CN114787154A - 一种Deucravacitinib的晶型及其制备方法和用途 - Google Patents
一种Deucravacitinib的晶型及其制备方法和用途 Download PDFInfo
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- CN114787154A CN114787154A CN202080082982.7A CN202080082982A CN114787154A CN 114787154 A CN114787154 A CN 114787154A CN 202080082982 A CN202080082982 A CN 202080082982A CN 114787154 A CN114787154 A CN 114787154A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
化合物(I)的晶型及其制备方法，含有该晶型的药物组合物，以及该晶型在制备TYK2抑制剂药物和治疗银屑病、系统性红斑狼疮和克罗恩病药物中的用途。化合物I的晶型比现有技术具有一种或多种改进的性质，对未来该药物的优化和开发具有重要价值。
Description
PCT国内申请，说明书已公开。
Claims (8)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010061688X | 2020-01-19 | ||
| CN202010061688 | 2020-01-19 | ||
| PCT/CN2020/139815 WO2021143498A1 (zh) | 2020-01-19 | 2020-12-28 | 一种Deucravacitinib的晶型及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114787154A true CN114787154A (zh) | 2022-07-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080082982.7A Pending CN114787154A (zh) | 2020-01-19 | 2020-12-28 | 一种Deucravacitinib的晶型及其制备方法和用途 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20230049130A1 (zh) |
| CN (1) | CN114787154A (zh) |
| WO (1) | WO2021143498A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116615200A (zh) * | 2020-10-20 | 2023-08-18 | 杭州领业医药科技有限公司 | 哒嗪衍生物的晶型 |
| WO2023102085A1 (en) | 2021-12-01 | 2023-06-08 | Teva Czech Industries S.R.O. | Solid state forms of deucravacitinib, deucravacitinib hcl and process for preparation of deucravacitinib and intermediates |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104884454A (zh) * | 2012-11-08 | 2015-09-02 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的酰胺取代的杂环化合物 |
| WO2018183656A1 (en) * | 2017-03-30 | 2018-10-04 | Bristol-Myers Squibb Company | Crystal form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
| WO2019232138A1 (en) * | 2018-05-31 | 2019-12-05 | Bristol-Myers Squibb Company | Crystalline form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2300013T3 (en) * | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
| EP3555111B1 (en) * | 2016-12-13 | 2022-01-26 | Bristol-Myers Squibb Company | Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of il-12, il-23, and/or ifn alpha responses |
-
2020
- 2020-12-28 WO PCT/CN2020/139815 patent/WO2021143498A1/zh active Application Filing
- 2020-12-28 US US17/787,992 patent/US20230049130A1/en active Pending
- 2020-12-28 CN CN202080082982.7A patent/CN114787154A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104884454A (zh) * | 2012-11-08 | 2015-09-02 | 百时美施贵宝公司 | 用作IL-12、IL-23和/或IFNα应答调节剂的酰胺取代的杂环化合物 |
| WO2018183656A1 (en) * | 2017-03-30 | 2018-10-04 | Bristol-Myers Squibb Company | Crystal form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
| CN110475774A (zh) * | 2017-03-30 | 2019-11-19 | 百时美施贵宝公司 | 用于制备6-(环丙烷酰氨基)-4-((2-甲氧基-3-(1-甲基-1h-1,2,4-三唑-3-基)苯基)氨基)-n-(甲基-d3)哒嗪-3-甲酰胺的方法 |
| WO2019232138A1 (en) * | 2018-05-31 | 2019-12-05 | Bristol-Myers Squibb Company | Crystalline form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
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| Publication number | Publication date |
|---|---|
| WO2021143498A1 (zh) | 2021-07-22 |
| US20230049130A1 (en) | 2023-02-16 |
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Application publication date: 20220722 |