
2019-01-23 |
2020-07-30 |
The Regents Of The University Of California |
Human genomic construct reporter cells and mouse models to screen therapeutics against microglia-expressed disease associated genes
|
|
MA54880A
(fr)
|
2019-02-01 |
2021-12-08 |
Avrobio Inc |
Compositions et procédés de traitement de troubles neurocognitifs
|
|
KR20210122814A
(ko)
|
2019-02-01 |
2021-10-12 |
시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 |
조작된 유전자 발현을 조절하기 위한 미세환경 센서
|
|
CA3127804A1
(en)
|
2019-02-01 |
2020-08-06 |
Avrobio, Inc. |
Compositions and methods for treating neurocognitive disorders
|
|
EP3927743A1
(en)
|
2019-02-20 |
2021-12-29 |
Denali Therapeutics Inc. |
Anti-trem2 antibodies and methods of use thereof
|
|
WO2020194317A1
(en)
|
2019-03-28 |
2020-10-01 |
Yeda Research And Development Co. Ltd. |
Method of treating lipid-related disorders
|
|
CN110320368A
(zh)
|
2019-05-30 |
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