JP2020514376A5 - - Google Patents
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- JP2020514376A5 JP2020514376A5 JP2019551352A JP2019551352A JP2020514376A5 JP 2020514376 A5 JP2020514376 A5 JP 2020514376A5 JP 2019551352 A JP2019551352 A JP 2019551352A JP 2019551352 A JP2019551352 A JP 2019551352A JP 2020514376 A5 JP2020514376 A5 JP 2020514376A5
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- 150000001413 amino acids Chemical group 0.000 claims 114
- 229940127121 immunoconjugate Drugs 0.000 claims 27
- 208000002780 macular degeneration Diseases 0.000 claims 25
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 21
- 229920002674 hyaluronan Polymers 0.000 claims 21
- 229960003160 hyaluronic acid Drugs 0.000 claims 21
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- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 5
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- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 4
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical group COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims 4
- 102100038568 Age-related maculopathy susceptibility protein 2 Human genes 0.000 claims 4
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- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 4
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- 101000691214 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 50S ribosomal protein L44e Proteins 0.000 claims 4
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 claims 4
- 101000808726 Homo sapiens Age-related maculopathy susceptibility protein 2 Proteins 0.000 claims 4
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 4
- 101000875027 Homo sapiens Collagen alpha-1(X) chain Proteins 0.000 claims 4
- 101000878136 Homo sapiens Complement factor H-related protein 3 Proteins 0.000 claims 4
- 101000941289 Homo sapiens Hepatic triacylglycerol lipase Proteins 0.000 claims 4
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 4
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 4
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims 4
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- 229940123429 VEGFR tyrosine kinase inhibitor Drugs 0.000 claims 4
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- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims 4
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- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023018086A JP2023065424A (ja) | 2017-03-22 | 2023-02-09 | 眼障害の治療のために最適化された抗体組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762475163P | 2017-03-22 | 2017-03-22 | |
| US62/475,163 | 2017-03-22 | ||
| PCT/US2018/023812 WO2018175752A1 (en) | 2017-03-22 | 2018-03-22 | Optimized antibody compositions for treatment of ocular disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023018086A Division JP2023065424A (ja) | 2017-03-22 | 2023-02-09 | 眼障害の治療のために最適化された抗体組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020514376A JP2020514376A (ja) | 2020-05-21 |
| JP2020514376A5 true JP2020514376A5 (OSRAM) | 2021-05-06 |
| JPWO2018175752A5 JPWO2018175752A5 (OSRAM) | 2022-09-22 |
| JP7227151B2 JP7227151B2 (ja) | 2023-02-21 |
Family
ID=61837830
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551352A Active JP7227151B2 (ja) | 2017-03-22 | 2018-03-22 | 眼障害の治療のために最適化された抗体組成物 |
| JP2023018086A Withdrawn JP2023065424A (ja) | 2017-03-22 | 2023-02-09 | 眼障害の治療のために最適化された抗体組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023018086A Withdrawn JP2023065424A (ja) | 2017-03-22 | 2023-02-09 | 眼障害の治療のために最適化された抗体組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11111291B2 (OSRAM) |
| EP (1) | EP3600442A1 (OSRAM) |
| JP (2) | JP7227151B2 (OSRAM) |
| KR (1) | KR20190138636A (OSRAM) |
| CN (1) | CN110612124B (OSRAM) |
| AR (1) | AR111249A1 (OSRAM) |
| AU (1) | AU2018237359B2 (OSRAM) |
| BR (1) | BR112019019706A2 (OSRAM) |
| CA (1) | CA3056248A1 (OSRAM) |
| CL (1) | CL2019002658A1 (OSRAM) |
| CO (1) | CO2019011582A2 (OSRAM) |
| CR (1) | CR20190481A (OSRAM) |
| IL (1) | IL269378A (OSRAM) |
| MA (1) | MA49279A (OSRAM) |
| MX (1) | MX2019011141A (OSRAM) |
| MY (1) | MY201701A (OSRAM) |
| PE (1) | PE20191758A1 (OSRAM) |
| PH (1) | PH12019502149A1 (OSRAM) |
| SG (1) | SG11201908650PA (OSRAM) |
| TW (1) | TWI839327B (OSRAM) |
| UA (1) | UA129242C2 (OSRAM) |
| WO (1) | WO2018175752A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009120893A2 (en) | 2008-03-28 | 2009-10-01 | The Regents Of The University Of California | Polypeptide-polymer conjugates and methods of use thereof |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CN113546178A (zh) | 2015-12-09 | 2021-10-26 | 加利福尼亚大学董事会 | 治疗眼部疾病或病症的方法 |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| PL3448391T3 (pl) | 2016-04-27 | 2024-09-16 | AbbVie Manufacturing Management Unlimited Company | Sposoby leczenia chorób, w których jest szkodliwa aktywność il-13, przy zastosowaniu przeciwciała anty-il-13 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| JP7403553B2 (ja) * | 2019-08-06 | 2023-12-22 | エフ． ホフマン－ラ ロシュ アーゲー | 眼科の疾患の個別化された治療 |
| CA3149350A1 (en) * | 2019-08-23 | 2021-03-04 | Igm Biosciences, Inc. | Igm glycovariants |
| CN114786731A (zh) * | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| CN113493519B (zh) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | 一种半衰期显著延长的治疗眼部血管新生疾病的融合蛋白 |
| US20230201354A1 (en) * | 2020-05-15 | 2023-06-29 | The Regents Of The University Of Michigan | Carbon nanotubes and complexes thereof for treating and detecting ocular tumors |
| CN116234822A (zh) * | 2020-07-07 | 2023-06-06 | 治纳辅医药科技有限公司 | 一种包括补体途径抑制剂和血管生成抑制剂的融合蛋白及其用途 |
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