JP2016504416A5 - - Google Patents

Download PDF

Info

Publication number
JP2016504416A5
JP2016504416A5 JP2015552725A JP2015552725A JP2016504416A5 JP 2016504416 A5 JP2016504416 A5 JP 2016504416A5 JP 2015552725 A JP2015552725 A JP 2015552725A JP 2015552725 A JP2015552725 A JP 2015552725A JP 2016504416 A5 JP2016504416 A5 JP 2016504416A5
Authority
JP
Japan
Prior art keywords
antigen
binding fragment
antibody
beta
pdgfr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015552725A
Other languages
English (en)
Japanese (ja)
Other versions
JP6367233B2 (ja
JP2016504416A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/010395 external-priority patent/WO2014109999A1/en
Publication of JP2016504416A publication Critical patent/JP2016504416A/ja
Publication of JP2016504416A5 publication Critical patent/JP2016504416A5/ja
Application granted granted Critical
Publication of JP6367233B2 publication Critical patent/JP6367233B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015552725A 2013-01-09 2014-01-07 抗pdgfr−ベータ抗体及びそれらの使用 Active JP6367233B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361750437P 2013-01-09 2013-01-09
US61/750,437 2013-01-09
US201361863452P 2013-08-08 2013-08-08
US61/863,452 2013-08-08
US201361909421P 2013-11-27 2013-11-27
US61/909,421 2013-11-27
PCT/US2014/010395 WO2014109999A1 (en) 2013-01-09 2014-01-07 ANTI-PDGFR-beta ANTIBODIES AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2016504416A JP2016504416A (ja) 2016-02-12
JP2016504416A5 true JP2016504416A5 (OSRAM) 2017-02-09
JP6367233B2 JP6367233B2 (ja) 2018-08-01

Family

ID=50002880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015552725A Active JP6367233B2 (ja) 2013-01-09 2014-01-07 抗pdgfr−ベータ抗体及びそれらの使用

Country Status (21)

Country Link
US (3) US9265827B2 (OSRAM)
EP (1) EP2943218B1 (OSRAM)
JP (1) JP6367233B2 (OSRAM)
KR (1) KR102146692B1 (OSRAM)
CN (1) CN104936614B (OSRAM)
AU (3) AU2014205641B2 (OSRAM)
BR (1) BR112015016312B1 (OSRAM)
CA (1) CA2897383C (OSRAM)
CL (2) CL2015001924A1 (OSRAM)
EA (2) EA201890143A3 (OSRAM)
IL (2) IL239552B (OSRAM)
JO (1) JO3405B1 (OSRAM)
MX (1) MX363635B (OSRAM)
MY (1) MY169165A (OSRAM)
NZ (1) NZ709683A (OSRAM)
PH (1) PH12015501493B1 (OSRAM)
SG (2) SG11201505035YA (OSRAM)
TW (1) TWI647239B (OSRAM)
UY (1) UY35258A (OSRAM)
WO (1) WO2014109999A1 (OSRAM)
ZA (1) ZA201504537B (OSRAM)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
MX2016000364A (es) 2013-07-12 2016-05-09 Ophthotech Corp Metodos para tratar o prevenir afecciones oftalmologicas.
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
RU2723940C2 (ru) * 2014-03-21 2020-06-18 Экс-Боди, Инк. Биспецифические антигенсвязывающие полипептиды
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
SG11201703428SA (en) 2014-11-10 2017-05-30 Hoffmann La Roche Bispecific antibodies and methods of use in ophthalmology
AU2015345322A1 (en) 2014-11-10 2017-04-06 F. Hoffmann-La Roche Ag Anti-PDGF-B antibodies and methods of use
WO2016075034A1 (en) 2014-11-10 2016-05-19 F. Hoffmann-La Roche Ag ANTI-IL-1beta ANTIBODIES AND METHODS OF USE
CA2963606A1 (en) 2014-11-10 2016-05-19 F.Hoffmann-La Roche Ag Anti-ang2 antibodies and methods of use
US20160144025A1 (en) * 2014-11-25 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and formulations for treating vascular eye diseases
JP2018506280A (ja) * 2015-02-06 2018-03-08 カドモン コーポレイション,リミティド ライアビリティ カンパニー 免疫調節薬
JP6836512B2 (ja) 2015-03-31 2021-03-03 イルドン ファーム カンパニー リミテッド 組織透過性ペプチドと抗血管内皮細胞成長因子製剤が融合された融合タンパク質を有効成分として含む眼疾患の予防及び治療用薬学的組成物
CN107849126B (zh) 2015-07-29 2022-04-08 阿勒根公司 仅有重链的抗ang-2抗体
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法(一)
PL3389636T3 (pl) 2015-12-16 2022-11-28 Regeneron Pharmaceuticals, Inc. Kompozycje i metody wytwarzania mikrocząstek białkowych
WO2017117464A1 (en) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Antibodies and conjugates thereof
BR112018076260A2 (pt) 2016-06-20 2019-03-26 Kymab Limited anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
CA3029332A1 (en) * 2016-07-01 2018-01-04 Ludwig Institute For Cancer Research Ltd Methods and compositions for pdgf-cc inhibition
KR102369014B1 (ko) 2016-08-16 2022-03-02 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
WO2018039499A1 (en) 2016-08-24 2018-03-01 Regeneron Pharmaceuticals, Inc. Host cell protein modification
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
CN109021104B (zh) * 2017-06-12 2022-08-12 上海睿智化学研究有限公司 一种抗人血小板衍生生长因子β受体的抗体及其应用
MX2020000228A (es) 2017-07-06 2020-08-10 Regeneron Pharma Proceso de cultivo celular para producir una glicoproteina.
JP7321159B2 (ja) 2017-12-22 2023-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 薬剤生成物不純物を特性決定するためのシステム及び方法
BR112020013336A2 (pt) 2018-01-31 2020-12-01 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário.
TWI786265B (zh) 2018-02-02 2022-12-11 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
MX2020008988A (es) 2018-02-28 2020-09-28 Regeneron Pharma Sistemas y metodos para la identificacion de contaminantes virales.
BR112020017872A2 (pt) 2018-03-02 2020-12-22 Kodiak Sciences Inc. Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
DK3768709T3 (da) 2018-03-19 2024-01-29 Regeneron Pharma Mikrochip-kapillærelektroforese-assays og reagenser
US12253490B2 (en) 2018-03-19 2025-03-18 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
GB201806918D0 (en) * 2018-04-27 2018-06-13 Enleofen Bio Pte Ltd Combination treatment for eye fibrosis
CN108586611B (zh) * 2018-04-28 2021-01-26 暨南大学 重组全人源抗破伤风毒素单克隆抗体
TW202016125A (zh) 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
BR112020026348A2 (pt) 2018-08-30 2021-03-30 Regeneron Pharmaceuticals, Inc. Método para avaliar a estequiometria e distribuição de tamanho de complexos de proteínas, para selecionar um medicamento de proteína principal e para caracterizar complexos de proteínas, e, composição farmacêutica
BR112021006352A2 (pt) 2018-10-05 2021-07-06 Univ Ewha Ind Collaboration anticorpo receptor de pdgf e uso do mesmo
FI3857237T3 (fi) 2019-01-16 2023-05-03 Regeneron Pharma Disulfidisidosten luonnehtimismenetelmiä
EP3935084B1 (en) * 2019-03-08 2024-06-12 LinXis B.V. Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation
CN114364693A (zh) 2019-05-03 2022-04-15 新加坡保健服务私人有限公司 代谢性疾病的治疗和预防
US20200363400A1 (en) 2019-05-13 2020-11-19 Regeneron Pharmaceuticals, Inc. Competitive Ligand Binding Assays
CN120334439A (zh) 2019-09-24 2025-07-18 里珍纳龙药品有限公司 用于色谱介质的使用和再生的系统及方法
WO2021072265A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN119318636A (zh) 2019-11-25 2025-01-17 里珍纳龙药品有限公司 使用非水性乳液的持续释放调配物
WO2021142086A1 (en) 2020-01-08 2021-07-15 Synthis Therapeutics, Inc. Alk5 inhibitor conjugates and uses thereof
EP4354145B1 (en) 2020-01-21 2025-09-17 Regeneron Pharmaceuticals, Inc. Deglycosylation methods for electrophoresis of glycosylated proteins
WO2021158110A1 (en) * 2020-02-07 2021-08-12 Biorion Technologies B.V. Platelet derived growth factor receptor (pdgfr) antibodies, conjugates, compositions, and uses thereof
BR112023003273A2 (pt) 2020-08-31 2023-05-02 Regeneron Pharma Estratégias de alimentação de asparagina para melhorar desempenho da cultura celular e mitigar variantes da sequência de asparagina
US20240325562A1 (en) * 2020-09-16 2024-10-03 Linxis B.V. Internalizing binding molecules
CA3191141A1 (en) 2020-11-25 2022-06-02 Hunter Chen Sustained release formulations using non-aqueous membrane emulsification
WO2022133135A1 (en) 2020-12-17 2022-06-23 Regeneron Pharmaceuticals, Inc. Fabrication of protein-encapsulating microgels
TW202233827A (zh) 2021-01-20 2022-09-01 美商再生元醫藥公司 改良細胞培養中蛋白質效價的方法
AR125585A1 (es) 2021-03-03 2023-08-02 Regeneron Pharma Sistemas y métodos para cuantificar y modificar la viscosidad de proteínas
IL305731A (en) 2021-03-26 2023-11-01 Regeneron Pharma Methods and systems for developing mixing protocols
BR112023024984A2 (pt) 2021-06-01 2024-02-20 Regeneron Pharma Tampão de amostra de eletroforese aquosa, método para identificar contaminantes ou impurezas em uma amostra de droga proteica, e, kit
TW202326138A (zh) 2021-09-08 2023-07-01 美商再生元醫藥公司 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法
CN118139881A (zh) 2021-09-20 2024-06-04 瑞泽恩制药公司 控制抗体异质性的方法
JP2024540835A (ja) 2021-10-07 2024-11-06 リジェネロン・ファーマシューティカルズ・インコーポレイテッド pHメーター較正及び補正
IL311245A (en) 2021-10-07 2024-05-01 Regeneron Pharma Systems and methods for pH modeling and control
CN118176167A (zh) 2021-10-26 2024-06-11 瑞泽恩制药公司 用于产生实验室用水和分配处于不同温度的实验室用水的系统和方法
CN119137473A (zh) 2022-03-18 2024-12-13 里珍纳龙药品有限公司 分析多肽变体的方法及系统
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition
EP4634659A1 (en) 2022-12-16 2025-10-22 Regeneron Pharmaceuticals, Inc. Methods and systems for assessing chromatographic column integrity
EP4655595A1 (en) 2023-01-25 2025-12-03 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
WO2024158880A1 (en) 2023-01-25 2024-08-02 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
TW202445138A (zh) 2023-02-01 2024-11-16 美商再生元醫藥公司 用於生物巨分子分析之具質譜法的不對稱流場流分離
WO2024178213A2 (en) 2023-02-22 2024-08-29 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
WO2024229136A1 (en) 2023-05-01 2024-11-07 Regeneron Pharmaceuticals, Inc. Multidose antibody drug products using phenol or benzyl alcohol
TW202528736A (zh) 2023-09-08 2025-07-16 美商再生元醫藥公司 用於評估層析管柱完整性的方法及系統
US20250095773A1 (en) 2023-09-18 2025-03-20 Regeneron Pharmaceuticals, Inc. Methods and systems for developing chromatography protocols
US20250109905A1 (en) 2023-09-29 2025-04-03 Regeneron Pharmaceuticals, Inc. Lyophilization using controlled nucleation
WO2025085594A1 (en) 2023-10-18 2025-04-24 Regeneron Pharmaceuticals, Inc. Rapid purification of monoclonal antibody from in-process upstream cell culture material
WO2025096932A1 (en) 2023-11-02 2025-05-08 Regeneron Pharmaceuticals, Inc. Methods for reducing lipase activity using stress
WO2025166281A1 (en) 2024-02-01 2025-08-07 Regeneron Pharmaceuticals, Inc. Platform for charge-detection mass spectrometry analysis of aavs
WO2025175164A1 (en) 2024-02-16 2025-08-21 Regeneron Pharmaceuticals, Inc. Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods
WO2025194043A1 (en) 2024-03-15 2025-09-18 Regeneron Pharmaceuticals, Inc. Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations
CN118440214B (zh) * 2024-04-02 2025-01-28 山东大学 一种靶向PDGFRβ的嵌合抗原受体、CAR-T细胞及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0584082B1 (en) 1991-01-31 2000-05-31 Cor Therapeutics, Inc. Domains of extracellular region of human platelet derived growth factor receptor polypeptides
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
NZ246242A (en) * 1991-12-02 1996-01-26 Cor Therapeutics Inc Inhibiting immunoglobulins acting on beta-platelet derived growth factor (pdgf)
US20020009443A1 (en) 1991-12-02 2002-01-24 Vanitha Ramakrishman Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
US5817310A (en) 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
US5620687A (en) 1993-02-25 1997-04-15 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors
US5882644A (en) 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
PL1660057T3 (pl) 2003-08-27 2012-10-31 Ophthotech Corp Terapia łączona do leczenia zaburzeń związanych z neowaskularyzacją gałki ocznej
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
CA2652976C (en) 2006-06-02 2015-08-11 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
BRPI0810374A2 (pt) * 2007-04-17 2014-10-29 Imclone Llc Inibidores específicos do pdgfrbeta
EP2155238B1 (en) 2007-06-05 2016-04-06 Yale University Antibody against d4 domain of the kit receptor and use thereor
WO2009026204A1 (en) 2007-08-22 2009-02-26 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
US9187535B2 (en) 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
EP2604280A3 (en) * 2008-03-27 2013-10-16 ZymoGenetics, Inc. Compositions and methods for inhibiting PDGFRBETA and VEGF-A
EP3165606A1 (en) 2009-05-01 2017-05-10 Ophthotech Corporation Methods for treating or preventing ophthalmological diseases
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
MX385629B (es) 2011-01-13 2025-03-18 Regeneron Pharma Uso de un antagonista de factor de crecimiento endotelial vascular para tratar trastornos oculares angiogenicos.
CN102250246A (zh) 2011-06-10 2011-11-23 常州亚当生物技术有限公司 抗VEGF/PDGFRβ双特异性抗体及其应用
CN102250249A (zh) 2011-06-18 2011-11-23 常州亚当生物技术有限公司 一种抗VEGF/PDGFRbeta双特异性抗体及其应用

Similar Documents

Publication Publication Date Title
JP2016504416A5 (OSRAM)
JP6877500B2 (ja) TGF−βに特異的な抗体
RU2015121755A (ru) Антагонисты ил-6 и их применение
CN109988237B (zh) 检查点调节物拮抗剂
JP7695187B2 (ja) HPTP-β(VE-PTP)およびVEGFを標的にする多特異性抗体
JP7107914B2 (ja) VE-PTP(HPTP-β)を標的化するヒト化モノクローナル抗体
JP2017535285A5 (OSRAM)
RU2014113046A (ru) Профилактика и лечение патологических состояний глаз, вызванных комплементом
WO2008154251A4 (en) C3b antibodies and methods for the prevention and treatment of complement- associated disorders
JP2019515027A5 (OSRAM)
JP2020514376A5 (OSRAM)
RU2012107286A (ru) Высокоаффинные человеческие антитела к человеческому ангиопоэтину-2
JP2013528607A5 (OSRAM)
JP2019510078A5 (OSRAM)
JP2012165745A5 (OSRAM)
JP2018510617A5 (OSRAM)
JP6446560B2 (ja) VEGFA/Ang2化合物
JP2018093875A5 (OSRAM)
JP2018527327A5 (OSRAM)
JP2017502023A (ja) 眼疾患を治療する組成物および方法
HRP20251312T1 (hr) Poboljšana protutijela za il-6
JP2021507677A5 (OSRAM)
CN113166244B (zh) 稳定性得到提高的抗c-肝细胞生长因子受体抗体或其抗原结合片段
CN105007939A (zh) 人抗vegfr-2/kdr抗体
JP2011503094A5 (OSRAM)