JP2020512380A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020512380A5 JP2020512380A5 JP2019553556A JP2019553556A JP2020512380A5 JP 2020512380 A5 JP2020512380 A5 JP 2020512380A5 JP 2019553556 A JP2019553556 A JP 2019553556A JP 2019553556 A JP2019553556 A JP 2019553556A JP 2020512380 A5 JP2020512380 A5 JP 2020512380A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- crystal
- slurry
- pyridazine
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- 239000002002 slurry Substances 0.000 claims 18
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 claims 13
- -1 methyl-d 3 Chemical class 0.000 claims 9
- 230000032683 aging Effects 0.000 claims 7
- DMYLUKNFEYWGCH-UHFFFAOYSA-N pyridazine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=N1 DMYLUKNFEYWGCH-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000706 filtrate Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000001144 powder X-ray diffraction data Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 235000019439 ethyl acetate Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000010935 polish filtration Methods 0.000 claims 2
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 claims 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000001757 thermogravimetry curve Methods 0.000 claims 1
- BAVYZALUXZFZLV-FIBGUPNXSA-N trideuteriomethanamine Chemical compound [2H]C([2H])([2H])N BAVYZALUXZFZLV-FIBGUPNXSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023010810A JP7476370B2 (ja) | 2017-03-30 | 2023-01-27 | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１Ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－Ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762478789P | 2017-03-30 | 2017-03-30 | |
| US62/478,789 | 2017-03-30 | ||
| PCT/US2018/025114 WO2018183656A1 (en) | 2017-03-30 | 2018-03-29 | Crystal form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010810A Division JP7476370B2 (ja) | 2017-03-30 | 2023-01-27 | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１Ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－Ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512380A JP2020512380A (ja) | 2020-04-23 |
| JP2020512380A5 true JP2020512380A5 (https=) | 2021-05-06 |
| JP7260481B2 JP7260481B2 (ja) | 2023-04-18 |
Family
ID=62002470
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553452A Active JP7113023B2 (ja) | 2017-03-30 | 2018-03-29 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP2019553556A Active JP7260481B2 (ja) | 2017-03-30 | 2018-03-29 | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１Ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－Ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 |
| JP2022117894A Active JP7457758B2 (ja) | 2017-03-30 | 2022-07-25 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP2023010810A Active JP7476370B2 (ja) | 2017-03-30 | 2023-01-27 | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１Ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－Ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 |
| JP2023208420A Active JP7837938B2 (ja) | 2017-03-30 | 2023-12-11 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP2025284416A Pending JP2026067880A (ja) | 2017-03-30 | 2025-12-26 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553452A Active JP7113023B2 (ja) | 2017-03-30 | 2018-03-29 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022117894A Active JP7457758B2 (ja) | 2017-03-30 | 2022-07-25 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP2023010810A Active JP7476370B2 (ja) | 2017-03-30 | 2023-01-27 | ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１Ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－Ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶形態 |
| JP2023208420A Active JP7837938B2 (ja) | 2017-03-30 | 2023-12-11 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| JP2025284416A Pending JP2026067880A (ja) | 2017-03-30 | 2025-12-26 | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US20200239449A1 (https=) |
| EP (4) | EP3601268B1 (https=) |
| JP (6) | JP7113023B2 (https=) |
| KR (4) | KR102642407B1 (https=) |
| CN (4) | CN110475774B (https=) |
| AU (3) | AU2018244451B2 (https=) |
| CA (2) | CA3058209A1 (https=) |
| CY (1) | CY1124194T1 (https=) |
| DK (1) | DK3601268T3 (https=) |
| EA (2) | EA201992308A1 (https=) |
| ES (2) | ES2970229T3 (https=) |
| HR (1) | HRP20210764T1 (https=) |
| HU (1) | HUE054886T2 (https=) |
| IL (3) | IL269586B (https=) |
| LT (1) | LT3601268T (https=) |
| MX (4) | MX2019011231A (https=) |
| PL (1) | PL3601268T3 (https=) |
| PT (1) | PT3601268T (https=) |
| RS (1) | RS61816B1 (https=) |
| SG (2) | SG11201909018VA (https=) |
| SI (1) | SI3601268T1 (https=) |
| SM (1) | SMT202100239T1 (https=) |
| WO (2) | WO2018183656A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3495358T (lt) | 2012-11-08 | 2022-05-25 | Bristol-Myers Squibb Company | Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai |
| JP7113023B2 (ja) * | 2017-03-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| KR102848769B1 (ko) * | 2018-05-31 | 2025-08-20 | 브리스톨-마이어스 스큅 컴퍼니 | 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3) 피리다진-3-카르복스아미드의 결정질 형태 |
| CN115448910B (zh) * | 2019-01-28 | 2024-04-19 | 江苏豪森药业集团有限公司 | 一种哒嗪类衍生物抑制剂、其制备方法和应用 |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| US12570637B2 (en) | 2019-06-12 | 2026-03-10 | Bristol-Myers Squibb Company | Crystalline salt forms 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyld3) pyridazine-3-carboxamide |
| JP7812785B2 (ja) | 2019-09-18 | 2026-02-10 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｙｋ２阻害薬の剤形 |
| CN114787152A (zh) * | 2019-12-27 | 2022-07-22 | 苏州科睿思制药有限公司 | 一种bms-986165晶型及其制备方法和用途 |
| WO2021143430A1 (zh) * | 2020-01-19 | 2021-07-22 | 苏州科睿思制药有限公司 | 一种bms-986165盐酸盐晶型及其制备方法和用途 |
| CN114787154A (zh) * | 2020-01-19 | 2022-07-22 | 苏州科睿思制药有限公司 | 一种Deucravacitinib的晶型及其制备方法和用途 |
| WO2021170046A1 (en) * | 2020-02-26 | 2021-09-02 | Beigene, Ltd. | Tyk-2 inhibitor |
| CN113735836B (zh) * | 2020-05-28 | 2023-05-30 | 江苏先声药业有限公司 | 哒嗪类化合物及其应用 |
| CN113773262B (zh) * | 2020-06-09 | 2024-08-09 | 江苏先声药业有限公司 | 哒嗪类化合物 |
| KR20230042278A (ko) | 2020-06-22 | 2023-03-28 | 베이진 엘티디 | Tyk-2 저해제 |
| CN115667246B (zh) * | 2020-07-24 | 2024-08-23 | 上海翰森生物医药科技有限公司 | 一种哒嗪类衍生物自由碱的晶型及其制备方法和应用 |
| WO2022021684A1 (zh) * | 2020-07-31 | 2022-02-03 | 苏州科睿思制药有限公司 | 一种bms-986165盐酸盐晶型csv及其制备方法和用途 |
| IL301389A (en) | 2020-09-18 | 2023-05-01 | Bristol Myers Squibb Co | Dosage forms for tyk2 inhibitors comprising swellable cores |
| WO2022083649A1 (zh) * | 2020-10-20 | 2022-04-28 | 杭州领业医药科技有限公司 | 哒嗪衍生物的晶型 |
| KR20230137962A (ko) * | 2021-01-29 | 2023-10-05 | 브리스톨-마이어스 스큅 컴퍼니 | 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3)피리다진-3-카르복스아미드의 결정 형태 |
| CN117377667A (zh) * | 2021-03-29 | 2024-01-09 | 百时美施贵宝公司 | 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的晶型 |
| PE20250262A1 (es) | 2021-05-14 | 2025-01-29 | Bristol Myers Squibb Co | Compuestos heterociclicos sustituidos |
| EP4387968B1 (en) | 2021-08-20 | 2025-11-12 | Bristol-Myers Squibb Company | Crystal forms of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide |
| EP4404930A1 (en) * | 2021-09-23 | 2024-07-31 | Bristol-Myers Squibb Company | Methods of treating hair-loss disorders with tyk2 inhibitors |
| JP2024539703A (ja) | 2021-10-28 | 2024-10-29 | ブリストル－マイヤーズ スクイブ カンパニー | デュークラバシチニブの局所製剤 |
| EP4441043A1 (en) | 2021-12-01 | 2024-10-09 | Teva Czech Industries s.r.o | Solid state forms of deucravacitinib, deucravacitinib hcl and process for preparation of deucravacitinib and intermediates |
| US12222104B2 (en) * | 2022-03-21 | 2025-02-11 | General Electric Company | Turbine engine combustor and combustor liner |
| WO2023181075A1 (en) * | 2022-03-24 | 2023-09-28 | Dr. Reddy's Laboratories Limited | Amorphous solid dispersions of deucravacitinib and processes for the preparation thereof |
| CN114989103B (zh) * | 2022-06-09 | 2024-07-09 | 杭州科巢生物科技有限公司 | 一种2-甲氧基-3-(1-甲基-1h-1,2,4-三唑-3-基)苯胺的制备方法 |
| CN117447411B (zh) * | 2022-07-18 | 2025-12-23 | 苏州鹏旭医药科技有限公司 | 一种杂环药物中间体的合成方法 |
| WO2024017150A1 (zh) * | 2022-07-18 | 2024-01-25 | 苏州鹏旭医药科技有限公司 | 一种氘可来昔替尼的合成方法 |
| WO2024088282A1 (zh) * | 2022-10-28 | 2024-05-02 | 浙江华海药业股份有限公司 | 一种哒嗪酰胺类化合物、其药物组合物及其作为tyk2抑制剂的用途 |
| EP4713315A1 (en) * | 2023-05-15 | 2026-03-25 | Alivus Life Sciences Limited | Process for the preparation of deucravacitinib, and crystalline forms thereof |
| EP4538259A1 (en) | 2023-10-09 | 2025-04-16 | Farmhispania Group, S.L. | Processes for the preparation of deucravacitinib |
| WO2025131031A1 (zh) * | 2023-12-22 | 2025-06-26 | 上海奥博生物医药股份有限公司 | 一种TyK2抑制剂及其中间体的制备方法 |
| WO2025173029A1 (en) * | 2024-02-14 | 2025-08-21 | Natco Pharma Limited | An improved process for the preparation of deucravacitinib |
| WO2025186427A1 (en) | 2024-03-08 | 2025-09-12 | Curia Spain, S.A.U. | Process for the preparation of deucravacitinib and intermediates thereof and method for purifying deucravacitinib |
| WO2025259267A1 (en) | 2024-06-11 | 2025-12-18 | Vector Vitale Ip Llc | Pharmaceutical compositions for modulating inflammation and oxidative stress comprising chemically enriched elements |
| ES3059443A1 (es) | 2024-09-17 | 2026-03-20 | Moehs Iberica Sl | Forma solida de 6-(ciclopropanocarboxamido)-4-((2-metoxi-3-(1-metil-1h-1,2,4-triazol-3-il)fenil)amino)piridazine-3-carboxilato de metilo o una sal del mismo, procedimiento para su preparacion y su uso en la sintesis de deucravacitinib |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6023649B2 (ja) | 1976-09-08 | 1985-06-08 | 東ソー株式会社 | 臭化水素酸による臭化メチルの製造方法 |
| JPS5455501A (en) | 1977-10-05 | 1979-05-02 | Toyo Soda Mfg Co Ltd | Continuous preparation of methyl bromide |
| US4254061A (en) * | 1979-09-11 | 1981-03-03 | E. I. Du Pont De Nemours And Company | Preparation of monomethylamine |
| ATE288420T1 (de) * | 1999-06-09 | 2005-02-15 | Yamanouchi Pharma Co Ltd | Neuartige heterocyclische carboxamid-derivate |
| CN100579579C (zh) | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
| CA2549385A1 (en) | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Triazole, oxadiazole and thiadiazole derivative as ppar modulators for the treatment of diabetes |
| EP1931466B1 (de) * | 2005-09-29 | 2012-11-14 | Basf Se | Formkörper enthaltend ein alumosilikat und aluminiumoxid und verfahren zur kontinuierlichen herstellung von methylaminen |
| KR20090111847A (ko) | 2007-01-19 | 2009-10-27 | 아디아 바이오사이언스즈 인크. | Ｍｅｋ 억제제 |
| BR112012006956A2 (pt) * | 2009-10-12 | 2015-09-15 | Bayer Cropscience Ag | 1- (pirida-3-il) -pirazóisol e 1- (pirimida-5-il) - pirazóisol como pesticidas |
| EP2542089B1 (en) * | 2010-03-05 | 2017-01-18 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
| JP5433087B2 (ja) * | 2010-03-18 | 2014-03-05 | ▲蘇▼州▲澤▼▲ジン▼生物制▲薬▼有限公司 | 重水素化メチルアミン及びその塩の製造方法 |
| WO2013047813A1 (ja) | 2011-09-30 | 2013-04-04 | 大鵬薬品工業株式会社 | １，２，４－トリアジン－６－カルボキサミド誘導体 |
| WO2013091011A1 (en) * | 2011-12-21 | 2013-06-27 | Biota Europe Ltd | Heterocyclic urea compounds |
| CN104159891B (zh) | 2012-01-10 | 2016-09-07 | 霍夫曼-拉罗奇有限公司 | 哒嗪酰胺化合物和它们作为syk 抑制剂的用途 |
| WO2013171643A1 (en) | 2012-05-14 | 2013-11-21 | Piramal Enterprises Limited | An improved process for preparation of irbesartan |
| LT3495358T (lt) * | 2012-11-08 | 2022-05-25 | Bristol-Myers Squibb Company | Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai |
| KR102233252B1 (ko) * | 2012-11-08 | 2021-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | ＩＬ-12, ＩＬ-23 및/또는 ＩＦＮα 반응의 조절제로서 유용한 알킬-아미드-치환된 피리딜 화합물 |
| TWI582077B (zh) | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| JP7113023B2 (ja) * | 2017-03-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| KR102848769B1 (ko) * | 2018-05-31 | 2025-08-20 | 브리스톨-마이어스 스큅 컴퍼니 | 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3) 피리다진-3-카르복스아미드의 결정질 형태 |
| JP7631193B2 (ja) * | 2018-10-22 | 2025-02-18 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| KR20230137962A (ko) * | 2021-01-29 | 2023-10-05 | 브리스톨-마이어스 스큅 컴퍼니 | 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3)피리다진-3-카르복스아미드의 결정 형태 |
| CN117377667A (zh) * | 2021-03-29 | 2024-01-09 | 百时美施贵宝公司 | 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的晶型 |
-
2018
- 2018-03-29 JP JP2019553452A patent/JP7113023B2/ja active Active
- 2018-03-29 HU HUE18718340A patent/HUE054886T2/hu unknown
- 2018-03-29 ES ES21155321T patent/ES2970229T3/es active Active
- 2018-03-29 SI SI201830252T patent/SI3601268T1/sl unknown
- 2018-03-29 PT PT187183405T patent/PT3601268T/pt unknown
- 2018-03-29 IL IL269586A patent/IL269586B/en unknown
- 2018-03-29 IL IL269594A patent/IL269594B2/en unknown
- 2018-03-29 SG SG11201909018V patent/SG11201909018VA/en unknown
- 2018-03-29 EP EP18718340.5A patent/EP3601268B1/en active Active
- 2018-03-29 RS RS20210559A patent/RS61816B1/sr unknown
- 2018-03-29 CN CN201880021649.8A patent/CN110475774B/zh active Active
- 2018-03-29 JP JP2019553556A patent/JP7260481B2/ja active Active
- 2018-03-29 AU AU2018244451A patent/AU2018244451B2/en active Active
- 2018-03-29 MX MX2019011231A patent/MX2019011231A/es unknown
- 2018-03-29 MX MX2019011092A patent/MX392693B/es unknown
- 2018-03-29 IL IL305615A patent/IL305615A/en unknown
- 2018-03-29 CA CA3058209A patent/CA3058209A1/en active Pending
- 2018-03-29 LT LTEP18718340.5T patent/LT3601268T/lt unknown
- 2018-03-29 EA EA201992308A patent/EA201992308A1/ru unknown
- 2018-03-29 US US15/767,388 patent/US20200239449A1/en not_active Abandoned
- 2018-03-29 KR KR1020197031635A patent/KR102642407B1/ko active Active
- 2018-03-29 US US16/498,442 patent/US10899745B2/en active Active
- 2018-03-29 EP EP21155321.9A patent/EP3882237B1/en active Active
- 2018-03-29 KR KR1020247034512A patent/KR102857398B1/ko active Active
- 2018-03-29 PL PL18718340T patent/PL3601268T3/pl unknown
- 2018-03-29 SG SG11201908947Q patent/SG11201908947QA/en unknown
- 2018-03-29 EP EP18718991.5A patent/EP3601270A1/en active Pending
- 2018-03-29 EA EA201992300A patent/EA201992300A1/ru unknown
- 2018-03-29 ES ES18718340T patent/ES2864450T3/es active Active
- 2018-03-29 KR KR1020197031634A patent/KR102720054B1/ko active Active
- 2018-03-29 CN CN201880022423.XA patent/CN110914260A/zh active Pending
- 2018-03-29 WO PCT/US2018/025114 patent/WO2018183656A1/en not_active Ceased
- 2018-03-29 SM SM20210239T patent/SMT202100239T1/it unknown
- 2018-03-29 CN CN202310552731.6A patent/CN116813561A/zh active Pending
- 2018-03-29 HR HRP20210764TT patent/HRP20210764T1/hr unknown
- 2018-03-29 CA CA3058177A patent/CA3058177A1/en active Pending
- 2018-03-29 WO PCT/US2018/025100 patent/WO2018183649A1/en not_active Ceased
- 2018-03-29 KR KR1020257017189A patent/KR20250080914A/ko active Pending
- 2018-03-29 DK DK18718340.5T patent/DK3601268T3/da active
- 2018-03-29 AU AU2018244916A patent/AU2018244916B2/en active Active
- 2018-03-29 EP EP23209227.0A patent/EP4296258A3/en active Pending
- 2018-03-29 CN CN202310263681.XA patent/CN116354939A/zh active Pending
-
2019
- 2019-09-20 MX MX2022010496A patent/MX2022010496A/es unknown
- 2019-09-20 MX MX2022010495A patent/MX2022010495A/es unknown
-
2020
- 2020-12-22 US US17/131,718 patent/US11649226B2/en active Active
-
2021
- 2021-04-29 CY CY20211100374T patent/CY1124194T1/el unknown
- 2021-08-11 US US17/400,100 patent/US12545665B2/en active Active
- 2021-11-01 AU AU2021261839A patent/AU2021261839B2/en active Active
-
2022
- 2022-07-25 JP JP2022117894A patent/JP7457758B2/ja active Active
-
2023
- 2023-01-27 JP JP2023010810A patent/JP7476370B2/ja active Active
- 2023-04-13 US US18/134,564 patent/US12565487B2/en active Active
- 2023-12-11 JP JP2023208420A patent/JP7837938B2/ja active Active
-
2025
- 2025-12-26 JP JP2025284416A patent/JP2026067880A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020512380A5 (https=) | ||
| TWI847144B (zh) | 奧美卡替莫卡必爾的合成 | |
| CA2614334A1 (en) | Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide | |
| JP2022533340A5 (https=) | ||
| JP2012500819A5 (https=) | ||
| JP2022533433A5 (https=) | ||
| JP2022517842A (ja) | ７－シクロペンチル－２－（５－ピペラジン－１－イル－ピリジン－２－イルアミノ）－７Ｈ－ピロロ［２，３－ｄ］ピリミジン－６－カルボン酸ジメチルアミドのコハク酸塩の新規な結晶形態 | |
| JP2010500406A5 (https=) | ||
| JP2024514090A5 (https=) | ||
| CN116924941A (zh) | Oab-14的晶型b及其制备方法 | |
| JP2018522945A5 (https=) | ||
| JP2024529763A5 (https=) | ||
| CN107954984B (zh) | 烟嘧磺隆的一种晶型的晶体及其制备方法 | |
| JP2010502682A5 (https=) | ||
| CN108530364B (zh) | 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用 | |
| CN1315818C (zh) | 一种雷尼替丁碱及其盐酸盐的合成方法 | |
| JP2020083892A5 (https=) | ||
| CN108033923B (zh) | 一种三氮唑钠盐或钾盐的制备方法 | |
| JP4655930B2 (ja) | キノリンカルボン酸誘導体溶媒和物の結晶 | |
| CN103980292B (zh) | 头孢克肟三水合物的结晶方法 | |
| JPH01242582A (ja) | キノロンカルボン酸化合物ｉ型結晶の製造法 | |
| CN111440081A (zh) | 一种制备粒度超均一的无水甜菜碱晶体的方法 | |
| KR101585189B1 (ko) | 사포그릴레이트 염산염 결정형 ⅱ의 제조방법 | |
| KR960015966B1 (ko) | 결정상 항생제 중간물질 | |
| JP2020536898A5 (https=) |