CN110475774B - 用于制备Tyk2抑制剂的方法 - Google Patents

用于制备Tyk2抑制剂的方法 Download PDF

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CN110475774B
CN110475774B CN201880021649.8A CN201880021649A CN110475774B CN 110475774 B CN110475774 B CN 110475774B CN 201880021649 A CN201880021649 A CN 201880021649A CN 110475774 B CN110475774 B CN 110475774B
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compound
following formula
formula
reaction
base
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CN110475774A (zh
Inventor
陈珂
J·迪尔伯格
D·林
M·杜梅尔丁格
B·伊南库尔
S·V·科洛图钦
李峻
A·J·罗杰斯
V·W·罗索
E·M·西蒙斯
M·C·D·苏梅兰特
D·S·特雷特尔
J·王
郑斌
M·J·史密斯
N·A·斯特罗门
S·泰蒙科
T·本科维奇
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
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    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201880021649.8A 2017-03-30 2018-03-29 用于制备Tyk2抑制剂的方法 Active CN110475774B (zh)

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US201762478789P 2017-03-30 2017-03-30
US62/478,789 2017-03-30
PCT/US2018/025100 WO2018183649A1 (en) 2017-03-30 2018-03-29 Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide

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CN201880021649.8A Active CN110475774B (zh) 2017-03-30 2018-03-29 用于制备Tyk2抑制剂的方法
CN201880022423.XA Pending CN110914260A (zh) 2017-03-30 2018-03-29 6-(环丙烷甲酰氨基)-4-((2-甲氧基-3-(1-甲基-1h-1,2,4-三唑-3-基)苯基)氨基)-n-(甲基-d3)哒嗪-3-甲酰胺的晶体形式
CN202310552731.6A Pending CN116813561A (zh) 2017-03-30 2018-03-29 用于制备Tyk2抑制剂的方法
CN202310263681.XA Pending CN116354939A (zh) 2017-03-30 2018-03-29 一种化合物的结晶形式

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CN201880022423.XA Pending CN110914260A (zh) 2017-03-30 2018-03-29 6-(环丙烷甲酰氨基)-4-((2-甲氧基-3-(1-甲基-1h-1,2,4-三唑-3-基)苯基)氨基)-n-(甲基-d3)哒嗪-3-甲酰胺的晶体形式
CN202310552731.6A Pending CN116813561A (zh) 2017-03-30 2018-03-29 用于制备Tyk2抑制剂的方法
CN202310263681.XA Pending CN116354939A (zh) 2017-03-30 2018-03-29 一种化合物的结晶形式

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CN (4) CN110475774B (https=)
AU (3) AU2018244451B2 (https=)
CA (2) CA3058209A1 (https=)
CY (1) CY1124194T1 (https=)
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EA (2) EA201992308A1 (https=)
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KR20230137962A (ko) * 2021-01-29 2023-10-05 브리스톨-마이어스 스큅 컴퍼니 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3)피리다진-3-카르복스아미드의 결정 형태
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CN117447411B (zh) * 2022-07-18 2025-12-23 苏州鹏旭医药科技有限公司 一种杂环药物中间体的合成方法
WO2024017150A1 (zh) * 2022-07-18 2024-01-25 苏州鹏旭医药科技有限公司 一种氘可来昔替尼的合成方法
WO2024088282A1 (zh) * 2022-10-28 2024-05-02 浙江华海药业股份有限公司 一种哒嗪酰胺类化合物、其药物组合物及其作为tyk2抑制剂的用途
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WO2025131031A1 (zh) * 2023-12-22 2025-06-26 上海奥博生物医药股份有限公司 一种TyK2抑制剂及其中间体的制备方法
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